For more information on this division please read:
Office of the Director
Basic & Early Translational Research Program
Adult & Pediatric Cardiac Research Program
Prevention and Population Sciences Program
Office of Research Training & Career Development
Office of Biostatistics Research
Office of Clinical Research
Advanced Technologies & Surgery Branch (ATS)
Atherothrombosis & Coronary Artery Diseases Branch (ACAD)
Heart Development and Structural Diseases Branch (HDSD)
Heart Failure & Arrhythmias Branch (HFA)
Vascular Biology & Hypertension Branch (VBH)
Clinical Applications & Prevention Branch (CAP)
Epidemiology Branch (EB)
DCVS provides leadership and supports basic, clinical, population, and health services research on the causes, prevention, and treatment of cardiovascular diseases. DCVS represents the union of two previously existing divisions, the Division of Cardiovascular Disease (DCVD) and the Division of Prevention and Population Sciences (DPPS).
The Division fosters research in disease areas, such as atherothrombosis, heart attack and heart failure, high blood pressure, stroke, atrial and ventricular arrhythmias, sudden cardiac death, adult and pediatric congenital heart disease, cardiovascular complications of diabetes and obesity, and other cardiovascular disorders. Technology development for the diagnosis and treatment of cardiovascular disorders is also supported. Research also includes a number of well-known epidemiological cohort studies that describe disease and risk factor patterns in populations; clinical trials of interventions to prevent disease and to prevent or modulate risk factors; studies of genetic, behavioral, sociocultural, health systems, and environmental influences on disease risk and outcomes; and studies of the application of prevention and treatment strategies to determine how to improve clinical care and public health. The Division supports training and career development for these areas of research. In addition to the Office of the Director, the Division is organized operationally as 3 Offices and 3 Programs that oversee 8 Branches.
David C. Goff, Jr., MD, PhD, Division Director
PROGRAM IN BASIC & EARLY TRANSLATIONAL RESEARCH
The Program supports and provides leadership for basic, pre-clinical and early translational studies on vascular biology and hypertension, cardiovascular surgery, and the development of advanced technologies for the diagnosis and treatment of cardiovascular diseases. The portfolio includes an integrated basic and clinical research program studying the biological basis for vascular diseases and hypertension, and their diagnosis, treatment and prevention. Research on cardiovascular surgery includes both basic and pre-clinical research on surgical approaches, and clinical trials to establish evidence-based surgical therapies. The development of diagnostics encompasses research on biosensors, imaging technologies, and the application of "omic" methodologies. Therapeutic development includes drug and nucleic acid delivery technologies, regenerative and reparative medicine, gene therapy, and device development. The Program also supports training and career development for these areas of research. The Program is divided into two branches: the Vascular Biology and Hypertension Branch, and the Advanced Technologies and Surgery Branch.
Denis Buxton, Ph.D., Director
PROGRAM IN ADULT & PEDIATRIC CARDIAC RESEARCH
The Program supports and provides leadership for basic, translational, and clinical research on the development, maturation, and functioning of the heart throughout all stages of life. The research portfolio includes a broad array of science including cardiac development and maturation, myocyte structure and function, myocardial energetics and metabolism, cardiac electrophysiology, coronary artery structure and function, the failing heart, valvular heart disease, exercise physiology, nutrition and the heart, congenital heart disease from birth through adulthood, the intrauterine environment and cardiovascular risk, cardiomyopathy, and coronary artery disease. A key function of the Program is to provide collaborative leadership for the systematic oversight of clinical research across the Division, including clinical research information technology and standard but flexible operating procedures. The Program also supports training and career development for these areas of research. The Program is organized into three major components: the Heart Failure and Arrhythmias Branch, the Heart Development and Structural Diseases Branch, and the Atherosclerosis and Coronary Artery Diseases Branch.
Gail Pearson, M.D., Sc.D, Director
PROGRAM IN PREVENTION & POPULATION SCIENCES
The Program of Prevention and Population Sciences supports and provides leadership for population- and clinic-based research on the causes, prevention, and clinical care of cardiovascular, lung, and blood diseases and sleep disorders. Research includes a broad array of epidemiological studies to describe disease and risk factor patterns in populations and to identify risk factors for disease; clinical trials of interventions to prevent disease; studies of genetic, behavioral, sociocultural, and environmental influences on disease risk and outcomes; and studies of the application of prevention and treatment strategies to determine how to improve clinical care and public health. The Program also supports training and career development for these areas of research. The Program is organized into two major components: the Epidemiology Branch and the Clinical Applications and Prevention Branch.
