Patient and health professional.

NHLBI Clinical Trials

These NHLBI-sponsored research studies are for patients who have heart, lung, blood, or sleep-related diseases.
Anemia

Do you have a critically ill child in the ICU?

The study will compare the use of fresh red blood cells and the standard blood bank cells, which are typically older, for blood transfusions in critically ill children in the intensive care unit (ICU). To participate, your child must be between 3 days and 16 years of age and require a blood transfusion in the ICU. The study is taking place at multiple locations across the United States, Canada, and Europe.

Were you or your child diagnosed with Diamond-Blackfan anemia?

The registry is collecting information from people with Diamond-Blackfan anemia to improve understanding of the condition. To participate, you or your child must be diagnosed with Diamond-Blackfan anemia. You will complete a questionnaire, provide access to your medical and laboratory records, and answer questions with study staff over the telephone. This study is taking place in Long Island, New York.
View more information about Diamond-Blackfan Anemia Registry (DBAR).

Did you have a heart attack and want to help determine the best strategy for blood transfusion?

The study is comparing two strategies for blood transfusions in patients who have had a heart attack and have anemia. This will help doctors decide whether to give a blood transfusion right away for heart attack patients who are anemic or wait and see whether their condition improves. To participate, you must be an adult hospitalized for a heart attack and have anemia. The study is taking place in New Brunswick, New Jersey.

Did you recently give birth to a very low birth-weight infant?

The study is investigating how anemia and red blood cell transfusions affect oxygen levels in the digestive tract of very low birth-weight infants. To participate, your newborn must have had a very low birth-weight and be within seven days of birth. The study is taking place in Atlanta, Georgia.

Do you want to take part in blood research?

The study aims to screen patients at the National Institutes of Health Clinical Center who have a blood disorder such as anemia and who may be eligible to participate in studies in the Hematology Branch. It will also determine whether it is safe for you to participate in those studies. To be screened, you or your child must be at least 2 years old and seen at the Clinical Center in Bethesda, Maryland.
View more information about Screening for Hematology Branch Protocols.
Apnea del sueño

¿Es usted un adulto al que le diagnosticaron apnea del sueño recientemente?

Este estudio evalúa si las personas sanas con apnea del sueño desarrollarán cambios precoces en los vasos pequeños del corazón y si estos cambios se resuelven con el uso de un equipo de CPAP. Para participar, debe tener entre 18 y 80 años y sufrir apnea obstructiva del sueño. El estudio se está realizando en Columbus, Ohio.
Arrhythmia

Do you have long QT syndrome or hypertrophic cardiomyopathy?

This study aims to assess the impact of regular exercise on the risk of arrhythmias and other potentially life-threatening complications experienced by patients with the conduction disorder known as long QT syndrome or with hypertrophic cardiomyopathy. Researchers will also document the impact of moderate and vigorous exercise on participants’ quality of life. To participate in this study, you must be between 8 and 60 years old. This study is in 39 locations in Arizona, California, Connecticut, Florida, Illinois, Indiana, Iowa, Kentucky, Maryland, Massachusetts, Michigan, Minnesota, Nebraska, New York, Ohio, Oregon, Pennsylvania, Tennessee, Texas, Utah, Washington, and Washington, D.C., and in Australia, Canada, New Zealand, and the United Kingdom.

Do you know someone who will be having heart surgery?

This study aims to identify what genetic patterns might cause atrial fibrillation and other adverse events that happen after heart surgery. To participate in this study, you must be between 20 and 90 years old. The study is in three locations in Massachusetts and Texas.

Do you have persistent atrial fibrillation?

Cardiac mapping is a tool doctors use to understand the pattern of electrical signals generating arrhythmia in a patient’s heart. This study aims to test a method for analyzing cardiac mapping results to see if it can improve the treatment of persistent atrial fibrillation. To participate in this study, you must be 21 or older and must have tried ablation to treat your atrial fibrillation once before. The study is located in Miami, Florida.

Are you planning to have an ablation procedure for atrial fibrillation?

This study aims to improve a medicine used to prevent a repeat atrial fibrillation event after ablation treatment. Researchers will compare different formulas of the medicine propafenone. To participate in this study, you must be 18 or older and be scheduled for your first ablation procedure to treat atrial fibrillation. The study is located in Nashville, Tennessee.

Do you have heart disease that requires an ICD to prevent sudden cardiac arrest?

This study aims to learn what signs distinguish patients who have a higher risk of an arrhythmia that leads to sudden cardiac arrest. Researchers plan to track patients with a recent ICD replacement for 10 years. To participate in this study, you must be between 18 and 85 years old. This study is located in Washington, D.C.; Baltimore, Maryland; and Richmond, Virginia.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken and grow weaker. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Are you being treated for atrial fibrillation?

This study aims to compare two types of ablation treatment for patients who continue to have symptoms of atrial fibrillation despite treatment with medicines. The two ablation procedures treat different areas of tissue. To participate in this study, you must be at least 21 years old. The study is located in Palo Alto and San Diego, California.

Do you have persistent atrial fibrillation?

This study will see if an injection of alcohol improves the standard ablation treatment for patients diagnosed with persistent atrial fibrillation. The additional technique targets heart tissue known as the vein of Marshall, which can be a source of premature heartbeats. To participate in this study, you must be between 18 and 85 years old. This study is in eight locations in Arizona, California, Georgia, Texas, and Virginia.
Atrial Fibrillation

Do you know someone who will be having heart surgery?

This study aims to identify what genetic patterns might cause atrial fibrillation and other adverse events that happen after heart surgery. To participate in this study, you must be between 20 and 90 years old. The study is in three locations in Massachusetts and Texas.

Do you have persistent atrial fibrillation?

Cardiac mapping is a tool doctors use to understand the pattern of electrical signals generating arrhythmia in a patient’s heart. This study aims to test a method for analyzing cardiac mapping results to see if it can improve the treatment of persistent atrial fibrillation. To participate in this study, you must be 21 or older and must have tried ablation to treat your atrial fibrillation once before. The study is located in Miami, Florida.

Are you planning to have an ablation procedure for atrial fibrillation?

This study aims to improve a medicine used to prevent a repeat atrial fibrillation event after ablation treatment. Researchers will compare different formulas of the medicine propafenone. To participate in this study, you must be 18 or older and be scheduled for your first ablation procedure to treat atrial fibrillation. The study is located in Nashville, Tennessee.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken and grow weaker. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Are you being treated for atrial fibrillation?

This study aims to compare two types of ablation treatment for patients who continue to have symptoms of atrial fibrillation despite treatment with medicines. The two ablation procedures treat different areas of tissue. To participate in this study, you must be at least 21 years old. The study is located in Palo Alto and San Diego, California.

Do you have persistent atrial fibrillation?

