The National, Heart, Lung, and Blood Institute (NHLBI) convened a Working Group on September 13-14, 2012 in Bethesda, MD to discuss the current knowledge and future research needs of hormone-induced thrombosis in women. The aim of the meeting was to improve our understanding of the mechanisms that affect the thrombotic challenges unique to women throughout their lifespan. The objectives of the Working Group were to:
The working group consisted of basic and clinical scientists, epidemiologists, and physicians with expertise in coagulation science, hematology, epidemiology, and obstetrics & gynecology including reproductive endocrinology, and maternal-fetal medicine. Representatives from the Women's Health Initiative in the NHLBI's Division of Cardiovascular Sciences (DCVS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Department of Health and Human Services (DHHS), the Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA) participated in the discussion. Dr. Janine Austin Clayton, Director of the NIH Office of Research on Women's Health addressed the group and summarized the NIH strategic plan for advancing women's health research (http://orwh.od.nih.gov/research/strategicplan/index.asp).
Exposure to elevated levels of estrogen +/- progestin has been linked with increased risk of both arterial and venous thrombosis in women. While women are naturally exposed to modulating levels of these hormones, exposure to exogenous sources may increase their health risks. Additionally, differences in the baseline state of coagulation factors between mature males and females may independently augment the thrombotic risk in women. Topics of discussion were organized into three sessions:
To adodress specific gaps in knowledge and research priorities, the Working Group made the following recommendations:
The Working Group committee will develop a report of the meeting for publication in an appropriate professional journal.
Last Updated: November 2012