Patient and health professional.

NHLBI Clinical Trials

These NHLBI-sponsored research studies are for patients who have heart, lung, blood, or sleep-related diseases.

Anemia (en español)

¿Desea participar en la investigación sobre la sangre?

El estudio tiene como objetivo evaluar en el Centro Clínico de Institutos Nacionales de la Salud a pacientes que tienen un trastorno sanguíneo como la anemia y que pueden ser elegibles para participar en los estudios en la rama de Hematología. También determinará si es seguro para usted participar en esos estudios. Para ser evaluado, usted o su hijo deben tener al menos dos años y ser atendidos en el Centro Clínico en Bethesda, Maryland.

¿Recientemente dio a luz a un bebé de muy bajo peso al nacer?

El estudio está investigando cómo la anemia y las transfusiones de glóbulos rojos afectan los niveles de oxígeno en el tracto digestivo de bebés que nacen con muy bajo peso. Para participar, su bebé recién nacido debe haber tenido un peso muy bajo al nacer y estar dentro de los siete días posteriores al nacimiento. El estudio se lleva a cabo en Atlanta, Georgia.

¿Tuvo un ataque al corazón y quiere ayudar a determinar la mejor estrategia para una transfusión de sangre?

El estudio está comparando dos estrategias para transfusiones de sangre en pacientes que han tenido un ataque al corazón y tienen anemia. Esto ayudará a los médicos a decidir si administrar una transfusión de sangre de inmediato a los pacientes con ataque cardíaco que están anémicos, o esperar y ver si su condición mejora. Para participar, debe ser un adulto hospitalizado por un ataque al corazón y tener anemia. El estudio se lleva a cabo en New Brunswick, Nueva Jersey.

¿Le diagnosticaron a usted o a su hijo anemia de Diamond-Blackfan?

El registro está recopilando información de personas con anemia de Diamond-Blackfan para mejorar la comprensión de la enfermedad. Para participar, usted o su hijo deben estar diagnosticados con anemia de Diamond-Blackfan. Completará un cuestionario, proporcionará acceso a sus registros médicos y de laboratorio y responderá preguntas por teléfono al personal del estudio. Este estudio se lleva a cabo en Long Island, Nueva York.

Anemia

Have you had a heart attack, and do you want to help improve strategies for blood transfusion?

The study is comparing two strategies for blood transfusions in heart attack patients who have anemia—whether to give a blood transfusion when the hemoglobin level is less than 10 g/dL, or to give blood only when the blood count is below 8 g/dL. To participate in this study, you must be at least 18 years old, have anemia, and be hospitalized for a heart attack. The study is located in New Brunswick, New Jersey.

Did you recently give birth to a very low birth weight infant?

The study is investigating how anemia and red blood cell transfusions affect oxygen levels in the digestive tract of very low birth weight infants. To participate in this study, your newborn must have had a very low birth weight and be within seven days of birth. The study is taking place in Atlanta, Georgia.

Anemia de células falciformes (en español)

¿Quiere saber si puede participar en estudios sobre trastornos sanguíneos

Este estudio recopila información médica de exámenes de salud y pruebas y procedimientos de rutina para ver si los participantes pueden inscribirse en otros estudios sobre trastornos sanguíneos. Para participar en este estudio, debe ser mayor de 8 años, con o sin anemia de células falciformes. Este estudio se hace en Bethesda, Maryland.

¿Es usted un adulto con enfermedad de células falciformes grave y tiene un hermano o hermana donante de células madre con buena compatibilidad?

Este estudio está explorando un nuevo procedimiento de trasplante de médula ósea que no requiere quimioterapia o destrucción de toda la médula ósea para evitar el rechazo. Los participantes deben tener entre 18 y 65 años de edad, enfermedad de células falciformes grave y un hermano o hermana que sea un donante de células madre con buena compatibilidad. Para información adicional y para saber cómo participar en este estudio visite: Trasplante alogénico no mieloablativo de células precursoras hematopoyéticas movilizadas a la sangre periférica para anemias congénitas graves como la enfermedad de células falciformes y la talasemia beta (en inglés).

¿Tiene un niño de 12 a 18 años que padece anemia de células falciformes y está interesado en la hipnosis?

Este estudio está evaluando si la hipnosis tiene un efecto sobre el flujo sanguíneo y el dolor en adolescentes que tienen anemia de células falciformes. Para participar en este estudio, debe tener entre 12 y 18 años, y dominar el inglés. Este estudio se hace en Los Ángeles, California.

¿Usted o su hijo tienen anemia de células falciformes o un trastorno de los glóbulos rojos?

Este estudio está interesado en comprender las crisis de dolor y las complicaciones pulmonares que ocurren en pacientes con anemia de células falciformes y en pacientes con otros trastornos de los glóbulos rojos. Para participar en este estudio, su hijo debe tener al menos 5 años, anemia de células falciformes conocida o sospechada, rasgo de células falciformes, u otros trastornos de glóbulos rojos. Los participantes se someterán a un examen físico y recibirán atención médica estándar para la anemia de células falciformes, incluidos los exámenes y los procedimientos de seguimiento de rutina. Este estudio se hace en Washington, D.C.

¿Es usted un adulto que tiene dolor crónico debido a la anemia de células falciformes?

Este estudio está probando un nuevo programa computarizado que tiene como objetivo ayudar a que los pacientes con anemia de células falciformes lidien con los síntomas del dolor. Los participantes deben tener al menos 18 años y dolor crónico. Este estudio se hace en Pittsburgh, Pensilvania.

¿Usted o su hijo tienen anemia de células falciformes, y también tienen interés en donar médula ósea para la investigación?

Este estudio busca recolectar médula ósea de pacientes que tienen anemia de células falciformes para usar en experimentos de laboratorio. Los participantes deben tener al menos 2 años, estar clínicamente estables y no tener complicaciones agudas durante dos semanas. Este estudio se hace en Memphis, Tennessee.

¿Tiene entre 16 y 20 años, y está dispuesto a responder preguntas sobre el control de su anemia de células falciformes?

Este estudio está investigando el cuidado y la calidad de vida de los pacientes que tienen anemia de células falciformes cuando hacen la transición de la atención pediátrica a la de adultos. Para participar en este estudio, debe tener entre 16 y 20 años, y ser paciente del hospital de investigación infantil St. Jude. Este estudio se hace en Memphis, Georgia.

¿Usted o su hijo tienen anemia de células falciformes y también, interés en contribuir a la recopilación de datos a largo plazo?

Este estudio monitorea pacientes y recolecta muestras biológicas de pacientes que tienen anemia de células falciformes para comprender mejor los resultados a largo plazo. Los participantes pueden ser de cualquier edad y deben tener un tipo de anemia de células falciformes. Este estudio se hace en seis sitios en Illinois, Luisiana, Carolina del Norte y Tennessee.

¿Está embarazada y dispuesta a donar sangre del cordón umbilical para apoyar tratamientos futuros para la enfermedad de células falciformes?

Este estudio busca determinar la mejor forma de recolectar, almacenar y manipular la sangre de los recién nacidos para ayudar a que los investigadores mejoren las terapias futuras de la anemia falciforme. Para participar en este estudio, debe estar embarazada, tener 45 años o menos y estar dispuesta a donar sangre de cordón umbilical de su recién nacido. Los recién nacidos pueden estar sanos, o en riesgo de anemia de células falciformes o de rasgo de células falciformes. Este estudio se hace en Bethesda, Maryland.

¿Tiene anemia de células falciformes y un interés en proporcionar información que puede ayudar a desarrollar una aplicación móvil?

Este estudio está investigando por qué los pacientes con anemia de células falciformes no pueden tomar hidroxiurea o tienen problemas para tomarla. Esto ayudará a que los investigadores desarrollen una aplicación móvil que ayude a que los pacientes tomen sus medicamentos según las indicaciones. Para participar en este estudio, debe tener entre 15 y 45 años, tener cualquier tipo de anemia de células falciformes y ser capaz de hablar inglés. Este estudio se hace en Memphis, Tennessee.

¿Tiene al menos 16 años, anemia de células falciformes y un donante de células madre?

Este estudio explora cómo mejorar los procedimientos de trasplante de médula ósea para que el cuerpo acepte mejor las células madre de los donantes. Para participar en este estudio, debe tener al menos 16 años, anemia de células falciformes y un donante de células madre. Este estudio se hace en Bethesda, Maryland.

¿Usted o su hijo necesitan un trasplante de células madre?

Este estudio está explorando el uso del tratamiento con ciertos medicamentos en combinación con radiación para un trasplante exitoso de células madre. Los participantes no deben tener más de 49 años y una enfermedad severa tratable con un trasplante de células madre. Este estudio se hace en varios sitios en los Estados Unidos, incluidos Aurora, Colorado; Seattle, Washington; y Milwaukee, Wisconsin.

Angina

Are you at risk of unstable angina?

This study aims to recruit people in an emergency room for angina who have low or moderate troponin levels in the blood. Troponin is a sign of damage to the heart. This study will assess whether cardiac magnetic resonance imaging (MRI) is as effective as invasive procedures, such as angiography or coronary artery bypass grafting, in helping health providers make decisions about treatment for this group of patients. To participate in this study, you must be at least 21 years old and in an emergency room with chest pain and slightly elevated troponin levels. This study is located in Royal Oak, Michigan; Jackson, Mississippi; Winston-Salem, North Carolina; and Columbus, Ohio.

Do you have diabetes and a history of heart attack?

This is a follow-on study of the Trial to Access Chelation Therapy (TACT), which showed that medicine to help remove metals in the blood reduced the risk of ischemic heart disease complications, including unstable angina, in people who have diabetes who had a prior heart attack. To participate in this study, you must be at least 50 years old and have a history of diabetes and heart attack. This study is located in Miami, Florida.

Aplastic Anemia

[At NIH Clinical Center] Blood disorder research

This study is collecting medical information from health exams and routine tests and procedures to see whether participants may be able to enroll in other studies on blood disorders. Participants in this study must be at least 8 years, with or without a blood disorder. This study is located in Bethesda, Maryland.

Are you considering a blood stem cell transplant?

This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. To participate in this study, you must have a well-matched donor; you and your donor must be between 4 and 80 years old; and you must not be a candidate for immunosuppressive therapy. This study is located in Bethesda, Maryland.

Do you or a family member have Diamond-Blackfan anemia?

This registry seeks to collect information from patients who have Diamond-Blackfan anemia (DBA), in order to help researchers and doctors learn more about the condition. The registry will also help connect patients with DBA to research and clinical studies, and possible treatment options. The registry accepts all patients diagnosed with DBA.
View more information about Diamond-Blackfan Anemia Registry (DBAR).

Do you or your child require care for a blood disorder?

This study provides training for NHLBI blood doctors in the evaluation and care of patients who have blood disorders. Participants in this study must be 2 years or older. This study is located in Bethesda, Maryland.

Are you younger than 55 and in need of a blood and bone marrow transplant?

This study is investigating the use of lower doses of radiation and chemotherapy before a blood and bone marrow transplant from a related, half-match donor. To participate in this study, you must be younger than 55, have severe aplastic anemia, and have no suitably matched related or unrelated donors. This study is located in Nashville, Tennessee, and Seattle, Washington.

Have you received a stem cell transplant?

This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. To participate in this study, you must be between 10 and 80 years old and had your transplant more than 3 years ago. This study is located in Bethesda, Maryland.

Do you have short telomeres and a telomere gene mutation?