This study will see if an injection of alcohol improves the standard ablation treatment for patients diagnosed with persistent atrial fibrillation. The additional technique targets heart tissue known as the vein of Marshall, which can be a source of premature heartbeats. To participate in this study, you must be between 18 and 85 years old. This study is in eight locations in Arizona, California, Georgia, Texas, and Virginia.
Blood and Bone Marrow Transplant

Do you or your child have sickle cell disease and an interest in donating bone marrow for research?

This study will collect bone marrow from patients who have sickle cell disease or β-thalassemia to help develop gene therapies. To participate in this study, you must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Are you 15 to 40 years old with severe sickle cell disease?

This study is comparing long-term outcomes for patients who receive blood and bone marrow transplants and those who receive standard treatment with medicines. Participants also have an option of contributing blood samples to be stored for future research. Participants must be 15 to 40 years old and have severe sickle cell disease. This study is located in Madison, Wisconsin.

Do you or your child have severe sickle cell disease and also know a half-matched bone marrow donor?

This study is seeking to improve bone marrow transplantation success from half-matched donors by testing a different conditioning procedure that uses a variety of medicines to prepare for the transplant. To participate in this study, you must be 15 to 45 years old and have severe sickle cell disease or have a child 5 to 14 years old who has had a stroke. This study is located in many sites across the United States, including Miami, Florida, and St. Louis, Missouri.

Do you or your child have severe sickle cell disease and an interest in a new type of stem cell transplant?

This study is exploring whether a new type of cell infusion may increase the success of stem cell transplants in patients who have both sickle cell disease and a donor who is only a partial match. To participate in this study, you must have undergone puberty and have severe sickle cell disease. This study is located in Atlanta, Georgia.

Are you an adult who has severe sickle cell disease and also knows a stem cell donor who is a partial match?

This study is testing new ways to improve a stem cell transplant procedure that involves a donor who is not a complete match, called a partial match. To participate in this study, you must be at least 18 years old and have both severe sickle cell disease and a donor who is a partial match. This study is located in Bethesda, Maryland.

Are you at least 16 years old with sickle cell disease, and have a stem cell donor?

This study is exploring how to improve bone marrow transplant procedures so the body better accepts donor stem cells. To participate in this study, you must be at least 16 years old, have sickle cell disease, and have a stem cell donor. This study is located in Bethesda, Maryland.

Do you or your child need a stem cell transplant?

This study is exploring the use of treatment with certain medicines in combination with radiation for a successful stem cell transplant. Participants must be no more than 49 years old and have a severe disease treatable by a stem cell transplant. This study is located in several sites across the United States, including Aurora, Colorado; Seattle, Washington; and Milwaukee, Wisconsin.
Bronchitis

Do you have COPD?

This study will be looking for genes that may play a role in the development of COPD by looking at the blood from patients who have COPD, as well as the blood from those patients’ family members. To participate in this study, you must be 52 years old or younger and must not be pregnant or have other serious lung diseases such as lung cancer. This study will be conducted in Boston, Massachusetts.

Do you have chronic bronchitis and COPD and want to improve treatment?

This study will be testing how well a medicine called ivacaftor that is used to treat cystic fibrosis works also to treat symptoms of chronic bronchitis. New research suggests chronic bronchitis may be due to a problem similar to cystic fibrosis. To participate in this study, you must be 40 to 80 years old, have a history of smoking, and have not been diagnosed with asthma or cystic fibrosis. This study will be conducted in Birmingham, Alabama.
Cardiomyopathy

Do you have long QT syndrome or hypertrophic cardiomyopathy?

This study aims to assess the impact of regular exercise on the risk of arrhythmias and other potentially life-threatening complications experienced by patients with the conduction disorder known as long QT syndrome or with hypertrophic cardiomyopathy. Researchers will also document the impact of moderate and vigorous exercise on participants’ quality of life. To participate in this study, you must be between 8 and 60 years old. This study is in 39 locations in Arizona, California, Connecticut, Florida, Illinois, Indiana, Iowa, Kentucky, Maryland, Massachusetts, Michigan, Minnesota, Nebraska, New York, Ohio, Oregon, Pennsylvania, Tennessee, Texas, Utah, Washington, and Washington, D.C., and in Australia, Canada, New Zealand, and the United Kingdom.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken and grow weaker. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.
Congenital Heart Defects

Has your child had a Fontan operation or had an MRI at Children’s Hospital of Philadelphia?

This study uses magnetic resonance imaging (MRI) and neurodevelopmental testing to understand how blood flow to the brain and brain lesions relate to neurodevelopmental problems in children who have had a Fontan operation to correct a single ventricle lesion. To participate in this study, your child must have congenital heart disease and have participated in a specific, previous study of blood flow to the brain. If your child did not participate in such a study, he or she should be between the ages of 3 and 15 and have completed the Fontan Operation or have had a clinically indicated MRI at the Children’s Hospital of Philadelphia to participate. This study is located in Philadelphia, Pennsylvania.

Do you or one of your children have a congenital heart defect?

This study will find both common genetic causes of congenital heart disease and ways that genes influence results of medical treatment. To participate in this study, you or your child must have congenital heart disease. This study is located in Los Angeles, Palo Alto, and San Francisco, California; New Haven, Connecticut; Boston, Massachusetts; New York and Rochester, New York; Philadelphia, Pennsylvania; and Salt Lake City, Utah.

Are you an adult with congenital heart disease?

This study uses whole exome sequencing and other genetic tests to identify causes of congenital heart diseases that occur in individuals and families. To participate in this study, you must be an adult with congenital heart disease with or without a family member with congenital heart disease. This study is located in Columbus, Ohio.
View more information about Genetics of Congenital Heart Disease.

Do you or your child over age 8 have a congenital heart defect and prior whole exome or whole genome sequencing results?

This study explores the association between genetic variants, neurodevelopmental disability, and magnetic resonance imaging (MRI) brain findings. To participate in this study, you or your child must be at least 8 years old and have congenital heart disease and have whole exome or whole genome sequencing results that show either damaging, spontaneous genetic variations or other harmful genetic variations. This study is located in Los Angeles and San Francisco, California; New Haven, Connecticut; Boston, Massachusetts; New York and Rochester, New York; and Salt Lake City, Utah.

Do you or your child have Pentalogy of Cantrell?

This study collects blood, urine, and other samples from people with Pentalogy of Cantrell (POC) to identify possible changes, or mutations, in the genes that may cause this congenital defect. To participate at the Bethesda, Maryland, location, participants must be at least age 2 or older. At all other locations, including San Francisco, California; Boston, Massachusetts; and Dallas, Texas, all ages are included in the study.

Are you or is your child going to have heart catheterization?

This study is investigating new techniques to perform heart catheterization using magnetic resonance imaging (MRI). Heart catheterization procedures are currently guided using X-rays, which exposes the patient to small amounts of radiation. This new MRI technique would allow the procedure to be performed without X-ray radiation. To participate in this study, you or your child must be 2 years of age and older, scheduled to have heart catheterization, and able to undergo MRI. This study is located in Bethesda, Maryland.