Gina Wei, M.D., M.P.H., Director
OFFICE OF RESEARCH TRAINING & CAREER DEVELOPMENT
The Office of Research Training and Career Development supports training and career development programs in cardiovascular research, offering opportunities to individuals at all educational levels from high school students to academic faculty, including programs for individuals from diverse populations. The programs promote opportunities for investigators, early in their research careers and under mentorship from senior scientists, to perform basic, preclinical or clinical cardiovascular research and to take emerging and promising scientific and technological advances from discovery through preclinical and clinical studies. The Office also collaborates with the scientific community and professional organizations to ensure that training programs meet both the current and future needs of the cardiovascular research workforce. Programs supported by the Office include:
- Institutional and individual research training programs and fellowships for training of promising cardiovascular scientists at the predoctoral, postdoctoral, junior faculty, and established investigator levels.
- Diversity Supplements to ongoing research grants for support of young investigators from diverse backgrounds, from the high school to the junior faculty level.
- The Pathway to Independence Program, which allows the recipient to bridge the gap between a career development award and a research award.
- Career development programs specifically designed for clinical research or for minority researchers and institutions.
Jane Scott, Sc.D, M.S.N., Director
OFFICE OF BIOSTATISTICS RESEARCH
The Office of Biostatistics Research (OBR) provides statistical expertise to members of all Divisions of the NHLBI and performs diverse functions in planning, designing, implementing and analyzing NHLBI-sponsored studies. The OBR has primary responsibility for providing objective, statistically sound, and medically relevant solutions to problems. When presented with a problem for which techniques are not yet available, the OBR is expected to provide a new and valid statistical solution. The OBR is concerned with designing efficient studies and monitoring data while studies are ongoing. All members of the professional staff have interests in statistical methodology relevant to clinical research studies. The OBR's methodological interest concern survival analysis, longitudinal data analysis, and efficient study designs, including the monitoring of ongoing clinical studies for efficacy and safety. Recently the OBR has made contributions to statistical genetics and has extended its expertise to bioinformatics.
Nancy Geller, Ph.D., Director
OFFICE OF CLINICAL RESEARCH
The Office of Clinical Research (OCR) provides administrative support to all Divisions of the NHLBI in matters related to the Institute’s oversight of clinical research. Activities include development of policies and procedures to guide NHLBI-funded clinical research, maintenance of educational web sites about clinical research such as the Staff Clinical Research Guide and the Clinical Research Guide for NHLBI Investigators, providing NHLBI liaison for the activities of ClinicalTrials.gov, and overseeing the NHLBI service center for Certificates of Confidentiality. Staff of the Office of Clinical Research support the Clinical Studies Operations Committee, which is chaired by Dr. Shurin, addresses trans-NHLBI policy and operational issues to foster consistent, effective, and efficient management of the Institute’s clinical research. The Clinical Studies Coordinating Committee, a clinical research think-tank, operates under the auspices of the Office of Clinical Research.
Gail Pearson, M.D., Sc.D, Director
ADVANCED TECHNOLOGIES & SURGERY BRANCH
The Advanced Technologies and Surgery Branch conducts and manages an integrated basic and clinical research program to study innovative and developing technologies for the diagnosis, prevention, and treatment of CVD. It promotes opportunities to translate promising scientific and technological advances from discovery through pre-clinical studies to clinical trials. Areas supported by the Branch include:
- Diagnostics: proteomic, genomic, and other biomarker technologies and imaging modalities/agents to identify CVD and guide therapy.
- Therapeutics: tissue, cell-, and gene-based/guided therapies; regenerative and reparative medicine; and devices for circulatory and cardiac support and repair.
- Surgery: improved surgical and image-guided approaches and evidence-based clinical research to advance promising new cardiovascular therapies, technologies, and surgical practices into clinical use.
- Enabling Technologies: bioinformatics, computational and systems biology, bioengineering, nanotechnology, materials research, and personalized medicine.
Marissa Miller, D.V.M., M.P.H., Branch Chief
ATHEROTHROMBOSIS & CORONARY ARTERY DISEASE BRANCH
The Atherothrombosis and Coronary Artery Disease Branch conducts and manages an integrated basic and clinical research program to study the etiology, pathogenesis, prevention, diagnosis, and treatment of CAD and atherothrombosis. It is responsible for translating promising scientific and technological advances from discovery through preclinical studies to networks and multisite clinical trials. Areas addressed by the Branch include:
- Atherothrombosis: initiation, progression, and regression of atherosclerotic lesions in coronary arteries and other arterial beds; lesion instability and thrombosis; risk factor mechanisms; interaction of lipid fractions and other systemic and humoral factors with the arterial wall; biomarker and imaging diagnostics to quantify atherosclerotic disease and its progression; vulnerable plaques and vulnerable patients; and diabetes, obesity, other metabolic disorders, and diet and exercise related to atherothrombosis.
- Coronary Artery Disease: acute and chronic coronary syndromes including myocardial infarction, acute ischemia and related events, angina, and silent ischemia; and percutaneous and surgical revascularization of stenotic and re-stenotic coronary lesions.
