Lab of Molecular Immunology and the Immunology Center - Computational Postdoctoral Position (Bioinformatics/Epigenetics/Genomics/Biostatistics)
Dr. Warren J. Leonard’s laboratory, which is located in the Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), is recruiting a computational postdoctoral researcher with expertise related to epigenomics, biostatistics, and systems biology approaches. Our laboratory focuses on molecular immunology and uses ChIP-Seq, RNA-Seq, and ATAC-Seq to analyze genome-wide distribution of chromatin modifications and DNA-binding factors, global gene expression, etc. as well as whole exome and whole genome analysis (for example, see Liao et al. Nature Immunol. 9:1288-96 (2008); Li et al. Nature 490:543-6 (2012); Lin et al. Immunity 36:586-99 (2012); Kazemian et al. Mol Syst Biol. 11:826 (2015); Roychoudhuri et al., Nature Immunol. 17:851-60 (2016)).
The incumbent will work closely with experimental biologists to integrate bioinformatics with wet lab approaches to elucidate normal cellular development and differentiation as well as the basis for disease states and pathological conditions in both animal models and humans. Opportunities for extensive collaborations with the research communities are available.
The ideal candidate will have a strong background in Computer Science or Statistics with knowledge of R or Matlab; Python or Perl; and ideally C or C++, and have received a Ph.D. within the past five years. The candidate will be supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH.
Appointees may be US citizens, resident aliens, or non-resident aliens with or eligible to obtain a valid employment authorized visa. Salary is commensurate with research experience and accomplishments.
Applications from women, minorities and persons with disabilities are strongly encouraged. Applicants should send a 1-2 page descriptive letter of interest and research proposal, curriculum vitae and complete bibliography, and arrange for three letters of reference to be sent to:
Dr. Warren J. Leonard
c/o Ms. Kelly Wittenberger at
Laboratory of Molecular Immunology
Bethesda, MD 20892-1674
Post-Doctoral Fellow - Sickle Cell Branch
The Division of Intramural Research (DIR) of the National Heart, Lung, and Blood Institute (NHLBI) is seeking to recruit an outstanding Post-Doctoral Fellow to join the Laboratory of Early Sickle Mortality Prevention. A position is available to join a team focused on developing methodology to identify and validate genetic biomarkers that will allow early detection and monitoring of severe sickle cell complications, using new genome technologies and deep phenotyping. She or he will perform essential data analysis of genome-wide experiments, including cell-free DNA/RNA, and single cell genomics. Additional information about the lab can be found at http://www.nhlbi.nih.gov/research/intramural/researchers/pi/thein-swee-lay
Ph.D in biomedical sciences
Expertise in programming languages such as Python, Perl, R
Proficiency in Unix/Linux operating system
Experience analyzing functional genomics experiments
Experience in conducting genetic association studies
Ability to conduct independent research and work cooperatively with other scientists.
Excellent communication skills
The existing faculty in the NHLBI DIR is an outstanding group of internationally recognized biomedical researchers covering a wide range of basic and clinical research topics (please see https://www.nhlbi.nih.gov/research/intramural) complemented by the other research institutes within the DIR (please see http://www.nih.gov/science/#campus).
The successful candidate should have a strong track record of achievement, expertise and experience in a research environment. Applicants must have a Ph.D. or equivalent, have completed formal mentored postdoctoral training in immunology and research, experience with training responsibilities, and evidence of scientific research productivity sufficient to carry out the duties and responsibilities. Salary is commensurate with research experience and accomplishments.
Appointees may be US citizens, resident aliens, or non-resident aliens with or eligible to obtain a valid employment authorized visa.
Interested applicants should send a cover letter, curriculum vitae, and the names, phone numbers and e-mail addresses of three people who could provide letters of reference by email to Swee Lay Thein at email@example.com or to the address below. Applications will be accepted until the position is filled.
Postdoctoral Researcher - Division of Intramural Research (DIR)
The Laboratory of Molecular Immunology of the Immunology Center, headed by Dr. Warren J. Leonard of the DIR, NHLBI, is recruiting for a postdoctoral researcher to work in the area of molecular immunology. Having previously discovered that mutations in the common cytokine receptor γ chain, γc, result in X-linked severe combined immunodeficiency in humans and that γc is a shared component of multiple cytokine receptors, the lab focuses on the cytokines that share γc (IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21), as well as the IL-7-related cytokine, TSLP. The laboratory has generated valuable transgenic and knockout mice and a wealth of other valuable reagents. The laboratory encompasses projects ranging from elucidating physiological and disease mechanisms to signal transduction, molecular mechanisms of gene regulation, and epigenetic mechanisms. State-of-the-art methodologies are used in human and murine systems, including in vitro and in vivo approaches, including ChIP-Seq, RNA-Seq, ATAC-Seq, as well as whole exome and whole genome methodology.
The ideal candidate will have a reasonable level of independence, be innovative and interactive, and will have a strong background in immunology and/or molecular biology. The candidate must have received a Ph.D. and/or an M.D. degree. The candidate will be supported with the excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH.
To apply, please e-mail Ms. Kelly Wittenberger, Staff Assistant, Immunology Center, at firstname.lastname@example.org with the subject line "IC Postdoctoral Research Fellow":
- Your curriculum vitae (with bibliography and description of research experience), and
- The contact information for three references.
The following positions may be opened in the future (subject to change). The vacancies will be advertised on www.usajobs.gov and open to all US citizens. Use key word “NHLBI”. To apply, submit your application through the USAJOBS online system by the closing date.
Division of Cardiovascular Sciences Opportunities
Clinician Scientist (Medical Officer)
The NHLBI is seeking one or more dynamic cardiologists or internists with clinical research leadership experience to join the Adult and Pediatric Cardiac Research Program in the Division of Cardiovascular Sciences.
The Adult and Pediatric Cardiac Research Program provides leadership for and supports basic, translational and clinical research on the development, maturation, and functioning of the heart throughout all stages of life. This Program is instrumental in driving the direction of the nation's biomedical science in these areas and promotes opportunities to translate promising scientific and technological advances from basic discovery through preclinical studies to multi-site clinical trials. The Program currently has an active leadership role in trials and networks such as:
- COAG (Clarification of Optimal Anticoagulation through Genetics), BARI-2D, FREEDOM
- Heart Failure Network, Pediatric Heart Network
- Resuscitation Outcomes Consortium
The successful candidate will:
- Participate in setting the national strategic direction for clinical research on cardiovascular disease
- Develop translational and clinical research initiatives in areas where NHLBI needs to take leadership in order to advance the science
- Participate as a scientific and administrative partner in NHLBI-initiated large projects, such as clinical trials and networks
For further information, please contact:
Gail Pearson, MD, ScD
Director, Adult and Pediatric Cardiac Research Program
Applicants must possess an MD or equivalent degree, with training and board certification in internal or cardiovascular medicine and experience leading clinical investigations. Ideal candidates will have an outstanding record of research accomplishments, excellent interpersonal and communication skills, and the ability to oversee complex research programs.
Research Training Opportunities
The Office of Education of the Division of Intramural Research coordinates and assists recruitment for all research training on the NIH campus. Programs are available within the Laboratories and Branches within the Division to provide specialized research training for high school students, college students, graduate and medical students, postdoctoral fellows and medical residents and fellows. The Office of Education provides assistance to applicants at each of these levels. NHLBI is committed to improving the representation of under represented groups, including minorities, women, and scientists with disabilities in the mainstream of basic and clinical research. The Office of Education website will provide you with more information and a way to apply for open positions.
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