High Blood Cholesterol for Health Professionals

Clinical Practice Guidelines

The IOM (2011) defined clinical practice guidelines as "statements that include recommendations intended to optimize patient care that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options."

Systematic Evidence Reviews

In 2011, the Institute of Medicine (IOM) defined a systematic evidence review as "a scientific investigation that focuses on a specific question and uses explicit, prespecified scientific methods to identify, select, assess, and summarize the findings of similar but separate studies.


Two researchers work together in a laboratory while wearing masks.
Research Feature
A cell-based look at how the body responds to immune threats may one day help researchers find better treatments for this major U.S. killer For more than a decade, researchers have known that a core component of human immune function – called complement – can influence how the body responds to immune threats. Now researchers from the NIH and around the world say they’ve gained new knowledge about how the body responds to these threats inside of cells, too. They specifically found that complement can activate pro-inflammatory responses, such as cholesterol crystals that can start accumulating...