Patient and health professional.

NHLBI Clinical Trials

These NHLBI-sponsored research studies are for patients who have heart, lung, blood, or sleep-related diseases.

Acute Respiratory Distress Syndrome

Is your child on a ventilator for acute respiratory distress syndrome (ARDS)?

This study is testing whether lying facedown and using a type of ventilation called high-frequency oscillatory ventilation improves breathing in children who have ARDS. To participate in this study, your child must be younger than age 18, diagnosed with ARDS, and on a ventilator. This study is located in 23 states in the United States, as well as in Australia, Canada, the Netherlands, and Thailand.

Alpha-1 Antitrypsin Deficiency

Are you an adult who is healthy or has lung disease?

This study aims to collect blood, urine, and airway samples from healthy volunteers and from people who have lung disease. Researchers will use the samples to study genes and proteins that may be involved in lung disease. To participate in this study, you must be at least 18 years old or older. This study is located in New York, New York.

Causes and progression of chronic lung disease

This study aims to develop a better understanding of lung disorders. This study also identifies patients who are eligible to participate in other research studies. To participate in this study, you must be between 7 and 90 years old and have symptoms of lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Anemia (en español)

¿Desea participar en la investigación sobre la sangre?

El estudio tiene como objetivo evaluar en el Centro Clínico de Institutos Nacionales de la Salud a pacientes que tienen un trastorno sanguíneo como la anemia y que pueden ser elegibles para participar en los estudios en la rama de Hematología. También determinará si es seguro para usted participar en esos estudios. Para ser evaluado, usted o su hijo deben tener al menos dos años y ser atendidos en el Centro Clínico en Bethesda, Maryland.

¿Recientemente dio a luz a un bebé de muy bajo peso al nacer?

El estudio está investigando cómo la anemia y las transfusiones de glóbulos rojos afectan los niveles de oxígeno en el tracto digestivo de bebés que nacen con muy bajo peso. Para participar, su bebé recién nacido debe haber tenido un peso muy bajo al nacer y estar dentro de los siete días posteriores al nacimiento. El estudio se lleva a cabo en Atlanta, Georgia.

¿Tuvo un ataque al corazón y quiere ayudar a determinar la mejor estrategia para una transfusión de sangre?

El estudio está comparando dos estrategias para transfusiones de sangre en pacientes que han tenido un ataque al corazón y tienen anemia. Esto ayudará a los médicos a decidir si administrar una transfusión de sangre de inmediato a los pacientes con ataque cardíaco que están anémicos, o esperar y ver si su condición mejora. Para participar, debe ser un adulto hospitalizado por un ataque al corazón y tener anemia. El estudio se lleva a cabo en New Brunswick, Nueva Jersey.

¿Le diagnosticaron a usted o a su hijo anemia de Diamond-Blackfan?

El registro está recopilando información de personas con anemia de Diamond-Blackfan para mejorar la comprensión de la enfermedad. Para participar, usted o su hijo deben estar diagnosticados con anemia de Diamond-Blackfan. Completará un cuestionario, proporcionará acceso a sus registros médicos y de laboratorio y responderá preguntas por teléfono al personal del estudio. Este estudio se lleva a cabo en Long Island, Nueva York.

Anemia

Have you had a heart attack, and do you want to help improve strategies for blood transfusion?

The study is comparing two strategies for blood transfusions in heart attack patients who have anemia—whether to give a blood transfusion when the hemoglobin level is less than 10 g/dL, or to give blood only when the blood count is below 8 g/dL. To participate in this study, you must be at least 18 years old, have anemia, and be hospitalized for a heart attack. The study is located in New Brunswick, New Jersey.

Did you recently give birth to a very low birth weight infant?

The study is investigating how anemia and red blood cell transfusions affect oxygen levels in the digestive tract of very low birth weight infants. To participate in this study, your newborn must have had a very low birth weight and be within seven days of birth. The study is taking place in Atlanta, Georgia.

Do you want to take part in blood research?

This study aims to screen patients at the National Institutes of Health Clinical Center who have a blood disorder such as anemia and who may be eligible to participate in studies in the Hematology Branch. It will also determine whether it is safe for you to participate in those studies. Participants in this study must be 2 years or older. This study is located in Bethesda, Maryland.
View more information about Screening for Hematology Branch Protocols.

Anemia de células falciformes (en español)

¿Es usted un adulto con dolor crónico debido a la anemia de células falciformes?

Este estudio prueba un nuevo programa computarizado que tiene como objetivo ayudar a los pacientes con la anemia de células falciformes a controlar el dolor. Los participantes deben tener al menos 18 años y tener dolor crónico. Este estudio está ubicado en Pittsburgh (Pensilvania).

Muestras de sangre para pruebas genéticas

Este estudio analizará si un gen en particular en personas con la anemia de células falciformes aumenta el riesgo de tener síntomas y complicaciones severos. Para participar en este estudio, debe tener entre 18 y 80 años y no haber recibido una transfusión de sangre en las 8 semanas anteriores. Este estudio está ubicado en Bethesda (Maryland).

Investigación sobre trastornos sanguíneos

Este estudio está recopilando información médica de exámenes de salud y pruebas y procedimientos de rutina para ver si los participantes pueden inscribirse en otros estudios sobre trastornos sanguíneos. Los participantes en este estudio deben tener al menos 8 años, con o sin un trastorno sanguíneo. Este estudio está ubicado en Bethesda (Maryland).

¿Tiene entre 16 y 20 años y está dispuesto a responder preguntas sobre el control de la anemia de células falciformes?

Este estudio investiga la atención y la calidad de vida de los pacientes con la anemia de células falciformes en la transición de la atención pediátrica a la de adultos. Para participar en este estudio, debe tener entre 16 y 20 años y ser paciente del hospital de investigación infantil St. Jude. Este estudio se encuentra en Memphis (Tennessee).

¿Tiene un niño de 12 a 18 años que tiene la anemia de células falciformes y está interesado en la hipnosis?

Este estudio prueba si la hipnosis tiene un efecto sobre el flujo sanguíneo y el dolor en adolescentes que tienen la anemia de células falciformes. Para participar en este estudio, debe tener entre 12 y 18 años y dominar el idioma inglés. Este estudio se encuentra en Los Ángeles (California).

Crisis de dolor y complicaciones pulmonares en la anemia de células falciformes

Este estudio está interesado en comprender las crisis de dolor y las complicaciones pulmonares que ocurren en pacientes con la anemia de células falciformes y pacientes con otros trastornos de los glóbulos rojos. Para participar en este estudio, debe tener al menos 2 años de edad, tener diagnostico de anemia de células falciformes, o la sospecha de que padece esta enfermedad, el rasgo de células falciformes, u otros trastornos de los glóbulos rojos. Los participantes tendrán un examen físico y recibirán atención médica estándar para la anemia de células falciformes, incluidas las pruebas y los procedimientos de seguimiento de rutina. Este estudio se encuentra en Washington, D.C. y en Bethesda (Maryland).

¿Usted o su hijo tienen talasemia HbSS o Sβ0 y están dispuestos a proporcionar muestras de sangre y orina durante una crisis de dolor?

Este estudio analizará si los cambios en la sangre y la orina se pueden usar para controlar si se ha desarrollado una lesión renal aguda como resultado de una crisis de dolor o un síndrome de tórax agudo. Los participantes en este estudio deben tener entre 1 y 25 años y ser admitidos con una crisis de dolor o síndrome de tórax agudo. Este estudio se encuentra en Birmingham (Alabama).

¿Está usted o su hijo interesado en donar una muestra de médula ósea para investigación?

Este estudio recogerá muestras de médula ósea de pacientes que tienen la anemia de células falciformes o β-talasemia para ayudar a desarrollar terapias genéticas. Los participantes en este estudio deben tener al menos 2 años y tener la anemia de células falciformes o β-talasemia. Puede continuar los tratamientos regulares mientras participa en el estudio. Este estudio se encuentra en Memphis (Tennessee).

Pruebas de la función renal y la anemia de células falciformes

Este estudio comparará dos pruebas de laboratorio diferentes para medir la función renal en adultos con la anemia de células falciformes. Los participantes en este estudio deben tener al menos 18 años y no haber experimentado una crisis de dolor en el último mes o un cambio en el tratamiento en los últimos 2 meses. Este estudio está ubicado en Bethesda (Maryland).

Trasplante de médula ósea para pacientes con anemias congénitas severas

Este estudio tiene como objetivo mejorar los procedimientos de trasplante de médula ósea (BMT, por sus siglas en inglés) para pacientes mayores mediante el uso de una dosis baja de radiación y dos medicamentos inmunosupresores en lugar de quimioterapia. Este tipo de procedimiento de BMT se describe como no mieloablativo porque no destruye la médula ósea. Los participantes en este estudio deben tener entre 2 y 65 años; tener una anemia congénita severa, como la anemia de células falciformes o beta talasemia; y tener un hermano que sea un donante de células madre altamente compatible. Este estudio está ubicado en Bethesda (Maryland).

¿Es usted un adulto que tiene la anemia de células falciformes y sibilancias no causadas por asma?

Este estudio probará una medicina inhalada llamada mometasona para las personas que tienen la anemia de células falciformes y sibilancias que no son causadas por el asma. Para participar en este estudio, debe tener al menos 18 años y no debe tener asma, síntomas respiratorios agudos o una crisis de dolor actual. Este estudio se encuentra en Nueva York (Nueva York).

¿Usted o su hijo tienen la anemia de células falciformes y presión arterial alta?

Este estudio explora si el uso de losartán, un medicamento comúnmente utilizado para reducir la presión arterial, es efectivo para tratar la presión arterial anormal durante la noche en niños y adultos jóvenes que tienen la anemia de células falciformes. Los participantes en este estudio deben tener entre 5 y 25 años, y tener presión arterial alta y un cierto tipo de anemia de células falciformes: hemoglobina SS o talasemia Sβ0. Este estudio se encuentra en Birmingham (Alabama).

¿Usted o su hijo tienen la anemia de células falciformes y también, interés en contribuir a la recopilación de datos a largo plazo?

Este estudio monitorea pacientes y recolecta muestras biológicas de pacientes que tienen la anemia de células falciformes para comprender mejor los resultados a largo plazo. Los participantes pueden ser de cualquier edad y deben tener la anemia de células falciformes. Este estudio se encuentra en seis sitios en Illinois, Luisiana, Carolina del Norte y Tennessee.

Embarazo y donación de cordón umbilical para la anemia de células falciformes

Este estudio busca determinar la mejor manera de recolectar, almacenar y manejar la sangre de los bebés recién nacidos para ayudar a los investigadores a mejorar las futuras terapias para la anemia de células falciformes. Para participar en este estudio, debe estar embarazada, tener 45 años o menos y estar dispuesta a donar sangre del cordón umbilical de su bebé recién nacido. Los bebés recién nacidos pueden estar sanos o correr el riesgo de tener la enfermedad o el rasgo de células falciformes. Este estudio está ubicado en Bethesda (Maryland).

¿Tiene anemia de células falciformes o talasemia, o es un voluntario saludable que está dispuesto a someterse a una IRM cerebral?

Este estudio tiene como objetivo comprender si la anemia de células falciformes o la talasemia afectan los procesos que aumentan naturalmente el flujo sanguíneo en el cerebro cuando las personas experimentan estrés. Los investigadores medirán el flujo sanguíneo con imágenes de resonancia magnética (IRM) cerebrales. Los participantes en este estudio deben tener al menos 7 años y tener la anemia de células falciformes o talasemia. También pueden participar los voluntarios sanos. Este estudio se encuentra en Los Ángeles (California).

¿Es usted un adulto que tiene dolor asociado a la anemia de células falciformes y tiene problemas para dormir?

Este estudio analizará si mejorar el sueño también reduce el dolor en personas con la anemia de células falciformes y dolor crónico. Los participantes en este estudio deben tener al menos 18 años, tener diagnosticada la anemia de células falciformes y experimentar insomnio y dolor crónico. Este estudio se encuentra en Baltimore (Maryland).

Mejora de los trasplantes de médula ósea

Este estudio está explorando cómo mejorar los procedimientos de trasplante de médula ósea para que el cuerpo acepte mejor las células madre de los donantes. Para participar en este estudio, debe tener al menos cuatro años, tener la anemia de células falciformes, y tener un donante de células madre. Este estudio está ubicado en Bethesda (Maryland).

¿Tiene entre 15 y 40 años y anemia de células falciformes severa?

Este estudio compara resultados a largo plazo para los pacientes que reciben trasplantes de sangre y médula ósea y aquellos que reciben un tratamiento estándar con medicinas. Los participantes también tienen la opción de contribuir con muestras de sangre que se almacenarán para futuras investigaciones. Los participantes deben tener entre 15 y 40 años y tener la anemia de células falciformes severa. Este estudio se encuentra en Madison (Wisconsin).

¿Usted o su hijo tienen anemia de células falciformes severa y también conocen a un donante de médula ósea semicompatible?

Este estudio busca mejorar el éxito del trasplante de médula ósea de donantes semicompatibles mediante la prueba de un procedimiento de acondicionamiento diferente que utiliza una variedad de medicinas para prepararse para el trasplante. Para participar en este estudio, debe tener entre 15 y 45 años y la anemia de células falciformes severa, o tener un hijo de 5 a 14 años que haya sufrido un derrame cerebral. Este estudio se encuentra en muchos sitios en todos los Estados Unidos, incluidos Miami, Florida y St. Louis (Missouri).

¿Usted o su hijo necesitan un trasplante de células madre?

Este estudio explora el uso del tratamiento con ciertas medicinas en combinación con radiación para un trasplante exitoso de células madre. Para participar en este estudio, debe ser menor de 49 años y tener una enfermedad severa tratable mediante un trasplante de células madre. Este estudio se encuentra en varios sitios en los Estados Unidos, incluidos Aurora (Colorado), Seattle (Washington) y Milwaukee (Wisconsin).

Anemia de células falciformes

Procedimiento de trasplante de células madre con una compatibilidad parcial

Este estudio está probando nuevas formas de mejorar un procedimiento de trasplante de células madre que involucra a un donante que no es totalmente compatible, llamada compatibilidad parcial. Para participar en este estudio, debe tener al menos 18 años y tener la anemia de células falciformes severa y un donante con compatibilidad parcial. Este estudio está ubicado en Bethesda (Maryland).

Angina (en español)

¿Tiene diabetes y antecedentes de ataque cardíaco?

Este es un estudio de seguimiento del Ensayo clínico para acceder a la terapia de quelación (en inglés, TACT por sus siglas en inglés), el cual reveló que los medicamentos para ayudar a eliminar los metales en la sangre redujeron el riesgo de complicaciones de la enfermedad isquémica del corazón (incluida la angina inestable) en personas con diabetes que habían tenido un ataque cardíaco previo. Para participar en este estudio, debe tener al menos 50 años y tener una historia clínica que incluya diabetes y ataque al corazón. Este estudio se realizaen Miami (Florida).

¿Desea participar en la investigación sobre el corazón?

Este estudio tiene como objetivo ayudar a capacitar al personal en una variedad de enfermedades cardíacas mediante la evaluación de pacientes de todas las edades que tienen enfermedades cardíacas (o corren el riesgo de sufrir dichas enfermedades) en el Centro Clínico de los Institutos Nacionales de la Salud. Los participantes en el estudio deben tener síntomas de enfermedades cardiovasculares o estar en riesgo de tener una. Algunos ejemplos de enfermedades cardiovasculares incluyen enfermedad isquémica del corazón, enfermedad valvular del corazón, cardiomiopatías, enfermedad arterial periférica, enfermedad congénita del corazón y enfermedad vascular de los riñones. Este estudio se encuentra en Bethesda, Maryland.

Angina

Evaluating heart conditions

This study aims to help train staff on a range of heart conditions by evaluating patients of all ages at the NIH Clinical Center who have heart disease or are at risk of heart disease. Participants in the study must be at risk for or have symptoms of cardiovascular diseases. Some examples of cardiovascular diseases include coronary heart disease, heart valve disease, cardiomyopathies, peripheral artery disease, congenital heart disease, and vascular disease of the kidneys. This study is located in Bethesda, Maryland.

Do you have diabetes and a history of heart attack?

This is a follow-on study of the Trial to Assess Chelation Therapy (TACT), which showed that medicine to help remove metals in the blood reduced the risk of ischemic heart disease complications, including stroke and unstable angina, in people who have diabetes who had a prior heart attack. To participate in this study, you must be at least 50 years old and have a history of diabetes and heart attack. This study is located in Miami, Florida.

Aplastic Anemia

Are you considering a blood stem cell transplant?

This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. To participate in this study, you must have a well-matched donor; you and your donor must be between 4 and 80 years old; and you must not be a candidate for immunosuppressive therapy. This study is located in Bethesda, Maryland.

Do you or a family member have Diamond-Blackfan anemia?

This registry seeks to collect information from patients who have Diamond-Blackfan anemia (DBA), in order to help researchers and doctors learn more about the condition. The registry will also help connect patients with DBA to research and clinical studies, and possible treatment options. The registry accepts all patients diagnosed with DBA.
View more information about Diamond-Blackfan Anemia Registry (DBAR).

Do you or your child require care for a blood disorder?

This study provides training for NHLBI blood doctors in the evaluation and care of patients who have blood disorders. Participants in this study must be 2 years or older. This study is located in Bethesda, Maryland.

Have you received a stem cell transplant?

This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. To participate in this study, you must be between 10 and 80 years old and had your transplant more than 3 years ago. This study is located in Bethesda, Maryland.

Do you have short telomeres and a telomere gene mutation?

Some people who have aplastic anemia have very short telomeres, which protect the ends of DNA in chromosomes. This study is testing whether low doses of the medicine danazol help prevent telomeres from getting shorter and reduce signs of damage from aplastic anemia or related conditions. Participants in this study must be 3 years or older and have a telomere disease and signs of aplastic anemia, lung disease such as pulmonary fibrosis, or liver disease. This study is located in Bethesda, Maryland.

Do you lack a well-matched donor for a blood and bone marrow transplant?

This study aims to determine whether a transplant of umbilical cord blood from an unrelated donor or a blood and bone marrow transplant from a partial match donor are suitable alternatives for people who do not have a well-matched donor. To participate in this study, you must be younger than 75, have severe aplastic anemia, have tried immunosuppressants without success, and not have a well-matched donor. This study is located in 28 cities across the United States.

Blood disorder research

This study is collecting medical information from health exams and routine tests and procedures to see whether participants may be able to enroll in other studies on blood disorders. Participants in this study must be at least 8 years, with or without a blood disorder. This study is located in Bethesda, Maryland.

Are you scheduled for a stem cell transplant with cord blood?

This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.

Apnea del sueño (en español)

¿Es usted un adulto con apnea del sueño que quiere ayudar a comprender esta enfermedad mediante el uso de un dispositivo bucal o boquilla?

Este estudio, el cual intenta comprender cómo se colapsan las vías respiratorias superiores en pacientes con apnea obstructiva del sueño durante el sueño, utilizará esta información para explicar por qué algunos pacientes presentan una gran mejoría en la apertura de las vías respiratorias superiores con el uso de un dispositivo bucal mientras que otros no. Deberá someterse a algunos exámenes especiales, como una endoscopia y estudios del sueño. Para participar, debe tener entre 21 y 70 años y sufrir apnea obstructiva del sueño. El estudio se está realizando en Boston.

¿Tiene un hijo o hija con apnea del sueño a quien le pueda interesar un nuevo tratamiento con aerosol nasal?

Este estudio evaluará el uso de un aerosol nasal para el tratamiento de la apnea obstructiva del sueño en niños. Para participar, los niños deben tener entre 5 y 10 años, no haber tenido cirugía para remover las amígdalas y nunca haber usado una máquina CPAP. El estudio se está realizando en Filadelfia.

¿Tiene a su cargo un adolescente o adulto joven con apnea del sueño y síndrome de Down?

El objetivo de este estudio es evaluar si un dispositivo que se implanta en el cuerpo para estimular los nervios de la lengua y que ya ha sido aprobado para su uso en adultos con apnea obstructiva del sueño puede implantarse y usarse con seguridad en adolescentes y adultos jóvenes con síndrome de Down. Para participar, los jóvenes con síndrome de Down deben tener entre 10 y 21 años, y se les deben haber extirpado las amígdalas. Los estudios se están realizando en Atlanta, Boston, Cincinnati, Cleveland y Pittsburgh.

¿Es usted un adulto con apnea del sueño y diabetes tipo 2?

Este estudio analiza si el uso de una máquina de CPAP puede mejorar los niveles de azúcar en sangre, disminuir la presión arterial y revertir el daño a los vasos sanguíneos en pacientes con apnea obstructiva del sueño y diabetes tipo 2. Para participar, debe tener entre 21 y 75 años y tener apnea obstructiva del sueño y diabetes tipo 2. El estudio se está realizando en Baltimore.

Arrhythmia

Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery?

This study will examine whether adding oral anti-blood clotting medicines to anti-platelet medicines (such as aspirin) helps prevent stroke and other complications in people who develop atrial fibrillation after CABG surgery. To participate in this study, you must be at least 18 years old and have been diagnosed with atrial fibrillation after having CABG surgery. The study is located in 63 places in 22 states, the District of Columbia, Canada, and Germany.

Do you know someone who will be having heart surgery?

This study aims to identify what genetic patterns might cause atrial fibrillation and other adverse events that happen after heart surgery. To participate in this study, you must be between 20 and 90 years old. The study is in three locations in Massachusetts and Texas.

Do you have persistent atrial fibrillation?