Some people who have aplastic anemia have very short telomeres, which protect the ends of DNA in chromosomes. This study is testing whether low doses of the medicine danazol help prevent telomeres from getting shorter and reduce signs of damage from aplastic anemia or related conditions. Participants in this study must be 3 years or older and have a telomere disease and signs of aplastic anemia, lung disease such as pulmonary fibrosis, or liver disease. This study is located in Bethesda, Maryland.

Do you lack a well-matched donor for a blood and bone marrow transplant?

This study aims to determine whether a transplant of umbilical cord blood from an unrelated donor or a blood and bone marrow transplant from a partial match donor are suitable alternatives for people who do not have a well-matched donor. To participate in this study, you must be younger than 75, have severe aplastic anemia, have tried immunosuppressants without success, and not have a well-matched donor. This study is located in 28 cities across the United States.

Are you interested in new approaches to cord blood stem cell transplants?

This study is investigating whether a blood stem cell transplant using a mix of umbilical cord blood from an unrelated donor and blood cells from a related, half-match donor is better than a single-donor cord blood transplant. To participate in this study, you must have severe aplastic anemia or myelodysplastic syndrome, not have a well-matched donor, and be between 4 and 55 years of age. This study is located in Bethesda, Maryland.

Are you scheduled for a stem cell transplant with cord blood?

This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.

Apnea del sueño (en español)

¿Es usted un adulto con apnea del sueño que quiere ayudar a comprender esta enfermedad mediante el uso de un dispositivo bucal o boquilla?

Este estudio, el cual intenta comprender cómo se colapsan las vías respiratorias superiores en pacientes con apnea obstructiva del sueño durante el sueño, utilizará esta información para explicar por qué algunos pacientes presentan una gran mejoría en la apertura de las vías respiratorias superiores con el uso de un dispositivo bucal mientras que otros no. Deberá someterse a algunos exámenes especiales, como una endoscopia y estudios del sueño. Para participar, debe tener entre 21 y 70 años y sufrir apnea obstructiva del sueño. El estudio se está realizando en Boston.

¿Tiene un hijo o hija con apnea del sueño a quien le pueda interesar un nuevo tratamiento con aerosol nasal?

Este estudio evaluará el uso de un aerosol nasal para el tratamiento de la apnea obstructiva del sueño en niños. Para participar, los niños deben tener entre 5 y 10 años, no haber tenido cirugía para remover las amígdalas y nunca haber usado una máquina CPAP. El estudio se está realizando en Filadelfia.

¿Tiene a su cargo un adolescente o adulto joven con apnea del sueño y síndrome de Down?

El objetivo de este estudio es evaluar si un dispositivo que se implanta en el cuerpo para estimular los nervios de la lengua y que ya ha sido aprobado para su uso en adultos con apnea obstructiva del sueño puede implantarse y usarse con seguridad en adolescentes y adultos jóvenes con síndrome de Down. Para participar, los jóvenes con síndrome de Down deben tener entre 10 y 21 años, y se les deben haber extirpado las amígdalas. Los estudios se están realizando en Atlanta, Boston, Cincinnati, Cleveland y Pittsburgh.

¿Es usted un adulto con apnea del sueño y diabetes tipo 2?

Este estudio analiza si el uso de una máquina de CPAP puede mejorar los niveles de azúcar en sangre, disminuir la presión arterial y revertir el daño a los vasos sanguíneos en pacientes con apnea obstructiva del sueño y diabetes tipo 2. Para participar, debe tener entre 21 y 75 años y tener apnea obstructiva del sueño y diabetes tipo 2. El estudio se está realizando en Baltimore.

Arrhythmia

Do you know someone who will be having heart surgery?

This study aims to identify what genetic patterns might cause atrial fibrillation and other adverse events that happen after heart surgery. To participate in this study, you must be between 20 and 90 years old. The study is in three locations in Massachusetts and Texas.

Do you have persistent atrial fibrillation?

Cardiac mapping is a tool doctors use to understand the pattern of electrical signals generating arrhythmia in a patient’s heart. This study aims to test a method for analyzing cardiac mapping results to see if it can improve the treatment of persistent atrial fibrillation. To participate in this study, you must be 21 or older and must have tried ablation to treat your atrial fibrillation once before. The study is located in Miami, Florida.

Are you planning to have an ablation procedure for atrial fibrillation?

This study aims to improve a medicine used to prevent a repeat atrial fibrillation event after ablation treatment. Researchers will compare different formulas of the medicine propafenone. To participate in this study, you must be 18 or older and be scheduled for your first ablation procedure to treat atrial fibrillation. The study is located in Nashville, Tennessee.

Do you have heart disease that requires an ICD to prevent sudden cardiac arrest?

This study aims to learn what signs distinguish patients who have a higher risk of an arrhythmia that leads to sudden cardiac arrest. Researchers plan to track patients with a recent ICD replacement for 10 years. To participate in this study, you must be between 18 and 85 years old. This study is located in Washington, D.C.; Baltimore, Maryland; and Richmond, Virginia.

Have you been treated for ventricular tachycardia?

This study tests the safety and effectiveness of a new tool for doing radiofrequency catheter ablations, a treatment for some conduction disorders. To participate in this study, you must be at least 18 years old and have ventricular tachycardia that has not gone away after treatment with medicine, ablation, and placement of an implantable cardioverter defibrillator (ICD). This study is located in Illinois and Minnesota.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Are you being treated for atrial fibrillation?

This study aims to compare two types of ablation treatment for patients who continue to have symptoms of atrial fibrillation despite treatment with medicines. The two ablation procedures treat different areas of tissue. To participate in this study, you must be at least 21 years old. The study is located in Palo Alto and San Diego, California.

Do you have a ventricular arrhythmia?

This study aims to evaluate the safety and effectiveness of low-energy shocks for the treatment of ventricular tachycardia and ventricular fibrillation. This approach will be tested during a catheter ablation or placement of an implantable cardioverter defibrillator (ICD). To participate in this study, you must be between 18 and 75 years old. This study is located in Minneapolis, Minnesota, and Austin, Texas.

Asbestos-Related Lung Diseases

Are you an adult who has idiopathic pulmonary fibrosis or an advanced lung cancer?

This study aims to see whether a new imaging dye for positron emission tomography (PET) is effective at looking at fibrosis in lung cancer and idiopathic pulmonary fibrosis (IPF). Participants will be given the imaging dye and then receive a PET scan. To participate in this study, you must either be between 18 and 80 years old and have lung cancer or be a healthy volunteer or be between 50 and 80 years old and have IPF. This study is located in Boston, Massachusetts.

Asma (en español)

¿Es usted un adulto que tiene asma y alergias y está dispuesto a someterse a estudios de imágenes cerebral?

Este estudio analizará si las reacciones en el cerebro están asociadas con inflamación en los pulmones. Los investigadores usarán estudios de imagen para monitorear la inflamación en el cerebro causada por la exposición a niveles ambientales de factores comunes que se sabe que causan asma. Para participar en este estudio, debe tener entre 18 y 50 años; haber tenido un resultado positivo en la prueba cutánea para ácaros del polvo del hogar, la ambrosía o el pelo de gato, y no tener ninguna otra enfermedad crónica. Este estudio se realiza en Madison, Wisconsin.

[NIH Clinical Center] ¿Es usted un adulto que tiene asma y quiere ayudar a comprender la biología de las vías respiratorias?

Este estudio analizará las diferencias entre las células de las vías respiratorias de las personas que tienen y las que no tienen asma. Los médicos usarán un procedimiento llamado broncoscopía para recolectar células. Para participar en este estudio, debe tener entre 18 y 75 años, no tener VIH y no estar embarazada o planeando quedar embarazada en este momento. Este estudio se realiza en Bethesda, Maryland.

¿Su hijo tiene asma y ancestros afroamericanos o puertorriqueños?

Este estudio analizará cómo hacer que los niños y los adolescentes identifiquen sus síntomas de asma temprano, por medio de un medidor de flujo máximo. Para participar en este estudio, su hijo debe tener entre 10 y 17 años, un diagnostico de asma y, al menos, un progenitor que se identifique como afroamericano o puertorriqueño. Este estudio se realiza en Bronx, Nueva York.

[NIH Clinical Center] ¿Es usted un adulto que tiene asma y quiere ayudar a que los investigadores entenderla mejor?

Este estudio recopilará información general sobre las personas que han tenido asma durante un período de 20 años para comprender por qué los pacientes responden de manera diferente al tratamiento. Para participar en este estudio, debe ser mayor de 18 años, haber recibido un diagnóstico de asma durante al menos un año y no tener ninguna otra afección importante. Este estudio se realiza en Bethesda, Maryland.

[NIH Clinical Center] Genes involucrados en el desarrollo de enfermedades pulmonares

Este estudio investigará los genes implicados en el proceso respiratorio y en el desarrollo de enfermedades pulmonares como el asma o la sarcoidosis para mejorar la comprensión del papel que ellos desempeñan. Para participar en este estudio, usted o su hijo deben tener entre 2 y 90 años y haber sido diagnosticado y estar viviendo con una enfermedad pulmonar. Este estudio se realiza en Bethesda, Maryland.

¿Es usted un joven adulto afroamericano que tiene asma y vive en o cerca de Detroit?

Este estudio probará una forma, basada en la tecnología, para ayudar a que los adultos jóvenes afroamericanos manejen su asma mediante el uso de mensajes de texto y mensajes de computadora para recordarles que tomen sus medicinas. Para participar en este estudio, debe tener entre 18 y 29 años, asma persistente moderada o grave, y acceso a un teléfono celular. Este estudio se realiza en Detroit, Michigan.

¿Su hijo tiene asma y vive en o cerca del Bronx?

Este estudio analizará la intervención realizada en un consultorio médico para ayudar a los niños en entornos urbanos a manejar mejor su asma. Para participar en este estudio, su hijo debe tener entre 2 y 12 años, asma difícil de controlar y ninguna otra afección médica importante. Este estudio se realiza en el Bronx, Nueva York.

¿Usted es un adulto que tiene asma e insomnio?

Este estudio está analizando si dos intervenciones diferentes, basadas en educación, pueden ayudar a mejorar la calidad de vida de los pacientes que tienen asma grave e insomnio. Para participar en este estudio, debe tener entre 18 y 75 años, insomnio y asma moderada o grave. Este estudio se realiza en Pittsburgh, Pennsylvania.

Asthma

[At NIH Clinical Center] Causes and progression of chronic lung disease

This study aims to develop a better understanding of lung disorders. This study also identifies patients who are eligible to participate in other research studies. To participate in this study, you must be between 7 and 90 years old and have symptoms of lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

[At NIH Clinical Center] Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Are you an adult who has asthma and allergies and is willing to undergo brain imaging tests?

This study will look at whether reactions in the brain are associated with inflammation in the lungs. Researchers will use imaging tests to monitor for inflammation in the brain due to exposure to environmental levels of common factors known to cause asthma. To participate in this study, you must be between 18 and 50 years old; have had a positive skin test result to house dust mites, ragweed, or cat hair; and not have any other chronic diseases. This study is located in Madison, Wisconsin.

Does your child have asthma and an African American or Puerto Rican family background?

This study will look at how to get children and teens to identify their asthma symptoms early, using a peak flow meter. To participate in this study, your child must be 10 to 17 years old, have been diagnosed with asthma, and have at least one parent who identifies as African American or Puerto Rican. This study is located in the Bronx, New York.
View more information about Childhood Asthma Perception Study (CAPS).

Are you a young African American adult who has asthma and lives in or near Detroit?

This study will test a technology-based way to help young African American adults manage their asthma by using texts and computer messages to remind them to take their medicine. To participate in this study, you must be between 18 and 29 years old, have moderate or severe persistent asthma, and have access to a cellphone. This study is located in Detroit, Michigan.

