NEWS & EVENTS
58th ASH Annual Meeting
December 3 - 6, 2016
San Diego, CA
Description

The National Institutes of Health National Heart, Lung, and Blood Institute (NHLBI) will be participating in 58th American Society of Hematology (ASH) Annual Meeting from December 3 – 6 in San Diego, California. NHLBI research and NHLBI-funded research will be presented at more than 40 sessions.

See the schedule below for a snapshot of NHLBI’s sessions at the ASH Annual Meeting. Schedule is subject to change. Visit ASH's website for a full schedule and updates.

Agenda

1 p.m.
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The National MDS Study

Session: The National MDS Study, 1 p.m., Room 5AB, San Diego Convention Center
Presenter: Nancy DiFronzo, Ph.D., National Institutes of Health National Heart, Lung, and Blood Institute

7:30 a.m.
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Type 1 Interferon Regulates Inflammation Associated RBC Alloimmunization By Promoting Monocyte-Derived Dendritic Cell Erythrophagocytosis in Mice

Session: 19: Type 1 Interferon Regulates Inflammation Associated RBC Alloimmunization By Promoting Monocyte-Derived Dendritic Cell Erythrophagocytosis in Mice, 7:30 a.m., Room 31, San Diego Convention Center
Presenter: David R. Gibb, M.D., Ph.D., Yale University

8 a.m.
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IgG Subtype Affects Immunomodulation through FcγRs, on Non-Macrophage Populations in a Murine Model – Mechanistic Implications for Anti-D

Session: 21: IgG Subtype Affects Immunomodulation through FcγRs, on Non-Macrophage Populations in a Murine Model – Mechanistic Implications for Anti-D, 8 a.m., Room 31, San Diego Convention Center
Presenter: James C. Zimring, M.D., Ph.D., University of Washington

10:45 a.m.
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The Impact of VWF on FVIII Immune Responses in Hemophilia a Mice with Pre-Existing Anti-FVIII Immunity

Session: 84: The Impact of VWF on FVIII Immune Responses in Hemophilia a Mice with Pre-Existing Anti-FVIII Immunity, 10:45 a.m., Room 28ABCD, San Diego Convention Center
Presenter: Juan Chen, Ph.D., Medical College of Wisconsin

1:15 p.m.
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Autonomic and Vascular Dysregulation Enhance Pain-Induced Peripheral Vasoconstriction in Sickle Cell Disease

Session: 126: Autonomic and Vascular Dysregulation Enhance Pain-Induced Peripheral Vasoconstriction in Sickle Cell Disease, 1:15 p.m., Room 28ABCD, San Diego Convention Center
Presenter: Patjanaporn Chalacheva, Ph.D., University of Southern California

2 p.m.
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Loss of Adrenergic Nerves in the Bone Marrow Microenvironment Drives an Aging HSC Niche Phenotype

Session: 169: Loss of Adrenergic Nerves in the Bone Marrow Microenvironment Drives an Aging HSC Niche Phenotype, 2 p.m., Room 28ABCD, San Diego Convention Center
Presenter: Maria Maryanovich, Ph.D., Albert Einstein College of Medicine

3:15 p.m.
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FXIIa Differentially Regulates Thrombin Generation during Steady State and Vaso-Occlusive Crisis in Sickle Cell Mice

Session: 162: FXIIa Differentially Regulates Thrombin Generation during Steady State and Vaso-Occlusive Crisis in Sickle Cell Mice, 3:15 p.m., Room 28ABCD, San Diego Convention Center
Presenter: Erica Sparkenbaugh, Ph.D., University of North Carolina Chapel Hill

10 a.m.
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Myelodysplastic Syndrome and Gastrointestinal Carcinomas Characterize the Cancer Risk in Diamond Blackfan Anemia: A Report from the Diamond Blackfan Anemia Registry

Session: 333: Myelodysplastic Syndrome and Gastrointestinal Carcinomas Characterize the Cancer Risk in Diamond Blackfan Anemia: A Report from the Diamond Blackfan Anemia Registry, 10 a.m., Marriott Grand 11 – 13, Marriott Marquis San Diego Marina
Presenter: Adrianna Vlachos, M.D., The Feinstein Institute for Medical Research, Cohen Children’s Medical Center, Hofstra Northwell School of Medicine

10:45 a.m.
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Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons

Session: 324: Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons, 10:45 a.m., Room 7AB, San Diego Convention Center
Presenter: Kestis Vaitkus, University of Illinois at Chicago

12 p.m.
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A Phase I Study of Donor Regulatory T Cells As Treatment for Steroid Dependent/Refractory Chronic Graft Versus Host Disease

Session: 385: A Phase I Study of Donor Regulatory T Cells As Treatment for Steroid Dependent/Refractory Chronic Graft Versus Host Disease, 12 p.m., Grand Hall C, Manchester Grand Hyatt San Diego
Presenter: Laura Johnston, M.D., Stanford University

12:30 p.m.
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ASH-EHA Joint Symposium: Pluripotent Stem Cells: Will They Be of Clinical Utility?