Cardiac mapping is a tool doctors use to understand the pattern of electrical signals generating arrhythmia in a patient’s heart. This study aims to test a method for analyzing cardiac mapping results to see if it can improve the treatment of persistent atrial fibrillation. To participate in this study, you must be 21 or older and must have tried ablation to treat your atrial fibrillation once before. The study is located in Miami, Florida.

Are you planning to have an ablation procedure for atrial fibrillation?

This study aims to improve a medicine used to prevent a repeat atrial fibrillation event after ablation treatment. Researchers will compare different formulas of the medicine propafenone. To participate in this study, you must be 18 or older and be scheduled for your first ablation procedure to treat atrial fibrillation. The study is located in Nashville, Tennessee.

Do you have heart disease that requires an ICD to prevent sudden cardiac arrest?

This study aims to learn what signs distinguish patients who have a higher risk of an arrhythmia that leads to sudden cardiac arrest. Researchers plan to track patients with a recent ICD replacement for 10 years. To participate in this study, you must be between 18 and 85 years old. This study is located in Washington, D.C.; Baltimore, Maryland; and Richmond, Virginia.

Are you a stroke survivor?

This study aims to develop an app for smartwatches and smartphones to test several atrial fibrillation monitoring devices for patients who have had a stroke or transient ischemic attack. To participate in this study, you must be at least 50 years old and have been admitted to the UMass Memorial Medical Center for a stroke or TIA. The study is located in Worcester, Massachusetts.

Have you been treated for ventricular tachycardia?

This study tests the safety and effectiveness of a new tool for doing radiofrequency catheter ablations, a treatment for some conduction disorders. To participate in this study, you must be at least 18 years old and have ventricular tachycardia that has not gone away after treatment with medicine, ablation, and placement of an implantable cardioverter defibrillator (ICD). This study is located in Illinois and Minnesota.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Are you being treated for atrial fibrillation?

This study aims to compare two types of ablation treatment for patients who continue to have symptoms of atrial fibrillation despite treatment with medicines. The two ablation procedures treat different areas of tissue. To participate in this study, you must be at least 21 years old. The study is located in Palo Alto and San Diego, California.

Do you have a ventricular arrhythmia?

This study aims to evaluate the safety and effectiveness of low-energy shocks for the treatment of ventricular tachycardia and ventricular fibrillation. This approach will be tested during a catheter ablation or placement of an implantable cardioverter defibrillator (ICD). To participate in this study, you must be between 18 and 75 years old. This study is located in Minneapolis, Minnesota, and Austin, Texas.

Asbestos-Related Lung Diseases

Are you an adult who has idiopathic pulmonary fibrosis or an advanced lung cancer?

This study aims to see whether a new imaging dye for positron emission tomography (PET) is effective at looking at fibrosis in lung cancer and idiopathic pulmonary fibrosis (IPF). Participants will be given the imaging dye and then receive a PET scan. To participate in this study, you must either be between 18 and 80 years old and have lung cancer or be a healthy volunteer or be between 50 and 80 years old and have IPF. This study is located in Boston, Massachusetts.

Asma (en español)

¿Es usted un adulto que tiene asma y alergias y está dispuesto a someterse a estudios de imágenes cerebral?

Este estudio analizará si las reacciones en el cerebro están asociadas con inflamación en los pulmones. Los investigadores usarán estudios de imagen para monitorear la inflamación en el cerebro causada por la exposición a niveles ambientales de factores comunes que se sabe que causan asma. Para participar en este estudio, debe tener entre 18 y 50 años; haber tenido un resultado positivo en la prueba cutánea para ácaros del polvo del hogar, la ambrosía o el pelo de gato, y no tener ninguna otra enfermedad crónica. Este estudio se realiza en Madison, Wisconsin.

¿Es usted un adulto que tiene asma y quiere ayudar a comprender la biología de las vías respiratorias?

Este estudio analizará las diferencias entre las células de las vías respiratorias de las personas que tienen y las que no tienen asma. Los médicos usarán un procedimiento llamado broncoscopía para recolectar células. Para participar en este estudio, debe tener entre 18 y 75 años, no tener VIH y no estar embarazada o planeando quedar embarazada en este momento. Este estudio se realiza en Bethesda, Maryland.

¿Su hijo tiene asma y ancestros afroamericanos o puertorriqueños?

Este estudio analizará cómo hacer que los niños y los adolescentes identifiquen sus síntomas de asma temprano, por medio de un medidor de flujo máximo. Para participar en este estudio, su hijo debe tener entre 10 y 17 años, un diagnostico de asma y, al menos, un progenitor que se identifique como afroamericano o puertorriqueño. Este estudio se realiza en Bronx, Nueva York.

¿Es usted un adulto que tiene asma y quiere ayudar a que los investigadores entenderla mejor?

Este estudio recopilará información general sobre las personas que han tenido asma durante un período de 20 años para comprender por qué los pacientes responden de manera diferente al tratamiento. Para participar en este estudio, debe ser mayor de 18 años, haber recibido un diagnóstico de asma durante al menos un año y no tener ninguna otra afección importante. Este estudio se realiza en Bethesda, Maryland.

Causas y progresión de la enfermedad pulmonar crónica

Este estudio tiene como objetivo desarrollar una mejor comprensión de los trastornos pulmonares. Este estudio también identifica a pacientes que son elegibles para participar en otros estudios de investigación. Para participar en este estudio, debe tener entre 7 y 90 años y tener síntomas de la enfermedad pulmonar. Este estudio se encuentra en Bethesda (Maryland) en el Centro Clínico de los NIH.

Genes involucrados en el desarrollo de enfermedades pulmonares

Este estudio investigará los genes implicados en el proceso respiratorio y en el desarrollo de enfermedades pulmonares como el asma o la sarcoidosis para mejorar la comprensión del papel que ellos desempeñan. Para participar en este estudio, usted o su hijo deben tener entre 2 y 90 años y haber sido diagnosticado y estar viviendo con una enfermedad pulmonar. Este estudio se realiza en Bethesda, Maryland.

¿Es usted un joven adulto afroamericano que tiene asma y vive en o cerca de Detroit?

Este estudio probará una forma, basada en la tecnología, para ayudar a que los adultos jóvenes afroamericanos manejen su asma mediante el uso de mensajes de texto y mensajes de computadora para recordarles que tomen sus medicinas. Para participar en este estudio, debe tener entre 18 y 29 años, asma persistente moderada o grave, y acceso a un teléfono celular. Este estudio se realiza en Detroit, Michigan.

¿Su hijo tiene asma y vive en o cerca del Bronx?

Este estudio analizará la intervención realizada en un consultorio médico para ayudar a los niños en entornos urbanos a manejar mejor su asma. Para participar en este estudio, su hijo debe tener entre 2 y 12 años, asma difícil de controlar y ninguna otra afección médica importante. Este estudio se realiza en el Bronx, Nueva York.

¿Usted es un adulto que tiene asma e insomnio?

Este estudio está analizando si dos intervenciones diferentes, basadas en educación, pueden ayudar a mejorar la calidad de vida de los pacientes que tienen asma grave e insomnio. Para participar en este estudio, debe tener entre 18 y 75 años, insomnio y asma moderada o grave. Este estudio se realiza en Pittsburgh, Pennsylvania.

Asthma

Do you have asthma and obesity and live near Aurora, Colorado?


Obesity can lead to widespread inflammation that may make asthma worse. This study will test whether a medicine called CXA-10 reduces inflammation in the airways and body and improves asthma symptoms in people who have obesity. To participate in this study, you must be between 18 and 65 years old, have a BMI of 30 or greater, and have been on long-acting controller medicine—such as inhaled corticosteroids or long-acting beta2-agonists—for at least three months. This study is located in Aurora, Colorado.

Are you an adult who has asthma and allergies and is willing to undergo brain imaging tests?

This study will look at whether reactions in the brain are associated with inflammation in the lungs. Researchers will use imaging tests to monitor for inflammation in the brain due to exposure to environmental levels of common factors known to cause asthma. To participate in this study, you must be between 18 and 50 years old; have had a positive skin test result to house dust mites, ragweed, or cat hair; and not have any other chronic diseases. This study is located in Madison, Wisconsin.

Does your child have asthma and an African American or Puerto Rican family background?

This study will look at how to get children and teens to identify their asthma symptoms early, using a peak flow meter. To participate in this study, your child must be 10-17 years old, have been diagnosed with asthma, and have at least one parent who identifies as African American or Puerto Rican. This study is located in the Bronx, New York
View more information about Childhood Asthma Perception Study (CAPS).

Are you a young African American adult who has asthma and lives in or near Detroit?

This study will test a technology-based way to help young African American adults manage their asthma by using texts and computer messages to remind them to take their medicine. To participate in this study, you must be between 18 and 29 years old, have moderate or severe persistent asthma, and have access to a cellphone. This study is located in Detroit, Michigan.

Causes and progression of chronic lung disease

This study aims to develop a better understanding of lung disorders. This study also identifies patients who are eligible to participate in other research studies. To participate in this study, you must be between 7 and 90 years old and have symptoms of lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Are you an adult who has asthma, or are you willing to be a healthy volunteer?

This study aims to test a new and less invasive way to look at the levels of a protein called GSNOR in people who have asthma. High levels of this protein can lead to inflammation (swelling) in the airways. Normally, doctors measure GSNOR levels with bronchoscopy (a tube inserted through your mouth into your airways). But this often requires you to be sedated. In the new approach being studied here, you will breathe in a chemical that your body makes, called GSNO. Researchers will look at how much of the chemical is broken down in your breath. This will tell them what your GSNOR levels are. They will compare the levels between people who have asthma and people who do not to see whether the test works. To participate in this study, you should be between 18 and 80 years old and either have been diagnosed with asthma for at least a year or not have asthma and not smoke. This study is located in Cleveland, Ohio.

Responses to asthma treatment

This study will gather general information over a 20-year period about people who have had asthma to understand why patients respond differently to treatment. To participate in this study, you must be age 18 or older, have been diagnosed with asthma for at least one year, and not have any other major conditions. This study is located in Bethesda, Maryland.

Does your child have asthma and live in or near the Bronx?

This study will look at a doctor’s office–based intervention for helping children in urban settings better manage their asthma. To participate in this study, your child must be 2-12 years old, have difficult-to-control asthma, and not have any other major medical conditions. This study is located in the Bronx, New York.

Do you have asthma, COPD, or asthma COPD overlap syndrome?

This study will look at whether a health coach can help people who have asthma, COPD, or asthma-COPD overlap syndrome with their condition. You will be randomly selected to meet with either a lung specialist alone or a lung specialist and a health coach, who will give you recommendations to improve your care and better manage your condition. To participate in this study, you must be age 18 or older, have asthma or COPD, and not already be seeing a lung specialist. You also must get your care from one of 10 health centers in San Francisco, California. This study is located in San Francisco, California.

Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Does your child have asthma and go to public school in Richmond, Virginia?

This study will test whether a program called RVA Breathes improves the health of children who have asthma. In the program, school nurses and community health workers will help educate you and your family about managing your child’s asthma. They will also try to help reduce things in your home that trigger your child’s asthma or make it worse. To participate in this study, your child must be between 5 and 11 years old and enrolled in a local public school. This study is located in Richmond, Virginia.

Asthma sample collections

This study will look at the differences between cells from the airways of people who do and do not have asthma. Doctors will use a procedure called bronchoscopy to collect cells. To participate in this study, you must be between 18 and 75 years old, not have HIV, and not be pregnant or planning to become pregnant. This study is located in Bethesda, Maryland.

Do you have asthma and insomnia?

This study is looking at whether two different education-based treatments can help improve the quality of life for people who have severe asthma and insomnia. To participate in this study, you must be 18 to 75 years old and have insomnia and moderate or severe asthma. This study is located in Pittsburgh, Pennsylvania.

Are you an adult who has asthma, or are you willing to be a healthy volunteer?

This study is looking at the DNA in airway cells to see how they differ between people who have asthma and people who do not. To get a sample of cells from your airways, you may have a bronchoscopy (a tube inserted through your mouth into your airways). To participate in this study, you must be between 18 and 70 years old, either with asthma or with no history of asthma. This study is located in San Francisco, California.

Do you live in or near Detroit and have a child who has asthma that is not controlled?

This study will compare two programs, REACH for Control (RFC) and Michigan MATCH, to see how well they help children and families manage asthma. A community health worker will visit your home and talk to your family about managing your child’s asthma. To participate in this study, your child must be between 12 and 16 years old and have been treated for an asthma attack at Children’s Hospital of Michigan. This study is located in Detroit, Michigan.

Do you have depression and act as caregiver for a child who has asthma?

This study will look at the effects on a child’s asthma when their caregiver is being treated for major depressive disorder. To participate in this study, the caregiver must be between 18 and 70 years old, be diagnosed with major depressive disorder, and not plan to become pregnant over the yearlong study. The child must be between 7 and 17 years old, have asthma, and not have other major illnesses. This study will take place in Dallas, Texas.

Do you have asthma, and are you struggling to reach a healthy weight?

This study is looking at a medicine called roflumilast for treating asthma that may also help you lose weight. Researchers are looking at whether the weight loss effects from the medicine will help improve asthma symptoms. To participate in this study, you must be age18 or older, have been on an asthma treatment for at least three months, and have obesity. This study is located in Tucson, Arizona; Chicago, Illinois; New York, New York; Durham, North Carolina; and Colchester, Vermont.

Wondering whether your asthma attack is caused by the common cold or other viruses?

This study is collecting information to help design a test for determining whether an asthma attack is caused by an infection with a virus. You will breathe out hard into a tube to collect your breath. Researchers will look at what substances are in your breath. This will help them see which substances differ depending on whether your asthma attack is caused by an infection with a virus or something else. To participate in this study, you must be age 12 or older, have a body mass index (BMI) of 18 or higher, and have early signs and symptoms of an asthma attack. This study is located in Sacramento, California.

Atherosclerosis

Do you or your child have obesity and high blood cholesterol or triglycerides?

This study is testing the use of a statin in young people to see whether early treatment of high blood cholesterol can affect the risk of developing plaque in blood vessels. Participants in this study must be age 10-17, have a body mass index (BMI) in the obese range, be fluent in English, and not be pregnant. This study is located in Wilmington, Delaware; Washington, DC; Atlanta, Georgia; Indianapolis, Indiana; Boston, Massachusetts; Ann Arbor, Michigan; Cincinnati, Ohio; Philadelphia and Pittsburgh, Pennsylvania; Charleston, South Carolina; Houston, Texas; Salt Lake City, Utah; and Toronto, Ontario, Canada.

Have you been diagnosed with carotid artery plaque?

This study aims to test whether a noninvasive ultrasound method can identify which people who have carotid artery disease benefit from carotid endarterectomy (a procedure to remove the plaque) to prevent stroke. To participate in this study, you must be at least 18 years old and have carotid artery disease. The study is located in Chapel Hill, North Carolina.

Atrial Fibrillation

Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery?

This study will examine whether adding oral anti-blood clotting medicines to anti-platelet medicines (such as aspirin) helps prevent stroke and other complications in people who develop atrial fibrillation after CABG surgery. To participate in this study, you must be at least 18 years old and have been diagnosed with atrial fibrillation after having CABG surgery. The study is located in 63 places in 22 states, the District of Columbia, Canada, and Germany.

Do you know someone who will be having heart surgery?

This study aims to identify what genetic patterns might cause atrial fibrillation and other adverse events that happen after heart surgery. To participate in this study, you must be between 20 and 90 years old. The study is in three locations in Massachusetts and Texas.

Do you have persistent atrial fibrillation?

Cardiac mapping is a tool doctors use to understand the pattern of electrical signals generating arrhythmia in a patient’s heart. This study aims to test a method for analyzing cardiac mapping results to see if it can improve the treatment of persistent atrial fibrillation. To participate in this study, you must be 21 or older and must have tried ablation to treat your atrial fibrillation once before. The study is located in Miami, Florida.

Are you being treated for a chronic health condition in Wisconsin?

This study assesses an online program for people 65 and older who have some combination of diabetes, high blood pressure, high blood cholesterol, COPD, obesity, congestive heart failure, chronic kidney disease, arrhythmia, pulmonary heart or vascular disease, chronic pain, and arthritis. Follow-up surveys will help researchers evaluate the effectiveness of the care and support offered through the online program and determine if it decreases the use of health care services and improves health measures. To participate in this study, you must be at least 65 years old and be receiving treatment for at least three chronic conditions at a University of Wisconsin health clinic. This study is located in Madison, Wisconsin.

Are you planning to have an ablation procedure for atrial fibrillation?

This study aims to improve a medicine used to prevent a repeat atrial fibrillation event after ablation treatment. Researchers will compare different formulas of the medicine propafenone. To participate in this study, you must be 18 or older and be scheduled for your first ablation procedure to treat atrial fibrillation. The study is located in Nashville, Tennessee.

Are you a stroke survivor?

This study aims to develop an app for smartwatches and smartphones to test several atrial fibrillation monitoring devices for patients who have had a stroke or transient ischemic attack. To participate in this study, you must be at least 50 years old and have been admitted to the UMass Memorial Medical Center for a stroke or TIA. The study is located in Worcester, Massachusetts.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Are you being treated for atrial fibrillation?

This study aims to compare two types of ablation treatment for patients who continue to have symptoms of atrial fibrillation despite treatment with medicines. The two ablation procedures treat different areas of tissue. To participate in this study, you must be at least 21 years old. The study is located in Palo Alto and San Diego, California.

Blood and Bone Marrow Transplant

Are you considering a blood stem cell transplant?

This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. To participate in this study, you must have a well-matched donor; you and your donor must be between 4 and 80 years old; and you must not be a candidate for immunosuppressive therapy. This study is located in Bethesda, Maryland.

Are you prone to bleeding because of low platelets or a bone marrow disorder?

This study aims to evaluate the effectiveness of tranexamic acid in preventing bleeding in patients who have thrombocytopenia, or low platelets, due to primary bone marrow disorders or chemotherapy, or blood or bone marrow transplants. To participate in this study, you must be at least 18 years old, have a bone marrow disorder, have low platelets, and be going through chemotherapy, immunotherapy, or a stem cell transplant. The study is located in Chapel Hill, North Carolina; Pittsburg, Pennsylvania; and Seattle, Washington.

Are you or your child interested in donating a sample of bone marrow for research?

This study will collect samples of bone marrow from patients who have sickle cell disease or β-thalassemia to help develop genetic therapies. Participants in this study must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Are you 15 to 40 years old and have severe sickle cell disease?

This study is comparing long-term outcomes for patients who receive blood and bone marrow transplants and those who receive standard treatment with medicines. Participants also have an option of contributing blood samples to be stored for future research. Participants must be 15 to 40 years old and have severe sickle cell disease. This study is located in Madison, Wisconsin.

Do you or your child have severe sickle cell disease and also know a half-matched bone marrow donor?

This study is seeking to improve bone marrow transplantation success from half-matched donors by testing a different conditioning procedure that uses a variety of medicines to prepare for the transplant. To participate in this study, you must be 15 to 45 years old and have severe sickle cell disease or have a child 5 to 14 years old who has had a stroke. This study is located in many sites across the United States, including Miami, Florida, and St. Louis, Missouri.

Blood and bone marrow transplant donors

This study is testing ways to reduce complications of blood and bone marrow transplants, which are used to treat some people who have serious blood disorders. Donors receive doses of a growth factor to increase the number of stem cells in their blood. Then, the donor has an apheresis procedure for removing the stem cells. The researchers are testing different processing steps after the donation to see how the stem cells and other cell types are affected. To participate, you must be between the ages of 18 and 60, and you need to meet certain health requirements for donors. This study is located in Bethesda, Maryland.

Bone marrow transplant procedures for severe anemia

This study aims to improve bone marrow transplant (BMT) procedures for older patients by using a low dose of radiation and two immunosuppressive drugs instead of chemotherapy. This type of BMT procedure is described as nonmyeloablative because it does not destroy bone marrow. Participants in this study must be between 2 and 65 years old; have a severe congenital anemia, such as sickle cell disease or beta thalassemia; and have a sibling who is a well-matched stem cell donor. This study is located in Bethesda, Maryland.

Have you received a stem cell transplant?

This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. To participate in this study, you must be between 10 and 80 years old and had your transplant more than 3 years ago. This study is located in Bethesda, Maryland.

Stem cell transplant procedure with a partial match

This study is testing new ways to improve a stem cell transplant procedure that involves a donor who is not a complete match, called a partial match. To participate in this study, you must be at least 18 years old and have both severe sickle cell disease and a donor who is a partial match. This study is located in Bethesda, Maryland.

Improving bone marrow transplants

This study is exploring how to improve bone marrow transplant procedures so the body better accepts donor stem cells. To participate in this study, you must be at least 4 years old, have sickle cell disease, and have a stem cell donor. This study is located in Bethesda, Maryland.

Healthy blood and bone marrow donors

This study is screening healthy participants who are willing to donate blood samples or who have apheresis procedures. Eligible donors may be asked to provide blood products for studies of blood disorders or to donate stem cells for people who are having a bone marrow transplant. To participate, you must be at least 18 years old and meet certain health requirements for donors. This study is located in Bethesda, Maryland.

Are you scheduled for a stem cell transplant with cord blood?

This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.

Do you or your child need a stem cell transplant?

This study is exploring the use of treatment with certain medicines in combination with radiation for a successful stem cell transplant. To participate in this study, you must be younger than 49 years old and have a severe disease treatable by a stem cell transplant. This study is located in several sites across the United States, including Aurora, Colorado; Seattle, Washington; and Milwaukee, Wisconsin.

