Research Priorities

The Compelling Questions (CQs) and Critical Challenges (CCs) submitted during the Visioning process were refined to yield a set of 132 Research Priorities that will guide the NHLBI for the next decade. NHLBI-solicited activities that result from the Research Priorities will advance our progress in achieving the eight Objectives and will have a profound effect on the health and well-being of people across this country and around the globe.

Investigator-initiated discovery science has been and will remain the bedrock of the NHLBI mission, and individual researchers will always be encouraged to pursue their ideas through investigator-initiated projects. However, NHLBI leadership can catalyze extramural investigations that take advantage of new scientific opportunities and close gaps in knowledge. One means by which this occurs is through Institute-solicited research initiatives supported through new Funding Opportunity Announcements (FOAs). The Research Priorities identify important opportunities in science that will shape the development of future FOAs and other NHLBI-solicited activities.

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Critical Challenge
Advances in methods of and models for assessing and characterizing exposures (e.g., environmental, dietary, social) are needed to improve research on normal biologic function and resilience. (1.CC.04)
Critical Challenge
Development and application of comprehensive single-cell biology analytics are needed to facilitate an integrated understanding of cellular diversity, cell-cell interactions, and cellular phenomena in HLBS health and disease risk. (1.CC.03)