NEWS & EVENTS
Sickle Cell in Focus Conference 2016
June 2 - 3, 2016
Natcher Conference Center, (Building 45), National Institutes of Health
45 Center Drive, Bethesda, MD 20892
Description

event logoSickle Cell in Focus (SCiF) is an annual two-day intensive and educational conference co-hosted by the National Heart, Lung and Blood Institutes (NHLBI) in Washington, DC and the South Thames Sickle Cell & Thalassaemia Network (STSTN) in London, UK. It highlights and discusses the emerging clinical complications and clinical management of sickle cell disease. The clinical and scientific research lectures are aimed at an audience of consultants, academics, trainee doctors and health professionals involved in the care of patients with the disease. It attracts local, national and international guest speakers and delegates. 

Recording of 2016 Sickle Cell in Focus Conference:

 
 
Agenda

8:00am
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Registration

9:00am
-
Welcome and Introduction

Gary Gibbons
Director, National Heart, Lung and Blood Institute, USA

9:05am-10:35am
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SESSION ONE - SICKLE CELL DISEASE: A GLOBAL HEALTH ISSUE

Chair: Kwaku Ohene-Frempong

9:05am, United States of America

Kathy Hassell
Colorado Sickle Cell Treatment and Research Center, University of Colorado, USA

9:20am, Europe

Beatrice Gulbis

Department of Clinical Chemistry and Molecular Genetic - Hôpital Erasme - U.L.B, Belgium

9:35am, Africa

Dapa A. Diallo
Department of Hematology, Faculty of Medicine & Dentistry, University of Bamako, Mali

Chair: Norma Lerner

09:50am, The Caribbean

Jennifer Knight
Sickle Cell Unit, Tropical Medicine Research Unit, University Hospital of the West Indies, Jamaica

10:05am, Brazil

Anna Barbara Proietti (Hematology Center in Belo Horizonte)
Hemominas Foundation, Belo Horizonte, Brazil

10:20am, India

Roshan B. Colah
National Institute of Immunohaematology, Mumbai, India

10:35am
-
BREAK

11:05am-12:35pm
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SESSION TWO - SICKLE CELL DISEASE AND MALARIA – MORE THAN JUST A BALANCING ACT?

Chair: Bill Eaton

11:05am, Protective role of HbS and other red blood cell defects on malaria

Tom Williams
Department of Medicine at Imperial College London, UK / KEMRI-Wellcome Trust, Collaborative Programme, Kilifi, Kenya

11:35am, The impact of iron availability on malaria and sickle cell disease severity

Hans Ackerman
National Heart, Lung and Blood Institute / National Institutes of Health, USA

12:05pm, A microfluidic platform to assess biorheology in malaria and sickle cell disease

Subra Suresh & Ming Dao
Carnegie Mellon University, Pittsburgh, USA  
Massachussetts Institute of Technology, USA

12:35pm
-
LUNCH

1:35pm-3:05pm
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SESSION THREE – VASCULAR INJURY AND INFLAMATION IN SICKLE CELL DISEASE

Chair: Alan Schechter

1:35pm, Inflammasomes in health and disease

Fayyaz Sutterwala
University of Iowa, USA

2:05pm, TLRs, inflammation and sickle cell disease - the innate connection

John Belcher
Division of Hematology, Oncology and Transplantation, University of Minnesota, USA

2:35pm, Drivers of inflammation in sickle cell disease- Role of neutrophils

Dachuan Zhang
Albert Einstein College of Medicine, New York, USA

3:05pm
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BREAK

3:30pm-4:45pm
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SESSION FOUR - UPDATES

Chair: Laura De Castro

3:30pm, Newborn screening and point-of-care testing in developing countries

Carolyn Hoppe
Children's Hospital & Research Center, Oakland, USA

3:55pm, Clinical trials

Deepa Manwani
The Children’s Hospital at Montefiore, New York

4:20pm, Bone marrow transplant

John Horan
Children’s Healthcare of Atlanta, USA

4:45pm
-
SHORT BREAK

5:00pm-6:00pm
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SESSION FIVE - DEBATE: HSCT IS RECOMMENDED FOR SECONDARY PREVENTION OF CEREBROVASCULAR INFARCTS IN SCD?

Chair: Oswaldo Castro

5:00pm, Pro: Michael DeBaun

Vanderbilt University School of Medicine, USA

5:20pm, Con: Elliott Vichinsky

Children's Hospital & Research Center, Oakland, USA

5:40pm, Debate

6:00pm
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DAY ONE CLOSE

8:00am
-
Registration

9:00am
-
Welcome and Introduction

Francis Collins
Director, National Institutes of Health, USA

9:05am-12:00pm
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SESSION ONE - GENETICS AND GENOMICS: PRIME TIME IN HEMOGLOBIN DISORDERS?

Chair: David Bodine

9:05am, Genetics and genomics in clinical studies –potentials and pitfalls

Steve Chanock
National Cancer Institute, Division of Cancer Epidemiology & Genetics, NIH, USA

9:35am, Impact of genetics and genomics in sickle cell disease

Swee Lay Thein
National Heart, Lung and Blood Institute / National Institutes of Health, USA

10:05am, Gene therapy

John Tisdale
National Heart, Lung and Blood Institute / National Institutes of Health, USA

10:35am, BREAK

Chair: Courtney Fitzhugh

11:00am, Application of genome editing in Hemoglobin disorders

Dan Bauer
Children’s Hospital Boston, USA

11:30pm, Environmental determinants of disease severity

David Rees
King’s College Hospital NHS Foundation Trust / King’s College London, UK

12:00pm
-
SHORT BREAK

12:15pm-1:30pm
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SESSION TWO - UPDATES ON MANAGEMENT (PART ONE)

Chair: Samir Ballas

12:15pm, Management of pain and opioid use in patients with sickle cell disease

Patrick Carroll
Johns Hopkins University School of Medicine, Baltimore, USA

12:40pm, Inflammation and pain in sickle cell disease

Deepika Darbari
Children's National Medical Center, Washington DC, USA

1:05 pm, Causes, complications and management of hypoxia in sickle cell disease

Roberto Machado
University of Illinois College of Medicine at Chicago, USA

1:30pm
-
LUNCH

2:30pm-3:55pm
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SESSION THREE – UPDATES ON MANAGEMENT (PART TWO)

Chair Paul Swerdlow

2:30pm, Expanding use of hydroxyurea in sickle cell disease

Jane Hankins 
St Jude Children’s Research Hospital, Memphis, USA

2:55pm, Blood transfusion, alloimmunization, and role of genotyping for variant antigens 

Stella Chou
The Children's Hospital of Philadelphia, USA

3:20pm, Coagulation activation in sickle cell disease

Kenneth Ataga
University of Pittsburgh / Johns Hopkins University School of Medicine / University of North Carolina, USA

3:55pm
-
BREAK

4:25pm-5:30pm
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SESSION FOUR - DEBATE: HIGH MORTALITY IN YOUNG ADULTS IS DUE TO BREAKDOWN IN TRANSITION TO ADULT CARE?

Chair: Kathy Hassell

4:25pm, Yes: Mariane de Montalembert
Necker-Enfants Malades Hospital, Paris France

4:45pm, No: Sophie Lanzkron
Johns Hopkins University School of Medicine, Baltimore, USA

5:05pm, Debate

5:30pm
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CLOSE OF CONFERENCE