Blood Donation

Blood and bone marrow transplant donors

This study is testing ways to reduce complications of blood and bone marrow transplants, which are used to treat some people who have serious blood disorders. Donors receive doses of a growth factor to increase the number of stem cells in their blood. Then, the donor has an apheresis procedure for removing the stem cells. The researchers are testing different processing steps after the donation to see how the stem cells and other cell types are affected. To participate, you must be between the ages of 18 and 60, and you need to meet certain health requirements for donors. This study is located in Bethesda, Maryland.

Healthy blood and bone marrow donors

This study is screening healthy participants who are willing to donate blood samples or who have apheresis procedures. Eligible donors may be asked to provide blood products for studies of blood disorders or to donate stem cells for people who are having a bone marrow transplant. To participate, you must be at least 18 years old and meet certain health requirements for donors. This study is located in Bethesda, Maryland.

Blood Transfusion

Are you prone to bleeding because of low platelets or a bone marrow disorder?

This study aims to evaluate the effectiveness of tranexamic acid in preventing bleeding in patients who have thrombocytopenia, or low platelets, due to primary bone marrow disorders or chemotherapy, or blood or bone marrow transplants. To participate in this study, you must be at least 18 years old, have a bone marrow disorder, have low platelets, and be going through chemotherapy, immunotherapy, or a stem cell transplant. The study is located in Chapel Hill, North Carolina; Pittsburg, Pennsylvania; and Seattle, Washington.

Have you had a heart attack, and do you want to help improve strategies for blood transfusion?

The study is comparing two strategies for blood transfusions in heart attack patients who have anemia—whether to give a blood transfusion when the hemoglobin level is less than 10 g/dL, or to give blood only when the blood count is below 8 g/dL. To participate in this study, you must be at least 18 years old, have anemia, and be hospitalized for a heart attack. The study is located in New Brunswick, New Jersey.

Bronchitis

Do you have COPD?

This study will be looking for genes that may play a role in the development of COPD by looking at the blood from patients who have COPD, as well as the blood from those patients’ family members. To participate in this study, you must be 52 years old or younger and must not be pregnant or have other serious lung diseases such as lung cancer. This study will be conducted in Boston, Massachusetts.

Do you have chronic bronchitis and COPD and want to improve treatment?

This study will be testing how well a medicine called ivacaftor that is used to treat cystic fibrosis works also to treat symptoms of chronic bronchitis. New research suggests chronic bronchitis may be due to a problem similar to cystic fibrosis. To participate in this study, you must be 40 to 80 years old, have a history of smoking, and have not been diagnosed with asthma or cystic fibrosis. This study will be conducted in Birmingham, Alabama.

Bronchopulmonary Dysplasia

Has your newborn been diagnosed with patent ductus arteriosus?

Patent ductus arteriosus (PDA) is a condition in which a connection between two major blood vessels close to the heart does not close properly after birth. This affects blood flow to the lungs and may cause neonatal respiratory diseases. PDA may correct itself, but sometimes treatment may be necessary. This study aims to identify ways by which doctors can predict which cases of PDA need to be treated. To participate in this study, your newborn must have been born between 23 and 29 weeks’ gestation and have been diagnosed with PDA. This study is located in Columbus, Ohio.

Is your premature newborn in a neonatal intensive care unit in Chicago, Illinois?

This study is investigating how brain development affects breathing in premature newborns. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and admitted to the neonatal intensive care unit within a week of birth. This study is located in Chicago, Illinois.

Is your newborn in the NICU at Holtz Children’s Hospital in Miami?

Newborns born very prematurely often need oxygen therapy or ventilation to help them breathe and survive. This study will help doctors understand how changes in oxygen and carbon dioxide levels while newborns are getting treatment affect how their lungs develop. While your newborn is in the newborn neonatal intensive care unit (NICU), researchers will record his or her oxygen and carbon dioxide levels, heart rate, and other measures. To participate in this study, your newborn must have been born prematurely between 23 and 28 weeks’ gestation, be less than 28 days old, and be receiving oxygen therapy. This study is located in Miami, Florida.

Was your newborn born prematurely?

This study aims to better understand the effects of premature delivery on a baby’s lungs during his or her first year of life. To participate in this study, your newborn must have been born prematurely between 24 and 36 weeks’ gestation and not have any congenital heart or lung defects. This study is located in Indianapolis, Indiana.

Is your newborn receiving care at the University of Alabama at Birmingham Women and Infants Center?

This study is testing new ways to help control breathing and oxygen and carbon dioxide levels in premature newborns. To participate in this study, your premature newborn must be in the neonatal intensive care unit or the critical care nursery at the Birmingham Women and Infants Center at the University of Alabama. This study is located in Birmingham, Alabama.

Is your newborn in the neonatal intensive care unit at St. Louis Children’s Hospital?

This study aims to better understand breathing problems and blood flow through the heart in premature newborns to better detect conditions such as pulmonary hypertension. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and be a patient in the Neonatal Intensive Care Unit at St. Louis Children’s Hospital. This study is located in St. Louis, Missouri.

Have you been diagnosed with high blood pressure while pregnant?

This study is investigating whether a mother’s blood pressure during pregnancy affects her newborn’s lung development. To participate in this study, your newborn must have been born either prematurely at more than 25 weeks’ gestation or at full term to a healthy mother or a mother who was diagnosed with high blood pressure during pregnancy. This study is located in Indianapolis, Indiana.

Bronchoscopy

Asthma sample collections

This study will look at the differences between cells from the airways of people who do and do not have asthma. Doctors will use a procedure called bronchoscopy to collect cells. To participate in this study, you must be between 18 and 75 years old, not have HIV, and not be pregnant or planning to become pregnant. This study is located in Bethesda, Maryland.

Cardiac Catheterization

Are you scheduled to have cardiac catheterization?

This study is looking at a new noninvasive imaging method for measuring pressures within the heart as an alternative to cardiac catheterization. The new method is called contrast echocardiography using the subharmonic-aided pressure estimation (SHAPE) method. To participate in this study, you must be at least 21 years old, be scheduled for cardiac catheterization, and be in medically stable condition. This study is located in Philadelphia, Pennsylvania.

Has your doctor recommended right heart cardiac catheterization for you?

This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be at least 18 years old, and your doctor must have recommended right heart catheterization for you. This study is located in Bethesda, Maryland.

Cardiac MRI

Has your doctor recommended right heart cardiac catheterization for you?

This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be at least 18 years old, and your doctor must have recommended right heart catheterization for you. This study is located in Bethesda, Maryland.

Cardiogenic Shock

Has your doctor recommended right heart cardiac catheterization for you?

This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be at least 18 years old, and your doctor must have recommended right heart catheterization for you. This study is located in Bethesda, Maryland.

Cardiomyopathy

Evaluating heart conditions

This study aims to help train staff on a range of heart conditions by evaluating patients of all ages at the NIH Clinical Center who have heart disease or are at risk of heart disease. Participants in the study must be at risk for or have symptoms of cardiovascular diseases. Some examples of cardiovascular diseases include coronary heart disease, heart valve disease, cardiomyopathies, peripheral artery disease, congenital heart disease, and vascular disease of the kidneys. This study is located in Bethesda, Maryland.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Carotid Artery Disease

Have you been diagnosed with carotid artery plaque?

This study aims to test whether a noninvasive ultrasound method can identify which people who have carotid artery disease benefit from carotid endarterectomy (a procedure to remove the plaque) to prevent stroke. To participate in this study, you must be at least 18 years old and have carotid artery disease. The study is located in Chapel Hill, North Carolina.

Catheter Ablation

Do you have a ventricular arrhythmia?

This study aims to evaluate the safety and effectiveness of low-energy shocks for the treatment of ventricular tachycardia and ventricular fibrillation. This approach will be tested during a catheter ablation or placement of an implantable cardioverter defibrillator (ICD). To participate in this study, you must be between 18 and 75 years old. This study is located in Minneapolis, Minnesota, and Austin, Texas.

Chest CT Scan

Do you have a first-degree relative diagnosed with an interstitial lung disease?

This study aims to better understand how interstitial lung diseases develop, by looking at the lungs of people who are at risk for an ILD. Participants will undergo a computed tomography (CT) scan, and researchers will look for visual evidence of the disease in an early stage. To participate in this study, you must be at least 35 years old and have a first-degree relative with a clinical diagnosis of ILD or be at least 50 years old with a smoking history of at least one pack of cigarettes per day. This study is located in New York, New York.

Chest MRI

Are you a healthy adult or an adult who has idiopathic pulmonary fibrosis and is interested in improving lung imaging methods?

This study aims to see whether an imaging method using magnetic resonance imaging (MRI) with an inhaled gas is better than traditional tests at detecting how the lungs respond to treatment for idiopathic pulmonary fibrosis (IPF). To participate in this study, you must be at least 18 years old and either have a diagnosis of idiopathic pulmonary fibrosis or be a healthy volunteer without lung disease. This study is located in Durham, North Carolina.

Circadian Rhythm Disorders

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours?

This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

Do you have overweight?

Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Are you an adult who does not have high blood pressure?

Circadian rhythms control daytime and nighttime changes in blood pressure. This study is examining the links between stress, loss of sodium through urine, and circadian rhythms in controlling blood pressure. To participate in this study, you must be at least 21 years old and not have high blood pressure. This study is located in New York, New York.

Circadian Rhythm Disorders (en español)

¿Tiene sobrepeso?

Los trastornos del ritmo circadiano pueden causar sobrepeso y obesidad. Este estudio examina cómo no dormir lo suficiente causa estas complicaciones. Para participar en este estudio, debe tener entre 20 y 40 años y tener sobrepeso, pero no obesidad. Este estudio se realiza en Nueva York (Nueva York).

¿Es un adulto que no trabaja de noche?

Este estudio prueba cómo el horario de sueño de una persona afecta sus ritmos circadianos, las habilidades de aprendizaje, la capacidad física y el estado de ánimo. Para participar en este estudio, debe tener entre 18 y 35 años y tener bajo peso u obesidad. Este estudio se realiza en Boston (Massachusetts).

¿Eres un adulto con un trastorno de fase del sueño?

Este estudio tiene como objetivo evaluar los patrones de sueño así como su calidad en personas que tienen trastornos de fase del sueño para determinar cómo los trastornos afectan sus ritmos circadianos. Para participar en este estudio, debe tener al menos 18 años de edad y tener un trastorno de fase del sueño, como el síndrome de fase del sueño avanzada o el síndrome de fase del sueño retardada. Este estudio se realiza en Chicago (Illinois).

Cómo funciona el corazón (en español)

¿Su hijo se someterá a una cirugía cardíaca por enfermedad cardíaca congénita?

Este estudio tiene como objetivo ayudar a los investigadores a comprender mejor el desarrollo del corazón y lo que controla la fuerza de sus latidos al compararlo con los corazones adultos. Los investigadores estudiarán pequeños pedazos del corazón que se extraen como parte normal de una cirugía o reparación para niños con enfermedad cardíaca congénita. Para participar en este estudio, su hijo debe someterse a una cirugía con derivación cardiopulmonar y tener 18 años o menos. Este estudio se encuentra en Atlanta, Georgia.

Estudio de resonancia magnética cardíaca (MRI, por sus siglas en inglés)

Este estudio tiene como objetivo mejorar las técnicas de resonancia magnética cardíaca (MRI). Los investigadores clínicos utilizarán nuevos métodos de resonancia magnética para observar a las personas saludables y las personas que tienen problemas cardíacos. Los participantes de este estudio deben tener al menos siete años, estar sanos o tener enfermedades cardiovasculares y no estar embarazadas. Este estudio se encuentra en Bethesda, Maryland.

Estudio de salud del corazón de miembros de iglesias predominantemente negras

Este estudio tiene como objetivo comprender la salud y las necesidades de salud de las personas en iglesias predominantemente negras en Washington, DC. Esta información ayudará a los investigadores a diseñar programas para mejorar la salud del corazón en estas comunidades. Para participar en este estudio, debe tener entre 19 y 85 años y debe asistir a una de las iglesias del estudio. Este estudio se encuentra en Bethesda, Maryland.

¿Está interesado en ayudar a los investigadores a comprender qué causa la insuficiencia cardíaca?

El estudio utiliza una técnica llamada espectroscopía de resonancia magnética (MRS, por sus siglas en inglés) durante una exploración de imágenes de resonancia magnética cardíaca (MRI, por sus siglas en inglés) para determinar si el metabolismo energético se ve interrumpido en la insuficiencia cardíaca y si esto contribuye a una función cardíaca deficiente. Para participar en este estudio, debe tener al menos 18 años y estar sano o tener una enfermedad coronaria, miocardiopatía dilatada o hipertrofia ventricular izquierda. Este estudio se encuentra en Baltimore, Maryland.

Cómo funciona el sueño (en español)

¿Es negro, tiene entre 18 y 35 años y está interesado en participar en un estudio sobre cómo el sueño afecta los vasos sanguíneos?

Este estudio prueba cómo el sueño afecta sus vasos sanguíneos, y si las recomendaciones personalizadas pueden mejorar su sueño. Para participar en este estudio, debe tener entre 18 y 35 años e identificarse como negro o afroamericano. Este estudio se realiza en Washington D.C.
Vea más informacion sobre Estrés, sueño y riesgo cardiovascular.

¿Está embarazada y tiene un IMC de 30 o más?

Este estudio examina la conexión entre la obesidad, los problemas respiratorios asociados con el sueño y los problemas del embarazo, como la preeclampsia. Para participar en este estudio, debe ser mayor de 18 años, estar embarazada y tener obesidad. Este estudio se realiza en Pittsburgh (Pensilvania).

¿Tiene un niño de 10 a 12 años que pasa de 7 a 8 horas en la cama de manera regular?

Este estudio prueba una intervención en línea para aumentar la cantidad de tiempo que su hijo pasa en la cama. Para participar en este estudio, su hijo debe tener entre 10 y 12 años y poder recibir mensajes de texto o correos electrónicos con mensajes sobre el sueño. Este estudio se realiza en Filadelfia (Pensilvania).

¿Es un adulto que no trabaja de noche?

Este estudio prueba cómo el horario de sueño de una persona afecta sus ritmos circadianos, las habilidades de aprendizaje, la capacidad física y el estado de ánimo. Para participar en este estudio, debe tener entre 18 y 35 años y tener bajo peso u obesidad. Este estudio se realiza en Boston (Massachusetts).

¿Su hijo es negro y tiene entre 8 y 11 años?

Este estudio prueba una forma de mejorar el sueño en niños con el objetivo de prevenir la obesidad. Para participar en este estudio, su hijo debe tener entre 8 y 11 años y debe ser negro o afroamericano. Este estudio se encuentra en Filadelfia (Pensilvania).

¿Eres un adulto con un trastorno de fase del sueño?

Este estudio tiene como objetivo evaluar los patrones de sueño así como su calidad en personas que tienen trastornos de fase del sueño para determinar cómo los trastornos afectan sus ritmos circadianos. Para participar en este estudio, debe tener al menos 18 años de edad y tener un trastorno de fase del sueño, como el síndrome de fase del sueño avanzada o el síndrome de fase del sueño retardada. Este estudio se realiza en Chicago (Illinois).

Cómo funcionan los pulmones (en español)

Genes involucrados en el desarrollo de las enfermedades pulmonares

Este estudio investigará los genes implicados en la respiración y en el desarrollo de las enfermedades pulmonares como el asma o la sarcoidosis para mejorar la comprensión del papel que desempeñan. Para participar en este estudio, usted o su hijo deben tener entre 2 y 90 años y haber sido diagnosticados y vivir con una enfermedad pulmonar. Este estudio se encuentra en Bethesda (Maryland) en el Centro Clínico de los NIH.

Causas y progresión de la enfermedad pulmonar crónica

Este estudio tiene como objetivo desarrollar una mejor comprensión de los trastornos pulmonares. Este estudio también identifica a pacientes que son elegibles para participar en otros estudios de investigación. Para participar en este estudio, debe tener entre 7 y 90 años y tener síntomas de la enfermedad pulmonar. Este estudio se encuentra en Bethesda (Maryland) en el Centro Clínico de los NIH.

¿Es un adulto sano o tiene una enfermedad pulmonar?

Este estudio tiene como objetivo recolectar muestras de sangre, orina y vías respiratorias de voluntarios sanos y de personas que tienen enfermedades pulmonares. Los investigadores usarán las muestras para estudiar genes y proteínas que pueden estar involucrados en la enfermedad pulmonar. Para participar en este estudio, debe ser mayor de 18 años. Este estudio se encuentra en Nueva York (Nueva York).

Conduction Disorders

Are you an adult living in Beijing, China, with a heart conduction disorder?

This study will investigate health outcomes among people with a heart conduction disorder that is sometimes treated with an implantable cardioverter defibrillator. To participate in this study, you must be between 18 and 60 years old and have complete left bundle branch block. The study takes place in Beijing, China.

Congenital Heart Defects

Has your child had a Fontan operation or had an MRI at Children’s Hospital of Philadelphia?

This study uses magnetic resonance imaging (MRI) and neurodevelopmental testing to understand how blood flow to the brain and brain lesions relate to neurodevelopmental problems in children who have had a Fontan operation to correct a single ventricle lesion. To participate in this study, your child must have congenital heart disease and have participated in a specific, previous study of blood flow to the brain. If your child did not participate in such a study, he or she should be between the ages of 3 and 15 and have completed the Fontan Operation or have had a clinically indicated MRI at the Children’s Hospital of Philadelphia to participate. This study is located in Philadelphia, Pennsylvania.

Do you or one of your children have a congenital heart defect?

This study will find both common genetic causes of congenital heart disease and ways that genes influence results of medical treatment. To participate in this study, you or your child must have congenital heart disease. This study is located in Los Angeles, Palo Alto, and San Francisco, California; New Haven, Connecticut; Boston, Massachusetts; New York and Rochester, New York; Philadelphia, Pennsylvania; and Salt Lake City, Utah.

Evaluating heart conditions

This study aims to help train staff on a range of heart conditions by evaluating patients of all ages at the NIH Clinical Center who have heart disease or are at risk of heart disease. Participants in the study must be at risk for or have symptoms of cardiovascular diseases. Some examples of cardiovascular diseases include coronary heart disease, heart valve disease, cardiomyopathies, peripheral artery disease, congenital heart disease, and vascular disease of the kidneys. This study is located in Bethesda, Maryland.

Does your developing baby have a heart defect? Have you had a stillborn baby?

This study tests a new technology to measure fetal heart activity and find possible problems early. These problems include fetal arrhythmia and conduction disorders such as Brugada syndrome. To participate in this study, you must be at least 18 years old and pregnant, and have one of five high-risk complications of pregnancy: a fetus with a major congenital heart defect, hydrops, or gastroschisis; a previous unexplained stillbirth; or twins who share a placenta. This study is located in Madison and Milwaukee, Wisconsin.

Are you an adult with congenital heart disease?

This study uses whole exome sequencing and other genetic tests to identify causes of congenital heart diseases that occur in individuals and families. To participate in this study, you must be an adult with congenital heart disease with or without a family member with congenital heart disease. This study is located in Columbus, Ohio.
View more information about Genetics of Congenital Heart Disease.

Do you or your child over age 8 have a congenital heart defect and prior whole exome or whole genome sequencing results?

This study explores the association between genetic variants, neurodevelopmental disability, and magnetic resonance imaging (MRI) brain findings. To participate in this study, you or your child must be at least 8 years old and have congenital heart disease and have whole exome or whole genome sequencing results that show either damaging, spontaneous genetic variations or other harmful genetic variations. This study is located in Los Angeles and San Francisco, California; New Haven, Connecticut; Boston, Massachusetts; New York and Rochester, New York; and Salt Lake City, Utah.

Are you or your child planning to undergo an MRI or cardiac catheterization procedure?

This study will help develop and test new magnetic resonance imaging (MRI) techniques that evaluate patients who have cardiovascular disease, congenital heart disease, and problems with the fetal heart and other organs during pregnancy. To participate in this study, you must be a healthy volunteer age 8 or older or be a patient of any age who needs an MRI or cardiac catheterization procedure. This study is located in Washington, D.C.

Developing new cardiovascular MRI imaging techniques

This study is comparing the ability of two types of magnetic resonance imaging (MRI) scanners to detect coronary heart disease, heart failure, congenital heart disease, and valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. To participate in this study, you should be healthy or have stable coronary heart disease and be at least 18 years old. This study is located in Bethesda, Maryland.

Are you a greater Boston resident aged 24 to 30?

This study aims to bridge the gap in knowledge between known executive function deficits in childhood congenital heart disease and adult well-being. The study is recruiting healthy volunteers. To participate in this study, you must be between the ages of 24 and 30, live in the greater Boston area, read fluently in English, and not have metal implants, a pacemaker, or orthodontia that would prevent MRI. This study is located in Boston, Massachusetts.

COPD

Do you have COPD?

This study will be looking for genes that may play a role in the development of COPD by looking at the blood from patients who have COPD, as well as the blood from those patients’ family members. To participate in this study, you must be 52 years old or younger and must not be pregnant or have other serious lung diseases such as lung cancer. This study will be conducted in Boston, Massachusetts.

Are you an adult who is healthy or has lung disease?

This study aims to collect blood, urine, and airway samples from healthy volunteers and from people who have lung disease. Researchers will use the samples to study genes and proteins that may be involved in lung disease. To participate in this study, you must be at least 18 years old or older. This study is located in New York, New York.

Causes and progression of chronic lung disease

This study aims to develop a better understanding of lung disorders. This study also identifies patients who are eligible to participate in other research studies. To participate in this study, you must be between 7 and 90 years old and have symptoms of lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Do you have COPD, or are you a healthy volunteer who is willing to do an imaging test?

