Description
The Division of Cardiovascular Sciences (DCVS) of the National Heart, Lung, and Blood Institute (NHLBI) convened a Working Group (WG) via webinar on March 27, 2:30-5:00PM EDT. Participants consisted of invited external experts in cardiovascular clinical trials, hypertrophic cardiomyopathy (HCM), alcohol septal ablation (ASA), surgical septal myectomy (SSM), clinical professional society registries, electronic health record-based research, HCM genetics, and biomedical statistics. The purpose of the WG was to examine clinical research questions relevant to the treatment of outflow tract obstruction in HCM by ASA or SSM and whether the highest priority questions could be answered feasibly and well through the development of a randomized clinical trial, a clinical research registry, or existing data. The participants were asked to provide insight into the public health importance of a comparative effectiveness study of these commonly used treatment modalities. The Working Group was responsive to NHLBI Strategic Plan Goals 2 and 3.