The National Heart, Lung, and Blood Institute (NHLBI), a major component of the National Institutes of Health (NIH), Department of Health and Human Services has an opening for an Epigenetics & Systems Biology postdoctoral researcher to study immune memory, cellular differentiation, and pathological conditions using genomics, epigenomics and systems biology approaches. Our laboratory has developed the ChIP-Seq, MNase-Seq, single-cell DNase-seq, and 3e Hi-C techniques to analyze genome-wide distribution of chromatin modifications and DNA-binding factors (Cell, 2007; Cell, 2008; Cell 2009; Cell 2012; Nature 2015; Mol Cell 2017; Nat. Immunol. 2017). More recently, we have developed the Trac-looping technique to analyze genome-wide promoter-enhancer interaction, chromatin accessibility and chromatin folding in one single assay (Nature Methods, 2018) and single-cell MNase-seq technique to map genome-wide nucleosome organization in single-cells (Nature 2018). Using these powerful techniques, we are studying the contribution of two-dimensional and three-dimensional nuclear structure to normal development and diseases. Future studies will investigate the function and regulation of three-dimensional nuclear structure during differentiation of hematopoietic stem cells to T cells.
The incumbent will focus on bench work or computation work or both depending on previous training and expertise. Opportunities for extensive collaborations with the research communities are available.
The ideal candidate must have a Ph.D. in Molecular Biology or Biochemistry or computational biology with a strong record of publication. The candidate must have received a Ph.D. within the past three years.
The candidate will be supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH. Salary is commensurate with research experience and accomplishments.
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