The National Heart, Lung, and Blood Institute (NHLBI), Division of Blood Disorders and Resources (DBDR) and the National Cancer Institute (NCI), Center for Strategic Scientific Initiatives (CSSI) convened a Working Group meeting on August 25 and 26, 2014, in Bethesda, MD, to bring together research scientists and clinicians to evaluate recent and emerging data regarding cancer-associated thrombosis, novel approaches to thrombotic risk assessment, and the results of clinical trials on anti-thrombotic treatment of cancer patients. The meeting goals integrated the DBDR mission to enhance health by promoting the prevention and treatment of thrombosis with the CSSI mission to employ trans-disciplinary approaches to enable progress in cancer research.
The close relationship between cancer and thrombosis was recorded as early as the 1820’s by Jean Baptiste Bouillard and further developed by Armand Trousseau, who described the clinical correlation between idiopathic venous thromboembolism (VTE) and occult malignancy in 1865.1,2 Today, we know that cancer is associated with a hypercoagulable state and a four- to seven- fold increase in venous thrombosis risk.3 Epidemiologic and population-based studies have provided detailed information on the disease burden of cancer-associated thrombosis and identified VTE risk factors, including those related to the tumor and its treatment (e.g. tumor type, clinical stage, chemotherapy, use of anti-angiogenic drugs or erythropoietic growth factors, surgery, and presence of central venous catheters), and those related to individual patient characteristics (e.g. sex, race, age, previous VTE history, blood cell counts, immobilization, and obesity). As thrombosis is a significant cause of morbidity and mortality in cancer patients, it is important to identify and appropriately treat patients at higher risk, especially prior to chemotherapy or surgery.
The Working Group discussion was organized along the following major topics:
The Working Group identified the following as major unmet needs in the field of cancer-related thrombosis:
Mechanistic studies of thrombosis in cancer to investigate:
Identification and validation of improved, actionable biomarkers and risk factors of VTE in cancer patients based upon:
Prospective cohort studies and intervention trials to investigate:
The Working Group emphasized the urgency and need for collaborative efforts of the NHLBI and NCI to address the clinically significant issue of cancer-related thrombosis.
The group intends to prepare a manuscript describing its discussions in more detail for publication in a peer-reviewed journal.
Andrei L. Kindzelski, M.D., Ph.D
Michelle Berny-Lang, Ph.D.
Nigel Key, M.D., University of North Carolina at Chapel Hill
Andrew Chan, M.D., M.P.H., Massachusetts General Hospital
Charles Francis, M.D., University of Rochester
Alok Khorana. M.D., Cleveland Clinic
Nigel Mackman, Ph.D., University of North Carolina at Chapel Hill
Owen McCarty, Ph.D., Oregon Health & Science University
Keith McCrae, M.D., Cleveland Clinic
Joseph Palumbo, M.D., Cincinnati Children’s Hospital Medical Center
Gary Raskob, Ph.D., University of Oklahoma Health Sciences Center
Anil Sood, M.D., University of Texas MD Anderson Cancer Center
Gilbert White II, M.D., Blood Center of Wisconsin
Anita Aggarwal, M.D., U.S. Department of Veterans Affairs
Richard Becker, M.D., University of Cincinnati College of Medicine
Wolfgang Bergmeier, Ph.D., University of North Carolina at Chapel Hill
Lisa Faulcon, M.D., U.S. Food and Drug Administration
Brunhilde Felding, Ph.D., The Scripps Research Institute
Aime Franco, Ph.D., University of Arkansas for Medical Science
Margaret Kresge, J.D., Patient Advocate
Nicole Kuderer, M.D., University of Washington
Gary Lyman, M.D., M.P.H., Fred Hutchinson Cancer Research Center
Dalia Mobarek, M.D., U.S. Department of Veterans Affairs
Daniel Myers, D.V.M., M.P.H., University of Michigan
Stephanie Omokaro, M.D., U.S. Food and Drug Administration
David Pinsky, M.D., University of Michigan
Alvin Schmaier, M.D., Case Western Reserve University
David Tarin, M.D., Ph.D., University of California, San Diego
Denisa Wagner, Ph.D., Children's Hospital Boston
Andrew Weyrich, Ph.D., University of Utah
Richard White, M.D., University of California, Davis
Randall Worth, Ph.D., University of Toledo
Donna DiMichele, M.D.
Keith Hoots, M.D.
Andrei Kindzelski. M.D., Ph.D.
Rebecca Link, Ph.D.
Traci Mondoro, Ph.D.
Ronald Warren, Ph.D.
Michelle Berny-Lang, Ph.D.
Emily Greenspan, Ph.D.
Jerry Lee, Ph.D.
Irina Lubensky, M.D.
Hala Makhlouf, M.D., Ph.D.
Larry Nagahara, Ph.D.
Nonniekaye Shelburne, C.R.N.P., M.S., A.O.C.N.
Elizabeth Woodhouse, Ph.D.
1Bouillard JB et al. De l’Obliteration des veines et de son influence sur la formation des hydropisies partielles:consideration sur la hydropisies passive et general. Archives of General Medicine 1823; 1: 188-204.
2Trousseau A. Phlegmasia alba dolens. Clinique Medicale de l’Hotel-Dieu de Paris (Paris: The Syndenham Society) 1865; 3: 654-712.
3Timp JF et al. Epidemiology of cancer-associated venous thrombosis. Blood 2013; 122: 1712-1723.