Has your doctor recommended right heart catheterization for you?

This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be 18 to 99 years of age and your doctor must be recommending right heart catheterization for you. This study is located in Bethesda, Maryland.

Are you or your child planning to undergo an MRI or cardiac catheterization procedure?

This study will help develop and test new magnetic resonance imaging (MRI) techniques that evaluate patients with cardiovascular disease, congenital heart disease, and problems with the fetal heart and other organs during pregnancy. To participate in this study, you must be a healthy volunteer age 8 or older or be a patient of any age who needs an MRI or cardiac catheterization procedure. This study is located in Washington, D.C.

Are you a greater Boston resident aged 24 to 30?

This study aims to bridge the gap in knowledge between known executive function deficits in childhood congenital heart disease and adult well-being. The study is recruiting healthy volunteers. To participate in this study, you must be between the ages of 24 and 30, live in the greater Boston area, read fluently in English, and not have metal implants, a pacemaker, or orthodontia that would prevent MRI. This study is located in Boston, Massachusetts.

Do you have a child between 30 days and 17 years old who will have elective surgery to close an atrial septal defect?

This study tests a tool that allows surgeons to tell the difference between various types of heart tissue and avoid injury. To participate in this study, your child must be between 30 days and 17 years old, be scheduled for elective surgery to close an atrial septal defect, and have both parents willing and able to attend a pre-operative clinic appointment to provide consent. This study is located in Boston, Massachusetts.
COPD

Do you have COPD?

This study will be looking for genes that may play a role in the development of COPD by looking at the blood from patients who have COPD, as well as the blood from those patients’ family members. To participate in this study, you must be 52 years old or younger and must not be pregnant or have other serious lung diseases such as lung cancer. This study will be conducted in Boston, Massachusetts.

Do you have chronic bronchitis and COPD and want to improve treatment?

This study will be testing how well a medicine called ivacaftor that is used to treat cystic fibrosis works also to treat symptoms of chronic bronchitis. New research suggests chronic bronchitis may be due to a problem similar to cystic fibrosis. To participate in this study, you must be 40 to 80 years old, have a history of smoking, and have not been diagnosed with asthma or cystic fibrosis. This study will be conducted in Birmingham, Alabama.
Defibrillators

Are you considering getting or replacing an implantable cardioverter defibrillator?

Implantable cardioverter defibrillators (ICDs) can present patients with many stressful decisions, and this study tests the effectiveness of educational videos and handouts to inform patients about ICDs and help them assess their options. To participate in this study, your doctor must have given you the option of implanting or replacing an ICD. The study is located in Denver, Colorado.

Are you an adult who was admitted to a hospital in Minnesota or Wisconsin due to sudden cardiac arrest?

This study is examining how hospital procedures affect outcomes for patients who are brought to an emergency department after being resuscitated from sudden cardiac arrest. To participate in this study, you must be between 18 and 75 years old and have had a ventricular arrhythmia that caused a sudden cardiac arrest. This study is located in Brooklyn Center, Edina, Minneapolis, and St. Paul, Minnesota, and in Milwaukee, Wisconsin.

Are you an adult living in Beijing, China, with a heart conduction disorder?

This study will investigate health outcomes among people with a heart conduction disorder that is sometimes treated with an implantable cardioverter defibrillator. To participate in this study, you must be between 18 and 60 years old and have complete left bundle branch block. The study takes place in Beijing, China.

Do you have heart disease that requires an ICD to prevent sudden cardiac arrest?

This study aims to learn what signs distinguish patients who have a higher risk of an arrhythmia that leads to sudden cardiac arrest. Researchers plan to track patients with a recent ICD replacement for 10 years. To participate in this study, you must be between 18 and 85 years old. This study is located in Washington, D.C.; Baltimore, Maryland; and Richmond, Virginia.

Are you an adult in the D.C. metro area who is considering an implantable cardioverter defibrillator replacement?

This study aims to understand which patients are at the greatest risk of sudden cardiac death. This will help doctors determine which patients will benefit from having their implantable cardioverter defibrillator (ICD) replaced. To participate in this study, you must be 18 to 85 years old, currently have an ICD, and meet certain criteria for heart function. The study is located in Baltimore, Maryland; Richmond, Virginia; and Washington, D.C.
High Blood Cholesterol

Do you or does your child have a lipid disorder and want to improve future diagnosis and treatment?

This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. To participate, you or your child must be at least 2 years old. The study is being conducted in Bethesda, Maryland.

Are you a healthy adult with no history of heart problems?

This study is testing whether a fish oil with high content of omega-11 fatty acid can contribute to a healthy lipid profile and decrease the risk of heart disease. To participate in this study, you must be 18 years old or older. Women should not be breastfeeding or using oral contraceptives. The study is being conducted in Bethesda, Maryland.

Are you 40 or older and being treated for HIV?

This study is testing whether a certain statin can prevent plaque from building up in the blood vessels of patients who are taking antiretroviral therapy to treat HIV. To participate in this study, you must be between 40 and 75 years old and have HIV. There are 128 study locations in 32 states, the District of Columbia, and Puerto Rico, Botswana, Brazil, Canada, India, Peru, South Africa, and Thailand.

Are you an adult who wants to prevent high blood cholesterol?

This study is investigating whether niacin, or vitamin B3, can prevent high blood cholesterol and its complications such as heart attacks. To participate in this study, you must be 18 years old or older. Women should not be pregnant or breast-feeding. The study is being conducted in Bethesda, Maryland.

Are you an adult who is interested in helping research on lipid disorders?

This study is comparing how lipids, or fats, such as cholesterol travel in the blood of healthy adult volunteers and adults who have lipid disorders, particularly disorders that may be caused by unknown genetics factors. To participate in this study, you must be 18 years old or older. Women should not be pregnant. The study is being conducted in Bethesda, Maryland.

Do you or your child have a lipid disorder and want to help research?

This study is assessing factors affecting proteins that transport lipids in the blood of patients with lipid disorders. Participants will follow a specific eating pattern during the study and will have blood tests. Information from this study may help improve the way in which lipid disorders are diagnosed or treated in the future. To participate, you must have been diagnosed with a lipid disorder. The study is being conducted in Bethesda, Maryland.
High Blood Pressure

Are you an adult who seeks treatment for high blood pressure in the emergency room?

This study is assessing techniques to help patients who have high blood pressure follow their treatment plan and decrease their visits to the emergency department. To participate, you must be between 21 and 85 years old. Please note that this study is in Nashville, Tennessee.

Are you an adult who is curious about how sodium affects your blood pressure?

This study is testing if limiting sodium can affect individuals with a specific genetic predisposition to high blood pressure. To participate you must be 18 years old or older and not have high blood pressure. Please note that this study is in Charlottesville, Virginia.

