Objective 4: Identify factors that account for individual differences in pathobiology and in responses to treatments
Research advances in areas such as genomics and other “omics” (e.g., proteomics, metabolomics) have provided new opportunities to deepen our understanding of heart, lung, blood, and sleep (HLBS) pathobiological processes and how these vary among individual patients. Accelerating progress toward precise, individualized prevention efforts and medical interventions will require research into biological factors, environmental exposures, and other influences that account for differences in pathobiology and unique responses to treatment (including drug reactions and other adverse events). This research will allow personal and clinical decisions, practices, and medical products to be tailored to the individual patient to help optimize outcomes.
- Develop precise clinical interventions based on individual environmental exposures, behaviors, genotypes, and molecular-cellular phenotypes.
- Accelerate the incorporation of new imaging, omics, and sensor technologies with advanced data analytics to inform more precise clinical classification of chronic diseases (e.g., asthma, pulmonary fibrosis, chronic obstructive lung disease, heart failure) and thereby enable more accurate diagnosis and treatment.
- Understand normal biological function and resilience
- Investigate newly discovered pathobiological mechanisms important to the onset and progression of HLBS diseases
- Investigate factors that account for differences in health among populations
- Identify factors that account for individual differences in pathobiology and in responses to treatments
- Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases
- Optimize clinical and implementation research to improve health and reduce disease
- Leverage emerging opportunities in data science to open new frontiers in HLBS research
- Further develop, diversify, and sustain a scientific workforce capable of accomplishing the NHLBI’s mission