Are you an adult who has asthma and wants to help researchers better understand it?

This study will gather general information about people who have had asthma over a 20-year period to understand why patients respond differently to treatment. To participate in this study, you must be 18 or older, have been diagnosed with asthma for at least one year, and not have any other major condition. This study is located in Bethesda, Maryland.

Does your child have asthma and live in or near the Bronx?

This study will look at a doctor’s office–based intervention for helping children in urban settings better manage their asthma. To participate in this study, your child must be 2 to 12 years old, have difficult-to-control asthma, and not have any other major medical condition. This study is located in the Bronx, New York.

Are you an adult who has asthma and wants to help with understanding airway biology?

This study will look at the differences between cells from the airways of people who do and do not have asthma. Doctors will use a procedure called bronchoscopy to collect cells. To participate in this study, you must be between 18 and 75 years old, not have HIV, and not be pregnant or planning to become pregnant. This study is located in Bethesda, Maryland.

Are you an adult who has asthma and insomnia?

This study is looking at whether two different education-based interventions can help improve the quality of life for patients who have severe asthma and insomnia. To participate in this study, you must be 18 to 75 years old and have insomnia and moderate or severe asthma. This study is located in Pittsburgh, Pennsylvania.

Do you have depression and act as caregiver for a child who has asthma?

This study will look at the effects on a child’s asthma when their caregiver is being treated for major depressive disorder. To participate in this study, the caregiver must be between 18 and 70 years old, be diagnosed with major depressive disorder, and not plan to become pregnant over the yearlong study. The child must be between 7 and 17 years old, have asthma, and not have other major illnesses. This study will take place in Dallas, Texas.

Atrial Fibrillation

Do you know someone who will be having heart surgery?

This study aims to identify what genetic patterns might cause atrial fibrillation and other adverse events that happen after heart surgery. To participate in this study, you must be between 20 and 90 years old. The study is in three locations in Massachusetts and Texas.

Do you have persistent atrial fibrillation?

Cardiac mapping is a tool doctors use to understand the pattern of electrical signals generating arrhythmia in a patient’s heart. This study aims to test a method for analyzing cardiac mapping results to see if it can improve the treatment of persistent atrial fibrillation. To participate in this study, you must be 21 or older and must have tried ablation to treat your atrial fibrillation once before. The study is located in Miami, Florida.

Are you being treated for a chronic health condition in Wisconsin?

This study assesses an online program for people 65 and older who have some combination of diabetes, high blood pressure, high blood cholesterol, COPD, obesity, congestive heart failure, chronic kidney disease, arrhythmia, pulmonary heart or vascular disease, chronic pain, and arthritis. Follow-up surveys will help researchers evaluate the effectiveness of the care and support offered through the online program and determine if it decreases the use of health care services and improves health measures. To participate in this study, you must be at least 65 years old and be receiving treatment for at least three chronic conditions at a University of Wisconsin health clinic. This study is located in Madison, Wisconsin.

Are you planning to have an ablation procedure for atrial fibrillation?

This study aims to improve a medicine used to prevent a repeat atrial fibrillation event after ablation treatment. Researchers will compare different formulas of the medicine propafenone. To participate in this study, you must be 18 or older and be scheduled for your first ablation procedure to treat atrial fibrillation. The study is located in Nashville, Tennessee.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Are you being treated for atrial fibrillation?

This study aims to compare two types of ablation treatment for patients who continue to have symptoms of atrial fibrillation despite treatment with medicines. The two ablation procedures treat different areas of tissue. To participate in this study, you must be at least 21 years old. The study is located in Palo Alto and San Diego, California.

Blood and Bone Marrow Transplant

[At NIH Clinical Center] Bone marrow transplant procedures for severe anemia

This study aims to improve bone marrow transplant (BMT) procedures for older patients by using a low dose of radiation and two immunosuppressive drugs instead of chemotherapy. This type of BMT procedure is described as nonmyeloablative because it does not destroy bone marrow. Participants in this study must be between 2 and 65 years old; have a severe congenital anemia, such as sickle cell disease or beta thalassemia; and have a sibling who is a well-matched stem cell donor. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Stem cell transplant procedure with a partial match

This study is testing new ways to improve a stem cell transplant procedure that involves a donor who is not a complete match, called a partial match. To participate in this study, you must be at least 18 years old and have both severe sickle cell disease and a donor who is a partial match. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Improving bone marrow transplants

This study is exploring how to improve bone marrow transplant procedures so the body better accepts donor stem cells. To participate in this study, you must be at least 4 years old, have sickle cell disease, and have a stem cell donor. This study is located in Bethesda, Maryland.

Are you considering a blood stem cell transplant?

This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. To participate in this study, you must have a well-matched donor; you and your donor must be between 4 and 80 years old; and you must not be a candidate for immunosuppressive therapy. This study is located in Bethesda, Maryland.

Are you prone to bleeding because of low platelets or a bone marrow disorder?

This study aims to evaluate the effectiveness of tranexamic acid in preventing bleeding in patients who have thrombocytopenia, or low platelets, due to primary bone marrow disorders or chemotherapy, or blood or bone marrow transplants. To participate in this study, you must be at least 18 years old, have a bone marrow disorder, have low platelets, and be going through chemotherapy, immunotherapy, or a stem cell transplant. The study is located in Chapel Hill, North Carolina; Pittsburg, Pennsylvania; and Seattle, Washington.

Are you or your child interested in donating a sample of bone marrow for research?

This study will collect samples of bone marrow from patients who have sickle cell disease or β-thalassemia to help develop genetic therapies. Participants in this study must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Are you 15 to 40 years old and have severe sickle cell disease?

This study is comparing long-term outcomes for patients who receive blood and bone marrow transplants and those who receive standard treatment with medicines. Participants also have an option of contributing blood samples to be stored for future research. Participants must be 15 to 40 years old and have severe sickle cell disease. This study is located in Madison, Wisconsin.

Do you or your child have severe sickle cell disease and also know a half-matched bone marrow donor?

This study is seeking to improve bone marrow transplantation success from half-matched donors by testing a different conditioning procedure that uses a variety of medicines to prepare for the transplant. To participate in this study, you must be 15 to 45 years old and have severe sickle cell disease or have a child 5 to 14 years old who has had a stroke. This study is located in many sites across the United States, including Miami, Florida, and St. Louis, Missouri.

[At NIH Clinical Center] Blood and bone marrow transplant donors

This study is testing ways to reduce complications of blood and bone marrow transplants, which are used to treat some people who have serious blood disorders. Donors receive doses of a growth factor to increase the number of stem cells in their blood. Then, the donor has an apheresis procedure for removing the stem cells. The researchers are testing different processing steps after the donation to see how the stem cells and other cell types are affected. To participate, you must be between the ages of 18 and 60, and you need to meet certain health requirements for donors. This study is located in Bethesda, Maryland.

Have you received a stem cell transplant?

This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. To participate in this study, you must be between 10 and 80 years old and had your transplant more than 3 years ago. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Healthy blood and bone marrow donors

This study is screening healthy participants who are willing to donate blood samples or who have apheresis procedures. Eligible donors may be asked to provide blood products for studies of blood disorders or to donate stem cells for people who are having a bone marrow transplant. To participate, you must be at least 18 years old and meet certain health requirements for donors. This study is located in Bethesda, Maryland.

Are you interested in new approaches to cord blood stem cell transplants?

This study is investigating whether a blood stem cell transplant using a mix of umbilical cord blood from an unrelated donor and blood cells from a related, half-match donor is better than a single-donor cord blood transplant. To participate in this study, you must have severe aplastic anemia or myelodysplastic syndrome, not have a well-matched donor, and be between 4 and 55 years of age. This study is located in Bethesda, Maryland.

Are you scheduled for a stem cell transplant with cord blood?

This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.

Do you or your child need a stem cell transplant?

This study is exploring the use of treatment with certain medicines in combination with radiation for a successful stem cell transplant. To participate in this study, you must be younger than 49 years old and have a severe disease treatable by a stem cell transplant. This study is located in several sites across the United States, including Aurora, Colorado; Seattle, Washington; and Milwaukee, Wisconsin.

Blood Donation

[At NIH Clinical Center] Blood and bone marrow transplant donors

This study is testing ways to reduce complications of blood and bone marrow transplants, which are used to treat some people who have serious blood disorders. Donors receive doses of a growth factor to increase the number of stem cells in their blood. Then, the donor has an apheresis procedure for removing the stem cells. The researchers are testing different processing steps after the donation to see how the stem cells and other cell types are affected. To participate, you must be between the ages of 18 and 60, and you need to meet certain health requirements for donors. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Healthy blood and bone marrow donors

This study is screening healthy participants who are willing to donate blood samples or who have apheresis procedures. Eligible donors may be asked to provide blood products for studies of blood disorders or to donate stem cells for people who are having a bone marrow transplant. To participate, you must be at least 18 years old and meet certain health requirements for donors. This study is located in Bethesda, Maryland.

Blood Transfusion

Are you prone to bleeding because of low platelets or a bone marrow disorder?

This study aims to evaluate the effectiveness of tranexamic acid in preventing bleeding in patients who have thrombocytopenia, or low platelets, due to primary bone marrow disorders or chemotherapy, or blood or bone marrow transplants. To participate in this study, you must be at least 18 years old, have a bone marrow disorder, have low platelets, and be going through chemotherapy, immunotherapy, or a stem cell transplant. The study is located in Chapel Hill, North Carolina; Pittsburg, Pennsylvania; and Seattle, Washington.

Have you had a heart attack, and do you want to help improve strategies for blood transfusion?

The study is comparing two strategies for blood transfusions in heart attack patients who have anemia—whether to give a blood transfusion when the hemoglobin level is less than 10 g/dL, or to give blood only when the blood count is below 8 g/dL. To participate in this study, you must be at least 18 years old, have anemia, and be hospitalized for a heart attack. The study is located in New Brunswick, New Jersey.

Bronchitis

Do you have COPD?

This study will be looking for genes that may play a role in the development of COPD by looking at the blood from patients who have COPD, as well as the blood from those patients’ family members. To participate in this study, you must be 52 years old or younger and must not be pregnant or have other serious lung diseases such as lung cancer. This study will be conducted in Boston, Massachusetts.

Do you have chronic bronchitis and COPD and want to improve treatment?

This study will be testing how well a medicine called ivacaftor that is used to treat cystic fibrosis works also to treat symptoms of chronic bronchitis. New research suggests chronic bronchitis may be due to a problem similar to cystic fibrosis. To participate in this study, you must be 40 to 80 years old, have a history of smoking, and have not been diagnosed with asthma or cystic fibrosis. This study will be conducted in Birmingham, Alabama.

Bronchopulmonary Dysplasia

Has your newborn been diagnosed with patent ductus arteriosus?

Patent ductus arteriosus (PDA) is a condition in which a connection between two major blood vessels close to the heart does not close properly after birth. This affects blood flow to the lungs and may cause neonatal respiratory diseases. PDA may correct itself, but sometimes treatment may be necessary. This study aims to identify ways by which doctors can predict which cases of PDA need to be treated. To participate in this study, your newborn must have been born between 23 and 29 weeks’ gestation and have been diagnosed with PDA. This study is located in Columbus, Ohio.

Is your premature newborn in a neonatal intensive care unit in Chicago, Illinois?

This study is investigating how brain development affects breathing in premature newborns. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and admitted to the neonatal intensive care unit within a week of birth. This study is located in Chicago, Illinois.

Is your newborn in the neonatal intensive care unit at Holtz Children’s Hospital in Miami?