This study will use an imaging test called single-photon emission computed tomography (SPECT) to compare the lung function of patients who have COPD with healthy volunteers who smoke and who do not smoke. The CT scan can detect death of cells in a process called apoptosis, which is linked to severe COPD and cannot be seen in the normal adult lung. To participate in this study, you must be at least 18 years old and either have moderate to severe COPD, not have COPD and be a smoker for longer than 10 years, or not have COPD and never smoked. This study is located in New York, New York.

Were you recently hospitalized for COPD, and are you eligible for pulmonary rehabilitation?

This study aims to add health coaching to pulmonary rehabilitation to determine if encouraging behavior change can decrease COPD re-hospitalizations and improve quality of life. To participate in this study, you must be at least 40 years old, have been hospitalized for COPD and be eligible for pulmonary rehabilitation. This study is located in Rochester, Minnesota.

Low-dose CT scan study

This study aims to discover if low-dose computed tomography (CT) scans are as effective as regular CT scans in monitoring your COPD. To participate in this study, you must be at least 18 years old and have been diagnosed with a lung disease such as COPD, chronic bronchitis, cystic fibrosis, or emphysema. This study is located in Bethesda, Maryland, at the NIH Clinical Center.
View more information about Low-Dose CT Scan Study.

Do you have COPD and are willing to use technology to track your medicine?

This study uses mobile health technology to assess the use of medicine in patients who have COPD and determine if medicine adherence can help prevent COPD re-hospitalizations. To participate in this study, you must be at least 40 years old, have COPD, and be prescribed a long-term controller medicine for COPD. This study is located in Baltimore, Maryland.

Do you have asthma, COPD, or asthma COPD overlap syndrome?

This study will look at whether a health coach can help people who have asthma, COPD, or asthma-COPD overlap syndrome with their condition. You will be randomly selected to meet with either a lung specialist alone or a lung specialist and a health coach, who will give you recommendations to improve your care and better manage your condition. To participate in this study, you must be age 18 or older, have asthma or COPD, and not already be seeing a lung specialist. You also must get your care from one of 10 health centers in San Francisco, California. This study is located in San Francisco, California.

Do you have COPD symptoms but do not qualify for long-term bronchodilator treatment?

This study aims to test whether current or former smokers who have respiratory symptoms and healthy lung function will benefit from the use of long-term bronchodilator treatment. To participate in this study, you must be between 40 and 80 years old. The study is located at multiple sites, including in Chicago, Illinois; Ann Arbor, Michigan; Baltimore, Maryland; and New York, New York.

Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Do you have chronic bronchitis and COPD and want to improve treatment?

This study will be testing how well a medicine called ivacaftor that is used to treat cystic fibrosis works also to treat symptoms of chronic bronchitis. New research suggests chronic bronchitis may be due to a problem similar to cystic fibrosis. To participate in this study, you must be 40 to 80 years old, have a history of smoking, and have not been diagnosed with asthma or cystic fibrosis. This study will be conducted in Birmingham, Alabama.

Coronary Artery Bypass Grafting

Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery?

This study will examine whether adding oral anti-blood clotting medicines to anti-platelet medicines (such as aspirin) helps prevent stroke and other complications in people who develop atrial fibrillation after CABG surgery. To participate in this study, you must be at least 18 years old and have been diagnosed with atrial fibrillation after having CABG surgery. The study is located in 63 places in 22 states, the District of Columbia, Canada, and Germany.

Coronary Heart Disease

Statin use to decrease cholesterol plaque buildup

This study aims to determine whether medicines called statins, which are prescribed to lower blood cholesterol levels, can reduce plaque in the heart’s arteries. Participants who are taking statins to reduce their risk for heart and blood vessel disease will have blood and imaging tests to measure any changes in plaque in their arteries. To participate in this study, men must be age 45-75 and women must be age 50-75. This study is located in Bethesda, Maryland.

Evaluating heart conditions

This study aims to help train staff on a range of heart conditions by evaluating patients of all ages at the NIH Clinical Center who have heart disease or are at risk of heart disease. Participants in the study must be at risk for or have symptoms of cardiovascular diseases. Some examples of cardiovascular diseases include coronary heart disease, heart valve disease, cardiomyopathies, peripheral artery disease, congenital heart disease, and vascular disease of the kidneys. This study is located in Bethesda, Maryland.

Do you have diabetes and a history of heart attack?

This is a follow-on study of the Trial to Assess Chelation Therapy (TACT), which showed that medicine to help remove metals in the blood reduced the risk of ischemic heart disease complications, including stroke and unstable angina, in people who have diabetes who had a prior heart attack. To participate in this study, you must be at least 50 years old and have a history of diabetes and heart attack. This study is located in Miami, Florida.

Cystic Fibrosis

Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Defibrillators

Are you considering getting or replacing an implantable cardioverter defibrillator?

Implantable cardioverter defibrillators (ICDs) can present patients with many stressful decisions, and this study tests the effectiveness of educational videos and handouts to inform patients about ICDs and help them assess their options. To participate in this study, your doctor must have given you the option of implanting or replacing an ICD. The study is located in Denver, Colorado.

Are you an adult living in Beijing, China, with a heart conduction disorder?

This study will investigate health outcomes among people with a heart conduction disorder that is sometimes treated with an implantable cardioverter defibrillator. To participate in this study, you must be between 18 and 60 years old and have complete left bundle branch block. The study takes place in Beijing, China.

Do you have heart disease that requires an ICD to prevent sudden cardiac arrest?

This study aims to learn what signs distinguish patients who have a higher risk of an arrhythmia that leads to sudden cardiac arrest. Researchers plan to track patients with a recent ICD replacement for 10 years. To participate in this study, you must be between 18 and 85 years old. This study is located in Washington, D.C.; Baltimore, Maryland; and Richmond, Virginia.

Have you been treated for ventricular tachycardia?

This study tests the safety and effectiveness of a new tool for doing radiofrequency catheter ablations, a treatment for some conduction disorders. To participate in this study, you must be at least 18 years old and have ventricular tachycardia that has not gone away after treatment with medicine, ablation, and placement of an implantable cardioverter defibrillator (ICD). This study is located in Illinois and Minnesota.

Do you have a ventricular arrhythmia?

This study aims to evaluate the safety and effectiveness of low-energy shocks for the treatment of ventricular tachycardia and ventricular fibrillation. This approach will be tested during a catheter ablation or placement of an implantable cardioverter defibrillator (ICD). To participate in this study, you must be between 18 and 75 years old. This study is located in Minneapolis, Minnesota, and Austin, Texas.

Enfermedad isquémica del corazón (en español)

Evaluación de afecciones del corazón

Este estudio tiene como objetivo ayudar a capacitar al personal en una variedad de enfermedades del corazón mediante la evaluación de pacientes de todas las edades que tienen enfermedades del corazón, o corren el riesgo de sufrir dichas enfermedades, en el Centro Clínico de los NIH. Los participantes en el estudio deben tener síntomas de enfermedades cardiovasculares o estar en riesgo de tener una. Algunos ejemplos de enfermedades cardiovasculares incluyen enfermedad coronaria, enfermedad valvular, cardiomiopatías, enfermedad arterial periférica, enfermedades congénitas del corazón y enfermedad vascular de los riñones. Este estudio se realiza en Bethesda (Maryland).

EPOC (en español)

Causas y progresión de la enfermedad pulmonar crónica

Este estudio tiene como objetivo desarrollar una mejor comprensión de los trastornos pulmonares. Este estudio también identifica a pacientes que son elegibles para participar en otros estudios de investigación. Para participar en este estudio, debe tener entre 7 y 90 años y tener síntomas de la enfermedad pulmonar. Este estudio se encuentra en Bethesda (Maryland) en el Centro Clínico de los NIH.

Fanconi Anemia

Are you considering a blood stem cell transplant?

This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. To participate in this study, you must have a well-matched donor; you and your donor must be between 4 and 80 years old; and you must not be a candidate for immunosuppressive therapy. This study is located in Bethesda, Maryland.

Do you or your child have Fanconi anemia with low blood cell counts?

This study will look at a newer medicine, eltrombopag, to treat anemia and low blood cell counts in patients who have Fanconi anemia. The FDA approved eltrombopag for severe aplastic anemia. Participants in this study must be 4 years or older. This study is located in Bethesda, Maryland.

Do you or your child require care for a blood disorder?

This study provides training for NHLBI blood doctors in the evaluation and care of patients who have blood disorders. Participants in this study must be 2 years or older. This study is located in Bethesda, Maryland.

Have you received a stem cell transplant?

This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. To participate in this study, you must be between 10 and 80 years old and had your transplant more than 3 years ago. This study is located in Bethesda, Maryland.

Blood disorder research

This study is collecting medical information from health exams and routine tests and procedures to see whether participants may be able to enroll in other studies on blood disorders. Participants in this study must be at least 8 years, with or without a blood disorder. This study is located in Bethesda, Maryland.

Are you scheduled for a stem cell transplant with cord blood?

This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.

Heart Attack

Have you had a heart attack, and do you want to help improve strategies for blood transfusion?

The study is comparing two strategies for blood transfusions in heart attack patients who have anemia—whether to give a blood transfusion when the hemoglobin level is less than 10 g/dL, or to give blood only when the blood count is below 8 g/dL. To participate in this study, you must be at least 18 years old, have anemia, and be hospitalized for a heart attack. The study is located in New Brunswick, New Jersey.

Do you have diabetes and a history of heart attack?

This is a follow-on study of the Trial to Assess Chelation Therapy (TACT), which showed that medicine to help remove metals in the blood reduced the risk of ischemic heart disease complications, including stroke and unstable angina, in people who have diabetes who had a prior heart attack. To participate in this study, you must be at least 50 years old and have a history of diabetes and heart attack. This study is located in Miami, Florida.

Heart Failure

Are you at least 21 years old, and do you have heart failure?

This study aims to use magnetic resonance imaging (MRI) to understand how certain molecules that are made in the body of people who have heart failure affect their ability to be physically active. To participate in this study, you must be at least 21 years old, be diagnosed with heart failure, and be medically stable. This study is located in Baltimore, Maryland.
View more information about Exercise Intolerance in Heart Failure.

Developing new cardiovascular MRI imaging techniques

This study is comparing the ability of two types of magnetic resonance imaging (MRI) scanners to detect coronary heart disease, heart failure, congenital heart disease, and valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. To participate in this study, you should be healthy or have stable coronary heart disease and be at least 18 years old. This study is located in Bethesda, Maryland.

Heart Failure (en español)

¿Tiene al menos 21 años y tiene insuficiencia del corazón?

Este estudio tiene como objetivo utilizar imágenes de resonancia magnética (IRM) para comprender cómo ciertas moléculas que se forman en el cuerpo de las personas con insuficiencia del corazón afectan su capacidad para ser físicamente activos. Para participar en este estudio, debe tener al menos 21 años, tener diagnóstico de insuficiencia del corazón y ser médicamente estable. Este estudio se realiza en Baltimore (Maryland).

Heart Valve Disease

Evaluating heart conditions

This study aims to help train staff on a range of heart conditions by evaluating patients of all ages at the NIH Clinical Center who have heart disease or are at risk of heart disease. Participants in the study must be at risk for or have symptoms of cardiovascular diseases. Some examples of cardiovascular diseases include coronary heart disease, heart valve disease, cardiomyopathies, peripheral artery disease, congenital heart disease, and vascular disease of the kidneys. This study is located in Bethesda, Maryland.

Developing new cardiovascular MRI imaging techniques

This study is comparing the ability of two types of magnetic resonance imaging (MRI) scanners to detect coronary heart disease, heart failure, congenital heart disease, and valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. To participate in this study, you should be healthy or have stable coronary heart disease and be at least 18 years old. This study is located in Bethesda, Maryland.

Heart-Healthy Lifestyle Changes

Are you an adult who wants to help understand how eating lots of added sugars affects your health?

This study will see how eating high amounts of added sugars affects risk factors for heart and blood vessel disease or diabetes in participants who are eating an energy-balanced diet to prevent weight gain or energy-imbalanced diet that can cause weight gain. To participate in this study, you must be 18 to 40 years of age and have a body mass index between 22 and 28 that has not changed in the past six months.

Are you an adult who is curious about how sodium affects your blood pressure?

This study is testing whether limiting sodium can affect individuals with a specific genetic predisposition to high blood pressure. To participate you must be 18 years old or older and not have high blood pressure. Please note that this study is in Charlottesville, Virginia.

Exploring diagnostic tests for lipid disorders

This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. Participants must be at least 2 years old. This study is located in Bethesda, Maryland.

Are you an African American new mother who has overweight or obesity and lives in Philadelphia?

This study will compare usual and community-specific treatment to see which is more effective at helping African American new mothers lose weight after childbirth. To participate, you must have overweight or obesity, be a Philadelphia WIC participant, and have given birth within the last six months. This study is located in Philadelphia, Pennsylvania.

Is your child black and 8 to 11 years old?

This study is testing a way of enhancing sleep in children with the goal of preventing obesity. To participate in this study, your child must be 8 to 11 years old and must be black or African American. This study is located in Philadelphia, Pennsylvania.

Evaluating heart conditions

This study aims to help train staff on a range of heart conditions by evaluating patients of all ages at the NIH Clinical Center who have heart disease or are at risk of heart disease. Participants in the study must be at risk for or have symptoms of cardiovascular diseases. Some examples of cardiovascular diseases include coronary heart disease, heart valve disease, cardiomyopathies, peripheral artery disease, congenital heart disease, and vascular disease of the kidneys. This study is located in Bethesda, Maryland.

Are you between 40 and 70 years of age, and do you have metabolic syndrome?

This study aims to test whether the medicine metformin, used to treat diabetes, can improve blood flow and the ability to do physical activity when combined with exercise in people who have metabolic syndrome. To participate in this study, you must be between 40 and 70 years old and have metabolic syndrome. This study is located in Charlottesville, Virginia.

Are you at least 21 years old, and do you have heart failure?

This study aims to use magnetic resonance imaging (MRI) to understand how certain molecules that are made in the body of people who have heart failure affect their ability to be physically active. To participate in this study, you must be at least 21 years old, be diagnosed with heart failure, and be medically stable. This study is located in Baltimore, Maryland.
View more information about Exercise Intolerance in Heart Failure.

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours?

This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

Are you an adult under 40 who recently had a spinal cord injury?

This study aims to test whether a physical training program called Functional Electrical Stimulation (FES) Row Training (RT) can improve exercise ability, and ultimately heart health, in those who have spinal cord injuries, compared with standard arms-only rowing exercises. FES-RT involves arm exercises combined with small electrical charges to weakened leg muscles. To participate in this study, you must be between 20 and 40 years old and have had a spinal cord injury in the previous 12 months. This study is located in Cambridge, Massachusetts.

Do you have overweight?

Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Do you have high blood pressure, and do you receive care at a community-based clinic in the South?

This study will explore an intensive high blood pressure management approach at participating community-based clinics. The approach aims to lower participants’ systolic blood pressure to 120 mm Hg. To participate in this study, you must be at least 40 years old, understand English, and not be pregnant. The study is located in Louisiana, Alabama, and Mississippi.

Are you an adult interested in comparing effects of different exercise training on blood pressure?

This study aims to compare how different types of exercise can affect blood pressure in African Americans. Participants will do either aerobic activities, focusing on raising their heart rate, or muscle-strengthening resistance activities, focusing on weights, for 24 to 26 weeks. To participate in this study, you must be between 18 and 50 years old, have a sedentary lifestyle and elevated blood pressure, and have been born in the United States to either two African American or two non-Hispanic Caucasian parents. This study is located in Chicago, Illinois.

Are you at least 35 years old, and do you have resistant high blood pressure?

This study aims to test the effectiveness of using lifestyle changes, such as healthy eating and physical activity, in addition to medicines to help treat high blood pressure. To participate in this study, you must be at least 35 years old, be overweight, and have high blood pressure that has not been successfully treated with medicines. This study is located in Durham, North Carolina.

Do you take medicine for high blood pressure or high blood cholesterol?

This study will test a program that asks pharmacists to reach out to patients who have high blood pressure, high blood cholesterol, or diabetes and help them stick to their plans for taking and refilling their medicines as prescribed. To participate in this study, you must be between 18 and 75 years old. The study location is in Bloomington, Minnesota.

Are you at least 18 years old and interested in testing a smartphone-based weight loss program?

This study aims to test a smartphone-based program to help people monitor their efforts to eat healthy and reach a healthy weight. The study will look how effective smartphone-based feedback messages are at engaging patients and promoting weight loss. To participate in this study, you must be 18 or older, own and use a smartphone regularly, and be able to engage in moderate-intensity physical activity. This study is located in Pittsburgh, Pennsylvania.

Are you an adult who has pulmonary hypertension and would like to see whether healthy lifestyle changes can help?

This study is looking at a high blood pressure condition called pulmonary arterial hypertension (PAH). It will test whether better blood sugar control in the body improves this condition. Researchers will test this by having participants who have PAH follow a healthy eating plan and get more physical activity. To participate in this study, you must be between 18 and 75 years old and have been diagnosed with pulmonary arterial hypertension. This study is located in Cleveland, Ohio.

Are you a healthy adult with no history of health problems who would be willing to train in breathing exercises?

This study aims to test whether breathing muscles affect blood pressure during physical activity by measuring oxygen levels and blood pressure during exercise on a recumbent bicycle. To participate in this study, you must be between 18 and 80 years old and have no history of heart, lung, brain, bone, muscle, or nerve diseases. This study is located in Rochester, Minnesota.

Increasing physical activity in African American women who are at risk for diabetes

This study is testing whether using mobile health technology, such as smartphone apps and activity monitors, can help increase physical activity in African American women who are at risk for diabetes. To participate in this study, you must be an African American woman between 25 and 75 years old, have evidence of insulin resistance, and live in Prince George’s County, Maryland, or Ward 5, 7, or 8 in Washington, D.C. This study is located in Bethesda, Maryland.

Understanding heart and blood vessel diseases

This study aims to collect data and samples from people who have a heart or blood vessel disease, their family members, and healthy people. Participants must be at least 2 years old. This study is located in Bethesda, Maryland.
View more information about Vascular Disease Discovery Protocol.

Heart-Healthy Living

Do you work at a desk and want to improve your health?

This study will investigate whether reducing the amount of time that participants spend sitting results in lower blood pressure. Participants will reduce their sitting by 2 to 4 hours a day for three months by using a sit-stand desk attachment and receiving alerts though text messages and an activity watch. They will also receive in-person and phone counselling on setting goals, overcoming barriers, self-monitoring, and social support. To participate in this study, you must be between 21 and 65 years old, get less than 150 minutes of physical activity per week, and have a stable desk job that is within 25 miles of the University of Pennsylvania. This study is located in Pittsburgh, Pennsylvania.

Are you an adult who has uncontrolled high blood pressure?

This study will see whether an early notification system for health professionals can help manage patients’ high blood pressure, especially among those who have had a stroke or have an increased risk of stroke. To participate in this study, you must be between 18 and 85 years old and have high blood pressure that is not controlled by medicine and lifestyle changes. This study is enrolling native English, Spanish, or Hmong speakers. The study is located in Minneapolis, Minnesota.

Hemolytic Anemia

Are you considering a blood stem cell transplant?

This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. To participate in this study, you must have a well-matched donor; you and your donor must be between 4 and 80 years old; and you must not be a candidate for immunosuppressive therapy. This study is located in Bethesda, Maryland.

Are you or your child interested in donating a sample of bone marrow for research?

This study will collect samples of bone marrow from patients who have sickle cell disease or β-thalassemia to help develop genetic therapies. Participants in this study must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Have you received a stem cell transplant?

This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. To participate in this study, you must be between 10 and 80 years old and had your transplant more than 3 years ago. This study is located in Bethesda, Maryland.

Do you want to take part in blood research?

This study aims to screen patients at the National Institutes of Health Clinical Center who have a blood disorder such as anemia and who may be eligible to participate in studies in the Hematology Branch. It will also determine whether it is safe for you to participate in those studies. Participants in this study must be 2 years or older. This study is located in Bethesda, Maryland.
View more information about Screening for Hematology Branch Protocols.

Blood disorder research

This study is collecting medical information from health exams and routine tests and procedures to see whether participants may be able to enroll in other studies on blood disorders. Participants in this study must be at least 8 years, with or without a blood disorder. This study is located in Bethesda, Maryland.

Are you scheduled for a stem cell transplant with cord blood?

This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.

High Blood Cholesterol

Are you living with HIV and high blood cholesterol or high blood pressure?

This study is evaluating a nurse-led reminder system to help people who have HIV stay on track with their heart medicines. Participants will have four visits with a nurse, who will help them manage their medicine schedule with telephone reminders. To participate in this study, you must be at least 18 years old; have HIV, high blood cholesterol, or high blood pressure or be taking medicines to manage these conditions; and have access to a telephone. This study is located in Cleveland, Ohio, and Durham, North Carolina.

Testing for cholesterol and other fats in the blood

This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. Participants in this study must be at least 2 years old. The study is being conducted in Bethesda, Maryland.

Statin use to decrease cholesterol plaque buildup

This study aims to determine whether medicines called statins, which are prescribed to lower blood cholesterol levels, can reduce plaque in the heart’s arteries. Participants who are taking statins to reduce their risk for heart and blood vessel disease will have blood and imaging tests to measure any changes in plaque in their arteries. To participate in this study, men must be age 45-75 and women must be age 50-75. This study is located in Bethesda, Maryland.

Do you or does your child have a lipid disorder and want to improve future diagnosis and treatment?