Are you an adult whose high blood pressure does not improve with lifestyle changes and medicines?

This study will assess whether minocycline, an antibiotic with anti-inflammatory effects, can improve blood pressure control in patients who do not respond to medicines in combination with lifestyle changes, such as physical activity, weight loss, and healthy eating patterns. To participate you must be at least 18 years old and have high blood pressure that does not respond to treatment with three different high blood pressure medicines even when used at the maximum doses. Please note that this study is in Gainesville, Florida.

Are you an adult with high blood pressure who prefers natural therapies?

This study is investigating whether modified citrus pectin, a dietary supplement derived from plants, can decrease heart failure and other complications of high blood pressure. To participate patients must be at least 21 years old and have an established treatment plan for high blood pressure. Please note that this study is in Boston, Massachusetts.

Are you an African American adult living in the Washington, D.C. metro area?

This study is assessing the association between DNA, health behaviors, social and environmental factors, and risk factors of heart disease, such as high blood pressure, in African Americans. To participate you must be an African American between 21 and 65 years old, living in Washington, D.C., or Montgomery or Prince Georges counties in Maryland. Please note that this study is being conducted in Bethesda, Maryland.

Are you an adult who has insomnia and high blood pressure?

This study is evaluating three different behavioral interventions for treatment of insomnia and the effects of insomnia on blood pressure. To participate, you must be at least 18 years old and have insomnia and high blood pressure. Please note that this study is in Pittsburgh, Pennsylvania.

Are you an adult whose high blood pressure has not improved with medicines?

This study is assessing whether a low-sodium and low-calorie eating pattern, along with aerobic exercise, can improve blood pressure in patients who do not respond to high blood pressure medicines. To participate you must be at least 35 years and have high blood pressure that does not respond to medicines. Please note that this study is in Durham, North Carolina.

Do you or your child have sickle cell disease and high blood pressure?

This study is exploring whether use of losartan, a medicine commonly used to lower blood pressure, is effective at treating abnormal nighttime blood pressure in children and young adults who have sickle cell disease. To participate in this study, you or your child must be 5 to 25 years old and have high blood pressure and a certain type of sickle cell disease: hemoglobin SS or Sβ0 thalassemia. This study is located in Birmingham, Alabama.
View more information about Preventing Sickle Cell Kidney Disease.

Do you know a child, teen, or young adult with sickle cell disease and high blood pressure?

This study is evaluating a possible treatment for patients with sickle cell disease and high blood pressure to prevent kidney damage. To participate, you must be between 5 and 25 years old and have sickle cell disease and high blood pressure. Please note that this study is in Birmingham, Alabama.
View more information about Preventing Sickle Cell Kidney Disease.
High Blood Triglycerides

Do you or your child have a lipid disorder and want to improve future diagnosis and treatment?

This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. To participate in this study, you or your family member must be at least 2 years old. This study is located in Bethesda, Maryland.

Do you want to help future diagnosis and treatment of lipid disorders?

This study is looking at lipoproteins in people with lipid disorders, such as high blood cholesterol and high blood triglycerides. Lipoproteins are particles that carry fats such as triglycerides through the bloodstream. Problems with your body’s lipoprotein levels lead to changes in how your body handles fats. Researchers will measure lipoprotein levels in the blood to develop better ways to diagnose and treat patients with diseases of lipoproteins. To participate in this study, you must have been diagnosed with a lipid disorder. This study is located in Bethesda, Maryland.
View more information about Evaluation of Lipoproteins.

Does your family have a lipid disorder?

This study is looking at the genes of family members who have high blood cholesterol and high blood triglycerides to try to find new gene changes that lead to lipid disorders. To participate in this study, you or your family member must be at least 2 years old. This study is located in Bethesda, Maryland.
View more information about Genes Involved in Lipid Disorders.
Hypersensitivity Pneumonitis

Are you or your child interested in providing healthy volunteer samples?

This study will collect tissue samples of healthy adults and children over the age of eight. These samples will allow investigators to define health across the lifespan and will be part of a control group in future studies of inflammatory or immune-mediated diseases.

Do inflammatory or immune-mediated diseases run in your family?

This study will collect tissue samples from family members over the age of two who have inflammatory or immune-mediated diseases. These samples will help investigators understand how genetic variation in the immune system contributes to these conditions.

Are you or your child eligible for future studies of inflammatory or immune-mediated diseases?

This study will screen adults and children over the age of two to see whether they are eligible to participate in future studies of inflammatory or immune-mediated diseases.

Are you an adult with advanced lung disease?

This study will examine how adults with advanced lung disease respond to the way six-minute walk tests are administered and whether behavior and different instructions influence test results.
Insomnia

Are you an adult who has insomnia and high blood pressure?

This study is evaluating three different behavioral interventions for treatment of insomnia and the effects of insomnia on blood pressure. To participate, you must be at least 18 years old and have insomnia and high blood pressure. Please note that this study is in Pittsburgh, Pennsylvania.
Iron-Deficiency Anemia

Are you a frequent blood donor living in New York City?

This study is looking at how iron-deficiency anemia in blood donors affects the quality of donated red blood cells, such as how well the red blood cells survive after transfusion. To participate, your blood must meet certain requirements and you must be healthy, 18 to 75 years old, weigh more than 110 pounds, and donate blood frequently. This study is located in New York City, and is recruiting by invitation only.
la Enfermedad de células falciformes

¿Tiene 15 años de edad o más, enfermedad de células falciformes y está dispuesto a recibir hidroxiurea?

Este pequeño estudio piloto está buscando la manera de optimizar la dosificación de hidroxiurea para maximizar los beneficios de más pacientes con enfermedad de células falciformes. Los participantes deben tener 15 años de edad o más y tener enfermedad de células falciformes por hemoglobina SS. Para información adicional y para saber cómo participar en este estudio, visite: Evaluación por algoritmo computarizado de la dosificación de la hidroxiurea en la respuesta de la hemoglobina fetal, las complicaciones agudas y la función de órganos en personas con enfermedad de células falciformes (en inglés).

¿Está embarazada y dispuesta a donar sangre del cordón umbilical para apoyar tratamientos futuros para la enfermedad de células falciformes?

Este estudio busca determinar la mejor manera de recoger, almacenar y manejar la sangre de los recién nacidos para ayudar a los investigadores a mejorar los tratamientos futuros para la enfermedad de células falciformes. Los participantes deben ser mujeres embarazadas de 45 años de edad o menos a quienes les gustaría donar la sangre del cordón umbilical de su recién nacido. Los recién nacidos pueden estar sanos, tener riesgo de enfermedad de células falciformes o ser portadores de esta enfermedad. Para información adicional o para saber cómo participar en este estudio visite: Recolección y almacenamiento de células madre hematopoyéticas del cordón umbilical para el tratamiento de la enfermedad de células falciformes (en inglés).