This study is interested in learning how frequent changes in a newborn’s levels of oxygen and carbon dioxide affect lung development. To participate in this study, your newborn must have been born prematurely between 23 and 28 weeks’ gestation, be less than 28 days old, and be receiving oxygen therapy. This study is located in Miami, Florida.

Was your newborn born prematurely?

This study aims to better understand the effects of premature delivery on a baby’s lungs during his or her first year of life. To participate in this study, your newborn must have been born prematurely between 24 and 36 weeks’ gestation and not have any congenital heart or lung defects. This study is located in Indianapolis, Indiana.

Is your newborn receiving care at the University of Alabama at Birmingham Women and Infants Center?

This study aims to examine new ways to help control breathing and oxygen levels in premature newborns. To participate in this study, your newborn must have been born prematurely between 22 and 29 weeks’ gestation, and be a patient at the neonatal intensive care unit or the critical care nursery at the University of Alabama at Birmingham Women and Infants Center. This study is located in Birmingham, Alabama.

Is your newborn in the neonatal intensive care unit at St. Louis Children’s Hospital?

This study aims to better understand breathing problems and blood flow through the heart in premature newborns to better detect conditions such as pulmonary hypertension. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and be a patient in the Neonatal Intensive Care Unit at St. Louis Children’s Hospital. This study is located in St. Louis, Missouri.

Have you been diagnosed with high blood pressure while pregnant?

This study is investigating whether a mother’s blood pressure during pregnancy affects her newborn’s lung development. To participate in this study, your newborn must have been born either prematurely at more than 25 weeks’ gestation or at full term to a healthy mother or a mother who was diagnosed with high blood pressure during pregnancy. This study is located in Indianapolis, Indiana.

Bronchoscopy

Are you an adult who has asthma and wants to help with understanding airway biology?

This study will look at the differences between cells from the airways of people who do and do not have asthma. Doctors will use a procedure called bronchoscopy to collect cells. To participate in this study, you must be between 18 and 75 years old, not have HIV, and not be pregnant or planning to become pregnant. This study is located in Bethesda, Maryland.

Cardiac Catheterization

Are you scheduled to have cardiac catheterization?

This study is looking at a new noninvasive imaging method for measuring pressures within the heart as an alternative to cardiac catheterization. The new method is called contrast echocardiography using the subharmonic-aided pressure estimation (SHAPE) method. To participate in this study, you must be at least 21 years old, be scheduled for cardiac catheterization, and be in medically stable condition. This study is located in Philadelphia, Pennsylvania.

Has your doctor recommended right heart cardiac catheterization for you?

This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be at least 18 years old, and your doctor must have recommended right heart catheterization for you. This study is located in Bethesda, Maryland.

Cardiac MRI

Has your doctor recommended right heart cardiac catheterization for you?

This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be at least 18 years old, and your doctor must have recommended right heart catheterization for you. This study is located in Bethesda, Maryland.

Cardiogenic Shock

Has your doctor recommended right heart cardiac catheterization for you?

This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be at least 18 years old, and your doctor must have recommended right heart catheterization for you. This study is located in Bethesda, Maryland.

Cardiomyopathy

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Catheter Ablation

Do you have a ventricular arrhythmia?

This study aims to evaluate the safety and effectiveness of low-energy shocks for the treatment of ventricular tachycardia and ventricular fibrillation. This approach will be tested during a catheter ablation or placement of an implantable cardioverter defibrillator (ICD). To participate in this study, you must be between 18 and 75 years old. This study is located in Minneapolis, Minnesota, and Austin, Texas.

Chest CT Scan

Do you have a first-degree relative diagnosed with an interstitial lung disease?

This study aims to better understand how interstitial lung diseases develop, by looking at the lungs of people who are at risk for an ILD. Participants will undergo a computed tomography (CT) scan, and researchers will look for visual evidence of the disease in an early stage. To participate in this study, you must be at least 35 years old and have a first-degree relative with a clinical diagnosis of ILD or be at least 50 years old with a smoking history of at least one pack of cigarettes per day. This study is located in New York, New York.

Chest MRI

Are you a healthy adult or an adult who has idiopathic pulmonary fibrosis and is interested in improving lung imaging methods?

This study aims to see whether an imaging method using magnetic resonance imaging (MRI) with an inhaled gas is better than traditional tests at detecting how the lungs respond to treatment for idiopathic pulmonary fibrosis (IPF). To participate in this study, you must be at least 18 years old and either have a diagnosis of idiopathic pulmonary fibrosis or be a healthy volunteer without lung disease. This study is located in Durham, North Carolina.

Circadian Rhythm Disorders

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours?

This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

Are you an adult who does not have high blood pressure?

Circadian rhythms control daytime and nighttime changes in blood pressure. This study is examining the links between stress, loss of sodium through urine, and circadian rhythms in controlling blood pressure. To participate in this study, you must be at least 21 years old and not have high blood pressure. This study is located in New York, New York.

Congenital Heart Defects

Has your child had a Fontan operation or had an MRI at Children’s Hospital of Philadelphia?

This study uses magnetic resonance imaging (MRI) and neurodevelopmental testing to understand how blood flow to the brain and brain lesions relate to neurodevelopmental problems in children who have had a Fontan operation to correct a single ventricle lesion. To participate in this study, your child must have congenital heart disease and have participated in a specific, previous study of blood flow to the brain. If your child did not participate in such a study, he or she should be between the ages of 3 and 15 and have completed the Fontan Operation or have had a clinically indicated MRI at the Children’s Hospital of Philadelphia to participate. This study is located in Philadelphia, Pennsylvania.

Do you or one of your children have a congenital heart defect?

This study will find both common genetic causes of congenital heart disease and ways that genes influence results of medical treatment. To participate in this study, you or your child must have congenital heart disease. This study is located in Los Angeles, Palo Alto, and San Francisco, California; New Haven, Connecticut; Boston, Massachusetts; New York and Rochester, New York; Philadelphia, Pennsylvania; and Salt Lake City, Utah.

Does your developing baby have a heart defect? Have you had a stillborn baby?

This study tests a new technology to measure fetal heart activity and find possible problems early. These problems include fetal arrhythmia and conduction disorders such as Brugada syndrome. To participate in this study, you must be at least 18 years old and pregnant, and have one of five high-risk complications of pregnancy: a fetus with a major congenital heart defect, hydrops, or gastroschisis; a previous unexplained stillbirth; or twins who share a placenta. This study is located in Madison and Milwaukee, Wisconsin.

Are you an adult with congenital heart disease?

This study uses whole exome sequencing and other genetic tests to identify causes of congenital heart diseases that occur in individuals and families. To participate in this study, you must be an adult with congenital heart disease with or without a family member with congenital heart disease. This study is located in Columbus, Ohio.
View more information about Genetics of Congenital Heart Disease.

Do you or your child over age 8 have a congenital heart defect and prior whole exome or whole genome sequencing results?

This study explores the association between genetic variants, neurodevelopmental disability, and magnetic resonance imaging (MRI) brain findings. To participate in this study, you or your child must be at least 8 years old and have congenital heart disease and have whole exome or whole genome sequencing results that show either damaging, spontaneous genetic variations or other harmful genetic variations. This study is located in Los Angeles and San Francisco, California; New Haven, Connecticut; Boston, Massachusetts; New York and Rochester, New York; and Salt Lake City, Utah.

Do you or your child have Pentalogy of Cantrell?

This study collects blood, urine, and other samples from people with Pentalogy of Cantrell (POC) to identify possible changes, or mutations, in the genes that may cause this congenital defect. To participate at the Bethesda, Maryland, location, participants must be at least age 2 or older. At all other locations, including San Francisco, California; Boston, Massachusetts; and Dallas, Texas, all ages are included in the study.

Are you or your child planning to undergo an MRI or cardiac catheterization procedure?

This study will help develop and test new magnetic resonance imaging (MRI) techniques that evaluate patients who have cardiovascular disease, congenital heart disease, and problems with the fetal heart and other organs during pregnancy. To participate in this study, you must be a healthy volunteer age 8 or older or be a patient of any age who needs an MRI or cardiac catheterization procedure. This study is located in Washington, D.C.

Do you want to help test a new type of scanner for detecting heart problems?

This study is comparing the ability of two types of magnetic resonance imaging (MRI) scanners to detect ischemic heart disease, heart failure, congenital heart disease, and valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. To participate in this study, you should be healthy or have stable ischemic heart disease and be at least 18 years old. This study is located in Bethesda, Maryland.

Are you a greater Boston resident aged 24 to 30?

This study aims to bridge the gap in knowledge between known executive function deficits in childhood congenital heart disease and adult well-being. The study is recruiting healthy volunteers. To participate in this study, you must be between the ages of 24 and 30, live in the greater Boston area, read fluently in English, and not have metal implants, a pacemaker, or orthodontia that would prevent MRI. This study is located in Boston, Massachusetts.

COPD

[At NIH Clinical Center] Causes and progression of chronic lung disease

This study aims to develop a better understanding of lung disorders. This study also identifies patients who are eligible to participate in other research studies. To participate in this study, you must be between 7 and 90 years old and have symptoms of lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

[At NIH Clinical Center] Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Do you have COPD?

This study will be looking for genes that may play a role in the development of COPD by looking at the blood from patients who have COPD, as well as the blood from those patients’ family members. To participate in this study, you must be 52 years old or younger and must not be pregnant or have other serious lung diseases such as lung cancer. This study will be conducted in Boston, Massachusetts.

Do you have chronic bronchitis and COPD and want to improve treatment?

This study will be testing how well a medicine called ivacaftor that is used to treat cystic fibrosis works also to treat symptoms of chronic bronchitis. New research suggests chronic bronchitis may be due to a problem similar to cystic fibrosis. To participate in this study, you must be 40 to 80 years old, have a history of smoking, and have not been diagnosed with asthma or cystic fibrosis. This study will be conducted in Birmingham, Alabama.

Cystic Fibrosis

[At NIH Clinical Center] Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Defibrillators

Are you considering getting or replacing an implantable cardioverter defibrillator?

Implantable cardioverter defibrillators (ICDs) can present patients with many stressful decisions, and this study tests the effectiveness of educational videos and handouts to inform patients about ICDs and help them assess their options. To participate in this study, your doctor must have given you the option of implanting or replacing an ICD. The study is located in Denver, Colorado.

Are you an adult living in Beijing, China, with a heart conduction disorder?

This study will investigate health outcomes among people with a heart conduction disorder that is sometimes treated with an implantable cardioverter defibrillator. To participate in this study, you must be between 18 and 60 years old and have complete left bundle branch block. The study takes place in Beijing, China.

Do you have heart disease that requires an ICD to prevent sudden cardiac arrest?

This study aims to learn what signs distinguish patients who have a higher risk of an arrhythmia that leads to sudden cardiac arrest. Researchers plan to track patients with a recent ICD replacement for 10 years. To participate in this study, you must be between 18 and 85 years old. This study is located in Washington, D.C.; Baltimore, Maryland; and Richmond, Virginia.

Have you been treated for ventricular tachycardia?

This study tests the safety and effectiveness of a new tool for doing radiofrequency catheter ablations, a treatment for some conduction disorders. To participate in this study, you must be at least 18 years old and have ventricular tachycardia that has not gone away after treatment with medicine, ablation, and placement of an implantable cardioverter defibrillator (ICD). This study is located in Illinois and Minnesota.

Do you have a ventricular arrhythmia?

This study aims to evaluate the safety and effectiveness of low-energy shocks for the treatment of ventricular tachycardia and ventricular fibrillation. This approach will be tested during a catheter ablation or placement of an implantable cardioverter defibrillator (ICD). To participate in this study, you must be between 18 and 75 years old. This study is located in Minneapolis, Minnesota, and Austin, Texas.