This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. To participate, you or your child must be at least 2 years old. The study is being conducted in Bethesda, Maryland.

Do you or your child have obesity and high blood cholesterol or triglycerides?

This study is testing the use of a statin in young people to see whether early treatment of high blood cholesterol can affect the risk of developing plaque in blood vessels. Participants in this study must be age 10-17, have a body mass index (BMI) in the obese range, be fluent in English, and not be pregnant. This study is located in Wilmington, Delaware; Washington, DC; Atlanta, Georgia; Indianapolis, Indiana; Boston, Massachusetts; Ann Arbor, Michigan; Cincinnati, Ohio; Philadelphia and Pittsburgh, Pennsylvania; Charleston, South Carolina; Houston, Texas; Salt Lake City, Utah; and Toronto, Ontario, Canada.

High levels of cholesterol and other fats in the blood

This study is looking at people who have high blood cholesterol and other fats (triglycerides) in their blood and at the particles that carry these fats through the bloodstream. Researchers will measure levels of cholesterol and other substances in the blood to find better ways to diagnose and treat patients with diseases involving blood cholesterol. Participants in this study must have been diagnosed with high blood cholesterol or triglycerides and be at least 2 years old. This study is located in Bethesda, Maryland.
View more information about Evaluation of Lipoproteins.

Studying genes in families that have high levels of cholesterol and other fats in the blood

This study is looking at the genes of people who have high levels of cholesterol and other lipids (triglycerides) in the blood to try to find gene changes that lead to these conditions. The study is also open to their family members. Participants in this study must be at least 2 years old. This study is located in Bethesda, Maryland. If a participant’s family member cannot travel to NIH, the study documents and consent form will be reviewed during a teleconference. A kit for collecting blood or sputum will be mailed to the relative.
View more information about Genes Involved in Lipid Disorders.

Research on cholesterol disorders

This study is comparing how lipids, or fats such as cholesterol, travel in the blood of healthy adult volunteers and adults who have lipid disorders, particularly disorders that may be caused by unknown genetic factors. To participate in this study, you must be at least 18 years old. Women should not be pregnant. The study is being conducted in Bethesda, Maryland.

Do you take medicine for high blood pressure or high blood cholesterol?

This study will test a program that asks pharmacists to reach out to patients who have high blood pressure, high blood cholesterol, or diabetes and help them stick to their plans for taking and refilling their medicines as prescribed. To participate in this study, you must be between 18 and 75 years old. The study location is in Bloomington, Minnesota.

Are you interested in getting text messages to remind you to take your medicines for heart health or diabetes?

This study is assessing whether text messages can help people remember to take statins for high blood cholesterol, blood pressure medicine, or medicines for atrial fibrillation or diabetes. To participate in this study, you must be taking one of these types of medicines, have either a landline or a cell phone, speak English or Spanish, be age 18-89, and not be pregnant. This study is located in Aurora and Denver, Colorado.

Do you or your child have a lipid disorder and want to help research?

This study is assessing factors affecting proteins that transport lipids in the blood of patients with lipid disorders. Participants will follow a specific eating pattern during the study and will have blood tests. Information from this study may help improve the way in which lipid disorders are diagnosed or treated in the future. To participate, you must have been diagnosed with a lipid disorder. The study is being conducted in Bethesda, Maryland.

High Blood Pressure

Are you living with HIV and high blood cholesterol or high blood pressure?

This study is evaluating a nurse-led reminder system to help people who have HIV stay on track with their heart medicines. Participants will have four visits with a nurse, who will help them manage their medicine schedule with telephone reminders. To participate in this study, you must be at least 18 years old; have HIV, high blood cholesterol, or high blood pressure or be taking medicines to manage these conditions; and have access to a telephone. This study is located in Cleveland, Ohio, and Durham, North Carolina.

Do you live in Iowa and want to work with a pharmacist to manage your high blood pressure?

This study will test a program that uses pharmacists to help people manage high blood pressure. You will be given a blood pressure monitor to take readings at home and text them to a pharmacist. You will then either talk to the pharmacist once or be part of the more intensive program where the pharmacist develops a care plan and monitors you for a year. To participate in this study, you must be older than 21, have had a systolic pressure greater than 145 mm Hg or diastolic pressure greater than 95 mm Hg at your previous clinic visit, and be patient at the Family Medicine, River Crossings, Scott Blvd, or Muscatine University of Iowa Clinics. This study is located in Iowa.

Are you age 18-40 and interested in helping advance science?

This study aims to investigate a component of blood vessels, called endothelin, that causes the blood vessels to narrow and is thought to play a role in high blood pressure. Investigators hope to see if endothelin works differently in people who have obesity. To participate in this study, you must be age 18-40. The study is located in Augusta, Georgia.

Do you want to get better at taking your blood pressure medicine?

This study will test a program aimed at helping motivate people to take their blood pressure medicine. Each day, participants who took their medicine will be eligible to win a prize through a smartphone app that tracks whether they are taking their medicine. To participate in this study, you must be at least 18 years old and have an active prescription for high blood pressure medication. This study is located in New York, New York.

Are you an adult who is curious about how sodium affects your blood pressure?

This study is testing whether limiting sodium can affect individuals with a specific genetic predisposition to high blood pressure. To participate you must be 18 years old or older and not have high blood pressure. Please note that this study is in Charlottesville, Virginia.

Are you an adult whose high blood pressure does not improve with lifestyle changes and medicines?

This study will assess whether minocycline, an antibiotic with anti-inflammatory effects, can improve blood pressure control in patients who do not respond to medicines in combination with lifestyle changes, such as physical activity, weight loss, and healthy eating patterns. To participate you must be at least 18 years old and have high blood pressure that does not respond to treatment with three different high blood pressure medicines even when used at the maximum doses. Please note that this study is in Gainesville, Florida.

Do you work at a desk and want to improve your health?

This study will investigate whether reducing the amount of time that participants spend sitting results in lower blood pressure. Participants will reduce their sitting by 2 to 4 hours a day for three months by using a sit-stand desk attachment and receiving alerts though text messages and an activity watch. They will also receive in-person and phone counselling on setting goals, overcoming barriers, self-monitoring, and social support. To participate in this study, you must be between 21 and 65 years old, get less than 150 minutes of physical activity per week, and have a stable desk job that is within 25 miles of the University of Pennsylvania. This study is located in Pittsburgh, Pennsylvania.

Are you an adult under age 50 interested in helping researchers understand blood pressure?

This study will explore endothelin, a molecule found in blood vessels, to better understand its role in blood pressure. For the study, you will take either a medicine that blocks this molecule or a placebo. Your blood pressure and heart and blood vessel functions will be measured with ultrasound, blood tests, and other tests. This will happen while you exercise and while you hold your hand in ice water. To participate in this study, you must be between 18 and 50 years old and identify as African American or white. You also must have a BMI between either 16 and 24 or 31 and 40. Women who are pregnant, menopausal, or post-menopausal cannot participate. This study is located in Augusta, Georgia.

Causes and risk factors for cardiovascular disease in African Americans

This study will examine how your genes and health behaviors and where you live and work contribute to your risk of heart disease. To participate you must be an African American age 21-65, living in Washington, D.C., or Montgomery or Prince Georges counties in Maryland. This study is located in Bethesda, Maryland.

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours?

This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

Do you have high blood pressure, and do you receive care at a community-based clinic in the South?

This study will explore an intensive high blood pressure management approach at participating community-based clinics. The approach aims to lower participants’ systolic blood pressure to 120 mm Hg. To participate in this study, you must be at least 40 years old, understand English, and not be pregnant. The study is located in Louisiana, Alabama, and Mississippi.

Do you want to take part in a supervised exercise program and help science?

This study will see how aerobic and resistance exercise affect blood pressure. In the study you will take part in one of these exercise programs for two months. You will be supervised by a physical therapist or an exercise physiologist during the exercises. To participate in this study, you must be between 18 and 55 years old, and not be taking medicine for high blood pressure. This study is located in Chicago, Illinois.

Are you at least 35 years old, and do you have resistant high blood pressure?

This study aims to test the effectiveness of using lifestyle changes, such as healthy eating and physical activity, in addition to medicines to help treat high blood pressure. To participate in this study, you must be at least 35 years old, be overweight, and have high blood pressure that has not been successfully treated with medicines. This study is located in Durham, North Carolina.

Is your high blood pressure resistant to medicines?

Some people have high blood pressure despite taking medicines, putting those individuals at risk of heart disease or stroke. This study will see whether the DASH heart-healthy eating plan and a special exercise program can help lower your blood pressure. To participate in this study, you must be at least 35 years old and be taking three or more medicines for high blood pressure. This study is located in Durham, North Carolina.

Do you take medicine for high blood pressure or high blood cholesterol?

This study will test a program that asks pharmacists to reach out to patients who have high blood pressure, high blood cholesterol, or diabetes and help them stick to their plans for taking and refilling their medicines as prescribed. To participate in this study, you must be between 18 and 75 years old. The study location is in Bloomington, Minnesota.

Are you an adult who has uncontrolled high blood pressure?

This study will see whether an early notification system for health professionals can help manage patients’ high blood pressure, especially among those who have had a stroke or have an increased risk of stroke. To participate in this study, you must be between 18 and 85 years old and have high blood pressure that is not controlled by medicine and lifestyle changes. This study is enrolling native English, Spanish, or Hmong speakers. The study is located in Minneapolis, Minnesota.

Are you an African American near Detroit who wants to better manage your blood pressure?

This study will test a mobile phone app for people with high blood pressure. The app helps people monitor their blood pressure, physical activity, and sodium (salt) intake; set goals; and remember to take their medicine. During the study you will learn how to use the app, which could help you improve your health. To participate in this study, you must be an African American adult age 25 to 70 who has high blood pressure. This study is located in Detroit, Michigan.

Are you an adult whose high blood pressure has not improved with medicines?

This study is assessing whether a low-sodium and low-calorie eating pattern, along with aerobic exercise, can improve blood pressure in patients who do not respond to high blood pressure medicines. To participate you must be at least 35 years and have high blood pressure that does not respond to medicines. Please note that this study is in Durham, North Carolina.

Do you want help remembering to refill your medicine prescriptions?

In this study, you will receive text messages to remind you to take your medicines and refill your prescriptions before they run out. To participate in this study, you must be between 18 and 89 years old and taking medicines for high blood pressure, high blood fats, diabetes, or atrial fibrillation. This study is located in Aurora and Denver, Colorado.

Are you a Hispanic/Latino adult who wants to improve your mental and emotional well-being?

This study aims to test the effect of improving mental and emotional well-being on blood pressure. Over the course of eight weeks, you will take part in activities that are designed to help you be more mindful, relaxed, and optimistic. Participants will take part in a program that encourages optimism, gratitude, mindfulness, and resilience for three months. To participate in this study, you must be Hispanic/Latino adult over age 18 and have high blood pressure. This study is located in Chicago, Illinois.

Do you or your child have sickle cell disease and high blood pressure?

This study is exploring whether use of losartan, a medicine commonly used to lower blood pressure, is effective at treating abnormal nighttime blood pressure in children and young adults who have sickle cell disease. Participants in this study must be between 5 and 25 years old and have high blood pressure and a certain type of sickle cell disease: hemoglobin SS or Sβ0 thalassemia. This study is located in Birmingham, Alabama.
View more information about Preventing Sickle Cell Kidney Disease.

Are you an adult who does not have high blood pressure?

Circadian rhythms control daytime and nighttime changes in blood pressure. This study is examining the links between stress, loss of sodium through urine, and circadian rhythms in controlling blood pressure. To participate in this study, you must be at least 21 years old and not have high blood pressure. This study is located in New York, New York.

Have you been diagnosed with high blood pressure while pregnant?

This study is investigating whether a mother’s blood pressure during pregnancy affects her newborn’s lung development. To participate in this study, your newborn must have been born either prematurely at more than 25 weeks’ gestation or at full term to a healthy mother or a mother who was diagnosed with high blood pressure during pregnancy. This study is located in Indianapolis, Indiana.

Do you struggle to take your blood pressure medicine as prescribed?

This study will investigate whether exercises that affirm one’s values help adults with high blood pressure take their medicine regularly. Stereotypes about race or ethnicity can affect your attitudes and behaviors about your health, which can prevent you from being as healthy as possible. The researchers think that the exercises in this study could help people overcome the negative influences of stereotypes and take better care of their health. To participate in this study, you must be a white or African American adult over age 21 who is currently taking blood pressure medicine. This study is located in Denver, Colorado, and Rockville, Maryland.

Do you want to help researchers understand the link between gut bacteria and high blood pressure?

This study aims to explore the relationship between gut microbiota (tiny organisms that live in the digestive system) and high blood pressure. The researchers will compare gut microbiota in participants with normal blood pressure, controlled high blood pressure, uncontrolled high blood pressure, and high blood pressure that is resistant to treatment. To participate in this study, you must be between 18 and 80 years old and not be pregnant or taking an antibiotic. This study is located in Gainesville, Florida.

High Blood Triglycerides

Testing for cholesterol and other fats in the blood

This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. Participants in this study must be at least 2 years old. The study is being conducted in Bethesda, Maryland.

Exploring diagnostic tests for lipid disorders

This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. Participants must be at least 2 years old. This study is located in Bethesda, Maryland.

Do you or your child have obesity and high blood cholesterol or triglycerides?

This study is testing the use of a statin in young people to see whether early treatment of high blood cholesterol can affect the risk of developing plaque in blood vessels. Participants in this study must be age 10-17, have a body mass index (BMI) in the obese range, be fluent in English, and not be pregnant. This study is located in Wilmington, Delaware; Washington, DC; Atlanta, Georgia; Indianapolis, Indiana; Boston, Massachusetts; Ann Arbor, Michigan; Cincinnati, Ohio; Philadelphia and Pittsburgh, Pennsylvania; Charleston, South Carolina; Houston, Texas; Salt Lake City, Utah; and Toronto, Ontario, Canada.

High levels of cholesterol and other fats in the blood

This study is looking at people who have high blood cholesterol and other fats (triglycerides) in their blood and at the particles that carry these fats through the bloodstream. Researchers will measure levels of cholesterol and other substances in the blood to find better ways to diagnose and treat patients with diseases involving blood cholesterol. Participants in this study must have been diagnosed with high blood cholesterol or triglycerides and be at least 2 years old. This study is located in Bethesda, Maryland.
View more information about Evaluation of Lipoproteins.

Studying genes in families that have high levels of cholesterol and other fats in the blood

This study is looking at the genes of people who have high levels of cholesterol and other lipids (triglycerides) in the blood to try to find gene changes that lead to these conditions. The study is also open to their family members. Participants in this study must be at least 2 years old. This study is located in Bethesda, Maryland. If a participant’s family member cannot travel to NIH, the study documents and consent form will be reviewed during a teleconference. A kit for collecting blood or sputum will be mailed to the relative.
View more information about Genes Involved in Lipid Disorders.

How Sleep Works

Are you an adult with a diagnosed sleep phase disorder?

This study aims to assess the sleep patterns and quality of sleep in people who have sleep phase disorders to determine how the disorders affect their circadian rhythms. To participate in this study, you must be at least 18 years old and have a sleep phase disorder, such as advanced sleep-wake phase syndrome or delayed sleep-wake phase syndrome. This study is located in Chicago, Illinois.

Is your child black and 8 to 11 years old?

This study is testing a way of enhancing sleep in children with the goal of preventing obesity. To participate in this study, your child must be 8 to 11 years old and must be black or African American. This study is located in Philadelphia, Pennsylvania.

Do you have overweight?

Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Are you an adult who does not work nights?

This study is examining how a person’s sleep schedule affects circadian rhythms, learning skills, physical ability, and mood. To participate in this study, you must be between 18 and 35 years old and not have underweight or obesity. This study is located in Boston, Massachusetts.

Are you pregnant, with a BMI of 30 or higher?

This study is examining the connection between obesity, breathing problems associated with sleep, and pregnancy problems such as preeclampsia. To participate in this study, you must be 18 or older, pregnant, and have obesity. This study is located in Pittsburgh, Pennsylvania.

How the Heart Works

Heart health study of members of predominately black churches

This study aims to understand the health and health needs of people in predominately black churches in Washington, D.C. This information will help researchers design programs to improve heart health in these communities. To participate in this study, you must be between 19 and 85 years old and attend one of the churches in the study. This study is based in Bethesda, Maryland.

Cardiac magnetic resonance imaging (MRI) study

This study aims to improve cardiac magnetic resonance imaging (MRI) techniques. The clinical investigators will use new MRI methods to look at healthy people and people who have heart problems. Participants in this study must be at least 7 years old, be healthy or have cardiovascular disease, and not be pregnant. This study is located in Bethesda, Maryland.

How the Lungs Work

Are you an adult who is healthy or has lung disease?

This study aims to collect blood, urine, and airway samples from healthy volunteers and from people who have lung disease. Researchers will use the samples to study genes and proteins that may be involved in lung disease. To participate in this study, you must be at least 18 years old or older. This study is located in New York, New York.

Causes and progression of chronic lung disease

This study aims to develop a better understanding of lung disorders. This study also identifies patients who are eligible to participate in other research studies. To participate in this study, you must be between 7 and 90 years old and have symptoms of lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Idiopathic Pulmonary Fibrosis

Are you between 40 and 85 with worsening idiopathic pulmonary fibrosis?

This study aims to test a new combination treatment for acute exacerbations, a life-threatening complication of idiopathic pulmonary fibrosis (IPF) that has no approved treatment. The treatment is meant to help stop part of the immune system from further injuring the lung tissue. To participate in this study, you must be between 40 and 85 years old and have worsening IPF. This study is located in Birmingham, Alabama; Boston, Massachusetts; Philadelphia, Pennsylvania; and Pittsburgh, Pennsylvania.

Are you an adult who is healthy or has lung disease?

This study aims to collect blood, urine, and airway samples from healthy volunteers and from people who have lung disease. Researchers will use the samples to study genes and proteins that may be involved in lung disease. To participate in this study, you must be at least 18 years old or older. This study is located in New York, New York.

Do you have a first-degree relative diagnosed with an interstitial lung disease?

This study aims to better understand how interstitial lung diseases develop, by looking at the lungs of people who are at risk for an ILD. Participants will undergo a computed tomography (CT) scan, and researchers will look for visual evidence of the disease in an early stage. To participate in this study, you must be at least 35 years old and have a first-degree relative with a clinical diagnosis of ILD or be at least 50 years old with a smoking history of at least one pack of cigarettes per day. This study is located in New York, New York.

Are you an adult who has idiopathic pulmonary fibrosis or an advanced lung cancer?

This study aims to see whether a new imaging dye for positron emission tomography (PET) is effective at looking at fibrosis in lung cancer and idiopathic pulmonary fibrosis (IPF). Participants will be given the imaging dye and then receive a PET scan. To participate in this study, you must either be between 18 and 80 years old and have lung cancer or be a healthy volunteer or be between 50 and 80 years old and have IPF. This study is located in Boston, Massachusetts.

Are you a healthy adult or an adult who has idiopathic pulmonary fibrosis and is interested in improving lung imaging methods?

This study aims to see whether an imaging method using magnetic resonance imaging (MRI) with an inhaled gas is better than traditional tests at detecting how the lungs respond to treatment for idiopathic pulmonary fibrosis (IPF). To participate in this study, you must be at least 18 years old and either have a diagnosis of idiopathic pulmonary fibrosis or be a healthy volunteer without lung disease. This study is located in Durham, North Carolina.

Insomnia

Have you previously been prescribed opioid medicines?

This study will find out whether waking up frequently during the night can affect the way your brain processes certain medicines. To participate in this study, you must be 18 to 48 years old, have a normal sleep cycle, and have previously taken opioid medicines to treat pain. This study is located in Baltimore, Maryland.

Do you have pain from sickle cell disease and trouble sleeping?

This study will look at whether improving sleep can reduce pain in people who have sickle cell disease and chronic pain. To participate in this study, you must be at least 18 years old, have been diagnosed with sickle cell disease, and experience insomnia and chronic pain. This study is located in Baltimore, Maryland.
View more information about Sleep and Pain in Sickle Cell Disease.

Do you have asthma and insomnia?

This study is looking at whether two different education-based treatments can help improve the quality of life for people who have severe asthma and insomnia. To participate in this study, you must be 18 to 75 years old and have insomnia and moderate or severe asthma. This study is located in Pittsburgh, Pennsylvania.

Do you have HIV and insomnia?

This study is looking at whether insomnia increases pain and inflammation in people who have HIV. To participate in this study, you must be 18 to 85 years old and either be healthy or diagnosed with HIV, with or without insomnia. This study is located in Birmingham, Alabama.

Interstitial Lung Diseases

Are you between 40 and 85 with worsening idiopathic pulmonary fibrosis?

This study aims to test a new combination treatment for acute exacerbations, a life-threatening complication of idiopathic pulmonary fibrosis (IPF) that has no approved treatment. The treatment is meant to help stop part of the immune system from further injuring the lung tissue. To participate in this study, you must be between 40 and 85 years old and have worsening IPF. This study is located in Birmingham, Alabama; Boston, Massachusetts; Philadelphia, Pennsylvania; and Pittsburgh, Pennsylvania.

Do you have a first-degree relative diagnosed with an interstitial lung disease?

This study aims to better understand how interstitial lung diseases develop, by looking at the lungs of people who are at risk for an ILD. Participants will undergo a computed tomography (CT) scan, and researchers will look for visual evidence of the disease in an early stage. To participate in this study, you must be at least 35 years old and have a first-degree relative with a clinical diagnosis of ILD or be at least 50 years old with a smoking history of at least one pack of cigarettes per day. This study is located in New York, New York.

