May 5, 2021
The purpose of the NHLBI R35 Program is to promote scientific productivity and innovation by providing long-term support and increased flexibility to experienced Principal Investigators (PIs) who are currently PIs on at least two NHLBI R01-equivalent awards and whose outstanding record of research demonstrate their ability to make major contributions to heart, lung, blood and sleep (HLBS) research. The R35 is intended to support a research program, rather than a research project, by providing the primary and most likely sole source of NHLBI funding on individual grant awards. This program is a renewal of the pilot NHLBI R35 Program, and RFAs HL-16-024, HL-16-025, HL-20-011, and HL-20-012, which are expired.
The R35 will support the research program of NHLBI-funded investigators for up to seven years. The R35 will provide investigators increased freedom to conduct research that breaks new ground or extends previous discoveries in new directions. It will also allow PIs to take greater risks and to pursue research that requires a longer timeframe. Research supported by the R35 must be within the scope of the NHLBI mission (https://www.nhlbi.nih.gov/about/mission-statement).
It is anticipated that the R35 will:
Below are answers to commonly asked questions regarding the NHLBI R35 OIA and the EIA Programs. Further questions about the NHLBI R35 Program should be sent to the NHLBI R35 mailbox.
To preserve the collaborative nature of the multi-PI awards, the NHLBI will not fold the multi-PI awards into the OIA/EIA during the Program. PIs with multi-PI applications should continue and complete the project. Meritorious OIA/EIA applications from PIs with multi-PI grants may initially be awarded at an amount commensurate with single investigator research awards that will be folded into the OIA/EIA (i.e., the OIA/EIA will be funded at a reduced level). At the end of the multiple-PI project period, the OIA/EIA investigator’s proportionate share from the multi-PI project will be added to the future year OIA/EIA commitments such that funding stability is maintained for seven years.
Below is an example of an award budget for a meritorious OIA/EIA application:
An investigator with a: