Patient and health professional.

NHLBI Clinical Trials

These NHLBI-sponsored research studies are for patients who have heart, lung, blood, or sleep-related diseases.
Hypersensitivity Pneumonitis

Are you an adult with advanced lung disease?

This study will examine how adults with advanced lung disease respond to the way six-minute walk tests are administered and whether behavior and different instructions influence test results. Visit The Six Minute Walk Test: Influence of Patient Effort on Results and Interpretation (fast vs far) for more information and to learn how to participate in this study.

Are you or your child eligible for future studies of inflammatory or immune-mediated diseases?

This study will screen adults and children over the age of two to see whether they are eligible to participate in future studies of inflammatory or immune-mediated diseases. Visit Screening Protocol for Subjects Being Evaluated for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Protocols for more information and to learn how to participate in this study.

Are you or your child interested in providing healthy volunteer samples?

This study will collect tissue samples of healthy adults and children over the age of eight. These samples will allow investigators to define health across the lifespan and will be part of a control group in future studies of inflammatory or immune-mediated diseases. Visit Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies for more information and to learn how to participate in this study.

Do inflammatory or immune-mediated diseases run in your family?

This study will collect tissue samples from family members over the age of two who have inflammatory or immune-mediated diseases. These samples will help investigators understand how genetic variation in the immune system contributes to these conditions. Visit Collection of Blood, Bone Marrow, Leukapheresis, and Tissue Biopsy Samples From Patients and Their Family Members for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases Laboratory Research Studies for more information and to learn how to participate in this study.
la Enfermedad de células falciformes

¿Es usted un adulto con enfermedad de células falciformes grave y tiene un hermano o hermana donante de células madre con buena compatibilidad?

Este estudio está explorando un nuevo procedimiento de trasplante de médula ósea que no requiere quimioterapia o destrucción de toda la médula ósea para evitar el rechazo. Los participantes deben tener entre 18 y 65 años de edad, enfermedad de células falciformes grave y un hermano o hermana que sea un donante de células madre con buena compatibilidad. Para información adicional y para saber cómo participar en este estudio visite: Trasplante alogénico no mieloablativo de células precursoras hematopoyéticas movilizadas a la sangre periférica para anemias congénitas graves como la enfermedad de células falciformes y la talasemia beta (en inglés).

¿Está embarazada y dispuesta a donar sangre del cordón umbilical para apoyar tratamientos futuros para la enfermedad de células falciformes?

Este estudio busca determinar la mejor manera de recoger, almacenar y manejar la sangre de los recién nacidos para ayudar a los investigadores a mejorar los tratamientos futuros para la enfermedad de células falciformes. Los participantes deben ser mujeres embarazadas de 45 años de edad o menos a quienes les gustaría donar la sangre del cordón umbilical de su recién nacido. Los recién nacidos pueden estar sanos, tener riesgo de enfermedad de células falciformes o ser portadores de esta enfermedad. Para información adicional o para saber cómo participar en este estudio visite: Recolección y almacenamiento de células madre hematopoyéticas del cordón umbilical para el tratamiento de la enfermedad de células falciformes (en inglés).

¿Quiere saber si puede participar en estudios relacionados con los trastornos de la sangre?

Este estudio está recopilando información médica de los exámenes de salud y de pruebas y procedimientos de rutina para determinar si los participantes podrían inscribirse en otros estudios sobre trastornos de la sangre. Los participantes deben ser mayores de ocho años de edad, con o sin enfermedad de células falciformes. Para información adicional o para saber cómo participar en este estudio visite: Selección de participantes para determinar si cumplen los requisitos para participar de manera segura en estudios relacionados con los trastornos de la sangre (en inglés).

¿Tiene 15 años de edad o más, enfermedad de células falciformes y está dispuesto a recibir hidroxiurea?

Este pequeño estudio piloto está buscando la manera de optimizar la dosificación de hidroxiurea para maximizar los beneficios de más pacientes con enfermedad de células falciformes. Los participantes deben tener 15 años de edad o más y tener enfermedad de células falciformes por hemoglobina SS. Para información adicional y para saber cómo participar en este estudio, visite: Evaluación por algoritmo computarizado de la dosificación de la hidroxiurea en la respuesta de la hemoglobina fetal, las complicaciones agudas y la función de órganos en personas con enfermedad de células falciformes (en inglés).