Are you an adult who has idiopathic pulmonary fibrosis or an advanced lung cancer?

This study aims to see whether a new imaging dye for positron emission tomography (PET) is effective at looking at fibrosis in lung cancer and idiopathic pulmonary fibrosis (IPF). Participants will be given the imaging dye and then receive a PET scan. To participate in this study, you must either be between 18 and 80 years old and have lung cancer or be a healthy volunteer or be between 50 and 80 years old and have IPF. This study is located in Boston, Massachusetts.

Are you a healthy adult or an adult who has idiopathic pulmonary fibrosis and is interested in improving lung imaging methods?

This study aims to see whether an imaging method using magnetic resonance imaging (MRI) with an inhaled gas is better than traditional tests at detecting how the lungs respond to treatment for idiopathic pulmonary fibrosis (IPF). To participate in this study, you must be at least 18 years old and either have a diagnosis of idiopathic pulmonary fibrosis or be a healthy volunteer without lung disease. This study is located in Durham, North Carolina.

Ischemic Heart Disease

Are you living with HIV and high blood cholesterol or high blood pressure?

This study is evaluating a nurse-led reminder system to help people who have HIV stay on track with their heart medicines. Participants will have four visits with a nurse, and the nurse will help them manage their medicine schedule with telephone reminders. To participate in this study, you must be at least 18 years old; have HIV, high blood cholesterol, or high blood pressure or be taking medicines to manage these conditions; and have access to a telephone. This study is located in Cleveland, Ohio, and Durham, North Carolina.

Do you have depression symptoms and have been diagnosed with coronary heart disease?

This study aims to find out whether an online tool can help improve symptoms of depression in people who have coronary heart disease and encourage them to start treatment for depression. To participate in this study, you must be at least 21 years old and have symptoms of depression and a history of coronary heart disease. This study is located in New York, New York.

Sample collection for studies of blood vessel diseases

This study is collecting blood samples to study the role of inflammation in diseases of the blood vessels, including coronary heart disease and sickle cell disease. To participate, you or your child must be at least 2 years old and either be healthy or have a disease affecting the blood vessels.

Did you have a heart attack in the past eight months?

This study is looking at the link between mental stress and heart disease in men and women. Taking part in this study involves one clinic visit, one week of at-home monitoring, and follow-up phone calls every six months for three years. To participate in this study, you must be no more than 60 years old and have a history of a heart attack in the past eight months. This study is located in Atlanta, Georgia.

Do you have coronary artery disease or arteriovenous malformation?

This study aims to learn about the genes that may lead to coronary artery disease, a type of coronary heart disease, or arteriovenous malformations, which are abnormal connections between arteries and veins. To participate in this study, you must be at least 45 years old and have a history of coronary artery disease or arteriovenous malformation, and you must have a living brother or sister who has the same heart condition. This study is located in Cleveland, Ohio.

Are you interested in getting text messages to remind you to take your medicines for heart health or diabetes?

This study is assessing whether text messages can help people remember to take statins for high blood cholesterol, blood pressure medicine, or medicines for atrial fibrillation or diabetes. To participate in this study, you must be taking one of these types of medicines, have either a landline or cell phone, speak English or Spanish, be between 18 and 89 years old, and not be pregnant. This study is located in Aurora and Denver, Colorado.

Link between psoriasis and heart diseases

This study is exploring possible links among several diseases associated with chronic inflammation. Participants with an inflammatory disease called psoriasis will be monitored to learn more about whether this condition affects their risk for developing high blood cholesterol, atherosclerosis, and cardiovascular disease, including coronary heart disease. To participate in this study, you must be at least 18 years old and have psoriasis. This study is located in Bethesda, Maryland.

Using MRI to better understand cardiovascular and brain function

This study aims to identify better MRI methods and new ways of imaging cardiovascular disease to understand cardiovascular and brain function. Researchers are also interested in seeing whether gadolinium, the commonly used MRI contrast agent, stays in the body long after an MRI is performed. To participate in this study, you or your child should be healthy or have a cardiovascular condition and be at least 7 years old.

Developing new cardiovascular MRI imaging techniques

This study is comparing the ability of two types of magnetic resonance imaging (MRI) scanners to detect coronary heart disease, heart failure, congenital heart disease, and valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. To participate in this study, you should be healthy or have stable coronary heart disease and be at least 18 years old. This study is located in Bethesda, Maryland.

Do you want to help improve heart imaging techniques?

This study aims to improve magnetic resonance imaging (MRI) methods to detect coronary heart disease. Healthy people and people who have coronary heart disease will have MRI scans while resting and after taking a medicine that temporarily makes your heart work harder. To participate in this study, you must be at least 18 years old and either healthy or diagnosed with coronary heart disease. The study is taking place in Los Angeles, California.

LAM

Monitoring sirolimus dosages to treat LAM

This study aims to identify the right dose of sirolimus to treat people who have LAM. To participate in this study, you must be female, between 18 and 90 years old, and diagnosed with LAM. This study is located in Bethesda, Maryland.

Are you an adult woman who would like to help develop methods to prevent the worsening of LAM?

This study aims to discover whether earlier and longer treatment with a lower dose of sirolimus can help prevent LAM from getting worse over time. To participate in this study, you must be female, be at least 18 years old, and have been diagnosed with LAM. This study is located in Atlanta, Georgia; Boston, Massachusetts; Chicago, Illinois; Cincinnati, Ohio; Denver, Colorado; Nashville, Tennessee; Palo Alto, California; Philadelphia, Pennsylvania; and Seattle, Washington.

Albuterol in patients who have LAM

This study is examining which delivery method of albuterol—inhaled or nebulizer—is better at improving lung function in adult women who have LAM. To participate in this study, you must be female, between 18 and 80 years old, and diagnosed with LAM. This study is located in Bethesda, Maryland.

Are you an adult woman willing to help improve treatments for LAM?

This study is examining whether using a combination of resveratrol and sirolimus is more effective than using sirolimus alone to treat LAM. To participate in this study, you must be female, be at least 18 years old, and have been diagnosed with LAM. This study is located in Cincinnati, Ohio.

Are you an adult woman diagnosed with LAM who wants to support future studies of a new treatment?

This study aims to test a new medicine called saracatinib to treat LAM and other cancers. To participate in this study, you must be female, be between 18 and 65 years old, and have been diagnosed with LAM. This study is located in Bethesda, Maryland; Chicago, Illinois; Cincinnati, Ohio; Houston, Texas; and Stanford, California.

Genetic causes of lung damage in patients who have LAM

This study is trying to understand the genes and proteins that are responsible for causing lung damage in patients with LAM. To participate in this study, you must be between 16 and 99 years old and diagnosed with LAM. This study is located in Bethesda, Maryland.

Low Blood Pressure

Have you been diagnosed with orthostatic intolerance?

This study aims to find out how the body’s regulation of basic functions, such as heart rate and blood pressure, is altered in people who have orthostatic intolerance. This condition, which has an unknown cause, is characterized by a racing heartbeat, dizziness, lightheadedness, and other symptoms that occur when a person stands up. To participate in this study, you must be between 18 and 80 years old and have orthostatic intolerance. This study is located in Nashville, Tennessee.

Narcolepsy

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours?

This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

Do you have overweight?

Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Are you pregnant, with a BMI of 30 or higher?

This study is examining the connection between obesity, breathing problems associated with sleep, and pregnancy problems such as preeclampsia. To participate in this study, you must be 18 or older, pregnant, and have obesity. This study is located in Pittsburgh, Pennsylvania.

Neonatal Respiratory Diseases

Has your newborn been diagnosed with patent ductus arteriosus?

Patent ductus arteriosus (PDA) is a condition in which a connection between two major blood vessels close to the heart does not close properly after birth. This affects blood flow to the lungs and may cause neonatal respiratory diseases. PDA may correct itself, but sometimes treatment may be necessary. This study aims to identify ways by which doctors can predict which cases of PDA need to be treated. To participate in this study, your newborn must have been born between 23 and 29 weeks’ gestation and have been diagnosed with PDA. This study is located in Columbus, Ohio.

Is your newborn in the NICU at Holtz Children’s Hospital in Miami?

Newborns born very prematurely often need oxygen therapy or ventilation to help them breathe and survive. This study will help doctors understand how changes in oxygen and carbon dioxide levels while newborns are getting treatment affect how their lungs develop. While your newborn is in the newborn neonatal intensive care unit (NICU), researchers will record his or her oxygen and carbon dioxide levels, heart rate, and other measures. To participate in this study, your newborn must have been born prematurely between 23 and 28 weeks’ gestation, be less than 28 days old, and be receiving oxygen therapy. This study is located in Miami, Florida.

Is your newborn receiving care at the University of Alabama at Birmingham Women and Infants Center?

This study is testing new ways to help control breathing and oxygen and carbon dioxide levels in premature newborns. To participate in this study, your premature newborn must be in the neonatal intensive care unit or the critical care nursery at the Birmingham Women and Infants Center at the University of Alabama. This study is located in Birmingham, Alabama.

Is your newborn in the neonatal intensive care unit at St. Louis Children’s Hospital?

This study aims to better understand breathing problems and blood flow through the heart in premature newborns to better detect conditions such as pulmonary hypertension. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and be a patient in the Neonatal Intensive Care Unit at St. Louis Children’s Hospital. This study is located in St. Louis, Missouri.

Have you been diagnosed with high blood pressure while pregnant?

This study is investigating whether a mother’s blood pressure during pregnancy affects her newborn’s lung development. To participate in this study, your newborn must have been born either prematurely at more than 25 weeks’ gestation or at full term to a healthy mother or a mother who was diagnosed with high blood pressure during pregnancy. This study is located in Indianapolis, Indiana.

Nivel alto de colesterol en sangre (en español)

¿Tiene usted o su hijo un trastorno de los lípidos y desea mejorar el diagnóstico y el tratamiento futuros?

Este estudio explora cómo las diferentes pruebas de diagnóstico pueden ayudarnos a entender la forma en que los trastornos de los lípidos, incluido el nivel alto de colesterol en sangre, afectan el cuerpo. La información de este estudio puede ayudar a mejorar la forma en que los trastornos de los lípidos se diagnosticarán o se tratarán en el futuro. Para participar, usted o su hijo debe tener al menos dos años. El estudio se lleva a cabo en Bethesda, Maryland.

¿Tiene usted o su hijo un trastorno de los lípidos y desea ayudar en la investigación?

Este estudio evalúa los factores que afectan las proteínas que transportan lípidos en la sangre de pacientes con trastornos de los lípidos. Los participantes seguirán un patrón de alimentación específico durante el estudio y se someterán a análisis de sangre. La información de este estudio puede ayudar a mejorar la forma en que los trastornos de los lípidos se diagnosticarán o tratarán en el futuro. Para participar, debe haber sido diagnosticado con un trastorno de los lípidos. El estudio se lleva a cabo en Bethesda, Maryland.
Vea más informacion sobre Evaluation of Lipoproteins (en inglés).

¿Es usted adulto y está interesado en ayudar en las investigaciones sobre trastornos de los lípidos?

Este estudio compara cómo los lípidos o las grasas, como el colesterol, se desplazan por la sangre de voluntarios adultos sanos y adultos que tienen trastornos de los lípidos, en particular trastornos causados por factores genéticos desconocidos. Para participar en este estudio, debe tener 18 años o más. Las mujeres no deben estar embarazadas. El estudio se lleva a cabo en Bethesda, Maryland.

Overweight and Obesity

Are you age 18-40 and interested in helping advance science?

This study aims to investigate a component of blood vessels, called endothelin, that causes the blood vessels to narrow and is thought to play a role in high blood pressure. Investigators hope to see if endothelin works differently in people who have obesity. To participate in this study, you must be age 18-40. The study is located in Augusta, Georgia.

Are you an adult who wants to help understand how eating lots of added sugars affects your health?

This study will see how eating high amounts of added sugars affects risk factors for heart and blood vessel disease or diabetes in participants who are eating an energy-balanced diet to prevent weight gain or energy-imbalanced diet that can cause weight gain. To participate in this study, you must be 18 to 40 years of age and have a body mass index between 22 and 28 that has not changed in the past six months.

Do you have asthma and obesity and live near Aurora, Colorado?


Obesity can lead to widespread inflammation that may make asthma worse. This study will test whether a medicine called CXA-10 reduces inflammation in the airways and body and improves asthma symptoms in people who have obesity. To participate in this study, you must be between 18 and 65 years old, have a BMI of 30 or greater, and have been on long-acting controller medicine—such as inhaled corticosteroids or long-acting beta2-agonists—for at least three months. This study is located in Aurora, Colorado.

Are you an African American new mother who has overweight or obesity and lives in Philadelphia?

This study will compare usual and community-specific treatment to see which is more effective at helping African American new mothers lose weight after childbirth. To participate, you must have overweight or obesity, be a Philadelphia WIC participant, and have given birth within the last six months. This study is located in Philadelphia, Pennsylvania.

Do you or your child have obesity and high blood cholesterol or triglycerides?

This study is testing the use of a statin in young people to see whether early treatment of high blood cholesterol can affect the risk of developing plaque in blood vessels. Participants in this study must be age 10-17, have a body mass index (BMI) in the obese range, be fluent in English, and not be pregnant. This study is located in Wilmington, Delaware; Washington, DC; Atlanta, Georgia; Indianapolis, Indiana; Boston, Massachusetts; Ann Arbor, Michigan; Cincinnati, Ohio; Philadelphia and Pittsburgh, Pennsylvania; Charleston, South Carolina; Houston, Texas; Salt Lake City, Utah; and Toronto, Ontario, Canada.

Is your child black and 8 to 11 years old?

This study is testing a way of enhancing sleep in children with the goal of preventing obesity. To participate in this study, your child must be 8 to 11 years old and must be black or African American. This study is located in Philadelphia, Pennsylvania.

Heart health study of members of predominately black churches

This study aims to understand the health and health needs of people in predominately black churches in Washington, D.C. This information will help researchers design programs to improve heart health in these communities. To participate in this study, you must be between 19 and 85 years old and attend one of the churches in the study. This study is based in Bethesda, Maryland.

Do you have overweight?

Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Are you pregnant, with a BMI of 30 or higher?

This study is examining the connection between obesity, breathing problems associated with sleep, and pregnancy problems such as preeclampsia. To participate in this study, you must be 18 or older, pregnant, and have obesity. This study is located in Pittsburgh, Pennsylvania.

Do you have asthma, and are you struggling to reach a healthy weight?

This study is looking at a medicine called roflumilast for treating asthma that may also help you lose weight. Researchers are looking at whether the weight loss effects from the medicine will help improve asthma symptoms. To participate in this study, you must be age18 or older, have been on an asthma treatment for at least three months, and have obesity. This study is located in Tucson, Arizona; Chicago, Illinois; New York, New York; Durham, North Carolina; and Colchester, Vermont.

Oxygen Therapy

Is your newborn in the NICU at Holtz Children’s Hospital in Miami?

Newborns born very prematurely often need oxygen therapy or ventilation to help them breathe and survive. This study will help doctors understand how changes in oxygen and carbon dioxide levels while newborns are getting treatment affect how their lungs develop. While your newborn is in the newborn neonatal intensive care unit (NICU), researchers will record his or her oxygen and carbon dioxide levels, heart rate, and other measures. To participate in this study, your newborn must have been born prematurely between 23 and 28 weeks’ gestation, be less than 28 days old, and be receiving oxygen therapy. This study is located in Miami, Florida.

Peripheral Artery Disease

Evaluating heart conditions

This study aims to help train staff on a range of heart conditions by evaluating patients of all ages at the NIH Clinical Center who have heart disease or are at risk of heart disease. Participants in the study must be at risk for or have symptoms of cardiovascular diseases. Some examples of cardiovascular diseases include coronary heart disease, heart valve disease, cardiomyopathies, peripheral artery disease, congenital heart disease, and vascular disease of the kidneys. This study is located in Bethesda, Maryland.

Understanding heart and blood vessel diseases

This study aims to collect data and samples from people who have a heart or blood vessel disease, their family members, and healthy people. Participants must be at least 2 years old. This study is located in Bethesda, Maryland.
View more information about Vascular Disease Discovery Protocol.

Pleural Disorders

Monitoring sirolimus dosages to treat LAM

This study aims to identify the right dose of sirolimus to treat people who have LAM. To participate in this study, you must be female, between 18 and 90 years old, and diagnosed with LAM. This study is located in Bethesda, Maryland.

Albuterol in patients who have LAM

This study is examining which delivery method of albuterol—inhaled or nebulizer—is better at improving lung function in adult women who have LAM. To participate in this study, you must be female, between 18 and 80 years old, and diagnosed with LAM. This study is located in Bethesda, Maryland.

Genetic causes of lung damage in patients who have LAM

This study is trying to understand the genes and proteins that are responsible for causing lung damage in patients with LAM. To participate in this study, you must be between 16 and 99 years old and diagnosed with LAM. This study is located in Bethesda, Maryland.

Pneumonia

Do you or a loved one have pneumonia?

This study will test whether combining two medicines (an inhaled corticosteroid and a beta agonist) can help prevent respiratory failure in people who have pneumonia. To participate in this study, you must be at least 18 years old and have severe pneumonia with low blood oxygen levels. This study is located in Scottsdale and Tucson, Arizona; Palo Alto, California; Gainesville and Jacksonville, Florida; Baltimore, Maryland; Rochester, Minnesota; New York, New York; Durham, North Carolina; and Philadelphia, Pennsylvania.
View more information about ARrest RESpiraTory Failure From PNEUMONIA.

Causes and progression of chronic lung disease

This study aims to develop a better understanding of lung disorders. This study also identifies patients who are eligible to participate in other research studies. To participate in this study, you must be between 7 and 90 years old and have symptoms of lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Presión arterial alta (en español)

¿Es usted un adulto cuya presión arterial alta no mejora con los cambios de estilo de vida y las medicinas?

Este estudio evaluará si la minociclina, un antibiótico con efectos antiinflamatorios, puede mejorar el control de presión arterial en pacientes que no responden a las medicinas combinadas con cambios de estilo de vida, tales como la actividad física, la pérdida de peso y los hábitos de alimentación saludable. Para participar, debe tener al menos 18 años de edad y sufrir de presión arterial alta que no responde al tratamiento con tres medicinas distintas para la hipertensión, incluso cuando se utilizan las dosis máximas. Tenga en cuenta que este estudio se realiza en Gainesville, Florida.

¿Es usted un adulto afrodescendiente que vive en el área metropolitana de Washington, D.C.?

Este estudio evalúa la relación entre el ADN, los comportamientos de salud, factores sociales y ambientales, y factores de riesgo de enfermedades del corazón, tales como, hipertensión en afrodescendientes. Para participar, usted debe ser un afrodescendiente de entre 21 y 65 años de edad, que viva en Washington, D.C. o en los condados de Montgomery o Prince Georges en Maryland. Tenga en cuenta que este estudio se realiza en Bethesda, Maryland.

¿Es usted un adulto cuya presión arterial alta no ha mejorado con medicinas?

Este estudio evalúa si los hábitos alimenticios bajos en calorías y sodio, junto con ejercicios aeróbicos, pueden mejorar la presión arterial en pacientes que no responden a las medicinas para la hipertensión. Para participar, usted debe tener al menos 35 años de edad y sufrir de presión arterial alta que no responda a medicinas. Tenga en cuenta que este estudio se realiza en Durham, Carolina del Norte.

¿Tiene presión arterial alta y recibe atención en una clínica comunitaria en el sur?

Este estudio explorará un enfoque de manejo intensivo de la presión arterial alta en las clínicas comunitarias participantes. El enfoque tiene como objetivo reducir la presión arterial sistólica de los participantes a 120 mmHg. Para participar en este estudio, debe tener al menos 40 años, entender inglés y no estar embarazada. El estudio se realiza en Luisiana, Alabama y Misisipi.

¿Tiene al menos 35 años y tiene presión arterial alta resistente?

Este estudio tiene como objetivo evaluar la efectividad del uso de cambios en el estilo de vida, como una alimentación saludable y actividad física, además de medicinas para tratar la presión arterial alta. Para participar en este estudio, debe tener al menos 35 años de edad, tener sobrepeso y tener presión arterial alta que no haya sido tratada con éxito con medicinas. Este estudio se realiza en Durham (Carolina del Norte).

¿Es un adulto que tiene presión arterial alta no controlada?

Este estudio examinará si un sistema de notificación temprana para profesionales de la salud puede ayudar a controlar la presión arterial alta de los pacientes, en especial entre aquellos que han tenido un derrame cerebral o tienen un mayor riesgo de sufrir un derrame cerebral. Para participar en este estudio, debe tener entre 18 y 85 años y tener presión arterial alta que no esté controlada con medicinas ni cambios en el estilo de vida. Este estudio está registrando hablantes nativos de inglés, español o hmong. El estudio se realiza en Minneapolis (Minnesota).

¿Conoce a un niño, adolescente o adulto joven con anemia falciforme y presión arterial alta?

Este estudio evalúa un posible tratamiento para pacientes con anemia falciforme y presión arterial alta para prevenir el daño renal. Para participar, debe tener entre 5 y 25 años de edad y sufrir de anemia falciforme e hipertensión. Tenga en cuenta que este estudio se realiza en Birmingham, Alabama.

¿Es usted un adulto que quiere saber cómo el sodio afecta su presión arterial?