¿Es usted un adulto con enfermedad de células falciformes grave y tiene un hermano o hermana donante de células madre con buena compatibilidad?

Este estudio está explorando un nuevo procedimiento de trasplante de médula ósea que no requiere quimioterapia o destrucción de toda la médula ósea para evitar el rechazo. Los participantes deben tener entre 18 y 65 años de edad, enfermedad de células falciformes grave y un hermano o hermana que sea un donante de células madre con buena compatibilidad. Para información adicional y para saber cómo participar en este estudio visite: Trasplante alogénico no mieloablativo de células precursoras hematopoyéticas movilizadas a la sangre periférica para anemias congénitas graves como la enfermedad de células falciformes y la talasemia beta (en inglés).

¿Tiene usted o su hijo enfermedad de células falciformes o un trastorno de glóbulos rojos?

Este estudio está interesado en entender las crisis de dolor y las complicaciones pulmonares que se presentan en los pacientes con enfermedad de células falciformes y en aquellos con otros trastornos de glóbulos rojos. Los participantes deben ser de cinco años de edad en adelante que tienen o que se sospecha que tienen la enfermedad de células falciformes, son portadores, o tienen otros trastornos de glóbulos rojos. A los participantes se les hará un examen físico y recibirán la atención médica estándar para la enfermedad de células falciformes que incluye pruebas y procedimientos de seguimiento rutinarios. Para información adicional o para saber cómo participar en este estudio visite: Estudios de la historia natural de la enfermedad de células falciformes (en inglés).

¿Tiene de 16 años de edad o más, enfermedad de células falciformes y cuenta con donante de células madre?

Este estudio está explorando la manera de mejorar los procedimientos para el trasplante de médula ósea para que el organismo acepte mejor las células madre del donante. Los participantes tienen que tener 16 años o más, tener enfermedad de células falciformes y contar con un donante de células madre. Para información adicional y para saber cómo participar en este estudio visite: Trasplante no mieloablativo de células precursoras hematopoyéticas movilizadas a la sangre periférica en pacientes con enfermedad de células falciformes y talasemia beta con alto riesgo de rechazo al trasplante (en inglés).

¿Quiere saber si puede participar en estudios relacionados con los trastornos de la sangre?

Este estudio está recopilando información médica de los exámenes de salud y de pruebas y procedimientos de rutina para determinar si los participantes podrían inscribirse en otros estudios sobre trastornos de la sangre. Los participantes deben ser mayores de ocho años de edad, con o sin enfermedad de células falciformes. Para información adicional o para saber cómo participar en este estudio visite: Selección de participantes para determinar si cumplen los requisitos para participar de manera segura en estudios relacionados con los trastornos de la sangre (en inglés).
LAM

Are you an adult woman with LAM who wants to support future studies of a new treatment or biomarker of disease severity?

This study is examining whether celecoxib is a safe and well tolerated in people who have LAM. Celecoxib inhibits COX-2, a protein known to have increased activity in TSC mutant cells. This study can help researchers optimize future studies aimed at determining how effective celecoxib is at shrinking growths of TSC mutant cells, improving lung function, and being a long-term treatment option for patients with LAM. This study is also exploring whether the amount of TSC-mutant LAM cells in the blood is a biomarker for disease severity. You must be a woman with LAM between the ages of 18 and 70 to participate.

Are you an adult woman with LAM who wants to try albuterol to improve lung function?

This study is examining which delivery method of albuterol—inhaled or nebulizer—is better at improving lung function in adult women with LAM.

Are you an adult woman with LAM interested in sirolimus or everolimus treatment?

This study is trying to optimize sirolimus or everolimus treatment to prevent progression to more advanced disease. You must be an adult woman with LAM to participate. It is not a requirement that you are already taking one of these medicines. If you are not taking one of these medicines and previously did not respond to or could not tolerate one of these medicines, you may still be able to participate in this study.

Are you an adult woman with LAM who wants to support future studies of a new treatment?

This study is examining whether saracatinib is safe and improves lung function in people who have LAM. Saracatinib inhibits Src kinase, a protein that is known to have increased activity in TSC mutant cells. You must be a woman with LAM between the ages of 18 and 65 to participate.

Are you 16 or older with LAM and interested in helping LAM research?

This study is trying to understand the genes and proteins that are responsible for causing lung damage in patients with LAM. You must be 16 years or older and have LAM or TSC-LAM. Visit for more information and to learn how to participate in this study.

Are you an adult with advanced lung disease?

This study will examine how adults with advanced lung disease respond to the way six-minute walk tests are administered and whether behavior and different instructions influence test results.
Overweight and Obesity

Are you an adult who wants to help understand how eating lots of added sugars affects your health?

This study will see how eating high amounts of added sugars affects risk factors for cardiovascular disease or diabetes in participants who are eating an energy-balanced diet to prevent weight gain or energy-imbalanced diet that can cause weight gain. To participate, you must be 18 to 40 years of age and have a body mass index between 22 and 28 that has been stable for the past six months.

Are you a new African-American mother who is overweight or obese and living in Philadelphia?

This study will compare usual and community-specific treatment to see which is more effective at helping new African-American mothers lose weight after childbirth. To participate, you must be an overweight or obese adult, be a Philadelphia WIC participant, and have given birth within the last six months.

Are you an obese adult with metabolic syndrome interested in new treatments?

This study will see if a medicine already approved to treat inflammation in other medical conditions can decrease inflammation due to obesity. It will also see if this medicine can help prevent complications of obesity, such as diabetes and cardiovascular disease. To participate, you must be an adult who has been diagnosed with obesity but who does not have diabetes.

Are you an overweight or obese teen or young adult with a smart phone?

This study will see if personalized lifestyle education delivered to teens and young adults via smart phones, can improve body mass measurements as well as current care methods.

Are you an obese black man or women living in Washington D.C.?

This study assesses cardiovascular health and other diseases such as diabetes, blood pressure, cholesterol, and weight, in black men and women who are obese. Based on the results of this assessment, the researchers will develop and test new behavioral weight loss strategies appropriated for this community.

Are you an obese teen or young adult with asthma?

This study is looking at whether fish oil supplements containing omega-3 fatty acids improve asthma in teens and young adults who are obese. It also will see how having a certain gene affects how well the fish oil controls asthma in these participants.

Do you work at Massachusetts General Hospital and want to help fight the obesity epidemic?

This study will see if personalized feedback about worksite food purchases, daily calorie goals, healthy eating, and financial incentives for healthy food purchases can help employees at Massachusetts General Hospital (MGH) prevent weight gain, reduce cardiovascular risk factors, and make healthier long-term food choices. If successful, the approach could be used by people at other worksites and food retailers to help fight the obesity epidemic. To participate, you must be an MGH employee who is 21 years or older and uses the hospital cafeteria.