Fanconi Anemia

[At NIH Clinical Center] Blood disorder research

This study is collecting medical information from health exams and routine tests and procedures to see whether participants may be able to enroll in other studies on blood disorders. Participants in this study must be at least 8 years, with or without a blood disorder. This study is located in Bethesda, Maryland.

Are you considering a blood stem cell transplant?

This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. To participate in this study, you must have a well-matched donor; you and your donor must be between 4 and 80 years old; and you must not be a candidate for immunosuppressive therapy. This study is located in Bethesda, Maryland.

Do you or your child have Fanconi anemia with low blood cell counts?

This study will look at a newer medicine, eltrombopag, to treat anemia and low blood cell counts in patients who have Fanconi anemia. The FDA approved eltrombopag for severe aplastic anemia. Participants in this study must be 4 years or older. This study is located in Bethesda, Maryland.

Do you or your child require care for a blood disorder?

This study provides training for NHLBI blood doctors in the evaluation and care of patients who have blood disorders. Participants in this study must be 2 years or older. This study is located in Bethesda, Maryland.

Do you or your child have Fanconi anemia?

This study will test a genetic therapy to treat Fanconi anemia, a rare, inherited blood disorder. Researchers will collect blood stem cells from patients, transfer a new gene to the cells, and put the cells back into the patient. Participants in this study must be 4 years or older, have Fanconi anemia, and be able to check in with the research team regularly for up to 15 years. This study is located in Seattle, Washington.
View more information about Gene Therapy for Fanconi Anemia.

Have you received a stem cell transplant?

This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. To participate in this study, you must be between 10 and 80 years old and had your transplant more than 3 years ago. This study is located in Bethesda, Maryland.

Are you interested in new approaches to cord blood stem cell transplants?

This study is investigating whether a blood stem cell transplant using a mix of umbilical cord blood from an unrelated donor and blood cells from a related, half-match donor is better than a single-donor cord blood transplant. To participate in this study, you must have severe aplastic anemia or myelodysplastic syndrome, not have a well-matched donor, and be between 4 and 55 years of age. This study is located in Bethesda, Maryland.

Are you scheduled for a stem cell transplant with cord blood?

This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.

Genetic Therapies

Are you or your child interested in donating a sample of bone marrow for research?

This study will collect samples of bone marrow from patients who have sickle cell disease or β-thalassemia to help develop genetic therapies. Participants in this study must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Heart Attack

Have you had a heart attack, and do you want to help improve strategies for blood transfusion?

The study is comparing two strategies for blood transfusions in heart attack patients who have anemia—whether to give a blood transfusion when the hemoglobin level is less than 10 g/dL, or to give blood only when the blood count is below 8 g/dL. To participate in this study, you must be at least 18 years old, have anemia, and be hospitalized for a heart attack. The study is located in New Brunswick, New Jersey.

Do you have diabetes and a history of heart attack?

This is a follow-on study of the Trial to Access Chelation Therapy (TACT), which showed that medicine to help remove metals in the blood reduced the risk of ischemic heart disease complications, including unstable angina, in people who have diabetes who had a prior heart attack. To participate in this study, you must be at least 50 years old and have a history of diabetes and heart attack. This study is located in Miami, Florida.

Heart Failure

Do you want to help test a new type of scanner for detecting heart problems?

This study is comparing the ability of two types of magnetic resonance imaging (MRI) scanners to detect ischemic heart disease, heart failure, congenital heart disease, and valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. To participate in this study, you should be healthy or have stable ischemic heart disease and be at least 18 years old. This study is located in Bethesda, Maryland.

Heart Valve Disease

Do you want to help test a new type of scanner for detecting heart problems?

This study is comparing the ability of two types of magnetic resonance imaging (MRI) scanners to detect ischemic heart disease, heart failure, congenital heart disease, and valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. To participate in this study, you should be healthy or have stable ischemic heart disease and be at least 18 years old. This study is located in Bethesda, Maryland.

Hemolytic Anemia

[At NIH Clinical Center] Blood disorder research

This study is collecting medical information from health exams and routine tests and procedures to see whether participants may be able to enroll in other studies on blood disorders. Participants in this study must be at least 8 years, with or without a blood disorder. This study is located in Bethesda, Maryland.

Are you considering a blood stem cell transplant?

This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. To participate in this study, you must have a well-matched donor; you and your donor must be between 4 and 80 years old; and you must not be a candidate for immunosuppressive therapy. This study is located in Bethesda, Maryland.

Are you or your child interested in donating a sample of bone marrow for research?

This study will collect samples of bone marrow from patients who have sickle cell disease or β-thalassemia to help develop genetic therapies. Participants in this study must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Have you received a stem cell transplant?

This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. To participate in this study, you must be between 10 and 80 years old and had your transplant more than 3 years ago. This study is located in Bethesda, Maryland.

Do you want to take part in blood research?

This study aims to screen patients at the National Institutes of Health Clinical Center who have a blood disorder such as anemia and who may be eligible to participate in studies in the Hematology Branch. It will also determine whether it is safe for you to participate in those studies. Participants in this study must be 2 years or older. This study is located in Bethesda, Maryland.
View more information about Screening for Hematology Branch Protocols.

Are you scheduled for a stem cell transplant with cord blood?

This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.

High Blood Cholesterol

Do you or does your child have a lipid disorder and want to improve future diagnosis and treatment?

This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. To participate, you or your child must be at least 2 years old. The study is being conducted in Bethesda, Maryland.

Are you an adult who is interested in helping research on lipid disorders?

This study is comparing how lipids, or fats, such as cholesterol travel in the blood of healthy adult volunteers and adults who have lipid disorders, particularly disorders that may be caused by unknown genetics factors. To participate in this study, you must be 18 years old or older. Women should not be pregnant. The study is being conducted in Bethesda, Maryland.

Do you or your child have a lipid disorder and want to help research?

This study is assessing factors affecting proteins that transport lipids in the blood of patients with lipid disorders. Participants will follow a specific eating pattern during the study and will have blood tests. Information from this study may help improve the way in which lipid disorders are diagnosed or treated in the future. To participate, you must have been diagnosed with a lipid disorder. The study is being conducted in Bethesda, Maryland.

High Blood Pressure

Are you an adult who is curious about how sodium affects your blood pressure?

This study is testing if limiting sodium can affect individuals with a specific genetic predisposition to high blood pressure. To participate you must be 18 years old or older and not have high blood pressure. Please note that this study is in Charlottesville, Virginia.

Are you an adult whose high blood pressure does not improve with lifestyle changes and medicines?

This study will assess whether minocycline, an antibiotic with anti-inflammatory effects, can improve blood pressure control in patients who do not respond to medicines in combination with lifestyle changes, such as physical activity, weight loss, and healthy eating patterns. To participate you must be at least 18 years old and have high blood pressure that does not respond to treatment with three different high blood pressure medicines even when used at the maximum doses. Please note that this study is in Gainesville, Florida.

Are you an African American adult living in the Washington, D.C. metro area?

This study is assessing the association between DNA, health behaviors, social and environmental factors, and risk factors of heart disease, such as high blood pressure, in African Americans. To participate you must be an African American between 21 and 65 years old, living in Washington, D.C., or Montgomery or Prince Georges counties in Maryland. Please note that this study is being conducted in Bethesda, Maryland.

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours?

This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

Are you an adult whose high blood pressure has not improved with medicines?

This study is assessing whether a low-sodium and low-calorie eating pattern, along with aerobic exercise, can improve blood pressure in patients who do not respond to high blood pressure medicines. To participate you must be at least 35 years and have high blood pressure that does not respond to medicines. Please note that this study is in Durham, North Carolina.

Do you or your child have sickle cell disease and high blood pressure?

This study is exploring whether use of losartan, a medicine commonly used to lower blood pressure, is effective at treating abnormal nighttime blood pressure in children and young adults who have sickle cell disease. Participants in this study must be between 5 and 25 years old and have high blood pressure and a certain type of sickle cell disease: hemoglobin SS or Sβ0 thalassemia. This study is located in Birmingham, Alabama.
View more information about Preventing Sickle Cell Kidney Disease.

Are you an adult who does not have high blood pressure?

Circadian rhythms control daytime and nighttime changes in blood pressure. This study is examining the links between stress, loss of sodium through urine, and circadian rhythms in controlling blood pressure. To participate in this study, you must be at least 21 years old and not have high blood pressure. This study is located in New York, New York.

Have you been diagnosed with high blood pressure while pregnant?

This study is investigating whether a mother’s blood pressure during pregnancy affects her newborn’s lung development. To participate in this study, your newborn must have been born either prematurely at more than 25 weeks’ gestation or at full term to a healthy mother or a mother who was diagnosed with high blood pressure during pregnancy. This study is located in Indianapolis, Indiana.

High Blood Triglycerides

Do you or your child have a lipid disorder and want to improve future diagnosis and treatment?

This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. To participate in this study, you or your family member must be at least 2 years old. This study is located in Bethesda, Maryland.

Do you want to help future diagnosis and treatment of lipid disorders?

This study is looking at lipoproteins in people with lipid disorders, such as high blood cholesterol and high blood triglycerides. Lipoproteins are particles that carry fats such as triglycerides through the bloodstream. Problems with your body’s lipoprotein levels lead to changes in how your body handles fats. Researchers will measure lipoprotein levels in the blood to develop better ways to diagnose and treat patients with diseases of lipoproteins. To participate in this study, you must have been diagnosed with a lipid disorder. This study is located in Bethesda, Maryland.
View more information about Evaluation of Lipoproteins.

Does your family have a lipid disorder?

This study is looking at the genes of family members who have high blood cholesterol and high blood triglycerides to try to find new gene changes that lead to lipid disorders. To participate in this study, you or your family member must be at least 2 years old. This study is located in Bethesda, Maryland.
View more information about Genes Involved in Lipid Disorders.

How Sleep Works

Are you an adult with a diagnosed sleep phase disorder?

This study aims to assess the sleep patterns and quality of sleep in people who have sleep phase disorders to determine how the disorders affect their circadian rhythms. To participate in this study, you must be at least 18 years old and have a sleep phase disorder, such as advanced sleep-wake phase syndrome or delayed sleep-wake phase syndrome. This study is located in Chicago, Illinois.

Do you have overweight?

Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Are you an adult who does not work nights?

This study is examining how a person’s sleep schedule affects circadian rhythms, learning skills, physical ability, and mood. To participate in this study, you must be between 18 and 35 years old and not have underweight or obesity. This study is located in Boston, Massachusetts.

Are you pregnant, with a BMI of 30 or higher?

This study is examining the connection between obesity, breathing problems associated with sleep, and pregnancy problems such as preeclampsia. To participate in this study, you must be 18 or older, pregnant, and have obesity. This study is located in Pittsburgh, Pennsylvania.

How the Heart Works

[At NIH Clinical Center] Heart health study of members of predominately black churches

This study aims to understand the health and health needs of people in predominately black churches in Washington, D.C. This information will help researchers design programs to improve heart health in these communities. To participate in this study, you must be between 19 and 85 years old and attend one of the churches in the study. This study is based in Bethesda, Maryland.

How the Lungs Work

[At NIH Clinical Center] Causes and progression of chronic lung disease

This study aims to develop a better understanding of lung disorders. This study also identifies patients who are eligible to participate in other research studies. To participate in this study, you must be between 7 and 90 years old and have symptoms of lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

[At NIH Clinical Center] Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Idiopathic Pulmonary Fibrosis

Are you between 40 and 85 with worsening idiopathic pulmonary fibrosis?

