Description
This meeting was convened by the NHLBI Division of Cardiovascular Sciences, Prevention and Population Sciences Program to obtain advice about research areas that a possible continuation of the Coronary Artery Risk Development in Young Adults (CARDIA) Study could uniquely address. External experts in cardiovascular and pulmonary diseases, social sciences and behavior, lifestyle, diabetes, metabolism, genetics, cognitive functioning, neurology, and population studies were invited to discuss future research opportunities in CARDIA.
The Working Group was welcomed by the DCVS Associate Director, who presented an overview of cohort studies supported and conducted by the Epidemiology Branch, and the overall charge. The Project Officer provided an overview of the design of CARDIA, Project Office preliminary plans for the future of CARDIA, and questions from the Project Office for the Working Group to consider. CARDIA investigators presented select findings from published reports, data on cohort retention, scientific productivity, details on morbidity and mortality ascertainment and experience to date, preliminary results from the 25th year follow-up examination currently in progress, and future research possibilities. After addressing questions from the Working Group, the CARDIA investigators departed. The remainder of the meeting involved discussions and recommendations from the Working Group in the absence of the CARDIA investigators.
Background
CARDIA is a study examining the etiology and natural history of cardiovascular disease (CVD) beginning in young adulthood. In 1985-1986, a cohort of 5115 healthy black and white men and women aged 18-30 years were selected to have approximately the same number of people in subgroups of age (18-24 and 25-30), sex, race, and education (high school or less and more than high school) within each of four US Field Centers. These same participants were asked to participate in follow-up examinations during 1987-1988 (Year 2), 1990-1991 (Year 5), 1992-1993 (Year 7), 1995-1996 (Year 10), 2000-2001 (Year 15), 2005-2006 (Year 20), and 2010-2011 (Year 25, currently on-going); the proportions of the surviving cohort that have returned for the first six follow-up examinations were 90%, 86%, 81%, 79%, 74%, and 72%, respectively. In addition to the follow-up examinations, participants are contacted regularly for the ascertainment of information on out-patient procedures and hospitalizations experienced between contacts. Within the past five years, 95% of the original surviving cohort has been contacted.
The current CARDIA contract period began on September 1, 2008 and ends on June 30, 2013. The Project Office envisions a potential renewal of the CARDIA contract to include a follow-up examination in 2015-2016, when participants will be 48-60 years, with an estimated cohort size of about 3400 (~70% of the surviving cohort); surveillance for morbid events and mortality would continue through 2018. NHLBI will take the Working Group recommendations into account, as well as consider other programs and priorities, and budget, in developing a possible Request for Proposals.
Working Group Members:
Bruce Psaty, MD, PhD (Chair), Michelle Albert, MD, MPH, Matthew Allison, MD, MPH, Jeanne Clark, MD, MPH, Susan Everson-Rose, PhD, David Knopman, MD, Edgar Miller III, MD, PhD (absent), George O?Connor, MD, MS, Scott Solomon, MD, June Stevens, PhD, Clyde Yancy, MD
CARDIA Investigators:
David Goff, MD, PhD, O. Dale Williams, PhD, Cora (Beth) Lewis, MD, MPH, Kiang Liu, PhD
NIH and NHLBI attendees:
Diane Bild (NHLBI), Jared Reis (NHLBI), Catherine Loria (NHLBI), Cheryl Jennings (NHLBI), Elizabeth Zoller (NHLBI), Paul Sorlie (NHLBI), Jean Olson (NHLBI), Lenore Launer (NIA), Megan Mitchell (NHLBI), Eser Tolunay (NHLBI), Phyliss Sholinsky (NHLBI), Jane Harman (NHLBI), Dale Burwen (NHLBI), Hanyu Ni (NHLBI), Jacqueline Wright (NHLBI)
Last Updated August 2011