¿Tiene de 16 años de edad o más, enfermedad de células falciformes y cuenta con donante de células madre?

Este estudio está explorando la manera de mejorar los procedimientos para el trasplante de médula ósea para que el organismo acepte mejor las células madre del donante. Los participantes tienen que tener 16 años o más, tener enfermedad de células falciformes y contar con un donante de células madre. Para información adicional y para saber cómo participar en este estudio visite: Trasplante no mieloablativo de células precursoras hematopoyéticas movilizadas a la sangre periférica en pacientes con enfermedad de células falciformes y talasemia beta con alto riesgo de rechazo al trasplante (en inglés).

¿Tiene usted o su hijo enfermedad de células falciformes o un trastorno de glóbulos rojos?

Este estudio está interesado en entender las crisis de dolor y las complicaciones pulmonares que se presentan en los pacientes con enfermedad de células falciformes y en aquellos con otros trastornos de glóbulos rojos. Los participantes deben ser de cinco años de edad en adelante que tienen o que se sospecha que tienen la enfermedad de células falciformes, son portadores, o tienen otros trastornos de glóbulos rojos. A los participantes se les hará un examen físico y recibirán la atención médica estándar para la enfermedad de células falciformes que incluye pruebas y procedimientos de seguimiento rutinarios. Para información adicional o para saber cómo participar en este estudio visite: Estudios de la historia natural de la enfermedad de células falciformes (en inglés).
LAM

Are you 16 or older with LAM and interested in helping LAM research?

This study is trying to understand the genes and proteins that are responsible for causing lung damage in patients with LAM. You must be 16 years or older and have LAM or TSC-LAM. Visit Study of the Disease Process of Lymphangioleiomyomatosis for more information and to learn how to participate in this study.

Are you an adult with advanced lung disease?

This study will examine how adults with advanced lung disease respond to the way six-minute walk tests are administered and whether behavior and different instructions influence test results. Visit The Six Minute Walk Test: Influence of Patient Effort on Results and Interpretation (fast vs far) for more information and to learn how to participate in this study.

Are you an adult woman with LAM interested in sirolimus or everolimus treatment?

This study is trying to optimize sirolimus or everolimus treatment to prevent progression to more advanced disease. You must be an adult woman with LAM to participate. It is not a requirement that you are already taking one of these medicines. If you are not taking one of these medicines and previously did not respond to or could not tolerate one of these medicines, you may still be able to participate in this study. Visit Safety and Durability of Sirolimus for Treatment of LAM (MIDAS) for more information and to learn how to participate in this study.

Are you an adult woman with LAM who wants to support future studies of a new treatment or biomarker of disease severity?

This study is examining whether celecoxib is a safe and well tolerated in people who have LAM. Celecoxib inhibits COX-2, a protein known to have increased activity in TSC mutant cells. This study can help researchers optimize future studies aimed at determining how effective celecoxib is at shrinking growths of TSC mutant cells, improving lung function, and being a long-term treatment option for patients with LAM. This study is also exploring whether the amount of TSC-mutant LAM cells in the blood is a biomarker for disease severity. You must be a woman with LAM between the ages of 18 and 70 to participate. Visit COLA: A Pilot Clinical Trial of COX-2 Inhibition in LAM and TSC (COLA) for more information and to learn how to participate in this study.

Are you an adult woman with LAM who wants to support future studies of a new treatment?

This study is examining whether saracatinib is safe and improves lung function in people who have LAM. Saracatinib inhibits Src kinase, a protein that is known to have increased activity in TSC mutant cells. You must be a woman with LAM between the ages of 18 and 65 to participate. Visit Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis (SLAM-2) for more information and to learn how to participate in this study.

Are you an adult woman with LAM who wants to try albuterol to improve lung function?

This study is examining which delivery method of albuterol—inhaled or nebulizer—is better at improving lung function in adult women with LAM. Visit Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis for more information and to learn how to participate in this study.
Overweight and Obesity

Are you a new African-American mother who is overweight or obese and living in Philadelphia?

This study will compare usual and community-specific treatment to see which is more effective at helping new African-American mothers lose weight after childbirth. To participate, you must be an overweight or obese adult, be a Philadelphia WIC participant, and have given birth within the last six months. Visit the Community-based Obesity Treatment in African American Women After Childbirth for more information and to learn how to participate in the study.

Are you an adult who wants to help understand how eating lots of added sugars affects your health?