Session: ASH-EHA Joint Symposium: Pluripotent Stem Cells: Will They Be of Clinical Utility?, 12:30 p.m., Hall AB, San Diego Convention Center
Presenter: Charles S. Abrams, M.D., American Society of Hematology and George Q. Daley, M.D., Boston Children’s Hospital

4:30 p.m.
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Completely Non-Myeloablative/Non-LyM.P.H.oablative Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins

Session: 493: Completely Non-Myeloablative/Non-LyM.P.H.oablative Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins, 4:30 p.m., Seaport Ballroom GH, Manchester Grand Hyatt San Diego
Presenter: Agnieszka Czechowicz, M.D., Ph.D., Harvard University, Harvard Stem Cell Institute, Boston Children’s Hospital, Harvard Medical School, Dana Farber Cancer Institute

5:30 p.m.
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Effects of Platelet Circulatory Age on Platelet Function

Session: 413: Effects of Platelet Circulatory Age on Platelet Function, 5:30 p.m., Ballroom 20D, San Diego Convention Center
Presenter: Moritz Stolla, M.D., Brigham and Women’s Hospital, Harvard Medical School

6 p.m.
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The Impact of Cognitive Function on Adherence to Hydroxyurea Therapy in Patients with Sickle Cell Disease

Session: 2493: The Impact of Cognitive Function on Adherence to Hydroxyurea Therapy in Patients with Sickle Cell Disease, 6 p.m., Hall GH, San Diego Convention Center
Presenter: Cristina Merkhofer, M.D., University of Pittsburgh Medical Center

7:15 a.m.
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NaïVe T Cell Depletion of PBSC Grafts Results in Very Low Rates of Chronic Gvhd and High Survival

Session: 668: NaïVe T Cell Depletion of PBSC Grafts Results in Very Low Rates of Chronic Gvhd and High Survival, 7:15 a.m., Grand Hall C, Manchester Grand Hyatt San Diego
Presenter: Marie Bleakley, M.D., Ph.D., Fred Hutchinson Cancer Research Institute

7:30 a.m.
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All-Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients

Session: 669: All-Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients, 7:30 a.m., Grand Hall C, Manchester Grand Hyatt San Diego
Presenter: Jonathan C. Poe, Ph.D., Duke University Medical Center

10:45 a.m.
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JAK1 As a Convergent Regulator of Hematopoietic Stem Cell Function and Stress Hematopoiesis

Session: 722: JAK1 As a Convergent Regulator of Hematopoietic Stem Cell Function and Stress Hematopoiesis, 10:45 a.m., Grand Hall A, Manchester Grand Hyatt San Diego
Presenter: Maria Kleppe, Ph.D., Memorial Sloan Kettering Cancer Center

4:45 p.m.
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Pediatric Emergency Department Adherence to the 2014 National Heart, Lung and Blood Institute Guidelines Targeting Analgesic Therapy in the Management of Vaso-Occlusive Pain Episodes in Children with Sickle Cell Disease: a Multicenter Perspective

Session: 1016: Pediatric Emergency Department Adherence to the 2014 National Heart, Lung and Blood Institute Guidelines Targeting Analgesic Therapy in the Management of Vaso-Occlusive Pain Episodes in Children with Sickle Cell Disease: a Multicenter Perspective, 4:45 p.m., Room 6DE, San Diego Convention Center
Presenter: Claudia R. Morris, M.D., Emory University School of Medicine, Children’s Healthcare of Atlanta

6 p.m.
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A Comparison of an Individualized and Weight-Based Opioid Protocols for the Treatment of Vaso-Occlusive Episodes in the Emergency Department

Session: 3674: A Comparison of an Individualized and Weight-Based Opioid Protocols for the Treatment of Vaso-Occlusive Episodes in the Emergency Department, 6 p.m., Hall GH, San Diego Convention Center
Presenter: Paula J. Tanabe, Ph.D., M.P.H., RN, Duke University

7:30 a.m.
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Comparison of Autologous Hematopoietic Cell Transplant (autoHCT), Bortezomib, Lenalidomide (Len) and Dexamethasone (RVD) Consolidation with Len Maintenance (ACM), Tandem Autohct with Len Maintenance (TAM) and Autohct with Len Maintenance (AM) for up-Front

9:45 – 11:45 a.m.
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NHLBI-Funded Research at the Presidential Symposium

NHLBI-Funded Research at the Presidential Symposium: 9:45 – 11:45 a.m., Hall AB, San Diego Convention Center

Session: Sickle Cell Disease: New Biology, New Therapeutics
Presenter: Charles S. Abrams, M.D., American Society of Hematology

Session: BCL11a and Transcriptional Regulators of Hemoglobin
Presenter: Daniel E. Bauer, M.D., Boston Children’s Hospital, Dana Farber Cancer Institute, Harvard Medical School

Session: Remodeling Chromatin Architecture to Regulate Beta-Globin Gene Expression
Presenter: Gerd A. Blobel, M.D., Ph.D., The Children’s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine

Session: Introduction on the Global Perspective of Sickle Cell Diseases
Presenter: Kwaku Ohene-Frempong, M.D., Sickle Cell Foundation of Ghana, Children’s Hospital of Philadelphia