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2019 American Society of Hematology (ASH)

December 6 - 10, 2019
Orange County Convention Center, Orlando, Florida

Description

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) is participating in the 61st American Society of Hematology (ASH) Annual Meeting & Exposition. NHLBI-supported research will be presented at more than 50 sessions. See the schedule below for a snapshot of the NHLBI’s sessions at #ASH19.

NOTE: Times are subject to change. Please consult ASH’s official schedule.


NHLBI Research Presentations at ASH 2019


Friday, December 6, 2019

Trainee Activities and Services—Blood Drop: Careers in Government

Time & Location: 1:30 p.m. & 1:45 p.m., Bays 124-129 (Topgolf Orlando)          

Presenter: Courtney D. Fitzhugh, M.D., NHLBI

 

Optimizing Stem Cell Collection and Alternative Conditioning

Time & Location: 3:40 p.m., W314, Level 3 (Orange County Convention Center)

Panelist: John F. Tisdale, M.D., NHLBI             

 

Panel Discussion

Time & Location: 4:15 p.m., W314, Level 3 (Orange County Convention Center)

Panelist: John F. Tisdale, M.D., NHLBI             

 

In Support of Cures

Time & Location: 5:05 p.m., W314, Level 3 (Orange County Convention Center)

Panelist: W. Keith Hoots, M.D., NHLBI              

 

National Heart, Lung, and Blood Institute—Update

Time & Location: 5:15 p.m., Tangerine 2 (WF2), Level 2 (Orange County Convention Center)     

Presenter: Asif Rizwan, Ph.D., NHLBI               


Saturday, December 7, 2019

174 Highly Potent BTK Degradation Induced By NRX0492 As a Therapeutic Strategy for CLL      

Time & Location: 1:15 p.m., W414AB, Level 4 (Orange County Convention Center)        

Presenter: Deyi Zhang, Ph.D., NHLBI

           

Sickle Cell Disease in Young and Old: A Time for Re-Evaluation—Optimal Disease Manage and Health Monitoring in Older Adults 

Time & Location: 2 p.m., W304, Level 3 (Orange County Convention Center)     

Presenter: Swee Lay Thein, D.Sc., NHLBI


Sunday, December 8, 2019

Sickle Cell Disease in Young and Old: A Time for Re-Evaluation—Optimal Disease Manage and Health Monitoring in Older Adults 

Time & Location: 9:30 a.m., W304, Level 3 (Orange County Convention Center)

Presenter: Swee Lay Thein, D.Sc., NHLBI

 

Topic 5: Sickle Cell Disease-Related Stem Cell Transplantation  

Time & Location: 12 p.m., Tangerine 2 (WF2), Level 2 (Orange County Convention Center)

Presenter: Courtney D. Fitzhugh, M.D., NHLBI

           

454 Outcomes in Pediatric Patients With Severe Aplastic Anemia Treated With Standard Immunosuppression and Eltrombopag    

Time & Location: 12:45 p.m., Tangerine 3 (WF3-4), Level 2 (Orange County Convention Center)

Presenter: Emma M. Groarke, M.D., NHLBI

 

Plenary Session: Plenary Scientific Session     

Time & Location: 2 p.m., Hall D, Level 2 (Orange County Convention Center)    

Plenary Introducer: Cynthia E. Dunbar, M.D., NHLBI


Monday, December 9, 2019

609 Preclinical Evaluation for Engraftment of Gene-Edited CD34+ Cells With a Sickle Cell Disease Mutation in a Rhesus Transplantation Model  

Time & Location: 7:30 a.m., Valencia BC (W415BC), Level 4 (Orange County Convention Center)

Presenter: Naoya Uchida, M.D., NHLBI, National Institute of Diabetes and Digestive and Kidney Diseases

 

610 A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

Time & Location: 7:45 a.m., Valencia BC (W415BC), Level 4 (Orange County Convention Center)

Presenter: John F. Tisdale, M.D., NHLBI

 

803 Characterization of Immune Cells Producing Regulatory Cytokines That Mediate Engraftment in Sickle Cell Disease Patients after Haploidentical Peripheral Blood Stem Cell Transplantation 

Time & Location: 3:45 p.m., W311EFGH, Level 3 (Orange County Convention Center)   

