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Annual Science Advances:Translation Research and Implementation Science

Improving translation and implementation science

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The NHLBI’s Center for Translation Research and Implementation Science works to move evidence-based interventions into clinical practice for patients with heart, lung, blood, and sleep disorders.

The Center is supporting a new area called Simulation Modeling and Systems Science (SMSS), which examines how a new or emerging intervention might work in different settings or among different populations. With this understanding, SMSS allows researchers to adjust and refine the intervention as needed to ensure its success, before implementing it in the real world. A current project is using SMSS to project the 10-and 30-year impact of six evidence-based obesity interventions at the national level and in six socioeconomically diverse states.

NHLBI-supported implementation science is also being applied to help people living with HIV, who are at higher risk of developing chronic heart, lung, blood, and sleep disorders, compared to people who are HIV-negative. The Heart, Lung, and Blood Co-morbidities Implementation Models in People Living with HIV (HLB-SIMPLe) initiative funds research to understand the risk factors for HIV-associated disorders (comorbidities) in low- and middle-income countries. This research is expected to lead to methods for earlier detection and prevention of these comorbidities, which could also benefit Americans living with HIV.


Explore the Science Advances


Heart Disease Research

Blood Disease Research

Lung Disease and Sleep Research

Translation Research and Implementation Science

Training and Career Development

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