Are you an obese adult with depression?

This study is investigating a behavioral weight-loss program and new care program for adults who have been diagnosed with obesity and depression. This study uses conventional medical care and modern technologies, including web, secure email, and mobile texting, to offer more individualized patient care.

Do you have an obese teenager who may benefit from exercise programs?

This study will examine the effects of a long-term aerobic exercise, resistance exercise, and a combination of both exercise regimens, and the risk for type 2 diabetes, total fatty tissue and abdominal fat in overweight boys and girls.

Are you an obese pregnant woman with sleep apnea?

This study will help to understand how sleep apnea, a common sleep disorder in obese individuals, may contribute to pregnancy complications. It also will see if use of continuous positive airway pressure (CPAP) devices, a common sleep apnea treatment, will improve pregnancy outcomes for you and your baby before birth.

Do you have an overweight or obese child with vitamin D deficiency?

This study will see if vitamin D supplements improve vascular health and reduce risk factors for cardiovascular disease in overweight or obese children who have vitamin D deficiency. Children must be 10 years or older to participate.
View more information about Vitamin D and Vascular Health in Children.
Sarcoidosis

Are you an adult with sarcoidosis who does not smoke or use other nicotine products?

This study will test whether nicotine patches are an effective treatment for sarcoidosis. To participate, you must be an adult between the ages of 18 and 75 with sarcoidosis, and you must not be a smoker or a user of smokeless tobacco products that contain nicotine. This study is located in Columbus, Ohio.

Are you an adult over age 18 who has progressive sarcoidosis?

This study will test the safety and effectiveness of a combination of medications called concomitant levaquin, ethambutol, azithromycin, and rifampin (CLEAR) therapy. The researchers will check participants’ lung function and chest X-rays before and after 16 weeks of CLEAR therapy. To participate, you must be at least 18 years old, have sarcoidosis that has progressed, and have evidence from a chest X-ray that the disease is present in certain places. This study is located in Albany, New York; Cincinnati, Ohio; Cleveland, Ohio; Columbus, Ohio; Charleston, South Carolina; and Nashville, Tennessee.

Do you have sarcoidosis or is your child an NIH patient older than 16 with sarcoidosis?

This study will investigate the genes involved in breathing and in lung disease to improve understanding of the role they play. To participate, you must have sarcoidosis and be at least 18 years old, or your child must be an NIH patient who is at least 16 years old and living with the disease. This study is located in Bethesda, Maryland.
Sickle Cell Disease

Do you or your child have sickle cell disease and an interest in donating bone marrow for research?

This study will collect bone marrow from patients who have sickle cell disease or β-thalassemia to help develop gene therapies. To participate in this study, you must be at least 2 years old and have sickle cell disease or β-thalassemia. You may continue regular treatments while participating in the study. This study is located in Memphis, Tennessee.
View more information about Bone Marrow for Hemoglobinopathy Research.

Are you 15 to 40 years old with severe sickle cell disease?

This study is comparing long-term outcomes for patients who receive blood and bone marrow transplants and those who receive standard treatment with medicines. Participants also have an option of contributing blood samples to be stored for future research. Participants must be 15 to 40 years old and have severe sickle cell disease. This study is located in Madison, Wisconsin.

Are you pregnant and willing to donate umbilical cord blood to support future sickle cell disease therapies?

This study seeks to determine the best way to collect, store, and handle blood from newborns to help researchers improve future sickle cell disease therapies. To participate in this study, you must be pregnant, 45 years old or younger, and willing to donate umbilical cord blood from your newborn. Newborns may be healthy or at risk for sickle cell disease or sickle cell trait. This study is located in Bethesda, Maryland.

Are you an adult who has chronic pain from sickle cell disease?

This study is testing a new computer-based program that aims to help patients with sickle cell disease deal with pain symptoms. Participants must be at least18 years old and have chronic pain. This study is located in Pittsburgh, Pennsylvania.

Are you at least 15 years, have sickle cell disease, and live in Virginia?

This study is exploring whether specialized health care workers, called patient navigators, help patients who have sickle cell disease take hydroxyurea as directed. Participants must be at least 15 years old and live in the state of Virginia. This study is located in Richmond, Virginia.

Do you or your child have severe sickle cell disease and also know a half-matched bone marrow donor?

This study is seeking to improve bone marrow transplantation success from half-matched donors by testing a different conditioning procedure that uses a variety of medicines to prepare for the transplant. To participate in this study, you must be 15 to 45 years old and have severe sickle cell disease or have a child 5 to 14 years old who has had a stroke. This study is located in many sites across the United States, including Miami, Florida, and St. Louis, Missouri.

Do you have a child between 9 and 36 months old who may benefit from hydroxyurea treatment?

This study aims to investigate whether hydroxyurea treatment at a very early age has the same beneficial effects as it does in older children who have sickle cell disease. To participate in this study, your child must be 9 to 36 months old and have a certain type of sickle cell disease: hemoglobin SS or Sβ0 thalassemia. This study is located in Atlanta, Georgia; Memphis, Tennessee; and Dallas, Texas.

Do you have a child 12 to 18 years old who has sickle cell disease and is interested in hypnosis?

This study is testing whether hypnosis has an effect on blood flow and pain in adolescents who have sickle cell disease. To participate in this study, you must be 12 to 18 years old and be fluent in English. This study is located in Los Angeles, California.

Do you or your child have severe sickle cell disease and an interest in a new type of stem cell transplant?

This study is exploring whether a new type of cell infusion may increase the success of stem cell transplants in patients who have both sickle cell disease and a donor who is only a partial match. To participate in this study, you must have undergone puberty and have severe sickle cell disease. This study is located in Atlanta, Georgia.

Do you or your child have sickle cell disease or a red blood cell disorder?

This study is interested in understanding pain crises and lung complications that occur in sickle cell disease patients and patients with other red blood cell disorders. To participate in this study, your child must be at least 5 years old with known or suspected sickle cell disease, sickle cell trait, or other red blood cell disorders. Participants will have a physical exam and receive standard medical care for sickle cell disease, including routine follow-up tests and procedures. This study is located in Washington, D.C.
View more information about Natural History of Sickle Cell Disease.

Are you an adult who has severe sickle cell disease and also knows a stem cell donor who is a partial match?

This study is testing new ways to improve a stem cell transplant procedure that involves a donor who is not a complete match, called a partial match. To participate in this study, you must be at least 18 years old and have both severe sickle cell disease and a donor who is a partial match. This study is located in Bethesda, Maryland.

Are you at least 16 years old with sickle cell disease, and have a stem cell donor?

This study is exploring how to improve bone marrow transplant procedures so the body better accepts donor stem cells. To participate in this study, you must be at least 16 years old, have sickle cell disease, and have a stem cell donor. This study is located in Bethesda, Maryland.