Presenter: Berline Francis, NHLBI, Georgetown University

 

893 A Machine Learning Algorithm to Improve Risk Assessment for Patients With Sickle Cell Disease      

Time & Location: 7:15 p.m., W304ABCD, Level 3 (Orange County Convention Center)   

Presenter: Vandana Sachdev, M.D., NHLBI


NHLBI-Funded Research Presentations at ASH 2019


Saturday, December 7, 2019

10 Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis
Time & Location: 8:15 a.m., Valencia BC (W415BC), Level 4 (Orange County Convention Center)
Presenter: Kandace Gollomp, M.D., Children's Hospital of Philadelphia

 

SCI-32 Fanconi Anemia: A Paradigm for Understanding DNA Repair During Replication.

Time & Location: 9:30 a.m., W331, Level 3 (Orange County Convention Center)

Presenter: Agata Smogorzewska, The Rockefeller University     

           

SCI-16 Aptamers as Rapid Onset and Rapidly Reversible Antithrombotic Agents 

Time & Location: 9:30 a.m., W311, Level 3 (Orange County Convention Center)

Presenter: Bruce A. Sullenger, Ph.D., Duke University

           

SCI-22 Biology and Application of Genome Editing        

Time & Location: 9:30 a.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Feng Zhang, Ph.D., The Broad Institute

 

SCI-20 Blood Cell Fate Decisions: Insights From Single-cell RNA-seq     

Time & Location: 9:30 a.m., W230, Level 2 (Orange County Convention Center)

Presenter: Merav Socolovsky, Ph.D., University of Massachusetts Medical School

 

SCI-28 Single Cell Approaches—Drilling Down Deeper Using Technology and Integrated Data Analyses  

Time & Location: 9:30 a.m., W224, Level 2 (Orange County Convention Center)

Presenter: Dan A. Landau, M.D., New York Genome Center      

 

SCI-33 Role of Genetic Evolution and Germline Mutations in SAMD9 and SAMD9L Genes           

Time & Location: 9:30 a.m., W331, Level 3 (Orange County Convention Center)

Presenter: Jeffery M. Klco, M.D., Ph.D., St. Jude Children’s Research Hospital  

 

SCI-34 The Role of Interferon, Inflammation and Infection in Aplastic Anemia      

Time & Location: 9:30 a.m., W331, Level 3 (Orange County Convention Center)

Presenter: Katherine C. MacNamara, Ph.D., Albany Medical College

 

SCI-29  Developmental Biology of the Blood System      

Time & Location: 9:30 a.m., W224, Level 2 (Orange County Convention Center)

Presenter: Nancy Speck, Ph.D., University of Pennsylvania

110 SETDB1 Mediated H3K9 Methylation Suppresses MLL-Fusion Target Expression and Leukemic Transformation
Time & Location: 9:45 a.m., Sunburst Room (W340) (Orange County Convention Center)
Presenter: Andrew G. Muntean, Ph.D., University of Michigan

 

74 Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury
Time & Location: 9:45 a.m., Valencia BC (W415BC), Level 4 (Orange County Convention Center)
Presenter: Solomon Fiifi Ofori-Acquah, University of Pittsburgh

 

75 Downregulation of Sprr1a Contributes to the Pathobiology of Sickle Cell Disease
Time & Location: 10:00 a.m., Valencia BC (W415BC), Level 4 (Orange County Convention Center)
Presenter: Donovan A. Argueta, University of California, Irvine

 

101 Type 1 Interferon Promotes RBC Alloimmunization in a Lupus Mouse Model
Time & Location: 10:30 a.m., W315, Level 3 (Orange County Convention Center)          
Presenter: David R Gibb, M.D., Ph.D., Cedars-Sinai

 

77 Cannabidiol Reduces Acute and Chronic Hyperalgesia in Humanized Sickle Mice
Time & Location: 10:30 a.m., Valencia BC (W415BC), Level 4 (Orange County Convention Center)        
Presenter: Varun Sagi, University of Minnesota
 

 

108 T Cell Landscape of Immune Aplastic Anemia Reveals a Convergent Antigen-Specific Signature       

Time & Location: 10:45 a.m., Tangerine 3 (WF3-4), Level 2 (Orange County Convention Center)

