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The IOM (2011) defined clinical practice guidelines as "statements that include recommendations intended to optimize patient care that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options."
In 2011, the Institute of Medicine (IOM) defined a systematic evidence review as "a scientific investigation that focuses on a specific question and uses explicit, prespecified scientific methods to identify, select, assess, and summarize the findings of similar but separate studies.
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) is participating i...