Are you an adult who is willing to contribute medical samples during a sickle cell pain crisis?

This study is exploring the biology behind pain crises in patients who have sickle cell disease. To participate in this study, you must be 18 to 80 years old and not be pregnant or on certain treatments that affect your immune system. This study is located in Bethesda, Maryland.

Are you an adult who has sickle cell disease and is interested in contributing stem cells for research?

This study is exploring whether a new medicine may help improve how stem cells are collected from patients who have sickle cell disease. To participate in this study, you must be at least 18 years old and not be pregnant. This study is located in Bethesda, Maryland, and Memphis, Tennessee.

Are you between 16 and 20 years old and willing to answer questions about managing your sickle cell disease?

This study is investigating the care and quality of life of patients who have sickle cell disease as they transition from pediatric to adult care. To participate in this study, you must be 16 to 20 years old and be a patient of St. Jude Children’s Research Hospital. This study is located in Memphis, Georgia.

Do you or your child have sickle cell disease and high blood pressure?

This study is exploring whether use of losartan, a medicine commonly used to lower blood pressure, is effective at treating abnormal nighttime blood pressure in children and young adults who have sickle cell disease. To participate in this study, you or your child must be 5 to 25 years old and have high blood pressure and a certain type of sickle cell disease: hemoglobin SS or Sβ0 thalassemia. This study is located in Birmingham, Alabama.
View more information about Preventing Sickle Cell Kidney Disease.

Do you have sickle cell disease and an interest in providing information that can help develop a mobile app?

This study is investigating why patients who have sickle cell disease may not be able to take hydroxyurea or have challenges taking it. This will help researchers develop a mobile application that helps patients take their medicine as directed. To participate in this study, you must be 15 to 45 years old, have any type of sickle cell disease, and be able to speak English. This study is located in Memphis, Tennessee.

Want to know whether you can participate in studies on blood disorders?

This study is collecting medical information from health exams and routine tests and procedures to see whether participants may be able to enroll in other studies on blood disorders. To participate in this study, you must be at least 8 years old with or without sickle cell disease. This study is located in Bethesda, Maryland.

Do you or your child have sickle cell disease and also have an interest in contributing to long-term data collection?

This study is monitoring patients and/or collecting biological samples from patients who have sickle cell disease to better understand long-term outcomes. Participants can be any age and must have a type of sickle cell disease. This study is located in six sites in Illinois, Louisiana, North Carolina, and Tennessee.

Are you an adult who has sickle cell disease and is interested in trying a new medicine?

This study is exploring a new medicine called ambrisentan and its ability to improve blood flow in the lungs, decrease inflammation, and reduce pain in patients who have sickle cell disease. To participate in this study, you must be 18 to 65 years old and have certain types of sickle cell disease: hemoglobin SS or Sβ0 thalassemia. This study is located in Augusta, Georgia.

Do you or your child need a stem cell transplant?

This study is exploring the use of treatment with certain medicines in combination with radiation for a successful stem cell transplant. Participants must be no more than 49 years old and have a severe disease treatable by a stem cell transplant. This study is located in several sites across the United States, including Aurora, Colorado; Seattle, Washington; and Milwaukee, Wisconsin.
Sleep Apnea

Do you have an adolescent or young adult with sleep apnea and Down syndrome?

The purpose of this study is to assess whether a device that is implanted in the body to stimulate the nerves of the tongue and that has already been approved for use in adults with obstructive sleep apnea can be safely implanted and used in adolescents and young adults who have Down syndrome. To participate, you must be 10 to 21 years old with Down syndrome and have had your tonsils removed. Trial locations are in Atlanta, Georgia; Boston, Massachusetts; Cincinnati, Ohio; Cleveland, Ohio; and Pittsburgh, Pennsylvania.

Are you an adult with sleep apnea who wants to help understand this disease by using an oral appliance?

This study, which aims to understand how the upper airway collapses in obstructive sleep apnea patients during sleep, will use this information to explain why some patients present a large improvement in opening of the upper airway with the use of an oral appliance while others do not. You will have some special exams, such as an endoscopy and sleep studies. To participate, you must be 21 to 70 years old and have obstructive sleep apnea. The trial is being conducted in Boston, Massachusetts.

Are you an adult with sleep apnea who would like to try a new treatment with facial exercises?

Some patients with obstructive sleep apnea have a small upper airway that can be modified by increasing the activity of some muscles in the mouth and the tongue. This study is assessing whether training these muscles will decrease the severity of the obstructive sleep apnea. To participate, you must be 18 to 79 years old and have been diagnosed with obstructive sleep apnea. The trial is being conducted in San Diego, California.

Are you an adult with sleep apnea and type 2 diabetes?

This study is looking at whether using a CPAP machine can improve blood sugar levels, decrease blood pressure, and reverse damage to the blood vessels in patients who have obstructive sleep apnea and type 2 diabetes. To participate, you must be 21 to 75 years old and have obstructive sleep apnea and type 2 diabetes. The trial is being conducted in Baltimore, Maryland.

Are you an adult who recently was diagnosed with sleep apnea?

This study is assessing whether healthy people with sleep apnea will develop early changes in the small vessels of the heart and whether these changes are resolved with use of a CPAP machine. To participate, you must be 18 to 80 years old and have obstructive sleep apnea. The trial is being conducted in Columbus, Ohio.

Are you a Minnesota resident with hypertrophic cardiomyopathy?

This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken and grow weaker. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Do you have a child with sleep apnea who is interested in a new treatment with a nasal spray?

This study will assess the use of a nasal spray for the treatment of obstructive sleep apnea in children. To participate, children must be 5 to 10 years old, have never had surgery to remove the tonsils, and have never used a CPAP machine. The trial is being conducted in Philadelphia, Pennsylvania.

Are you an adult with sleep apnea who finds it hard to use your CPAP machine?

This study is assessing whether receiving educational information about sleep apnea, its consequences, and the need for treatment may help increase compliance among people using a CPAP machine to treat their obstructive sleep apnea. To participate, you must be 21 to 80 years old and not have any conditions besides obstructive sleep apnea. The trial is being conducted in Denver, Colorado.
Sobrepeso y obesidad

¿Es adulto y quiere ayudarnos a comprender cómo influye en la salud el consumo de grandes cantidades de azúcares agregados?

En este estudio se analizará de qué manera el consumo de grandes cantidades de azúcares agregados influye en los factores de riesgo de enfermedad cardiovascular o diabetes en participantes que llevan una dieta equilibrada energéticamente para prevenir el aumento de peso o una dieta desequilibrada energéticamente que puede producir un aumento de peso. Para participar, debe tener entre 18 y 40 años de edad y tener un índice de masa corporal de entre 22 y 28 que se haya mantenido estable durante los últimos seis meses.

¿Es una mujer afrodescendiente, tuvo un hijo hace poco, tiene sobrepeso u obesidad y vive en Filadelfia?