This study aims to test a new combination treatment for acute exacerbations, a life-threatening complication of idiopathic pulmonary fibrosis (IPF) that has no approved treatment. The treatment is meant to help stop part of the immune system from further injuring the lung tissue. To participate in this study, you must be between 40 and 85 years old and have worsening IPF. This study is located in Birmingham, Alabama; Boston, Massachusetts; Philadelphia, Pennsylvania; and Pittsburgh, Pennsylvania.

Are you 40 years old or older with idiopathic pulmonary fibrosis?

This study aims to test whether an antibiotic treatment helps improve outcomes for patients who have idiopathic pulmonary fibrosis (IPF). To participate in this study, you must be at least 40 years old and diagnosed with IPF. This study is located in 25 different locations throughout the United States.

Are you an adult who is healthy or has lung disease?

This study aims to collect blood, urine, and airway samples from healthy volunteers and from people who have lung disease. Researchers will use the samples to study genes and proteins that may be involved in lung disease. To participate in this study, you must be at least 18 years old or older. This study is located in New York, New York.

Do you have a first-degree relative diagnosed with an interstitial lung disease?

This study aims to better understand how interstitial lung diseases develop, by looking at the lungs of people who are at risk for an ILD. Participants will undergo a computed tomography (CT) scan, and researchers will look for visual evidence of the disease in an early stage. To participate in this study, you must be at least 35 years old and have a first-degree relative with a clinical diagnosis of ILD or be at least 50 years old with a smoking history of at least one pack of cigarettes per day. This study is located in New York, New York.

Are you an adult who has idiopathic pulmonary fibrosis or an advanced lung cancer?

This study aims to see whether a new imaging dye for positron emission tomography (PET) is effective at looking at fibrosis in lung cancer and idiopathic pulmonary fibrosis (IPF). Participants will be given the imaging dye and then receive a PET scan. To participate in this study, you must either be between 18 and 80 years old and have lung cancer or be a healthy volunteer or be between 50 and 80 years old and have IPF. This study is located in Boston, Massachusetts.

Are you a healthy adult or an adult who has idiopathic pulmonary fibrosis and is interested in improving lung imaging methods?

This study aims to see whether an imaging method using magnetic resonance imaging (MRI) with an inhaled gas is better than traditional tests at detecting how the lungs respond to treatment for idiopathic pulmonary fibrosis (IPF). To participate in this study, you must be at least 18 years old and either have a diagnosis of idiopathic pulmonary fibrosis or be a healthy volunteer without lung disease. This study is located in Durham, North Carolina.

Insomnia

Are you an adult who has asthma and insomnia?

This study is looking at whether two different education-based interventions can help improve the quality of life for patients who have severe asthma and insomnia. To participate in this study, you must be 18 to 75 years old and have insomnia and moderate or severe asthma. This study is located in Pittsburgh, Pennsylvania.

Interstitial Lung Diseases

Are you between 40 and 85 with worsening idiopathic pulmonary fibrosis?

This study aims to test a new combination treatment for acute exacerbations, a life-threatening complication of idiopathic pulmonary fibrosis (IPF) that has no approved treatment. The treatment is meant to help stop part of the immune system from further injuring the lung tissue. To participate in this study, you must be between 40 and 85 years old and have worsening IPF. This study is located in Birmingham, Alabama; Boston, Massachusetts; Philadelphia, Pennsylvania; and Pittsburgh, Pennsylvania.

Are you 40 years old or older with idiopathic pulmonary fibrosis?

This study aims to test whether an antibiotic treatment helps improve outcomes for patients who have idiopathic pulmonary fibrosis (IPF). To participate in this study, you must be at least 40 years old and diagnosed with IPF. This study is located in 25 different locations throughout the United States.

Do you have a first-degree relative diagnosed with an interstitial lung disease?

This study aims to better understand how interstitial lung diseases develop, by looking at the lungs of people who are at risk for an ILD. Participants will undergo a computed tomography (CT) scan, and researchers will look for visual evidence of the disease in an early stage. To participate in this study, you must be at least 35 years old and have a first-degree relative with a clinical diagnosis of ILD or be at least 50 years old with a smoking history of at least one pack of cigarettes per day. This study is located in New York, New York.

Are you an adult who has idiopathic pulmonary fibrosis or an advanced lung cancer?

This study aims to see whether a new imaging dye for positron emission tomography (PET) is effective at looking at fibrosis in lung cancer and idiopathic pulmonary fibrosis (IPF). Participants will be given the imaging dye and then receive a PET scan. To participate in this study, you must either be between 18 and 80 years old and have lung cancer or be a healthy volunteer or be between 50 and 80 years old and have IPF. This study is located in Boston, Massachusetts.

Are you a healthy adult or an adult who has idiopathic pulmonary fibrosis and is interested in improving lung imaging methods?

This study aims to see whether an imaging method using magnetic resonance imaging (MRI) with an inhaled gas is better than traditional tests at detecting how the lungs respond to treatment for idiopathic pulmonary fibrosis (IPF). To participate in this study, you must be at least 18 years old and either have a diagnosis of idiopathic pulmonary fibrosis or be a healthy volunteer without lung disease. This study is located in Durham, North Carolina.

Ischemic Heart Disease

Do you need an imaging test for a heart or blood vessel problem?

This study is exploring whether new lower-radiation methods of computed tomography (CT) angiography are as effective as standard CT methods for detecting plaque buildup in the coronary arteries. To participate in this study, you must be at least 18 years old and in need of a CT scan to help diagnose problems in heart structure or with the heart’s blood vessels. This study is located in Bethesda, Maryland.

Are you an adult who wants to help improve MRI scans for assessing blood vessels of the heart?

This study is looking for ways to improve a special type of magnetic resonance imaging (MRI) scan to evaluate obstructive and nonobstructive coronary artery disease. To participate in this study, you must be healthy or have heart disease and be at least 18 years old. This study is located in Bethesda, Maryland.

Do you have diabetes and a history of heart attack?

This is a follow-on study of the Trial to Access Chelation Therapy (TACT), which showed that medicine to help remove metals in the blood reduced the risk of ischemic heart disease complications, including unstable angina, in people who have diabetes who had a prior heart attack. To participate in this study, you must be at least 50 years old and have a history of diabetes and heart attack. This study is located in Miami, Florida.

Do you want to help improve heart imaging techniques?

This study aims to improve magnetic resonance imaging (MRI) methods to detect ischemic heart disease. Healthy people and people who have ischemic heart disease will have MRI scans while resting and during a stress test. To participate in this study, you must be at least 18 years old and either healthy or diagnosed with ischemic heart disease. The study is taking place in Los Angeles, California.

LAM

[At NIH Clinical Center] Albuterol in patients who have LAM

This study is examining which delivery method of albuterol—inhaled or nebulizer—is better at improving lung function in adult women who have LAM. To participate in this study, you must be female, between 18 and 80 years old, and diagnosed with LAM. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Genetic causes of lung damage in patients who have LAM

This study is trying to understand the genes and proteins that are responsible for causing lung damage in patients with LAM. To participate in this study, you must be between 16 and 99 years old and diagnosed with LAM. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Monitoring sirolimus dosages to treat LAM

This study aims to identify the right dose of sirolimus to treat people who have LAM. To participate in this study, you must be female, between 18 and 90 years old, and diagnosed with LAM. This study is located in Bethesda, Maryland.

Are you an adult woman who would like to help develop methods to prevent the worsening of LAM?

This study aims to discover whether earlier and longer treatment with a lower dose of sirolimus can help prevent LAM from getting worse over time. To participate in this study, you must be female, be at least 18 years old, and have been diagnosed with LAM. This study is located in Atlanta, Georgia; Boston, Massachusetts; Chicago, Illinois; Cincinnati, Ohio; Denver, Colorado; Nashville, Tennessee; Palo Alto, California; Philadelphia, Pennsylvania; and Seattle, Washington.

Are you an adult woman willing to help improve treatments for LAM?

This study is examining whether using a combination of resveratrol and sirolimus is more effective than using sirolimus alone to treat LAM. To participate in this study, you must be female, be at least 18 years old, and have been diagnosed with LAM. This study is located in Cincinnati, Ohio.

Are you an adult woman diagnosed with LAM and interested in the long-term effects of LAM treatments?

This study is evaluating whether the sirolimus and everolimus medicines are safe and effective long-term treatments for LAM. To participate in this study, you must be female, at least 18 years old, and diagnosed with LAM. You can participate in this study if you are currently taking sirolimus or everolimus, if you are considering taking these medicines to treat LAM, or if you have previously been unable to take these medicines. This study is located in 20 states in the United States.

Are you an adult woman diagnosed with LAM who wants to support future studies of a new treatment?

This study aims to test a new medicine called saracatinib to treat LAM and other cancers. To participate in this study, you must be female, be between 18 and 65 years old, and have been diagnosed with LAM. This study is located in Bethesda, Maryland; Chicago, Illinois; Cincinnati, Ohio; Houston, Texas; and Stanford, California.

Low Blood Pressure

Have you been diagnosed with orthostatic intolerance?

This study aims to find out how the body’s regulation of basic functions, such as heart rate and blood pressure, is altered in people who have orthostatic intolerance. This condition, which has an unknown cause, is characterized by a racing heartbeat, dizziness, lightheadedness, and other symptoms that occur when a person stands up. To participate in this study, you must be between 18 and 80 years old and have orthostatic intolerance. This study is located in Nashville, Tennessee.

Narcolepsy

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours?

This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

Do you have overweight?

Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Are you pregnant, with a BMI of 30 or higher?

This study is examining the connection between obesity, breathing problems associated with sleep, and pregnancy problems such as preeclampsia. To participate in this study, you must be 18 or older, pregnant, and have obesity. This study is located in Pittsburgh, Pennsylvania.

Neonatal Respiratory Diseases

Has your newborn been diagnosed with patent ductus arteriosus?

Patent ductus arteriosus (PDA) is a condition in which a connection between two major blood vessels close to the heart does not close properly after birth. This affects blood flow to the lungs and may cause neonatal respiratory diseases. PDA may correct itself, but sometimes treatment may be necessary. This study aims to identify ways by which doctors can predict which cases of PDA need to be treated. To participate in this study, your newborn must have been born between 23 and 29 weeks’ gestation and have been diagnosed with PDA. This study is located in Columbus, Ohio.

Is your newborn in the neonatal intensive care unit at St. Louis Children’s Hospital?

This study aims to better understand breathing problems and blood flow through the heart in premature newborns to better detect conditions such as pulmonary hypertension. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and be a patient in the Neonatal Intensive Care Unit at St. Louis Children’s Hospital. This study is located in St. Louis, Missouri.

Have you been diagnosed with high blood pressure while pregnant?

This study is investigating whether a mother’s blood pressure during pregnancy affects her newborn’s lung development. To participate in this study, your newborn must have been born either prematurely at more than 25 weeks’ gestation or at full term to a healthy mother or a mother who was diagnosed with high blood pressure during pregnancy. This study is located in Indianapolis, Indiana.

Nivel alto de colesterol en sangre (en español)

¿Tiene usted o su hijo un trastorno de los lípidos y desea mejorar el diagnóstico y el tratamiento futuros?

Este estudio explora cómo las diferentes pruebas de diagnóstico pueden ayudarnos a entender la forma en que los trastornos de los lípidos, incluido el nivel alto de colesterol en sangre, afectan el cuerpo. La información de este estudio puede ayudar a mejorar la forma en que los trastornos de los lípidos se diagnosticarán o se tratarán en el futuro. Para participar, usted o su hijo debe tener al menos dos años. El estudio se lleva a cabo en Bethesda, Maryland.