This study will see how eating high amounts of added sugars affects risk factors for cardiovascular disease or diabetes in participants who are eating an energy-balanced diet to prevent weight gain or energy-imbalanced diet that can cause weight gain. To participate, you must be 18 to 40 years of age and have a body mass index between 22 and 28 that has been stable for the past six months. Visit Adverse Metabolic Effects of Dietary Sugar for more information and to learn how to participate in the study.

Are you an obese adult with depression?

This study is investigating a behavioral weight-loss program and new care program for adults who have been diagnosed with obesity and depression. This study uses conventional medical care and modern technologies, including web, secure email, and mobile texting, to offer more individualized patient care. Visit Research Aimed at Improving Both Mood and Weight for more information and to learn how to participate in this study.

Are you an obese adult with metabolic syndrome interested in new treatments?

This study will see if a medicine already approved to treat inflammation in other medical conditions can decrease inflammation due to obesity. It will also see if this medicine can help prevent complications of obesity, such as diabetes and cardiovascular disease. To participate, you must be an adult who has been diagnosed with obesity but who does not have diabetes. Visit Effects of colchicine in Non-Diabetic Adults with Metabolic Syndrome for more information and to learn how to participate in this study.

Are you an obese black man or women living in Washington D.C.?

This study assesses cardiovascular health and other diseases such as diabetes, blood pressure, cholesterol, and weight, in black men and women who are obese. Based on the results of this assessment, the researchers will develop and test new behavioral weight loss strategies appropriated for this community. Visit the Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention for more information and to learn how to participate in this study.

Are you an obese pregnant woman with sleep apnea?

This study will help to understand how sleep apnea, a common sleep disorder in obese individuals, may contribute to pregnancy complications. It also will see if use of continuous positive airway pressure (CPAP) devices, a common sleep apnea treatment, will improve pregnancy outcomes for you and your baby before birth. Visit the Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP) for more information and to learn how to participate in this study.

Are you an obese teen or young adult with asthma?

This study is looking at whether fish oil supplements containing omega-3 fatty acids improve asthma in teens and young adults who are obese. It also will see how having a certain gene affects how well the fish oil controls asthma in these participants. Visit Obesity and Asthma: Nutrigenetic Response to Omega-3 Fatty Acids for more information and to learn how to participate in this study.

Are you an overweight or obese teen or young adult with a smart phone?

This study will see if personalized lifestyle education delivered to teens and young adults via smart phones, can improve body mass measurements as well as current care methods. Visit the EMPower: Electronic Media Powering Positive Health Changes in Youth for more information and to learn how to participate in this study.

Do you have an obese teenager who may benefit from exercise programs?

This study will examine the effects of a long-term aerobic exercise, resistance exercise, and a combination of both exercise regimens, and the risk for type 2 diabetes, total fatty tissue and abdominal fat in overweight boys and girls. Visit the Resistance and Cardiorespiratory Time-matched Exercise in Youth: A Randomized Clinical Trial (RCT:RCT) for more information and to learn how to participate in this study.

Do you have an overweight or obese child with vitamin D deficiency?

This study will see if vitamin D supplements improve vascular health and reduce risk factors for cardiovascular disease in overweight or obese children who have vitamin D deficiency. Children must be 10 years or older to participate. Visit Vitamin D and Vascular Health in Children for more information and to learn how to participate in the study.

Do you work at Massachusetts General Hospital and want to help fight the obesity epidemic?

This study will see if personalized feedback about worksite food purchases, daily calorie goals, healthy eating, and financial incentives for healthy food purchases can help employees at Massachusetts General Hospital (MGH) prevent weight gain, reduce cardiovascular risk factors, and make healthier long-term food choices. If successful, the approach could be used by people at other worksites and food retailers to help fight the obesity epidemic. To participate, you must be an MGH employee who is 21 years or older and uses the hospital cafeteria. Visit Promoting Employee Health Through the Worksite Food Environment (ChooseWell 365) for more information and to learn how to participate in the study.
Sickle Cell Disease

Are you 15 or older with sickle cell disease and willing to be on hydroxyurea?

This small pilot study is exploring how to optimize hydroxyurea dosing to maximize benefits for more patients with sickle cell disease. Participants must be 15 years or older with the hemoglobin SS type of sickle cell disease. Visit Assessment of Computerized Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People with Sickle Cell Disease for more information and to learn how to participate in this study.

Are you 16 or older with sickle cell disease and have a stem cell donor?