En este estudio se compararán los tratamientos habituales y los tratamientos orientados a comunidades específicas para averiguar cuál es el más efectivo a la hora de ayudar a las nuevas madres afrodescendientes a adelgazar después del parto. Para participar, debe ser una mujer adulta, tener sobrepeso u obesidad, participar en el programa WIC de Filadelfia y haber tenido su parto hace menos de seis meses.

¿Es adulto y obeso, tiene síndrome metabólico y está interesado en nuevos tratamientos?

En este estudio se analizará si un medicamento ya aprobado para tratar la inflamación producida por otras afecciones puede reducir la inflamación debida a la obesidad. También se analizará si el medicamento puede contribuir a prevenir el desarrollo de complicaciones a causa de la obesidad, como la diabetes y la enfermedad cardiovascular. Para participar, debe ser adulto y tener un diagnóstico de obesidad, pero no tener diabetes.

¿Eres adolescente o adulto joven, tienes obesidad o sobrepeso y tienes un teléfono celular inteligente?

En este estudio se analizará si el envío, por teléfono celular inteligente, de información personalizada sobre el estilo de vida a adolescentes y adultos jóvenes puede mejorar la masa corporal y los métodos actuales de atención.

¿Es un hombre o una mujer afrodescendiente con obesidad y vive en Washington, D.C.?

En este estudio se evalúa la salud cardiovascular y otras afecciones (como la diabetes, la presión arterial, el colesterol y el peso) de personas afrodescendientes obesas de ambos sexos. A partir de los resultados de la evaluación, los investigadores desarrollarán y pondrán a prueba nuevas estrategias de conducta para bajar de peso que sean adecuadas para esa comunidad.

¿Eres adolescente o adulto joven, eres obeso y tienes asma?

En este estudio se analiza si los suplementos de aceite de pescado que contienen ácidos grasos omega 3 mejoran el asma en adolescentes y adultos jóvenes con obesidad. También se analizará si cierto gen influye en la eficacia con la que el aceite de pescado permite controlar el asma de esos participantes.

¿Trabaja en el Hospital General de Massachusetts y quiere ayudar a combatir la epidemia de obesidad?

En este estudio se analizará si brindar información personalizada sobre la compra de alimentos en el lugar de trabajo, los objetivos calóricos diarios, la alimentación saludable y los incentivos económicos para la compra de alimentos saludables puede ayudar a los empleados del Hospital General de Massachusetts (Massachusetts General Hospital, MGH) a prevenir el aumento de peso, reducir los factores de riesgo cardiovascular y tomar decisiones sobre la alimentación más saludables a largo plazo. Si la iniciativa tiene éxito, podría ser adoptada por empleados de otros establecimientos y por los vendedores de alimentos para ayudar a combatir la epidemia de obesidad. Para participar, debe ser empleado del MGH, tener más de 21 años y utilizar la cafetería del hospital.

¿Es adulto, obeso y tiene depresión?

En este estudio se investiga un programa de modificación de conducta para adelgazar y un nuevo programa de atención para adultos con diagnóstico de obesidad y depresión. Se emplean servicios convencionales de atención médica y tecnologías modernas, por ejemplo sitios web, servicios de correo electrónico seguro y mensajes de texto, a fin de brindarle una atención más personalizada a cada paciente.

¿Tiene un hijo pequeño con sobrepeso u obesidad y deficiencia de vitamina D?

En este estudio se analizará si los suplementos de vitamina D mejoran la salud vascular y reducen los factores de riesgo de enfermedad cardiovascular en niños con sobrepeso u obesidad y deficiencia de vitamina D. Para participar, los niños deben ser mayores de 10 años de edad.

¿Es mujer, tiene obesidad, está embarazada y tiene apnea del sueño?

Este estudio servirá para comprender de qué manera la apnea del sueño, un trastorno del sueño frecuente en las personas obesas, podría contribuir al desarrollo de complicaciones durante el embarazo. También se analizará si el uso de dispositivos de presión positiva continua de las vías respiratorias, un tratamiento frecuente para la apnea del sueño, mejora las respuestas del embarazo para usted y para el bebé antes del parto.

¿Tiene un hijo adolescente obeso que podría beneficiarse al participar en programas de ejercicio?

En este estudio se examinarán los efectos a largo plazo del ejercicio aeróbico, el ejercicio de resistencia y una combinación de ambos tipos de ejercicio, así como el riesgo de diabetes tipo 2, el tejido graso total y la grasa abdominal, en adolescentes de ambos sexos con sobrepeso.
Total Artificial Heart

Do you have a mechanical circulatory support device and would like to join a registry to help others?

This is an observational registry of adult and pediatric patients with end stage heart failure who receive a mechanical circulatory support device, such as a total artificial heart. To participate, you must have an approved device. Please note that this study is in Birmingham, Alabama.
Venous Thromboembolism

Do you know someone being treated for cancer who may be at risk for VTE?

This study will assess a medicine called isoquercetin to see if it can prevent a venous thromboembolism (VTE) in patients getting treatment for pancreatic, colorectal, and non-small cell lung cancer. To participate in this study, you must be at least 18 years old and must not have been diagnosed with VTE in the last two years. The study has nine locations in California, Connecticut, Maine, Massachusetts, Missouri, Vermont, and Washington, D.C.

Were you or your child recently diagnosed with VTE?

This study is testing a six-week course of blood-thinning medicines for the treatment of venous thromboembolisms (VTE) to see if they are as effective as the standard treatment course of three months. To participate in this study, you or your child must be younger than 21 years old. This study has 54 locations in Alabama, Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland, Massachusetts, Michigan, Missouri, New Jersey, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, South Carolina, Texas, Utah, Virginia, Wisconsin, Australia, Austria, Canada, Israel, and the Netherlands.

Have you or your child been diagnosed with DVT?

This study is comparing two treatments for blockages in veins of the thigh or back: a medicine delivered directly to the blood clot via a tube and standard blood-thinning medicine. The researchers will compare how well both treatments work to resolve the deep vein thrombosis (DVT) in the short term and whether long-term outcomes differ at two years after the initial treatments. To participate in this study, you must be 6 to 21 years old. This study is located in Denver, Colorado.

Was your child recently diagnosed with DVT?

This study will investigate physical activity habits among children recovering from a deep vein thrombosis (DVT) to see if a fitness tracker can help them maintain regular physical activity. The study will also assess the impact of exercise on their health and quality of life. To participate in this study, your child must be between 7 to 21 years old. The study is located in Dallas, Texas.

Do you know a child or young adult recently treated for VTE?

This study is exploring why some people experience complications after venous thromboembolism (VTE) treatment and why others do not. Someday this may help doctors predict which children or young adults are likely to develop complications. To participate in this study, you must have been recently treated for VTE and be younger than 21 years old. This study is located in Dallas, Texas.