Yves Rosenberg, M.D., M.P.H., Branch Chief
HEART DEVELOPMENT & STRUCTURAL DISEASES BRANCH
The Heart Development and Structural Disease Branch conducts and manages an integrated basic and clinical research program to study normal and abnormal cardiovascular development. It is also responsible for overseeing research related to the etiology, pathogenesis, prevention, diagnosis, and treatment of pediatric and adult structural heart disease. The Branch is a focal point for coordination of activities and development of educational materials related to clinical research on pediatric CVD within the NHLBI and the NIH . It promotes opportunities to translate promising scientific and technological advances from discovery through preclinical studies to network and multisite clinical trials. Areas supported by the Branch include:
- Heart Development: normal and abnormal cardiovascular development, molecular and genetic etiology of cardiovascular malformations, cardiomyogenic differentiation of stem cells, and gene-environment interactions in development of congenital heart disease.
- Structural Disease: congenital heart disease from embryology through adulthood, valve disease and determinants of degeneration, myocardial response to valvular disease, neurodevelopmental outcome in congenital heart disease, exercise physiology in congenital heart disease, pediatric cardiomyopathy and heart transplantation, and pediatric cardiac inflammation and infection.
Jonathan Kaltman, M.D., Branch Chief
HEART FAILURE & ARRHYTHMIAS BRANCH
The Heart Failure and Arrhythmias Branch conducts and manages an integrated basic and clinical research program to study normal cardiac function and pathogenesis to improve diagnosis, treatment, and prevention of heart failure and arrhythmias. It promotes opportunities to translate promising scientific and technological advances from discovery through preclinical studies to multisite and network clinical trials. Areas supported by the Branch include:
- Heart Failure: devices and medical and cell-based therapies targeting heart failure, myocardial protection, and pathogenesis and treatment of heart failure and cardiomyopathies.
- Arrhythmias: arrhythmogenesis, genetic and environmental bases of normal cardiac electrical activity and arrhythmias, etiology of rare and common arrhythmias, and sudden cardiac death.
- Myocardial Protection: myocardial preconditioning, amelioration and prevention of myocardial stunning and hibernation, and protection from ischemic/reperfusion injury.
- Resuscitation Science: mechanisms and management of clinical and experimental pathophysiologic states of whole body oxygen deprivation; systemic hypovolemia and resulting multi-organ failure; organ preservation; and cell, tissue, and organ protection during cardiac arrest and traumatic shock.
David Lathrop, Ph.D., Branch Chief
VASCULAR BIOLOGY & HYPERTENSION
The Vascular Biology and Hypertension Branch conducts and manages an integrated basic and clinical, extramural, research program to investigate vascular biology and the etiology, pathogenesis, prevention, diagnosis, and treatment of hypertension and vascular diseases. It promotes opportunities to translate promising scientific and technological advances from discovery through preclinical studies to networks and multisite clinical trials. Areas supported by the Branch include:
- Vascular Biology: biology of the vascular wall; vascular biology (related to hypertension; cerebrovascular, renal, and peripheral vascular disease; aneurysms; and lymphatic diseases); development of arteries, veins, lymphatics, and microcirculation; and angiogenesis.
- Vascular Medicine: cerebrovascular, renal, and peripheral vascular disease; and aneurysms.
- Hypertension: blood pressure regulation including central, renal, and vascular control; and cerebrovascular disease resulting from high blood pressure.
Zorina Galis, Ph.D., Branch Chief
CLINICAL APPLICATIONS & PREVENTION BRANCH
The Clinical Applications and Prevention Branch supports, designs, and conducts research and supports training on behavioral, environmental, clinical, and healthcare approaches to reduce occurrence and consequences of cardiovascular diseases. Prevention research examines effects of interventions to slow or halt risk factor or disease development or progression; interventions use high-risk individual and population approaches, including medications, behavioral strategies, and environmental change. Studies examine lifestyle, nutrition and exercise, psychological and sociocultural factors, and environmental and genetic influences relevant to prevention. Clinical application research examines approaches to improve healthcare delivery and patient outcomes. Studies include clinical and community trials and selected observational studies.
Lawrence Fine, M.D., Branch Chief
The Epidemiology Branch supports, designs, and conducts research and supports training in the epidemiology of cardiovascular, lung, blood, and sleep diseases and disorders. Studies are conducted to identify temporal trends and population patterns in the prevalence, incidence, morbidity, and mortality from these diseases and include single- and multi-center observational epidemiology studies of the development, progression, and treatment of cardiovascular, lung, blood, and sleep diseases and disorders. Studies identify environmental, lifestyle, physiological, and genetic risk factors for disease and risk factor development, including characterization of gene/gene and gene/environment interactions. The Branch also distributes data from all eligible NHLBI studies to researchers as a national data resource, adhering to guidelines that protect participant privacy and confidentiality.
Paul Sorlie, Ph.D., Branch Chief