Laboratory of Imaging Technology

The Laboratory of Imaging Technology Program, led by Marcus Chen, is focused on the development of advanced MRI techniques that leverage modern acquisition and reconstruction techniques for cardiac imaging, lung imaging and MRI-guided cardiovascular catheterization procedures.

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Videos

Videos
Multi-section imaging of the lung using T2-weighted MRI (1.1mm x 1.1 mm x 6mm) in a woman with lymphangioleiomyomatosis resulting in innumerable thin walled pulmonary cysts. Adapted from Campbell-Washburn AE, et al, Radiology: Cardiothoracic Imaging https://doi.org/10.1148/ryct.2021200611 (Online ahead of print)
ECG-gated spiral in-out bSSFP cine imaging at 0.55T (spiral readout duration = 6.5ms, TR = 8ms). Advanced acquisition strategies increase SNR with limited artifacts at 0.55T. Adapted from Restivo MC, et al, Magn Reson Med, 2020; 84(5):2364-2375.
Interactive real-time imaging for MRI-guided cardiovascular catheterization at 0.55T. The bright gadolinium-filled balloon at the tip of the catheter is navigated in different heart chambers. Adapted from Campbell-Washburn et al, Radiology, 2019; 293(2):384-393.

Images

Late gadolinium enhancement (scar imaging) at 0.55T and 1.5T in three example patients with myocardial infarction.
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Late gadolinium enhancement (scar imaging) at 0.55T and 1.5T in three example patients with myocardial infarction.

These comparisons demonstrate diagnostic similarity between the research 0.55T MRI and clinical 1.5T MRI. Adapted from Bandettini et al, JACC: Cardiovascular Imaging, DOI: 10.1016/j.jcmg.2021.02.024 (Online ahead of print)

Measurement of regional lung function using oxygen-enhanced MRI.
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Measurement of regional lung function using oxygen-enhanced MRI.

3D stack-of-spirals ultrashort-TE imaging in a healthy volunteer during inhalation of room air versus 100% oxygen. Lung signal intensity histograms demonstrate signal enhancement on T1-weighted imaging with hyperoxia, which results in signal enhancement visible in percent enhancement maps. Adapted from Bhattacharya et al, NMR in Biomedicine, 2021;e4562 (Online ahead of print)

Clinical Trials and Studies

Desarrollo técnico de la resonancia magnética cardiovascular (RMC) mediante un sistema de escáner de baja tasa de absorción específica (SAR)

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Adultos, Ancianos
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Se Aceptan Voluntaries Saludables
Desarrollo de nuevas técnicas de imagen por resonancia magnética cardiovascular. Este estudio compara la eficacia de dos tipos de escáneres de resonancia magnética (RM) para detectar diferentes tipos de cardiopatías, como la cardiopatía coronaria, la insuficiencia cardíaca, las cardiopatías congénitas y las valvulopatías cardíacas. El nuevo tipo de escáner de RM de este estudio usa menos energía que un escáner tradicional y puede ser adecuado para personas que tienen dispositivos metálicos en el cuerpo. Para participar en este estudio, debe ser sano o debe tener diagnóstico de cardiopatía coronaria estable y debe tener al menos 18 años. Este estudio se lleva a cabo en Bethesda (Maryland).

Featured Publications

Opportunities in Interventional and Diagnostic Imaging by Using High-Performance Low-Field-Strength MRI.

Authors: Campbell-Washburn AE, Ramasawmy R, Restivo MC, Bhattacharya I, Basar B, Herzka DA, Hansen MS, Rogers T, Bandettini WP, McGuirt DR, Mancini C, Grodzki D, Schneider R, Majeed W, Bhat H, Xue H, Moss J, Malayeri AA, Jones EC, Koretsky AP, Kellman P, Chen MY..
Radiology. 2019 Nov 01;293(2):384-393
Read Publication on Opportunities in Interventional and Diagnostic Imaging by Using High-Performance Low-Field-Strength MRI.

Right heart catheterization using metallic guidewires and low SAR cardiovascular magnetic resonance fluoroscopy at 1.5 Tesla: first in human experience.

Authors: Campbell-Washburn AE, Rogers T, Stine AM, Khan JM, Ramasawmy R, Schenke WH, McGuirt DR, Mazal JR, Grant LP, Grant EK, Herzka DA, Lederman RJ.
J Cardiovasc Magn Reson. 2018 Jun 21;20(1):41
Read Publication on Right heart catheterization using metallic guidewires and low SAR cardiovascular magnetic resonance fluoroscopy at 1.5 Tesla: first in human experience.
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Meet the Team

Marcus Chen, M.D.

Staff Clinician

Marcus Chen, M.D., is an assistant clinical investigator who leads the Laboratory of Imaging Technology at the NHLBI.

Alumni

Burcu Basar, MSc

Engineer

Björn Wieslander, M.D., Ph.D.

Adv. Pulmonary Imaging Fellow