Presenter: Jani Huuhtanen, B.Med., University of Helsinki

 

152 Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis
Time & Location: 12:15 p.m., W331, Level 3 (Orange County Convention Center)
Presenter: Marlies P. Rossmann, M.D., Ph.D., Harvard University

 

Ham-Wasserman Lecture: Gene Therapy for Haemophilia        
Time & Location: 12:45 p.m., Hall D, Level 2 (Orange County Convention Center)
Presenter: Amit C. Nathwani, M.D., Ph.D., University College London

 

166 In Vitro Effects of the Novel Platelet αIIbβ3 Receptor Antagonist RUC-4 on the Verifynow Assays: Potential for Point-of-Care Monitoring of RUC-4 Therapy       
Time & Location: 12:45 p.m., W314, Level 3 (Orange County Convention Center)
Presenter: Ohad S. Bentur, M.D., The Rockefeller University     

 

197 Single Cell Immune Profiling of Colitogenic T Cells during Acute Graft Versus Host Disease Reveals Two Novel Transcriptionally Distinct CD4+ GM-CSF+ Lineages       
Time & Location: 1:00 p.m., W315, Level 3 (Orange County Convention Center)
Presenter: Clinton Piper, Medical College of Wisconsin

 

217 Exome Sequencing Identifies Glycosylation Defects As a Probable Cause of Immune Thrombotic Thrombocytopenic Purpura       
Time & Location: 2:00 p.m., W311, Level 3 (Orange County Convention Center)
Presenter: Felipe Massicano, Ph.D., The University of Alabama at Birmingham

 

206 The Relationships Between Target Gene Transduction, Engraftment of HSCs and RBC Physiology in Sickle Cell Disease Gene Therapy 

Time & Location: 2:15 p.m., W414AB, Level 4 (Orange County Convention Center)

Presenter: Melissa Bonner, Ph.D., bluebird bio, Inc.

 

220 The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction
Time & Location: 2:45 p.m., W311, Level 3 (Orange County Convention Center)
Presenter: Brian Estevez, Ph.D., Children's Hospital of Philadelphia

 

SCI-37 Synthetic Platelets for Treatment of Traumatic Hemorrhage and Thrombocytopenia         

Time & Location: 4 p.m., W315, Level 3 (Orange County Convention Center)

Presenter: Anirban Sen Gupta, Ph.D., Case Western Reserve University

 

SCI-38 Nanoparticles Mimicking Platelets and Platelet Cloaking  

Time & Location: 4 p.m., W315, Level 3 (Orange County Convention Center)     

Presenter: Liangfang Zhang, Ph.D., University of California-San Diego  

           

SCI-39 The Mitochondrion: A Link Between Hemolysis and Platelet Activation     

Time & Location: 4 p.m., W311, Level 3 (Orange County Convention Center)     

Presenter: Sruti Shiva, Ph.D., University of Pittsburgh

 

SCI-40 Links Between Complement Activation and Thrombosis  

Time & Location: 4 p.m., W311, Level 3 (Orange County Convention Center)

Presenter: Wolfram Ruf, M.D., The Scripps Research Institute   


Sunday, December 8, 2019        

SCI-16 Aptamers as Rapid Onset and Rapidly Reversible Antithrombotic Agents 

Time & Location: 7:30 a.m., W308, Level 3 (Orange County Convention Center)

Presenter: Bruce A. Sullenger, Ph.D., Duke University

 

SCI-22 Biology and Application of Genome Editing        

Time & Location: 7:30 a.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Feng Zhang, Ph.D., The Broad Institute

 

SCI-39 The Mitochondrion: A Link Between Hemolysis and Platelet Activation     

Time & Location: 9:30 a.m., Sunburst Room (W340) (Orange County Convention Center)

Presenter: Sruti Shiva, Ph.D., University of Pittsburgh   

 

SCI-40 Links Between Complement Activation and Thrombosis  

Time & Location: 9:30 a.m., Sunburst Room (W340) (Orange County Convention Center)

Presenter: Wolfram Ruf, M.D., The Scripps Research Institute

 

SCI-20 Blood Cell Fate Decisions: Insights From Single-cell RNA-seq     

Time & Location: 9:30 a.m., W230, Level 2 (Orange County Convention Center)

