Understanding Circadian Mechanisms of Sudden Cardiac Death

June 20 - 21, 2019
6701 Rockledge Dr. (Room 9100/9104), Bethesda, MD 20892


The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop on “Understanding Circadian Mechanisms of Sudden Cardiac Death” in Bethesda, Maryland.  Members of this workshop included leading experts in basic, translational, and clinical research in cardiovascular and sleep disorders, circadian biology and neuroscience, and representatives of academic institutions, federal, and non-federal agencies.  The charge of the workshop was to identify the highest priority research gaps and opportunities for future research strategies to guide the field of research into Sudden cardiac death.  The specific focus of this working group was to address the following objectives:

  • To identify knowledge gaps and barriers in basic and translational research regarding how the circadian system and daily pattern of behaviors interact to increase the risk for Sudden cardiac death in vulnerable individuals.
  • To identify how consideration of circadian myocardial physiology and acute Sudden cardiac death triggers might be particularly effective in prevention of sudden cardiac death.
  • To identify basic science findings that are ready for translation into clinical research.
  • To identify prioritized opportunities to augment advancement of basic, translational, and clinical research to facilitate risk stratification and develop effective therapies to prevent sudden cardiac death.

The workshop is responsive to NHLBI Strategic Vision Objectives 1, 4, and 5.