The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of 27 international experts in the field on, “Meeting the Challenges of Myocarditis: New Opportunities for Prevention, Detection, and Intervention.” The workshop was conducted virtually on May 3, 4, and 6, 2021 to address the following objectives:
The workshop included a concurrent poster session for trainees in the field and provided them with an opportunity to engage in a panel discussion with workshop speakers.
The workshop is responsive to NHLBI Strategic Vision Objectives 1-5.
Myocarditis is defined as an inflammation of the myocardium based on histological findings. Myocarditis can be triggered by a wide range of pathogens, including viruses, bacteria (e.g., chlamydia, and rickettsia), fungi, and protozoa, as well as non-infectious causes, such as hypersensitivity to drugs, hyper-eosinophilia of different origins, and autoimmune responses. In addition, new causes of myocarditis, such as side effects of cancer therapies, are emerging. Mild myocarditis can involve symptoms such as chest pain or shortness of breath, or even no symptoms. However, significant morbidity and mortality are associated with severe myocarditis, particularly in children and young adults. This heterogeneity of etiologies, presentations, outcomes, and lack of accurate noninvasive prognostic testing makes prevention, detection, and intervention challenging. There is a critical need to understand the molecular, immunological, and pathological mechanisms of myocarditis and lower the overall burden of disease.
Presentations and discussions focused on five primary areas: clinical presentation; pathogenesis; diagnostic testing; new diagnostic and therapeutic targets; and lessons learned from cardiac immunology for application to myocarditis research.
Overarching Goals: Workshop participants identified two overarching goals for future studies in myocarditis:
Gaps and Opportunities: Workshop participants identified the following gaps and opportunities to guide future research:
A white paper outlining the gaps and opportunities that were identified at the workshop is in preparation.
Speakers and Moderators