Presenter: Merav Socolovsky, Ph.D., University of Massachusetts Medical School

 

SCI-32 Fanconi Anemia: A Paradigm for Understanding DNA Repair During Replication

Time & Location: 9:30 a.m., W331, Level 3 (Orange County Convention Center)

Presenter: Agata Smogorzewska, The Rockefeller University     

 

SCI-33 Role of Genetic Evolution and Germline Mutations in SAMD9 and SAMD9L Genes           

Time & Location: 9:30 a.m., W331, Level 3 (Orange County Convention Center)

Presenter: Jeffery M. Klco, M.D., Ph.D., St. Jude Children’s Research Hospital  

           

SCI-34 The Role of Interferon, Inflammation and Infection in Aplastic Anemia      

Time & Location: 9:30 a.m., W331, Level 3 (Orange County Convention Center)

Presenter: Katherine C. MacNamara, Ph.D., Albany Medical College

 

418 Engagement in Cognitive-Behavioral Therapy for Chronic Pain Management Is Associated with Reductions in Healthcare Utilization in Pediatric Sickle Cell Disease
Time & Location: 10:15 a.m., W308, Level 3 (Orange County Convention Center)
Presenter: Soumitri Sil, Ph.D., Emory University School of Medicine and Children's Healthcare of Atlanta

 

419 The Relationship between Mental Health, Educational Attainment, Employment Outcomes, and Pain in Sickle Cell Disease
Time & Location: 10:30 a.m., W308, Level 3 (Orange County Convention Center)
Presenter: Kelly M. Harris, Ph.D., Washington University in St. Louis, School of Medicine

 

427 Regulation of Erythroid Heme Synthesis By the Mitochondrial Clpx Unfoldase
Time & Location: 12:00 p.m., W331, Level 3 (Orange County Convention Center)
Presenter: Yvette Y. Yien, Ph.D., University of Delaware

 

445 Pulsation Activates Mechanosensitive Piezo1 to Form Long-Term Hematopoietic Stem Cells
Time & Location: 12:00 p.m., W230, Level 2 (Orange County Convention Center)
Presenter: Giorgia Scapin, Ph.D., The Research Institute at Nationwide Children's Hospital

 

ASH-EHA Joint Symposium: Hemato-Metabolism—Linking Cellular Metabolism to Blood Diseases 

North American Perspective: Metabolic Control of Emergency Hematopoiesis

Time & Location: 12:30 p.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Emmanuelle Passegue, Ph.D., Columbia University  

 

ASH-EHA Joint Symposium: Hemato-Metabolism—Linking Cellular Metabolism to Blood Diseases

European Perspective: Systems Biology Approaches Identify Metabolic Mechanisms Underlying Hematologic Disorders

Time & Location: 12:30 p.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Brian J.P. Huntly, M.B. Ch.B., FRCPath, Ph.D., T-MRC Cambridge Stem Cell Institute

 

Announcement of Awards: The 2019 ASH Mentor Award for a Clinical Investigator

Time & Location: 1:30 p.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Michael R. DeBaun, M.D., Vanderbilt University School of Medicine

 

SCI-37 Synthetic Platelets for Treatment of Traumatic Hemorrhage and Thrombocytopenia         

Time & Location: 4:30 p.m., W315, Level 3 (Orange County Convention Center)

Presenter: Anirban Sen Gupta, Ph.D., Case Western Reserve University

 

SCI-38 Nanoparticles Mimicking Platelets and Platelet Cloaking  

Time & Location: 4:30 p.m., W315, Level 3 (Orange County Convention Center)

Presenter: Liangfang Zhang, Ph.D., University of California-San Diego

 

SCI-29 Developmental Biology of the Blood System      

Time & Location: 4:30 p.m., W224, Level 2 (Orange County Convention Center)

Presenter: Nancy Speck, Ph.D., University of Pennsylvania

           

SCI-28 Single Cell Approaches—Drilling Down Deeper Using Technology and Integrated Data Analyses  

Time & Location: 4:30 p.m. W224, Level 2 (Orange County Convention Center)

Presenter: Dan A. Landau, M.D., New York Genome Center


Monday, December 9, 2019

Redox Biology in Thrombosis: Oxidative Signaling in Platelets

Time & Location: 10:30 a.m. p.m., W307, Level 3 (Orange County Convention Center)