This study is exploring how to improve bone marrow transplant procedures so the body better accepts donor stem cells. Participants must be 16 years or older with sickle cell disease and have a stem cell donor. Visit Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People with Higher Risk of Transplant Failure for more information and to learn how to participate in this study.

Are you an adult with severe sickle cell disease and a well-matched sibling stem cell donor?

This study is exploring a new bone marrow transplant procedure that does not require chemotherapy or destruction of all bone marrow to prevent rejection. Participants must be 18 to 65 with severe sickle cell disease and have a sibling who is a well-matched stem cell donor. Visit Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-Thalassemia for more information and to learn how to participate in this study.

Are you an adult with sickle cell disease and interested in a new therapy for chronic pain?

This study is assessing whether a new therapy can help manage chronic pain due to sickle cell disease. Participants must be 18 years or older with sickle cell disease. Visit Vaporized Cannabis for Chronic Pain Associated with Sickle Cell Disease for more information and to learn how to participate in this study.

Are you an adult with sickle cell disease and worried about pulmonary hypertension?

This study is exploring how common pulmonary hypertension is in sickle cell disease patients and how genes affect whether this complication will occur or respond to treatment. Participants must be 18 years or older with sickle cell disease. Visit Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients with Sickle Cell Anemia for more information and to learn how to participate in this study.

Are you an adult with sickle cell disease who may visit the emergency department for pain?

This small pilot study is comparing four pain treatments to improve pain-management protocols that emergency departments use to treat adults experiencing vaso-occlusive crises due to sickle cell disease. Participants must be 21 years or older with sickle cell disease. Visit Comparing Acute Pain Management Protocols for Patients with Sickle Cell Disease for more information and to learn how to participate in this study.

Are you an adult with sickle cell disease without a well-matched stem cell donor?

This study is exploring how to improve bone marrow transplant procedures for adults with sickle cell disease who do not have a full-match stem cell donor. If successful, the study could help make transplant procedures possible for a larger number of patients with sickle cell disease. Participants must be 18 years or older with sickle cell disease and have a family member aged two to 80 who is the correct type of stem cell donor. Visit Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-Thalassemia for more information and to learn how to participate in this study.

Are you pregnant and willing to donate umbilical cord blood to support future sickle cell disease therapies?

This study seeks to determine the best way to collect, store, and handle blood from newborns to help researchers improve future sickle cell disease therapies. Participants must be pregnant women who are 45 years or younger who would like to donate umbilical cord blood from their newborn. Newborns may be healthy or at risk for sickle cell disease or sickle cell trait. Visit Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease Therapy for more information and to learn how to participate in this study.

Do you or your child have sickle cell disease or a red blood cell disorder?

This study is interested in understanding pain crises and lung complications that occur in sickle cell disease patients and those with other red blood cell disorders. Participants must be five years or older with known or suspected sickle cell disease, sickle cell trait, or other red blood cell disorders. Participants will have a physical exam and receive standard medical care for sickle cell disease including routine follow-up tests and procedures. Visit Studies of the Natural History of Sickle Cell Disease for more information and to learn how to participate in this study.

Want to know if you can participate in studies on blood disorders?

This study is collecting medical information from health exams and routine tests and procedures to see if participants may be able to enroll in other studies on blood disorders. Participants must be eight years or older with or without sickle cell disease. Visit Screening of Subjects to Determine Eligibility to Safely Participate in Blood Disorders Studies for more information and to learn how to participate in this study.
Sobrepeso y obesidad

¿Eres adolescente o adulto joven, eres obeso y tienes asma?

En este estudio se analiza si los suplementos de aceite de pescado que contienen ácidos grasos omega 3 mejoran el asma en adolescentes y adultos jóvenes con obesidad. También se analizará si cierto gen influye en la eficacia con la que el aceite de pescado permite controlar el asma de esos participantes.

¿Eres adolescente o adulto joven, tienes obesidad o sobrepeso y tienes un teléfono celular inteligente?

En este estudio se analizará si el envío, por teléfono celular inteligente, de información personalizada sobre el estilo de vida a adolescentes y adultos jóvenes puede mejorar la masa corporal y los métodos actuales de atención.

¿Es adulto y obeso, tiene síndrome metabólico y está interesado en nuevos tratamientos?