Este estudio evalúa si la limitación del sodio puede afectar a personas con una predisposición genética específica a la presión arterial alta. Para participar debe tener 18 años de edad o más y no sufrir de presión arterial alta. Tenga en cuenta que este estudio se realiza en Charlottesville (Virginia).
Obtenga más información sobre respuesta de la presión arterial al sodio en la dieta

Prueba de esfuerzo (en español)

¿Quiere ayudar a mejorar las técnicas de imagen del corazón?

Este estudio tiene como objetivo mejorar los métodos de resonancia magnética (IRM) para detectar la enfermedad arterial coronaria. Las personas sanas y las personas con enfermedad arterial coronaria se realizarán una resonancia magnética mientras descansan y durante una prueba de esfuerzo. Para participar en este estudio, debe tener al menos 18 años y estar sano o bien diagnosticado con enfermedad arterial coronaria. El estudio se lleva a cabo en Los Ángeles, California.

¿Su hijo nació con tetralogía de Fallot (TOF)?

Este estudio investiga si la cirugía de reemplazo de la válvula pulmonar puede mejorar la calidad de vida en adolescentes y adultos jóvenes que nacieron con TOF. Los investigadores determinarán si esta cirugía mejora la función cardiaca y previene las complicaciones de la TOF mediante varios métodos, incluidas las pruebas de esfuerzo. Los participantes de este estudio deben tener entre 13 y 21 años y estar diagnosticados con TOF. El estudio se lleva a cabo en Filadelfia, Pensilvania.

Pulmonary Hypertension

Are you an adult with obesity and pulmonary hypertension who is interested in a new treatment?

This study is looking at a medicine called metformin, which is normally used to treat diabetes, as possible treatment for pulmonary hypertension in people who have obesity. To participate in this study, you must be 30 to 75 years old, have a body mass index (BMI) of 30 or greater, and have experienced shortness of breath. This study is located in Boston, Massachusetts.

Is your newborn in the neonatal intensive care unit at St. Louis Children’s Hospital?

This study aims to better understand breathing problems and blood flow through the heart in premature newborns to better detect conditions such as pulmonary hypertension. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and be a patient in the Neonatal Intensive Care Unit at St. Louis Children’s Hospital. This study is located in St. Louis, Missouri.

Are you an adult who has pulmonary hypertension and would like to see whether healthy lifestyle changes can help?

This study is looking at a high blood pressure condition called pulmonary arterial hypertension (PAH). It will test whether better blood sugar control in the body improves this condition. Researchers will test this by having participants who have PAH follow a healthy eating plan and get more physical activity. To participate in this study, you must be between 18 and 75 years old and have been diagnosed with pulmonary arterial hypertension. This study is located in Cleveland, Ohio.

Has your doctor recommended right heart cardiac catheterization for you?

This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be at least 18 years old, and your doctor must have recommended right heart catheterization for you. This study is located in Bethesda, Maryland.

Pulmonary Rehabilitation

Were you recently hospitalized for COPD, and are you eligible for pulmonary rehabilitation?

This study aims to add health coaching to pulmonary rehabilitation to determine if encouraging behavior change can decrease COPD re-hospitalizations and improve quality of life. To participate in this study, you must be at least 40 years old, have been hospitalized for COPD and be eligible for pulmonary rehabilitation. This study is located in Rochester, Minnesota.

Rehabilitación pulmonar (en español)

¿Fue hospitalizado recientemente por EPOC y reúne los requisitos para recibir rehabilitación pulmonar?

Este estudio tiene como objetivo agregar asesoramiento en salud de rehabilitación pulmonar para determinar si alentar cambios en el comportamiento puede disminuir los reingresos al hospital por EPOC y mejorar la calidad de vida. Para participar en este estudio, debe tener al menos 40 años de edad, haber sido hospitalizado por EPOC y reunir los requisitos para recibir rehabilitación pulmonar. Este estudio se centra en Rochester, Minnesota.

¿Tiene una lesión de la médula espinal o tetraplejia?

Este estudio probará un dispositivo de terapia respiratoria que funciona como una armónica. El estudio hará un seguimiento de la frecuencia con la que un paciente experimenta disnea a lo largo del tiempo y verá si un programa de ejercicios de respiración basado en un juego ayuda a mejorar la función pulmonar del paciente. Para participar en este estudio, debe ser mayor de 18 años y tener una lesión de la médula espinal o tetraplejia. Este estudio se encuentra en Albany (Nueva York).

¿Tiene su hijo fibrosis quística?

Este estudio investiga qué tan bien los niños con fibrosis quística aprenden a realizar una técnica de respiración para ayudar a eliminar la mucosidad de los pulmones con un dispositivo de entrenamiento que utiliza un videojuego. Para participar en este estudio, su hijo debe tener entre 5 y 17 años. Este estudio se encuentra en Albany (Nueva York).

¿Está planeando someterse a una cirugía abdominal?

Este estudio tiene como objetivo evaluar qué tan bien los juegos utilizando tabletas pueden ayudar a prevenir la atelectasia, un tipo de colapso pulmonar que puede ocurrir después de la cirugía, alentando a los pacientes a respirar profundamente, una técnica utilizada en la rehabilitación pulmonar. Para participar en este estudio, debe ser mayor de 18 años y estar programado para a una cirugía de la parte superior del abdomen, como una cirugía para perder peso o para extraer la vesícula biliar. Este estudio se encuentra en Albany (Nueva York).

¿Fuma y tiene EPOC?

Este estudio analizará cómo un programa de rehabilitación pulmonar de 12 semanas realizado en el hogar afecta los resultados del paciente. Para participar en este estudio, debe ser mayor de 40 años, ser fumador actual o exfumador y tener un diagnóstico de EPOC. Este estudio se encuentra en Jacksonville (Florida) y Rochester (Minnesota).

Respiratory Distress Syndrome

Has your newborn been diagnosed with patent ductus arteriosus?

Patent ductus arteriosus (PDA) is a condition in which a connection between two major blood vessels close to the heart does not close properly after birth. This affects blood flow to the lungs and may cause neonatal respiratory diseases. PDA may correct itself, but sometimes treatment may be necessary. This study aims to identify ways by which doctors can predict which cases of PDA need to be treated. To participate in this study, your newborn must have been born between 23 and 29 weeks’ gestation and have been diagnosed with PDA. This study is located in Columbus, Ohio.

Is your premature newborn in a neonatal intensive care unit in Chicago, Illinois?

This study is investigating how brain development affects breathing in premature newborns. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and admitted to the neonatal intensive care unit within a week of birth. This study is located in Chicago, Illinois.

Is your newborn in the NICU at Holtz Children’s Hospital in Miami?

Newborns born very prematurely often need oxygen therapy or ventilation to help them breathe and survive. This study will help doctors understand how changes in oxygen and carbon dioxide levels while newborns are getting treatment affect how their lungs develop. While your newborn is in the newborn neonatal intensive care unit (NICU), researchers will record his or her oxygen and carbon dioxide levels, heart rate, and other measures. To participate in this study, your newborn must have been born prematurely between 23 and 28 weeks’ gestation, be less than 28 days old, and be receiving oxygen therapy. This study is located in Miami, Florida.

Was your newborn born prematurely?

This study aims to better understand the effects of premature delivery on a baby’s lungs during his or her first year of life. To participate in this study, your newborn must have been born prematurely between 24 and 36 weeks’ gestation and not have any congenital heart or lung defects. This study is located in Indianapolis, Indiana.

Is your newborn receiving care at the University of Alabama at Birmingham Women and Infants Center?

This study is testing new ways to help control breathing and oxygen and carbon dioxide levels in premature newborns. To participate in this study, your premature newborn must be in the neonatal intensive care unit or the critical care nursery at the Birmingham Women and Infants Center at the University of Alabama. This study is located in Birmingham, Alabama.

Is your newborn in the neonatal intensive care unit at St. Louis Children’s Hospital?

This study aims to better understand breathing problems and blood flow through the heart in premature newborns to better detect conditions such as pulmonary hypertension. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and be a patient in the Neonatal Intensive Care Unit at St. Louis Children’s Hospital. This study is located in St. Louis, Missouri.

Have you been diagnosed with high blood pressure while pregnant?

This study is investigating whether a mother’s blood pressure during pregnancy affects her newborn’s lung development. To participate in this study, your newborn must have been born either prematurely at more than 25 weeks’ gestation or at full term to a healthy mother or a mother who was diagnosed with high blood pressure during pregnancy. This study is located in Indianapolis, Indiana.

Respiratory Failure

Do you or a loved one have pneumonia?

This study will test whether combining two medicines (an inhaled corticosteroid and a beta agonist) can help prevent respiratory failure in people who have pneumonia. To participate in this study, you must be at least 18 years old and have severe pneumonia with low blood oxygen levels. This study is located in Scottsdale and Tucson, Arizona; Palo Alto, California; Gainesville and Jacksonville, Florida; Baltimore, Maryland; Rochester, Minnesota; New York, New York; Durham, North Carolina; and Philadelphia, Pennsylvania.
View more information about ARrest RESpiraTory Failure From PNEUMONIA.

Are you being treated in the ICU for acute respiratory failure?

This study is looking at whether treating depression along with physical therapy helps people recover faster from respiratory failure. After leaving the ICU, you will be visited at your home by a physical therapist and occupational therapist who will talk to you about your goals for recovery and what activities you value the most. They will then design a plan for you that includes a type of talk therapy for depression called behavioral activation. To participate in this study, you must be at least 18 years old and undergoing treatment for acute respiratory failure for more than 24 hours in the ICU. This study is located in Baltimore, Maryland.

Is your child on a ventilator at Children’s Hospital Los Angeles?

Ventilators can sometimes weaken the muscles around the lungs, especially in children. This study is testing whether a new computer method to control ventilators can help prevent muscle weakness in children. To participate in this study, your child must be between 1 month and 18 years old and have been on a ventilator for less than 48 hours (or 72 if they were transferred from another hospital) because of a serious lung disease. This study is located in Los Angeles, California.

Are you or a loved one on a ventilator in the hospital in Minnesota?

This study is finding out whether people who are on a ventilator sleep better and have less anxiety if they can control their own sedation medicine. To participate in this study, you must be at least 18 years old and receiving mechanical ventilation while hospitalized. This study is located in Minneapolis and Rochester, Minnesota.

Sarcoidosis

Are you an adult with sarcoidosis who does not smoke or use other nicotine products?

This study will test whether nicotine patches are an effective treatment for sarcoidosis. To participate, you must be an adult between the ages of 18 and 75 with sarcoidosis, and you must not be a smoker or a user of smokeless tobacco products that contain nicotine. This study is located in Columbus, Ohio.

Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Sarcoidosis (en español)

Genes involucrados en el desarrollo de enfermedades pulmonares

Este estudio investigará los genes implicados en el proceso respiratorio y en el desarrollo de enfermedades pulmonares como el asma o la sarcoidosis para mejorar la comprensión del papel que ellos desempeñan. Para participar en este estudio, usted o su hijo deben tener entre 2 y 90 años y haber sido diagnosticado y estar viviendo con una enfermedad pulmonar. Este estudio se realiza en Bethesda, Maryland.

¿Es usted un adulto con sarcoidosis que no fuma ni usa otros productos de nicotina?

Este estudio probará si los parches de nicotina son un tratamiento efectivo para la sarcoidosis. Para participar, debe ser un adulto entre las edades de 18 y 75 con sarcoidosis, y no debe fumar ni consumir productos de tabaco sin humo que contengan nicotina. Este estudio se realiza en Columbus, Ohio.

Sickle Cell Disease

Sickle cell disease and kidney function tests

This study will compare two different lab tests to measure kidney function in adults with sickle cell disease. Participants in this study must be at least 18 years old and cannot have experienced a pain crisis in the last month or a change in treatment in the last 2 months. This study is located in Bethesda, Maryland.

Are you or your child interested in donating a sample of bone marrow for research?

This study will collect samples of bone marrow from patients who have sickle cell disease or β-thalassemia to help develop genetic therapies. Participants in this study must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Are you 15 to 40 years old and have severe sickle cell disease?

This study is comparing long-term outcomes for patients who receive blood and bone marrow transplants and those who receive standard treatment with medicines. Participants also have an option of contributing blood samples to be stored for future research. Participants must be 15 to 40 years old and have severe sickle cell disease. This study is located in Madison, Wisconsin.

Pregnancy and umbilical cord donation for sickle cell disease

This study seeks to determine the best way to collect, store, and handle blood from newborns to help researchers improve future sickle cell disease therapies. To participate in this study, you must be pregnant, 45 years old or younger, and willing to donate umbilical cord blood from your newborn. Newborns may be healthy or at risk for sickle cell disease or sickle cell trait. This study is located in Bethesda, Maryland.

Are you an adult who has chronic pain from sickle cell disease?

This study is testing a new computer-based program that aims to help patients who have sickle cell disease manage pain. Participants must be at least 18 years old and have chronic pain. This study is located in Pittsburgh, Pennsylvania.

Blood samples for genetic testing

This study will look at whether a particular gene in people who have sickle cell disease increases the risk for more severe symptoms and complications. To participate in this study, you must be between 18 and 80 and not have had a blood transfusion in the previous 8 weeks. This study is located in Bethesda, Maryland.

Do you or your child have severe sickle cell disease and also know a half-matched bone marrow donor?

This study is seeking to improve bone marrow transplantation success from half-matched donors by testing a different conditioning procedure that uses a variety of medicines to prepare for the transplant. To participate in this study, you must be 15 to 45 years old and have severe sickle cell disease or have a child 5 to 14 years old who has had a stroke. This study is located in many sites across the United States, including Miami, Florida, and St. Louis, Missouri.

Bone marrow transplant procedures for severe anemia

This study aims to improve bone marrow transplant (BMT) procedures for older patients by using a low dose of radiation and two immunosuppressive drugs instead of chemotherapy. This type of BMT procedure is described as nonmyeloablative because it does not destroy bone marrow. Participants in this study must be between 2 and 65 years old; have a severe congenital anemia, such as sickle cell disease or beta thalassemia; and have a sibling who is a well-matched stem cell donor. This study is located in Bethesda, Maryland.

Do you have a child 12 to 18 years old who has sickle cell disease and is interested in hypnosis?

This study is testing whether hypnosis has an effect on blood flow and pain in adolescents who have sickle cell disease. To participate in this study, you must be between 12 and 18 years old and be fluent in English. This study is located in Los Angeles, California.

Pain crises and lung complications in sickle cell disease

This study is interested in understanding pain crises and lung complications that occur in sickle cell disease patients and patients who have other red blood cell disorders. To participate in this study, you must be at least 2 years old with known or suspected sickle cell disease, sickle cell trait, or other red blood cell disorders. Participants will have a physical exam and receive standard medical care for sickle cell disease, including routine follow-up tests and procedures. This study is located in Washington, D.C., and Bethesda, Maryland.
View more information about Natural History of Sickle Cell Disease.

Stem cell transplant procedure with a partial match

This study is testing new ways to improve a stem cell transplant procedure that involves a donor who is not a complete match, called a partial match. To participate in this study, you must be at least 18 years old and have both severe sickle cell disease and a donor who is a partial match. This study is located in Bethesda, Maryland.

Improving bone marrow transplants

This study is exploring how to improve bone marrow transplant procedures so the body better accepts donor stem cells. To participate in this study, you must be at least 4 years old, have sickle cell disease, and have a stem cell donor. This study is located in Bethesda, Maryland.

Are you between 16 and 20 years old and willing to answer questions about managing your sickle cell disease?

This study is investigating the care and quality of life of patients who have sickle cell disease as they transition from pediatric to adult care. To participate in this study, you must be between 16 and 20 years old and be a patient of St. Jude Children’s Research Hospital. This study is located in Memphis, Tennessee.

Do you or your child have sickle cell disease and high blood pressure?

This study is exploring whether use of losartan, a medicine commonly used to lower blood pressure, is effective at treating abnormal nighttime blood pressure in children and young adults who have sickle cell disease. Participants in this study must be between 5 and 25 years old and have high blood pressure and a certain type of sickle cell disease: hemoglobin SS or Sβ0 thalassemia. This study is located in Birmingham, Alabama.
View more information about Preventing Sickle Cell Kidney Disease.

Blood disorder research

This study is collecting medical information from health exams and routine tests and procedures to see whether participants may be able to enroll in other studies on blood disorders. Participants in this study must be at least 8 years, with or without a blood disorder. This study is located in Bethesda, Maryland.

Do you or your child have sickle cell disease and also have an interest in contributing to long-term data collection?

This study is monitoring patients and collecting biological samples from patients who have sickle cell disease to better understand long-term outcomes. Participants can be any age and must have sickle cell disease. This study is located in six sites in Illinois, Louisiana, North Carolina, and Tennessee.

Do you have pain from sickle cell disease and trouble sleeping?

This study will look at whether improving sleep can reduce pain in people who have sickle cell disease and chronic pain. To participate in this study, you must be at least 18 years old, have been diagnosed with sickle cell disease, and experience insomnia and chronic pain. This study is located in Baltimore, Maryland.
View more information about Sleep and Pain in Sickle Cell Disease.

Do you or your child need a stem cell transplant?

This study is exploring the use of treatment with certain medicines in combination with radiation for a successful stem cell transplant. To participate in this study, you must be younger than 49 years old and have a severe disease treatable by a stem cell transplant. This study is located in several sites across the United States, including Aurora, Colorado; Seattle, Washington; and Milwaukee, Wisconsin.

Sleep Apnea

Do you have an adolescent or young adult with sleep apnea and Down syndrome?

The purpose of this study is to assess whether a device that is implanted in the body to stimulate the nerves of the tongue and that has already been approved for use in adults with obstructive sleep apnea can be safely implanted and used in adolescents and young adults who have Down syndrome. To participate, you must be 10 to 21 years old with Down syndrome and have had your tonsils removed. Trial locations are in Atlanta, Georgia; Boston, Massachusetts; Cincinnati, Ohio; Cleveland, Ohio; and Pittsburgh, Pennsylvania.

Are you an adult with sleep apnea who wants to help understand this disease by using an oral appliance?

This study, which aims to understand how the upper airway collapses in obstructive sleep apnea patients during sleep, will use this information to explain why some patients present a large improvement in opening of the upper airway with the use of an oral appliance while others do not. You will have some special exams, such as an endoscopy and sleep studies. To participate, you must be 21 to 70 years old and have obstructive sleep apnea. The trial is being conducted in Boston, Massachusetts.

Are you an adult with sleep apnea and type 2 diabetes?

This study is looking at whether using a CPAP machine can improve blood sugar levels, decrease blood pressure, and reverse damage to the blood vessels in patients who have obstructive sleep apnea and type 2 diabetes. To participate, you must be 21 to 75 years old and have obstructive sleep apnea and type 2 diabetes. The trial is being conducted in Baltimore, Maryland.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Do you have a child with sleep apnea who is interested in a new treatment with a nasal spray?

This study will assess the use of a nasal spray for the treatment of obstructive sleep apnea in children. To participate, children must be 5 to 10 years old, have never had surgery to remove the tonsils, and have never used a CPAP machine. The trial is being conducted in Philadelphia, Pennsylvania.

Sleep Deprivation and Deficiency

Are you an adult with a diagnosed sleep phase disorder?

This study aims to assess the sleep patterns and quality of sleep in people who have sleep phase disorders to determine how the disorders affect their circadian rhythms. To participate in this study, you must be at least 18 years old and have a sleep phase disorder, such as advanced sleep-wake phase syndrome or delayed sleep-wake phase syndrome. This study is located in Chicago, Illinois.

Sleep Deprivation and Deficiency (en español)

¿Eres un adulto con un trastorno de fase del sueño?

Este estudio tiene como objetivo evaluar los patrones de sueño así como su calidad en personas que tienen trastornos de fase del sueño para determinar cómo los trastornos afectan sus ritmos circadianos. Para participar en este estudio, debe tener al menos 18 años de edad y tener un trastorno de fase del sueño, como el síndrome de fase del sueño avanzada o el síndrome de fase del sueño retardada. Este estudio se realiza en Chicago (Illinois).

Sobrepeso y obesidad (en español)

¿Es un adulto que quiere ayudar a entender cómo comer muchos azúcares agregados afecta su salud?

Este estudio examinará cómo comer grandes cantidades de azúcares agregados afecta los factores de riesgo de enfermedad del corazón y de los vasos sanguíneos o diabetes en participantes que están ingiriendo una dieta balanceada en energía para prevenir el aumento de peso, o una dieta con desequilibrio energético que puede causar el aumento de peso. Para participar en este estudio, debe tener entre 18 y 40 años y tener un índice de masa corporal entre 22 y 28 que no haya cambiado en los últimos seis meses.

¿Está embarazada y tiene un IMC de 30 o más?

Este estudio examina la conexión entre la obesidad, los problemas respiratorios asociados con el sueño y los problemas del embarazo, como la preeclampsia. Para participar en este estudio, debe ser mayor de 18 años, estar embarazada y tener obesidad. Este estudio se realiza en Pittsburgh (Pensilvania).

¿Tiene sobrepeso?

Los trastornos del ritmo circadiano pueden causar sobrepeso y obesidad. Este estudio examina cómo no dormir lo suficiente causa estas complicaciones. Para participar en este estudio, debe tener entre 20 y 40 años y tener sobrepeso, pero no obesidad. Este estudio se realiza en Nueva York (Nueva York).

¿Su hijo es negro y tiene entre 8 y 11 años?

Este estudio prueba una forma de mejorar el sueño en niños con el objetivo de prevenir la obesidad. Para participar en este estudio, su hijo debe tener entre 8 y 11 años y debe ser negro o afroamericano. Este estudio se encuentra en Filadelfia (Pensilvania).