Presenter: Craig N. Morrell, D.V.M., Ph.D., Unversity of Rochester

 

617 Phase-I Study of ETA Receptor Antagonist Ambrisentan in Sickle Cell Disease

Time & Location: 11:30 a.m., W304ABCD, Level 3 (Orange County Convention Center)
Presenter: Abdullah Kutlar, M.D., Augusta University

 

636 Incidence, Natural History and Outcomes of Transient and Persistent Antiphospholipid Antibodies in Children and Young Adults with Provoked Venous Thromboembolism: Analysis of the Kids-DOTT Trial

Time & Location: 11:45 a.m, Valencia BC (W415BC), Level 4 (Orange County Convention Center)
Presenter: Marisol Betensky, M.D.,, MPH, Johns Hopkins All Children's Hospital

 

716 Increased Expression of Type 1 Interferon Stimulated Genes in Sickle Cell Disease and a Potential Association with RBC Alloimmunization

Time & Location: 3:00 p.m., W315, Level 3 (Orange County Convention Center)
Presenter: Emaan Madany, Cedars-Sinai Medical Center

 

Special Symposium on the Basic Science of Hemostasis and Thrombosis

Developmental Differences Between Neonatal and Adult Megakaryopoiesis        

Time & Location: 4:30 p.m., Tangerine 3 (WF3-4), Level 2 (Orange County Convention Center)

Presenter: Martha Sola-Visner, M.D., Boston Children’s Hospital

 

874 Single-Cell RNA-Seq Identifies Potentially Pathogenic B Cell Populations That Uniquely Circulate in Patients with Chronic Gvhd

Time & Location: 5:15 p.m., W230, Level 2 (Orange County Convention Center)
Presenter: Jonathan C Poe, Ph.D.,, Duke University Medical Center

 

901 Higher Incidence of Neutralizing Anti-FVIII Antibodies (Inhibitors) in Black and Hispanic American Hemophilia A Patients Enrolled in the My Life, Our Future Programme

Time & Location: 6:15 p.m., Tangerine 1 (WF1), Level 2 (Orange County Convention Center)

Presenter: Kathleen P. Pratt, Ph.D. Uniformed Services University of the Health Sciences

 

931 Impact of Residual Effects and Complications of Thrombotic Thrombocytopenic Purpura (TTP) on Daily Living: A Qualitative Study

Time & Location: 6:15 p.m., W314, Level 3 (Orange County Convention Center)

Presenter: Deirdra Terrell, Ph.D., University of Oklahoma Health Sciences Center


Tuesday, December 10, 2019

Presidential Symposium: Big Data Informatics’ Role in Healthcare Delivery and in Speeding the Pipeline for New Therapeutics    

Time & Location: 9:45 a.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Amy Abernethy, M.D., Ph.D., U.S. Food and Drug Administration

           

Presidential Symposium: The Use of Registries to Inform Therapeutic Decisions for the Treatment of Hematologic Diseases With Cellular and Immune Therapies

Time & Location: 9:45 a.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Mary Horowitz, M.D., Medical College of Wisconsin

           

Presidential Symposium: Role of Pharmacogenomics, Computational Biology, and Other "Omics" Approaches in Precision Medicine and Regulatory Science

Time & Location: 9:45 a.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Russ B. Altman, M.D., Ph.D., Stanford University


NHLBI Grantee Award Sessions at ASH 2019


Monday, December 9, 2019

E. Donnall Thomas Lecture and Prize: The Long Road to Develop Adoptive Therapy With T cells That Can Effectively Target AML and Other Malignancies

Time & Location: 9 a.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Philip Greenberg, M.D., Fred Hutchinson Cancer Research Center

 

Ernest Beutler Lecture and Prize: Clinical Science/Translational Research       

Time & Location: 1:30 p.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Jeffrey I. Weitz, M.D., McMaster University

 

Ernest Beutler Lecture and Prize: Basic Research       

Time & Location: 1:30 p.m., Hall D, Level 2 (Orange County Convention Center)

Presenter: Sriram M. Krishnaswamy, Ph.D., Children’s Hospital of Philadelphia