En este estudio se analizará si un medicamento ya aprobado para tratar la inflamación producida por otras afecciones puede reducir la inflamación debida a la obesidad. También se analizará si el medicamento puede contribuir a prevenir el desarrollo de complicaciones a causa de la obesidad, como la diabetes y la enfermedad cardiovascular. Para participar, debe ser adulto y tener un diagnóstico de obesidad, pero no tener diabetes.

¿Es adulto y quiere ayudarnos a comprender cómo influye en la salud el consumo de grandes cantidades de azúcares agregados?

En este estudio se analizará de qué manera el consumo de grandes cantidades de azúcares agregados influye en los factores de riesgo de enfermedad cardiovascular o diabetes en participantes que llevan una dieta equilibrada energéticamente para prevenir el aumento de peso o una dieta desequilibrada energéticamente que puede producir un aumento de peso. Para participar, debe tener entre 18 y 40 años de edad y tener un índice de masa corporal de entre 22 y 28 que se haya mantenido estable durante los últimos seis meses.

¿Es adulto, obeso y tiene depresión?

En este estudio se investiga un programa de modificación de conducta para adelgazar y un nuevo programa de atención para adultos con diagnóstico de obesidad y depresión. Se emplean servicios convencionales de atención médica y tecnologías modernas, por ejemplo sitios web, servicios de correo electrónico seguro y mensajes de texto, a fin de brindarle una atención más personalizada a cada paciente.

¿Es mujer, tiene obesidad, está embarazada y tiene apnea del sueño?

Este estudio servirá para comprender de qué manera la apnea del sueño, un trastorno del sueño frecuente en las personas obesas, podría contribuir al desarrollo de complicaciones durante el embarazo. También se analizará si el uso de dispositivos de presión positiva continua de las vías respiratorias, un tratamiento frecuente para la apnea del sueño, mejora las respuestas del embarazo para usted y para el bebé antes del parto.

¿Es un hombre o una mujer afrodescendiente con obesidad y vive en Washington, D.C.?

En este estudio se evalúa la salud cardiovascular y otras afecciones (como la diabetes, la presión arterial, el colesterol y el peso) de personas afrodescendientes obesas de ambos sexos. A partir de los resultados de la evaluación, los investigadores desarrollarán y pondrán a prueba nuevas estrategias de conducta para bajar de peso que sean adecuadas para esa comunidad.

¿Es una mujer afrodescendiente, tuvo un hijo hace poco, tiene sobrepeso u obesidad y vive en Filadelfia?

En este estudio se compararán los tratamientos habituales y los tratamientos orientados a comunidades específicas para averiguar cuál es el más efectivo a la hora de ayudar a las nuevas madres afrodescendientes a adelgazar después del parto. Para participar, debe ser una mujer adulta, tener sobrepeso u obesidad, participar en el programa WIC de Filadelfia y haber tenido su parto hace menos de seis meses.

¿Tiene un hijo adolescente obeso que podría beneficiarse al participar en programas de ejercicio?

En este estudio se examinarán los efectos a largo plazo del ejercicio aeróbico, el ejercicio de resistencia y una combinación de ambos tipos de ejercicio, así como el riesgo de diabetes tipo 2, el tejido graso total y la grasa abdominal, en adolescentes de ambos sexos con sobrepeso.

¿Tiene un hijo pequeño con sobrepeso u obesidad y deficiencia de vitamina D?

En este estudio se analizará si los suplementos de vitamina D mejoran la salud vascular y reducen los factores de riesgo de enfermedad cardiovascular en niños con sobrepeso u obesidad y deficiencia de vitamina D. Para participar, los niños deben ser mayores de 10 años de edad.

¿Trabaja en el Hospital General de Massachusetts y quiere ayudar a combatir la epidemia de obesidad?

En este estudio se analizará si brindar información personalizada sobre la compra de alimentos en el lugar de trabajo, los objetivos calóricos diarios, la alimentación saludable y los incentivos económicos para la compra de alimentos saludables puede ayudar a los empleados del Hospital General de Massachusetts (Massachusetts General Hospital, MGH) a prevenir el aumento de peso, reducir los factores de riesgo cardiovascular y tomar decisiones sobre la alimentación más saludables a largo plazo. Si la iniciativa tiene éxito, podría ser adoptada por empleados de otros establecimientos y por los vendedores de alimentos para ayudar a combatir la epidemia de obesidad. Para participar, debe ser empleado del MGH, tener más de 21 años y utilizar la cafetería del hospital.