¿Tiene usted o su hijo un trastorno de los lípidos y desea ayudar en la investigación?

Este estudio evalúa los factores que afectan las proteínas que transportan lípidos en la sangre de pacientes con trastornos de los lípidos. Los participantes seguirán un patrón de alimentación específico durante el estudio y se someterán a análisis de sangre. La información de este estudio puede ayudar a mejorar la forma en que los trastornos de los lípidos se diagnosticarán o tratarán en el futuro. Para participar, debe haber sido diagnosticado con un trastorno de los lípidos. El estudio se lleva a cabo en Bethesda, Maryland.
Vea más informacion sobre Evaluation of Lipoproteins (en inglés).

¿Es usted adulto y está interesado en ayudar en las investigaciones sobre trastornos de los lípidos?

Este estudio compara cómo los lípidos o las grasas, como el colesterol, se desplazan por la sangre de voluntarios adultos sanos y adultos que tienen trastornos de los lípidos, en particular trastornos causados por factores genéticos desconocidos. Para participar en este estudio, debe tener 18 años o más. Las mujeres no deben estar embarazadas. El estudio se lleva a cabo en Bethesda, Maryland.

Overweight and Obesity

Are you an adult who wants to help understand how eating lots of added sugars affects your health?

This study will see how eating high amounts of added sugars affects risk factors for cardiovascular disease or diabetes in participants who are eating an energy-balanced diet to prevent weight gain or energy-imbalanced diet that can cause weight gain. To participate, you must be 18 to 40 years of age and have a body mass index between 22 and 28 that has been stable for the past six months.

Are you a new African-American mother who is overweight or obese and living in Philadelphia?

This study will compare usual and community-specific treatment to see which is more effective at helping new African-American mothers lose weight after childbirth. To participate, you must be an overweight or obese adult, be a Philadelphia WIC participant, and have given birth within the last six months.

Are you an obese adult with metabolic syndrome interested in new treatments?

This study will see if a medicine already approved to treat inflammation in other medical conditions can decrease inflammation due to obesity. It will also see if this medicine can help prevent complications of obesity, such as diabetes and cardiovascular disease. To participate, you must be an adult who has been diagnosed with obesity but who does not have diabetes.

Are you an overweight or obese teen or young adult with a smart phone?

This study will see if personalized lifestyle education delivered to teens and young adults via smart phones, can improve body mass measurements as well as current care methods.

Is your child black and 8 to 11 years old?

This study is testing a way of enhancing sleep in children with the goal of preventing obesity. To participate in this study, your child must be 8 to 11 years old and must be black or African American. This study is located in Philadelphia, Pennsylvania.

Are you an obese black man or women living in Washington D.C.?

This study assesses cardiovascular health and other diseases such as diabetes, blood pressure, cholesterol, and weight, in black men and women who are obese. Based on the results of this assessment, the researchers will develop and test new behavioral weight loss strategies appropriated for this community.

Do you have overweight?

Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Are you pregnant, with a BMI of 30 or higher?

This study is examining the connection between obesity, breathing problems associated with sleep, and pregnancy problems such as preeclampsia. To participate in this study, you must be 18 or older, pregnant, and have obesity. This study is located in Pittsburgh, Pennsylvania.

Pneumonia

[At NIH Clinical Center] Causes and progression of chronic lung disease

This study aims to develop a better understanding of lung disorders. This study also identifies patients who are eligible to participate in other research studies. To participate in this study, you must be between 7 and 90 years old and have symptoms of lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Presión arterial alta (en español)

¿Es usted un adulto cuya presión arterial alta no mejora con los cambios de estilo de vida y las medicinas?

Este estudio evaluará si la minociclina, un antibiótico con efectos antiinflamatorios, puede mejorar el control de presión arterial en pacientes que no responden a las medicinas combinadas con cambios de estilo de vida, tales como la actividad física, la pérdida de peso y los hábitos de alimentación saludable. Para participar, debe tener al menos 18 años de edad y sufrir de presión arterial alta que no responde al tratamiento con tres medicinas distintas para la hipertensión, incluso cuando se utilizan las dosis máximas. Tenga en cuenta que este estudio se realiza en Gainesville, Florida.

¿Es usted un adulto afrodescendiente que vive en el área metropolitana de Washington, D.C.?

Este estudio evalúa la relación entre el ADN, los comportamientos de salud, factores sociales y ambientales, y factores de riesgo de enfermedades del corazón, tales como, hipertensión en afrodescendientes. Para participar, usted debe ser un afrodescendiente de entre 21 y 65 años de edad, que viva en Washington, D.C. o en los condados de Montgomery o Prince Georges en Maryland. Tenga en cuenta que este estudio se realiza en Bethesda, Maryland.

¿Es usted un adulto cuya presión arterial alta no ha mejorado con medicinas?

Este estudio evalúa si los hábitos alimenticios bajos en calorías y sodio, junto con ejercicios aeróbicos, pueden mejorar la presión arterial en pacientes que no responden a las medicinas para la hipertensión. Para participar, usted debe tener al menos 35 años de edad y sufrir de presión arterial alta que no responda a medicinas. Tenga en cuenta que este estudio se realiza en Durham, Carolina del Norte.

¿Conoce a un niño, adolescente o adulto joven con anemia falciforme y presión arterial alta?

Este estudio evalúa un posible tratamiento para pacientes con anemia falciforme y presión arterial alta para prevenir el daño renal. Para participar, debe tener entre 5 y 25 años de edad y sufrir de anemia falciforme e hipertensión. Tenga en cuenta que este estudio se realiza en Birmingham, Alabama.

¿Es usted un adulto que tiene curiosidad y desea saber cómo el sodio afecta su presión arterial?

Este estudio evalúa si la limitación del sodio puede afectar a personas con una predisposición genética específica a la hipertensión. Para participar debe tener 18 años de edad o más y no sufrir de hipertensión. Tenga en cuenta que este estudio se realiza en Charlottesville, Virginia.

Pulmonary Hypertension

Are you an adult with obesity and pulmonary hypertension who is interested in a new treatment?

This study is looking at a medicine called metformin, which is normally used to treat diabetes, as possible treatment for pulmonary hypertension in people who have obesity. To participate in this study, you must be 30 to 75 years old, have a body mass index (BMI) of 30 or greater, and have experienced shortness of breath. This study is located in Boston, Massachusetts.

Is your newborn in the neonatal intensive care unit at St. Louis Children’s Hospital?

This study aims to better understand breathing problems and blood flow through the heart in premature newborns to better detect conditions such as pulmonary hypertension. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and be a patient in the Neonatal Intensive Care Unit at St. Louis Children’s Hospital. This study is located in St. Louis, Missouri.

Has your doctor recommended right heart cardiac catheterization for you?

This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be at least 18 years old, and your doctor must have recommended right heart catheterization for you. This study is located in Bethesda, Maryland.

Respiratory Distress Syndrome

Has your newborn been diagnosed with patent ductus arteriosus?

Patent ductus arteriosus (PDA) is a condition in which a connection between two major blood vessels close to the heart does not close properly after birth. This affects blood flow to the lungs and may cause neonatal respiratory diseases. PDA may correct itself, but sometimes treatment may be necessary. This study aims to identify ways by which doctors can predict which cases of PDA need to be treated. To participate in this study, your newborn must have been born between 23 and 29 weeks’ gestation and have been diagnosed with PDA. This study is located in Columbus, Ohio.

Is your premature newborn in a neonatal intensive care unit in Chicago, Illinois?

This study is investigating how brain development affects breathing in premature newborns. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and admitted to the neonatal intensive care unit within a week of birth. This study is located in Chicago, Illinois.

Is your newborn in the neonatal intensive care unit at Holtz Children’s Hospital in Miami?

This study is interested in learning how frequent changes in a newborn’s levels of oxygen and carbon dioxide affect lung development. To participate in this study, your newborn must have been born prematurely between 23 and 28 weeks’ gestation, be less than 28 days old, and be receiving oxygen therapy. This study is located in Miami, Florida.

Was your newborn born prematurely?

This study aims to better understand the effects of premature delivery on a baby’s lungs during his or her first year of life. To participate in this study, your newborn must have been born prematurely between 24 and 36 weeks’ gestation and not have any congenital heart or lung defects. This study is located in Indianapolis, Indiana.

Is your newborn receiving care at the University of Alabama at Birmingham Women and Infants Center?

This study aims to examine new ways to help control breathing and oxygen levels in premature newborns. To participate in this study, your newborn must have been born prematurely between 22 and 29 weeks’ gestation, and be a patient at the neonatal intensive care unit or the critical care nursery at the University of Alabama at Birmingham Women and Infants Center. This study is located in Birmingham, Alabama.

Is your newborn in the neonatal intensive care unit at St. Louis Children’s Hospital?

This study aims to better understand breathing problems and blood flow through the heart in premature newborns to better detect conditions such as pulmonary hypertension. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and be a patient in the Neonatal Intensive Care Unit at St. Louis Children’s Hospital. This study is located in St. Louis, Missouri.

Have you been diagnosed with high blood pressure while pregnant?

This study is investigating whether a mother’s blood pressure during pregnancy affects her newborn’s lung development. To participate in this study, your newborn must have been born either prematurely at more than 25 weeks’ gestation or at full term to a healthy mother or a mother who was diagnosed with high blood pressure during pregnancy. This study is located in Indianapolis, Indiana.

Sarcoidosis

[At NIH Clinical Center] Genes involved in development of lung diseases

This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old and have been diagnosed and living with a lung disease. This study is located in Bethesda, Maryland, at the NIH Clinical Center.

Are you an adult with sarcoidosis who does not smoke or use other nicotine products?

This study will test whether nicotine patches are an effective treatment for sarcoidosis. To participate, you must be an adult between the ages of 18 and 75 with sarcoidosis, and you must not be a smoker or a user of smokeless tobacco products that contain nicotine. This study is located in Columbus, Ohio.

Sarcoidosis (en español)

[NIH Clinical Center] Genes involucrados en el desarrollo de enfermedades pulmonares

Este estudio investigará los genes implicados en el proceso respiratorio y en el desarrollo de enfermedades pulmonares como el asma o la sarcoidosis para mejorar la comprensión del papel que ellos desempeñan. Para participar en este estudio, usted o su hijo deben tener entre 2 y 90 años y haber sido diagnosticado y estar viviendo con una enfermedad pulmonar. Este estudio se realiza en Bethesda, Maryland.

¿Es usted un adulto con sarcoidosis que no fuma ni usa otros productos de nicotina?

Este estudio probará si los parches de nicotina son un tratamiento efectivo para la sarcoidosis. Para participar, debe ser un adulto entre las edades de 18 y 75 con sarcoidosis, y no debe fumar ni consumir productos de tabaco sin humo que contengan nicotina. Este estudio se realiza en Columbus, Ohio.

Sickle Cell Disease

[At NIH Clinical Center] Bone marrow transplant procedures for severe anemia

This study aims to improve bone marrow transplant (BMT) procedures for older patients by using a low dose of radiation and two immunosuppressive drugs instead of chemotherapy. This type of BMT procedure is described as nonmyeloablative because it does not destroy bone marrow. Participants in this study must be between 2 and 65 years old; have a severe congenital anemia, such as sickle cell disease or beta thalassemia; and have a sibling who is a well-matched stem cell donor. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Pain crises and lung complications in sickle cell disease

This study is interested in understanding pain crises and lung complications that occur in sickle cell disease patients and patients who have other red blood cell disorders. To participate in this study, you must be at least 2 years old with known or suspected sickle cell disease, sickle cell trait, or other red blood cell disorders. Participants will have a physical exam and receive standard medical care for sickle cell disease, including routine follow-up tests and procedures. This study is located in Washington, D.C., and Bethesda, Maryland.
View more information about 5. Natural History of Sickle Cell Disease.

