- NCSDR DIRECTOR'S REPORT, Michael Twery, PhD
- TRANS – NIH INSTITUTES AND CENTERS UPDATES
- OVERVIEW OF NHLBI WORKSHOP: CIRCADIAN HEALTH AND LIGHT, Phyllis Zee, MD, PH.D.
- NIH SLEEP DISORDERS RESEARCH PLAN REVISION, Patrick J. Strollo, Jr., MD, FACP, FCCP,
FAASM and Marishka Brown, Ph.D.
- PUBLIC COMMENT AND DISCUSSION
- DAY ONE SUMMARY, Patrick J. Strollo, Jr., MD, FACP, FCCP, FAASM
- COMMENTS OF THE DIRECTOR, DIVISION OF LUNG DISEASES, James Kiley, Ph.D.
- NIH AND FEDERAL AGENCY UPDATES
- PLANNING, DISCUSSION FOLLOW-UP, AND SUMMARY
- UPDATES FROM PUBLIC STAKEHOLDERS
BOARD MEMBERS PRESENT
Dr. Patrick Strollo, Chair
Dr. Ravi Allada
Dr. Mona El-Sheikh
Dr. Clete Kushida
Dr. Ketema Paul (Participated via WebEx)
Ms. Susan Plawsky
Dr. Naresh Punjabi
Ms. Nancy Rothstein
Ms. Linda Secretan
Dr. Virend Somers
Dr. Kenneth Wright Jr.
BOARD MEMBERS ABSENT
Dr. Julea Steiner
EX OFFICIO MEMBERS PRESENT
Dr. Michael Twery, NHLBI, Executive Secretary
FEDERAL EMPLOYEES PRESENT
Mr. Dean Allen, NCMRR, NICHD
Dr. Windy Boyd, NIEHS, NIH
Dr. Marishka Brown, NHLBI, NIH
Dr. Rina Das, NIMHD
Dr. Irwin Feuerstein, ORWH
Mr. Peyvand Ghofrani, NHLBI, NIH
Dr. Michelle Hamlet, NINR, NIH
Dr. Janet He, NINDS
Dr. J. Stephen Higgins, NHTSA
Dr. James Kiley, NHLBI, NIH
Dr. Patricia Labosky, OSC, NIH
Dr. Aaron Laposky, NHLBI, NIH
Dr. Mack Mackiewicz, NIA, NIH
Dr. Mary Ellen Michel, NCMRR, NICHD
Dr. Lanay Mudd, NCCIH, NIH
Ms. Ann Rothgeb, NHLBI, NIH
Dr. Kate Stoney, NHLBI, NIH
Dr. Karen Teff, NIDDK, NIH
Dr. Hilary Uyhelji, FAA
PUBLIC MEMBERS PRESENT
Dr. Alison Evans
Mr. Philip Goglas II
Mr. Jonathan Heald
Dr. Peter Mansbach
Dr. Allan Pack
Ms. Melissa Patterson
Dr. Katie Sharkey
Dr. Phyllis Zee
FEDERAL EMPLOYEES ATTENDING REMOTELY
Dr. Claire Caruso, CDC/NIOSH/DART
Dr. Lisa Gallicchio, NCI, NIH
Dr. Michael Sesma, NIGMS, NIH
Dr. Anne Wheaton, CDC
PUBLIC MEMBERS ATTENDING REMOTELY
Dr. James Andry
Dr. Christopher Depner
Dr. Janalyn Edmonds
Mr. Balaji Goparaju
Ms. Patricia Kobor
Dr. Clifford Saper
- The meeting was called into session at 1:00pm as previously announced in the Federal Register [FR Doc. 2016–15732]; public access by teleconference was provided.
- The Sleep Disorders Research Advisory Board (SDRAB) is a Federal Advisory Committee established by the NIH Revitalization Act of 1993 (42 USC Sec. 285b-7).
- Members of the Board were informed of their status as special government employees during the meeting and that conflict of interest (COI) guidelines apply. In the event a conflict of interest emerges during discussion, board members are to recuse themselves by leaving the room immediately.
- Overview of support for sleep and circadian research NIH-wide, including a breakdown by human subject involvement, awards to Early Stage Investigators, and awards for training (K, F, and T).
- A summary of major sleep research projects and initiatives shaping the program.
- Summary of NHLBI proposals to CDC supporting the collection of sleep health data in a nationally representative surveillance study, NHANES.
- Summary of NHLBI proposals to the NIH Precision Medicine Initiative to include the collection of sleep data.
- Summary of recent NCSDR led seminars, workshops, scientific conferences, invited lectures and presentations. NCSDR continues to collaborate with the SRS Trainee Day and the AASM Young Investigator Research Forum on grantsmanship skills.
- An update of progress on revisions to the NIH Sleep Disorders Research Plan
- Institute representatives presented brief updates of sleep and circadian activities.
- NICHD Identified specific interests in the sleep disorders of persons with disabilities.
- NIA Described how support from Congress for Alzheimer’s disease research is being used for Program Announcements that include sleep.
- NINDS Studies to explore sleep and circadian disturbances in neurological disorders.