¿Recientemente se convirtió en madre, y es afroamericana que tiene sobrepeso u obesidad y vive en Filadelfia?

Este estudio comparará el tratamiento habitual y el específico de la comunidad para ver cuál es más efectivo para ayudar a las afroamericanas que recientemente se convirtieron en madres a perder peso después del parto. Para participar, debe tener sobrepeso u obesidad, ser participante del Programa Especial de Nutrición Suplementaria para Mujeres, Infantes y Niños (WIC, por sus siglas en inglés) en Filadelfia y haber tenido un parto en los últimos seis meses. Este estudio se realiza en Filadelfia (Pensilvania).

Sobrepeso y obesidad

¿Es un hombre o una mujer afrodescendiente con obesidad y vive en Washington, D.C.?

En este estudio se evalúa la salud cardiovascular y otras afecciones (como la diabetes, la presión arterial, el colesterol y el peso) de personas afrodescendientes obesas de ambos sexos. A partir de los resultados de la evaluación, los investigadores desarrollarán y pondrán a prueba nuevas estrategias de conducta para bajar de peso que sean adecuadas para esa comunidad.

¿Es mujer, tiene obesidad, está embarazada y tiene apnea del sueño?

Este estudio servirá para comprender de qué manera la apnea del sueño, un trastorno del sueño frecuente en las personas obesas, podría contribuir al desarrollo de complicaciones durante el embarazo. También se analizará si el uso de dispositivos de presión positiva continua de las vías respiratorias, un tratamiento frecuente para la apnea del sueño, mejora las respuestas del embarazo para usted y para el bebé antes del parto.

Stress Test

Do you want to help improve heart imaging techniques?

This study aims to improve magnetic resonance imaging (MRI) methods to detect coronary heart disease. Healthy people and people who have coronary heart disease will have MRI scans while resting and after taking a medicine that temporarily makes your heart work harder. To participate in this study, you must be at least 18 years old and either healthy or diagnosed with coronary heart disease. The study is taking place in Los Angeles, California.

Stroke

Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery?

This study will examine whether adding oral anti-blood clotting medicines to anti-platelet medicines (such as aspirin) helps prevent stroke and other complications in people who develop atrial fibrillation after CABG surgery. To participate in this study, you must be at least 18 years old and have been diagnosed with atrial fibrillation after having CABG surgery. The study is located in 63 places in 22 states, the District of Columbia, Canada, and Germany.

Are you an adult who has uncontrolled high blood pressure?

This study will see whether an early notification system for health professionals can help manage patients’ high blood pressure, especially among those who have had a stroke or have an increased risk of stroke. To participate in this study, you must be between 18 and 85 years old and have high blood pressure that is not controlled by medicine and lifestyle changes. This study is enrolling native English, Spanish, or Hmong speakers. The study is located in Minneapolis, Minnesota.

Are you a stroke survivor?

This study aims to develop an app for smartwatches and smartphones to test several atrial fibrillation monitoring devices for patients who have had a stroke or transient ischemic attack. To participate in this study, you must be at least 50 years old and have been admitted to the UMass Memorial Medical Center for a stroke or TIA. The study is located in Worcester, Massachusetts.

Have you been diagnosed with carotid artery plaque?

This study aims to test whether a noninvasive ultrasound method can identify which people who have carotid artery disease benefit from carotid endarterectomy (a procedure to remove the plaque) to prevent stroke. To participate in this study, you must be at least 18 years old and have carotid artery disease. The study is located in Chapel Hill, North Carolina.

Do you have diabetes and a history of heart attack?

This is a follow-on study of the Trial to Assess Chelation Therapy (TACT), which showed that medicine to help remove metals in the blood reduced the risk of ischemic heart disease complications, including stroke and unstable angina, in people who have diabetes who had a prior heart attack. To participate in this study, you must be at least 50 years old and have a history of diabetes and heart attack. This study is located in Miami, Florida.

Terapias Genéticas (en español)

¿Usted o un niño que conoce tienen linfoma?

Este estudio está probando una terapia genética para la prevención de linfoma recurrente. Los participantes en este estudio deben tener al menos 3 años y un alto riesgo de linfoma recurrente según lo determine su médico. Este estudio se encuentra en Chapel Hill (Carolina del Norte).

¿Es un adulto que tiene cáncer de riñón?

Este estudio evaluará cómo funciona una nueva técnica de terapia genética para pacientes con cáncer de riñón. Los glóbulos blancos de un paciente se modificarán en el laboratorio mediante terapias genéticas. Los pacientes recibirán diferentes dosis de sus propios glóbulos blancos modificados. Para participar en este estudio, debe tener entre 18 y 70 años y haber sido diagnosticado con un carcinoma de células renales progresivo. Este estudio se encuentra en Bethesda, Maryland.

¿Conoces a un recién nacido o un niño pequeño que tenga inmunodeficiencia combinada grave?

Este estudio evaluará la seguridad y la eficacia de las terapias genéticas para tratar la inmunodeficiencia combinada grave ligada al cromosoma X (SCID-X1), un trastorno genético inmunológico poco común. Las terapias podrían significar un nuevo enfoque para tratar la SCID-X1 en personas que no tienen un hermano o hermana que sea donante para un trasplante de células madre. Para participar en este estudio, el niño o niña debe tener 2 años o menos. Este estudio se encuentra en Memphis (Tennessee); San Francisco (California); y Seattle (Washington).

Thalassemias

Are you or your child interested in donating a sample of bone marrow for research?

This study will collect samples of bone marrow from patients who have sickle cell disease or β-thalassemia to help develop genetic therapies. Participants in this study must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Bone marrow transplant procedures for severe anemia

This study aims to improve bone marrow transplant (BMT) procedures for older patients by using a low dose of radiation and two immunosuppressive drugs instead of chemotherapy. This type of BMT procedure is described as nonmyeloablative because it does not destroy bone marrow. Participants in this study must be between 2 and 65 years old; have a severe congenital anemia, such as sickle cell disease or beta thalassemia; and have a sibling who is a well-matched stem cell donor. This study is located in Bethesda, Maryland.

Trastornos hemorrágicos (en español)

¿Usted o su hijo tienen un trastorno de plaquetas, de sangrado, o de glóbulos blancos?

Este estudio analiza personas que tienen trastornos de plaquetas u otros trastornos de la sangre. Los investigadores utilizarán una muestra de sangre para buscar problemas con las plaquetas y una posible causa genética en el ADN o ARN del participante. Para participar en este estudio, debe ser un niño o adulto que esté sano o tenga un trastorno de plaquetas, un trastorno de coagulación o un trastorno de los glóbulos blancos. Este estudio se encuentra en Nueva York, Nueva York.

¿Usted es un adulto que planea someterse a un procedimiento quirúrgico?

Este estudio tiene como objetivo determinar si el suministro de plasma sanguíneo antes de un procedimiento quirúrgico puede ayudar a reducir las complicaciones de sangrado en personas que tienen resultados de pruebas ligeramente anormales en la prueba de tiempo de protrombina (PT). Para participar en este estudio, debe ser mayor de 21 años, estar programado para un procedimiento quirúrgico y no tener un trastorno hemorrágico causado por la genética u otra enfermedad. Este estudio se encuentra en Baltimore, Maryland y New Brunswick, Nueva Jersey.

Venous Thromboembolism

Do you know someone being treated for cancer who may be at risk for VTE?

This study will assess a medicine called isoquercetin to see if it can prevent a venous thromboembolism (VTE) in patients getting treatment for pancreatic, colorectal, and non-small cell lung cancer. To participate in this study, you must be at least 18 years old and must not have been diagnosed with VTE in the last two years. The study has nine locations in California, Connecticut, Maine, Massachusetts, Missouri, Vermont, and Washington, D.C.

Were you or your child recently diagnosed with VTE?

This study is testing a six-week course of blood-thinning medicines for the treatment of venous thromboembolisms (VTE) to see if they are as effective as the standard treatment course of three months. To participate in this study, you or your child must be younger than 21 years old. This study has 54 locations in Alabama, Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland, Massachusetts, Michigan, Missouri, New Jersey, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, South Carolina, Texas, Utah, Virginia, Wisconsin, Australia, Austria, Canada, Israel, and the Netherlands.

Was your child recently diagnosed with DVT?

This study will investigate physical activity habits among children recovering from a deep vein thrombosis (DVT) to see if a fitness tracker can help them maintain regular physical activity. The study will also assess the impact of exercise on their health and quality of life. To participate in this study, your child must be between 7 to 21 years old. The study is located in Dallas, Texas.

Do you know a child or young adult recently treated for VTE?

This study is exploring why some people experience complications after treatment for venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism. To participate in this study, you must have been recently treated for VTE and be younger than 21 years old. This study is located in Dallas, Texas.

Ventilator/Ventilator Support

Are you on a ventilator and do you want to test a device that makes sure you are lying in the best position?

If you are on a ventilator, it is important for doctors and nurses to put you in the right position to lower your chances of developing pneumonia. This study is testing a device that alerts doctors and nurses when you are not in the right position. To participate in this study, you must be ages 18-75 year and on a ventilator. This study is located in New York, New York.

Is your newborn in the NICU at Holtz Children’s Hospital in Miami?

Newborns born very prematurely often need oxygen therapy or ventilation to help them breathe and survive. This study will help doctors understand how changes in oxygen and carbon dioxide levels while newborns are getting treatment affect how their lungs develop. While your newborn is in the newborn neonatal intensive care unit (NICU), researchers will record his or her oxygen and carbon dioxide levels, heart rate, and other measures. To participate in this study, your newborn must have been born prematurely between 23 and 28 weeks’ gestation, be less than 28 days old, and be receiving oxygen therapy. This study is located in Miami, Florida.

Is your newborn receiving care at the University of Alabama at Birmingham Women and Infants Center?

This study is testing new ways to help control breathing and oxygen and carbon dioxide levels in premature newborns. To participate in this study, your premature newborn must be in the neonatal intensive care unit or the critical care nursery at the Birmingham Women and Infants Center at the University of Alabama. This study is located in Birmingham, Alabama.

Is your child on a ventilator for acute respiratory distress syndrome (ARDS)?

This study is testing whether lying facedown and using a type of ventilation called high-frequency oscillatory ventilation improves breathing in children who have ARDS. To participate in this study, your child must be younger than age 18, diagnosed with ARDS, and on a ventilator. This study is located in 23 states in the United States, as well as in Australia, Canada, the Netherlands, and Thailand.

Is your child on a ventilator at Children’s Hospital Los Angeles?

Ventilators can sometimes weaken the muscles around the lungs, especially in children. This study is testing whether a new computer method to control ventilators can help prevent muscle weakness in children. To participate in this study, your child must be between 1 month and 18 years old and have been on a ventilator for less than 48 hours (or 72 if they were transferred from another hospital) because of a serious lung disease. This study is located in Los Angeles, California.

Are you or a loved one on a ventilator in the hospital in Minnesota?

This study is finding out whether people who are on a ventilator sleep better and have less anxiety if they can control their own sedation medicine. To participate in this study, you must be at least 18 years old and receiving mechanical ventilation while hospitalized. This study is located in Minneapolis and Rochester, Minnesota.

Vida saludable para el corazón (en español)

Aumento de la actividad física en mujeres afroamericanas con riesgo de diabetes

Este estudio está probando si el uso de tecnología de salud móvil, como las aplicaciones de teléfonos inteligentes y los monitores de actividad, puede ayudar a aumentar la actividad física en mujeres afroamericanas que están en riesgo de padecer diabetes. Para participar en este estudio, debe ser una mujer afroamericana de entre 25 y 75 años de edad, tener evidencia de resistencia a la insulina y vivir en el condado de Prince George, Maryland, o Ward 5, 7 u 8 en Washington (DC). Este estudio se realiza en Bethesda (Maryland).

Exploración de pruebas de diagnóstico para trastornos de los lípidos

Este estudio explora cómo las diferentes pruebas de diagnóstico pueden ayudarnos a entender la forma en que los trastornos de los lípidos, incluido el nivel alto de colesterol y los triglicéridos altos en la sangre, afectan el cuerpo. La información de este estudio puede ayudar a mejorar la forma en que los trastornos de los lípidos se diagnosticarán o tratarán en el futuro. Los participantes deben tener al menos 2 años de edad. Este estudio se realiza en Bethesda (Maryland).

¿Es un adulto sano sin antecedentes de problemas de salud que estaría dispuesto a practicar ejercicios de respiración?

Este estudio tiene como objetivo evaluar si los músculos respiratorios afectan la presión arterial durante la actividad física midiendo los niveles de oxígeno y la presión arterial durante el ejercicio en una bicicleta reclinada. Para participar en este estudio, debe tener entre 18 y 80 años y no tener antecedentes de enfermedades del corazón, los pulmonares, cerebrales, óseas, musculares o nerviosas. Este estudio se realiza en Rochester (Minnesota).

¿Tiene entre 40 y 70 años de edad y tiene síndrome metabólico?

Este estudio tiene como objetivo evaluar si la medicina metformina, utilizada para tratar la diabetes, puede mejorar el flujo sanguíneo y la capacidad de realizar actividad física cuando se combina con ejercicios en personas con síndrome metabólico. Para participar en este estudio, debe tener entre 40 y 70 años y tener síndrome metabólico. Este estudio se realiza en Charlottesville (Virginia).

¿Es un adulto que quiere ayudar a entender cómo comer muchos azúcares agregados afecta su salud?

Este estudio examinará cómo comer grandes cantidades de azúcares agregados afecta los factores de riesgo de enfermedad del corazón y de los vasos sanguíneos o diabetes en participantes que están ingiriendo una dieta balanceada en energía para prevenir el aumento de peso, o una dieta con desequilibrio energético que puede causar el aumento de peso. Para participar en este estudio, debe tener entre 18 y 40 años y tener un índice de masa corporal entre 22 y 28 que no haya cambiado en los últimos seis meses.

¿Es un adulto menor de 40 años que recientemente ha tenido una lesión en la médula espinal?

Este estudio tiene como objetivo evaluar si un programa de entrenamiento físico llamado Entrenamiento en fila (RT, por sus siglas en inglés) de estimulación eléctrica funcional (FES, por sus siglas en inglés) puede mejorar la capacidad de ejercicio y, en última instancia, la salud del corazón, en aquellos que tienen lesiones de la médula espinal, en comparación con los ejercicios estándar de remo solo con los brazos. El FES-RT implica ejercicios de brazo combinados con pequeñas cargas eléctricas hacia los músculos debilitados de las piernas. Para participar en este estudio, debe tener entre 20 y 40 años y haber sufrido una lesión en la médula espinal en los últimos 12 meses. Este estudio se realiza en Cambridge (Massachusetts).

Evaluación de afecciones del corazón

Este estudio tiene como objetivo ayudar a capacitar al personal en una variedad de enfermedades del corazón mediante la evaluación de pacientes de todas las edades que tienen enfermedades del corazón, o corren el riesgo de sufrir dichas enfermedades, en el Centro Clínico de los NIH. Los participantes en el estudio deben tener síntomas de enfermedades cardiovasculares o estar en riesgo de tener una. Algunos ejemplos de enfermedades cardiovasculares incluyen enfermedad coronaria, enfermedad valvular, cardiomiopatías, enfermedad arterial periférica, enfermedades congénitas del corazón y enfermedad vascular de los riñones. Este estudio se realiza en Bethesda (Maryland).

¿Es un adulto sano que duerme regularmente 6.5 horas o menos?

Este estudio examina si dormir lo suficiente puede reducir el riesgo de presión arterial alta. Para participar en este estudio, debe tener entre 18 y 65 años, dormir con regularidad durante 6.5 horas o menos, y poder ajustar su horario de sueño para el estudio. Este estudio se realiza en Rochester (Minnesota).

¿Tiene sobrepeso?

Los trastornos del ritmo circadiano pueden causar sobrepeso y obesidad. Este estudio examina cómo no dormir lo suficiente causa estas complicaciones. Para participar en este estudio, debe tener entre 20 y 40 años y tener sobrepeso, pero no obesidad. Este estudio se realiza en Nueva York (Nueva York).

¿Tiene presión arterial alta y recibe atención en una clínica comunitaria en el sur?

Este estudio explorará un enfoque de manejo intensivo de la presión arterial alta en las clínicas comunitarias participantes. El enfoque tiene como objetivo reducir la presión arterial sistólica de los participantes a 120 mmHg. Para participar en este estudio, debe tener al menos 40 años, entender inglés y no estar embarazada. El estudio se realiza en Luisiana, Alabama y Misisipi.

¿Tiene al menos 35 años y tiene presión arterial alta resistente?

Este estudio tiene como objetivo evaluar la efectividad del uso de cambios en el estilo de vida, como una alimentación saludable y actividad física, además de medicinas para tratar la presión arterial alta. Para participar en este estudio, debe tener al menos 35 años de edad, tener sobrepeso y tener presión arterial alta que no haya sido tratada con éxito con medicinas. Este estudio se realiza en Durham (Carolina del Norte).

¿Tiene al menos 21 años y tiene insuficiencia del corazón?

Este estudio tiene como objetivo utilizar imágenes de resonancia magnética (IRM) para comprender cómo ciertas moléculas que se forman en el cuerpo de las personas con insuficiencia del corazón afectan su capacidad para ser físicamente activos. Para participar en este estudio, debe tener al menos 21 años, tener diagnóstico de insuficiencia del corazón y ser médicamente estable. Este estudio se realiza en Baltimore (Maryland).

¿Su hijo es negro y tiene entre 8 y 11 años?

Este estudio prueba una forma de mejorar el sueño en niños con el objetivo de prevenir la obesidad. Para participar en este estudio, su hijo debe tener entre 8 y 11 años y debe ser negro o afroamericano. Este estudio se encuentra en Filadelfia (Pensilvania).

¿Es un adulto que tiene hipertensión pulmonar y le gustaría ver si los cambios saludables en el estilo de vida pueden ayudarlo?

Este estudio analiza una afección de presión arterial alta llamada hipertensión arterial pulmonar (HAP). Examinará si un mejor control del azúcar en la sangre en el cuerpo mejora esta afección. Los investigadores probarán esto haciendo que los participantes que tienen HAP sigan un plan de alimentación saludable y realicen más actividad física. Para participar en este estudio, debe tener entre 18 y 75 años y debe habérsele diagnosticado hipertensión arterial pulmonar. Este estudio se realiza en Cleveland (Ohio).

¿Es un adulto interesado en comparar los efectos de diferentes entrenamientos físicos sobre la presión arterial?

Este estudio tiene como objetivo comparar cómo los diferentes tipos de ejercicio pueden afectar la presión arterial en los afroamericanos. Los participantes realizarán actividades aeróbicas, centrándose en aumentar su ritmo cardíaco, o actividades de resistencia para fortalecer los músculos, centrándose en pesas, durante 24 a 26 semanas. Para participar en este estudio, debe tener entre 18 y 50 años, tener un estilo de vida sedentario y presión arterial elevada, haber nacido en los Estados Unidos y tener dos padres afroamericanos o dos caucásicos no hispanos. Este estudio se realiza en Chicago (Illinois).

¿Es un adulto que tiene presión arterial alta no controlada?

Este estudio examinará si un sistema de notificación temprana para profesionales de la salud puede ayudar a controlar la presión arterial alta de los pacientes, en especial entre aquellos que han tenido un derrame cerebral o tienen un mayor riesgo de sufrir un derrame cerebral. Para participar en este estudio, debe tener entre 18 y 85 años y tener presión arterial alta que no esté controlada con medicinas ni cambios en el estilo de vida. Este estudio está registrando hablantes nativos de inglés, español o hmong. El estudio se realiza en Minneapolis (Minnesota).

¿Tiene al menos 18 años y está interesado en probar un programa de pérdida de peso basado en un teléfono inteligente?

Este estudio tiene como objetivo probar un programa basado en teléfono inteligente para ayudar a las personas a controlar sus esfuerzos para comer sano y alcanzar un peso saludable. El estudio analizará que tan efectivos son los mensajes de retroalimentación basados en teléfono inteligente para involucrar a los pacientes y promover la pérdida de peso. Para participar en este estudio, debe ser mayor de 18 años, poseer y usar un teléfono inteligente con regularidad, y poder realizar actividades físicas de intensidad moderada. Este estudio se realiza en Pittsburgh (Pensilvania).

Comprender las enfermedades del corazón y los vasos sanguíneos

Este estudio tiene como objetivo recopilar datos y muestras de personas que tienen una enfermedad del corazón o vascular, sus familiares y personas sanas. Los participantes deben tener al menos 2 años de edad. Este estudio se realiza en Bethesda (Maryland).

¿Es usted un adulto que quiere saber cómo el sodio afecta su presión arterial?

Este estudio evalúa si la limitación del sodio puede afectar a personas con una predisposición genética específica a la presión arterial alta. Para participar debe tener 18 años de edad o más y no sufrir de presión arterial alta. Tenga en cuenta que este estudio se realiza en Charlottesville (Virginia).
Obtenga más información sobre respuesta de la presión arterial al sodio en la dieta

¿Recientemente se convirtió en madre, y es afroamericana que tiene sobrepeso u obesidad y vive en Filadelfia?

Este estudio comparará el tratamiento habitual y el específico de la comunidad para ver cuál es más efectivo para ayudar a las afroamericanas que recientemente se convirtieron en madres a perder peso después del parto. Para participar, debe tener sobrepeso u obesidad, ser participante del Programa Especial de Nutrición Suplementaria para Mujeres, Infantes y Niños (WIC, por sus siglas en inglés) en Filadelfia y haber tenido un parto en los últimos seis meses. Este estudio se realiza en Filadelfia (Pensilvania).