Research Respiratory Tract Procedures

The goal of this study is to obtain bronchoalveolar lavage fluid and epithelial cells from endobronchial and nasal mucosal biopsies for studies of infection susceptibility.

Natural History of Bronchiectasis & Bronchiectasis Research Registry

The goal of this study is to evaluate patients with chronic recurring airway infections that result in bronchiectasis to determine underlying etiologies and assess the natural history of disease with particular focus on associations with genetic etiologies and risk factors.

Cross-sectional Characterization of Idiopathic Bronchiectasis

Part of Rare Disease Clinical Research Consortium. The goal of this multi-site study is to characterize the physical, radiographic, and microbiologic phenotype of a cohort of patients with idiopathic bronchiectasis stratified by gender and the presence/absence of nontuberculous mycobacteria to correlate with genetic determinants of disease.

A Randomized, Double-Blind, Placebo Controlled Study of Liposomal Amikacin for Inhalation (ArikaceTM) in Patients with Recalcitrant Nontuberculous Mycobacterial Lung Disease

Protocol developed at NIAID and being conducted at 19 US/Canada sites. Goal is to assess efficacy, safety, and tolerability of a novel formulation of liposomal encapsulated amikacin in patients with treatment refractory NTM disease.

Procedural Protocol for Humanitarian Use Device: IBV (Registered Trademark) Valve System, a Humanitarian Use Device intended to Control Prolonged Air Leaks

The goal of this protocol is to enable the placement of these devices in primary immunodeficiency patients with spontaneous or post-surgical bronchopulmonary fistulae due to impaired lung healing.