- ORWH NIH coordination of research to advance sleep health in women.
- NCCIH Supplements to study non-pharmacologic treatments impacting sleep and pain.
- NIDDK Sex differences in sleep, and a new FOA on sleep and metabolism in FY2017.
- NINR Patient outcomes associated with sleep across the lifespan, including sleep disorder comorbidity in other conditions such as cancer and irritable bowel syndrome.
Dr. Zee summarized the recommendations of an NHLBI organized Circadian Health and Light workshop. The workshop assessed the evidence base establishing light as a fundamental biological requirement for human development, health, and achievement across the lifespan. An executive summary of workshop recommendations to be published on the NHLBI website.
NIH SLEEP DISORDERS RESEARCH PLAN REVISION, Patrick J. Strollo, Jr., MD, FACP, FCCP, FAASM and Marishka Brown, Ph.D.
- Overarching goals of the 2011 Sleep Disorders Research Plan were reviewed.
- The sleep community was updated by a panel discussion led by Dr. Strollo at the APSS/SLEEP 2016 annual meeting in Denver, Colorado.
- Public input in response to RFI NOT-HL-16-312 was summarized and discussed.
- The Board discussed candidate opportunities for major research directions to headline the revised plan. The value of selecting an overarching strategic intent/vision was discussed.
- Progress under the 2011 NIH Sleep Research Plan: Portfolio Analysis
- The overall distribution of grants across basic, clinical, sleep medicine, translational, and research training categories of the 2011 NIH Sleep plan with changes across time were presented.
- Since 2011, the analysis revealed increases in some research training categories and an overall trend for a decline in research activity in scientific categories.
- A breakdown of sleep grants supported by Institute/Center indicates that sleep research plan goals are funded NIH wide.
- Sleep Research Society, Dr. Allan Pack. The SRS identified the development of sleep biomarkers as a critical element in the revision of the plan now underway. SRS organized a full day Biomarker Workshop in conjunction with 2017 SLEEP meeting.
- Circadian Sleep Disorders Network, Mr. Mansbach identified the participation of board member Susan Plawsky (patient representative) to signal the NIH commitment to research involving circadian sleep disorders.
The meeting recessed at 5 pm on August 18 and reconvened, 8 am, August 19 as published in Federal Register [FR Doc. 2016–15732]. Public access was provided in-person and by teleconference.
- A brief update on the organizational standing of NCSDR
- Dr. Brown was introduced as a new program officer and Chief of the Sleep Disorders Medicine Program.
- NHLBI welcomes potential candidates for the position of Director, NCSDR. Interested individuals may contact Dr. Kiley directly.
- Sleep figures prominently in the newly released NHLBI Strategic Visioning Plan. The NHLBI Vision emerged from input received from stakeholders world-wide.
- A core element of NCSDR contribution is in coordination through regular meetings of the transNIH Sleep Research Coordination Committee and developing relationships with other Federal agencies.
- Board members and stakeholders were encouraged to provide input on the revision of the NIH Sleep Disorders Research plan now underway.
- NIEHS, Dr. Windy Boyd, National Toxicology Program (via WebEx)
Update on an evidence-based review to assess the dangers associated with Artificial Light at Night with respect general health and cancer. Publication of reports expected in 2017.
- FAA, Dr. Hilary Uyhelji, Aviation Medicine Fatigue Biomarker Research,
Fatigue is a safety concern for transportation and health in general. The FAA is exploring gene expression as biomarkers predicting sleep loss and cognitive impairment.
- NHTSA, Dr. James Higgins, Drowsy Driving and First Responder Management,
Fatigue is a major threat to transportation safety on the highway. NHTSA is developing a Drowsy Driving Research and Program Plan. A public meeting in November 2015 highlighted the risks, “Asleep at the Wheel: A Nation of Drowsy Drivers”. Plans are underway to launch a drowsy driving prevention campaign with law enforcement participation.
- NIH/OD Common Fund, Dr. Patricia Labosky – Mechanisms of Fatigue in Health
NIH is considering opportunities to advance our understanding of the neurobiological mechanisms of fatigue in otherwise healthy people. Fatigue is an understudied symptom of diseases spanning the breadth of NIH science.
- NIMHD, Dr. Rina Das -- Social Epigenomics Research
New initiatives (PAR-16-355, PAR-16-356) aim to stimulate the discovery of epigenetic mechanisms contributing to minority health disparities. Sleep has a close relationship to the mechanism of epigenetics and sleep deficiency is prevalent among low SES and racial/ethnic minority communities. The FOA presents new avenues for sleep researchers.
- Centers for Disease Control, Dr. Anne Wheaton (via WebEx)
An overview of ongoing and future national surveillance of sleep health were presented. Updates to unique online data resources including new “Fact Sheets” describing the prevalence of sleep health at the county-level nation-wide.
- SDRAB will continue to refine ideas for the revision of the NIH Sleep Disorders Research Plan, which will be released in the Spring of 2017.
- Develop and adopt a vision (Strategic Intent) with the sleep and circadian community.
- Narcolepsy Network
- AASM, update
The meeting was adjourned at 3pm EDT.