Description
The National Heart, Lung, and Blood Institute (NHLBI) convened a working group of multidisciplinary researchers on June 10, 2016, in Bethesda, MD to share current scientific knowledge regarding the role of microbiota in blood pressure regulation, and to explore and identify scientific gaps and challenges.
The working group is responsive to NHLBI Strategic Plan Objectives 1, 2, 3, and 4.
Background
Dysregulation of commensal microbiota can contribute to the pathophysiology of a variety of disorders, including obesity, colitis, metabolic syndrome, cardiovascular disease, and kidney disease. A few recent studies have suggested that gut and oral microbiota may also play a role in the maintenance of blood pressure homeostasis. The microbiota can be altered or potentially corrected in response to various factors, such as diet, thus providing a promising base to develop innovative intervention strategies for treating hypertension. Furthermore, several studies have suggested the existence of cross-talk between gut microbiota and brain (gut-brain axis), gut microbiota and vasculature (gut-vascular axis), gut microbiota and kidney (gut-kidney axis), and oral microbiota and circulating nitrate and nitrite levels (entero-salivary axis). At present, the role of these axes on blood pressure regulation is poorly understood, and it is unknown whether other interactions exist.