[At NIH Clinical Center] Stem cell transplant procedure with a partial match

This study is testing new ways to improve a stem cell transplant procedure that involves a donor who is not a complete match, called a partial match. To participate in this study, you must be at least 18 years old and have both severe sickle cell disease and a donor who is a partial match. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Improving bone marrow transplants

This study is exploring how to improve bone marrow transplant procedures so the body better accepts donor stem cells. To participate in this study, you must be at least 4 years old, have sickle cell disease, and have a stem cell donor. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Pain crises and sickle cell disease

This study is exploring the biology behind pain crises in patients who have sickle cell disease. To participate in this study, you must be between 18 and 80 years old and not be pregnant or on certain treatments that affect your immune system. This study is located in Bethesda, Maryland.

[At NIH Clinical Center] Blood disorder research

This study is collecting medical information from health exams and routine tests and procedures to see whether participants may be able to enroll in other studies on blood disorders. Participants in this study must be at least 8 years, with or without a blood disorder. This study is located in Bethesda, Maryland.

Are you or your child interested in donating a sample of bone marrow for research?

This study will collect samples of bone marrow from patients who have sickle cell disease or β-thalassemia to help develop genetic therapies. Participants in this study must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Are you 15 to 40 years old and have severe sickle cell disease?

This study is comparing long-term outcomes for patients who receive blood and bone marrow transplants and those who receive standard treatment with medicines. Participants also have an option of contributing blood samples to be stored for future research. Participants must be 15 to 40 years old and have severe sickle cell disease. This study is located in Madison, Wisconsin.

Are you pregnant and willing to donate umbilical cord blood to support future sickle cell disease therapies?

This study seeks to determine the best way to collect, store, and handle blood from newborns to help researchers improve future sickle cell disease therapies. To participate in this study, you must be pregnant, 45 years old or younger, and willing to donate umbilical cord blood from your newborn. Newborns may be healthy or at risk for sickle cell disease or sickle cell trait. This study is located in Bethesda, Maryland.

Are you an adult who has chronic pain from sickle cell disease?

This study is testing a new computer-based program that aims to help patients who have sickle cell disease manage pain. Participants must be at least 18 years old and have chronic pain. This study is located in Pittsburgh, Pennsylvania.

Do you or your child have severe sickle cell disease and also know a half-matched bone marrow donor?

This study is seeking to improve bone marrow transplantation success from half-matched donors by testing a different conditioning procedure that uses a variety of medicines to prepare for the transplant. To participate in this study, you must be 15 to 45 years old and have severe sickle cell disease or have a child 5 to 14 years old who has had a stroke. This study is located in many sites across the United States, including Miami, Florida, and St. Louis, Missouri.

Do you have a child 12 to 18 years old who has sickle cell disease and is interested in hypnosis?

This study is testing whether hypnosis has an effect on blood flow and pain in adolescents who have sickle cell disease. To participate in this study, you must be between 12 and 18 years old and be fluent in English. This study is located in Los Angeles, California.

Are you between 16 and 20 years old and willing to answer questions about managing your sickle cell disease?

This study is investigating the care and quality of life of patients who have sickle cell disease as they transition from pediatric to adult care. To participate in this study, you must be between 16 and 20 years old and be a patient of St. Jude Children’s Research Hospital. This study is located in Memphis, Tennessee.

Do you or your child have sickle cell disease and high blood pressure?

This study is exploring whether use of losartan, a medicine commonly used to lower blood pressure, is effective at treating abnormal nighttime blood pressure in children and young adults who have sickle cell disease. Participants in this study must be between 5 and 25 years old and have high blood pressure and a certain type of sickle cell disease: hemoglobin SS or Sβ0 thalassemia. This study is located in Birmingham, Alabama.
View more information about Preventing Sickle Cell Kidney Disease.

Do you have sickle cell disease and an interest in providing information that can help develop a mobile app?

This study is investigating why patients who have sickle cell disease may not be able to take hydroxyurea or have challenges taking it. This will help researchers develop a mobile application that helps patients take their medicine as directed. To participate in this study, you must be between 15 and 45 years old, have sickle cell disease, and be able to speak English. This study is located in Memphis, Tennessee.

Do you or your child have sickle cell disease and also have an interest in contributing to long-term data collection?

This study is monitoring patients and collecting biological samples from patients who have sickle cell disease to better understand long-term outcomes. Participants can be any age and must have sickle cell disease. This study is located in six sites in Illinois, Louisiana, North Carolina, and Tennessee.

Do you or your child need a stem cell transplant?

This study is exploring the use of treatment with certain medicines in combination with radiation for a successful stem cell transplant. To participate in this study, you must be younger than 49 years old and have a severe disease treatable by a stem cell transplant. This study is located in several sites across the United States, including Aurora, Colorado; Seattle, Washington; and Milwaukee, Wisconsin.

Sleep Apnea

Do you have an adolescent or young adult with sleep apnea and Down syndrome?

The purpose of this study is to assess whether a device that is implanted in the body to stimulate the nerves of the tongue and that has already been approved for use in adults with obstructive sleep apnea can be safely implanted and used in adolescents and young adults who have Down syndrome. To participate, you must be 10 to 21 years old with Down syndrome and have had your tonsils removed. Trial locations are in Atlanta, Georgia; Boston, Massachusetts; Cincinnati, Ohio; Cleveland, Ohio; and Pittsburgh, Pennsylvania.

Are you an adult with sleep apnea who wants to help understand this disease by using an oral appliance?

This study, which aims to understand how the upper airway collapses in obstructive sleep apnea patients during sleep, will use this information to explain why some patients present a large improvement in opening of the upper airway with the use of an oral appliance while others do not. You will have some special exams, such as an endoscopy and sleep studies. To participate, you must be 21 to 70 years old and have obstructive sleep apnea. The trial is being conducted in Boston, Massachusetts.

Are you an adult with sleep apnea and type 2 diabetes?

This study is looking at whether using a CPAP machine can improve blood sugar levels, decrease blood pressure, and reverse damage to the blood vessels in patients who have obstructive sleep apnea and type 2 diabetes. To participate, you must be 21 to 75 years old and have obstructive sleep apnea and type 2 diabetes. The trial is being conducted in Baltimore, Maryland.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Do you have a child with sleep apnea who is interested in a new treatment with a nasal spray?

This study will assess the use of a nasal spray for the treatment of obstructive sleep apnea in children. To participate, children must be 5 to 10 years old, have never had surgery to remove the tonsils, and have never used a CPAP machine. The trial is being conducted in Philadelphia, Pennsylvania.

Sleep Deprivation and Deficiency

Are you an adult with a diagnosed sleep phase disorder?

This study aims to assess the sleep patterns and quality of sleep in people who have sleep phase disorders to determine how the disorders affect their circadian rhythms. To participate in this study, you must be at least 18 years old and have a sleep phase disorder, such as advanced sleep-wake phase syndrome or delayed sleep-wake phase syndrome. This study is located in Chicago, Illinois.

Sobrepeso y obesidad

¿Es adulto y quiere ayudarnos a comprender cómo influye en la salud el consumo de grandes cantidades de azúcares agregados?

En este estudio se analizará de qué manera el consumo de grandes cantidades de azúcares agregados influye en los factores de riesgo de enfermedad cardiovascular o diabetes en participantes que llevan una dieta equilibrada energéticamente para prevenir el aumento de peso o una dieta desequilibrada energéticamente que puede producir un aumento de peso. Para participar, debe tener entre 18 y 40 años de edad y tener un índice de masa corporal de entre 22 y 28 que se haya mantenido estable durante los últimos seis meses.

¿Es una mujer afrodescendiente, tuvo un hijo hace poco, tiene sobrepeso u obesidad y vive en Filadelfia?

En este estudio se compararán los tratamientos habituales y los tratamientos orientados a comunidades específicas para averiguar cuál es el más efectivo a la hora de ayudar a las nuevas madres afrodescendientes a adelgazar después del parto. Para participar, debe ser una mujer adulta, tener sobrepeso u obesidad, participar en el programa WIC de Filadelfia y haber tenido su parto hace menos de seis meses.

¿Eres adolescente o adulto joven, tienes obesidad o sobrepeso y tienes un teléfono celular inteligente?

En este estudio se analizará si el envío, por teléfono celular inteligente, de información personalizada sobre el estilo de vida a adolescentes y adultos jóvenes puede mejorar la masa corporal y los métodos actuales de atención.

¿Es un hombre o una mujer afrodescendiente con obesidad y vive en Washington, D.C.?

En este estudio se evalúa la salud cardiovascular y otras afecciones (como la diabetes, la presión arterial, el colesterol y el peso) de personas afrodescendientes obesas de ambos sexos. A partir de los resultados de la evaluación, los investigadores desarrollarán y pondrán a prueba nuevas estrategias de conducta para bajar de peso que sean adecuadas para esa comunidad.

¿Es mujer, tiene obesidad, está embarazada y tiene apnea del sueño?

Este estudio servirá para comprender de qué manera la apnea del sueño, un trastorno del sueño frecuente en las personas obesas, podría contribuir al desarrollo de complicaciones durante el embarazo. También se analizará si el uso de dispositivos de presión positiva continua de las vías respiratorias, un tratamiento frecuente para la apnea del sueño, mejora las respuestas del embarazo para usted y para el bebé antes del parto.

Thalassemias

[At NIH Clinical Center] Bone marrow transplant procedures for severe anemia

This study aims to improve bone marrow transplant (BMT) procedures for older patients by using a low dose of radiation and two immunosuppressive drugs instead of chemotherapy. This type of BMT procedure is described as nonmyeloablative because it does not destroy bone marrow. Participants in this study must be between 2 and 65 years old; have a severe congenital anemia, such as sickle cell disease or beta thalassemia; and have a sibling who is a well-matched stem cell donor. This study is located in Bethesda, Maryland.

Are you or your child interested in donating a sample of bone marrow for research?

This study will collect samples of bone marrow from patients who have sickle cell disease or β-thalassemia to help develop genetic therapies. Participants in this study must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Venous Thromboembolism

Do you know someone being treated for cancer who may be at risk for VTE?

This study will assess a medicine called isoquercetin to see if it can prevent a venous thromboembolism (VTE) in patients getting treatment for pancreatic, colorectal, and non-small cell lung cancer. To participate in this study, you must be at least 18 years old and must not have been diagnosed with VTE in the last two years. The study has nine locations in California, Connecticut, Maine, Massachusetts, Missouri, Vermont, and Washington, D.C.

Were you or your child recently diagnosed with VTE?

This study is testing a six-week course of blood-thinning medicines for the treatment of venous thromboembolisms (VTE) to see if they are as effective as the standard treatment course of three months. To participate in this study, you or your child must be younger than 21 years old. This study has 54 locations in Alabama, Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland, Massachusetts, Michigan, Missouri, New Jersey, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, South Carolina, Texas, Utah, Virginia, Wisconsin, Australia, Austria, Canada, Israel, and the Netherlands.

Was your child recently diagnosed with DVT?

This study will investigate physical activity habits among children recovering from a deep vein thrombosis (DVT) to see if a fitness tracker can help them maintain regular physical activity. The study will also assess the impact of exercise on their health and quality of life. To participate in this study, your child must be between 7 to 21 years old. The study is located in Dallas, Texas.

Do you know a child or young adult recently treated for VTE?

This study is exploring why some people experience complications after treatment for venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism. To participate in this study, you must have been recently treated for VTE and be younger than 21 years old. This study is located in Dallas, Texas.