DIR Core Facilities

Core Facilities provide scientific resources, cutting-edge technologies and novel approaches to support DIR scientists. Availability of specialized expertise creates a robust environment for conducting a wide range of studies and accelerates the pace at which scientific discovery can take place.

Our Programs

Animal Surgery and Resources Core

The Animal Surgery and Resource Core services for NHLBI research animals include animal model development, surgery, surgical support, imaging support, and post-operative care, as well as technical services such as radiography, blood & tissue collection. These services include both rodents and large animals.


Biochemistry Core

The mission of the Biochemistry Core is to provide expert services and consultation in biochemical enzyme assays and protein purification. All users are provided with on-site instrumentation training and if necessary, assistance with data processing and analyses.


Biophysics Core

The Biophysics Core’s mission is to provide support in the study of macromolecular interactions, dynamics, and stability by offering consultations, training, professional collaborations, and instrument access. This Core assists NHLBI researchers with comprehensive biophysical characterization of biomolecules, including proteins, polynucleotides, nanoparticles, and their ligands.


DNA Sequencing and Genomics Core

The DNA Sequencing and Genomics Core provides NHLBI investigators with fast and cost-effective next-generation sequencing services to facilitate DIR basic and translational research. The services include sequencing experiment consultation, various library preparations, data acquisition and FASTQ file generation, as well as sequencing technology training for postdoctoral and clinical fellows. The core strives to maintain cutting-edge sequencing instrumentation and genome technology.


Electron Microscopy Core

The Electron Microscopy Core provides advice, technical services, training and use of facilities to NHLBI DIR investigators who require electron microscopy (EM) to answer specific research topics. In general, this refers to questions involving subcellular, supramolecular or macromolecular structure at a level of resolution below that of the light microscope. The facility is equipped with transmission electron microscopes (TEM) and scanning electron microscope (SEM), as well as the preparative equipment for most biological EM applications. One TEM is a current model equipped for electron tomography and automated montage acquisition.

Contact: Valentina Baena Echeverri Ph.D., Interim Co-Director, valentina.baenaecheverri@nih.gov and Zulfeqhar Syed Ph.D., Interim Co-Director, zulfeqhar.syed@nih.gov