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- Expert Panel Report 4 (EPR-4) Working Group
Expert Panel Report 4 (EPR-4) Working Group
National Asthma Education and Prevention Program Coordinating Committee
The National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC) Expert Panel 4 (EPR-4) Working Group was established in 2018 to update the 2007 Guidelines for the Diagnosis and Management of Asthma, Expert Panel Report 3 (EPR-3). The EPR-4 Working Group members used findings from five systematic reviews to update the guidelines. The topic areas included:
- Role of Immunotherapy in the Treatment of Asthma
- Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonist for Asthma
- Effectiveness of Indoor Allergen Reduction in Management of Asthma
- Effectiveness and Safety of Bronchial Thermoplasty in Management of Asthma
- The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management
NHLBI engaged the Agency for Healthcare Research and Quality (AHRQ) and provided support for rigorous systematic evidence reviews through the AHRQ Evidence-based Practice Centers. The EPR-4 Working Group followed the Institute of Medicine’s recommendations and standards for using systematic evidence reviews in the development of trustworthy guidelines. In December 2020, the NAEPPCC published the 2020 Focused Updates to the Asthma Management Guidelines.
Roster
- Expert Panel Report 4 (EPR-4) Working Group
NAEPPCC EPR-4 Working Group
Chair
- Expert Panel Report 4 (EPR-4) Working Group
Michelle M. Cloutier, M.D.
University of Connecticut School of Medicine
Hartford, CT
Members
- Expert Panel Report 4 (EPR-4) Working Group
Alan Baptist, M.D., M.P.H.
University of Michigan
Ann Arbor, MI
Kathryn Blake, Pharm.D., BCPS, FCCP, CIP
Nemours Children's Specialty Care
Jacksonville, FL
University of Texas Health Science Center
San Antonio, TX
Emily DiMango, M.D.
Columbia University Medical Center
New York, NY
Ann Dixon, M.A., B.M., B.Ch.
Burlington, VT
Kurtis S. Elward, M.D., M.P.H., FAAFP
Virginia Commonwealth University
Charlottesville, VA
Tina Hartert, M.D., M.P.H.
Vanderbilt School of Medicine
Nashville, TN
Jerry Krishnan, M.D., Ph.D.
University of Illinois Hospital & Health Sciences System
Chicago, IL
Robert Frederick Lemanske, M.D.
University of Wisconsin School of Medicine and Public Health
Madison, WI
Daniel R. Ouellette, M.D., FCCP
Henry Ford Health System
Detroit, MI
Wilson Pace, M.D., FAAFP
University of Colorado School of Medicine
Aurora, CO
Michael Schatz, M.D., M.S.
Kaiser Permanente
San Diego, CA
Neil Skolnik, MD
Abington Jefferson Health
Abington, PA
Tyra Bryant Stephens, M.D.
Children's Hospital of Philadelphia
Philadelphia PA
Jim Stout, M.D., M.P.H.
University of Washington
Seattle, WA
Stephen Teach, M.D., M.P.H.
George Washington University
Washington, DC
Craig Umscheid, M.D., M.S.C.E.
Penn Medicine
Philadelphia, PA
Colin G. Walsh, M.D., M.A.
Vanderbilt University Medical Center
Nashville, TN
Related Publications
- Expert Panel Report 4 (EPR-4) Working Group
Mensah GA, Kiley JP, Gibbon GH. Generating Evidence to Inform an Update of Asthma Clinical Practice Guidelines: Perspectives from the National Heart, Lung, and Blood Institute. J Allergy Clin Immunol 2018. Article in Press: 10.1016/j.jaci.2018.07.004
Ballas ZK. Asthma Clinical Practice Guidelines: Time for an update. J Allergy Clin Immunol 2018: Article in Press: 10.1016/j.jaci.2018.07.008
Rice JL, Diette GB, Suarez-Cuervo C, Brigham EP, Lin SY, Ramanathan M Jr, Robinson KA, Azar A. Allergen-Specific Immunotherapy in the Treatment of Pediatric Asthma: A Systematic Review. Pediatrics. 2018 May;141(5). pii:e20173833. doi: 10.1542/peds.2017-3833. Epub 2018 Mar 23. Review. PubMed PMID: 29572287.
Sobieraj DM, Baker WL, Nguyen E, et al. Association of inhaled corticosteroids and long-acting muscarinic antagonists with asthma control in patients with uncontrolled, persistent asthma: a systematic review and meta-analysisexternal link [published online March 19, 2018]. JAMA. doi:10.1001/jama.2018.2757.
Sobieraj DM, Weeda ER, Nguyen E, et al. Association of inhaled corticosteroids and long-acting β-agonists as controller and quick relief therapy with exacerbations and symptom control in persistent asthma: a systematic review and meta-analysisexternal link [published online March 19, 2018]. JAMA. doi: 10.1001/jama.2018.2769.
Leas BF, D’Anci KE, Apter AJ, et al. Effectiveness of indoor allergen reduction in the management of asthma: a systematic review.external link The Journal of Allergy and Clinical Immunology. 13 Feb 2018. [Epub ahead of print.] http://www.jacionline.org/article/S0091-6749(18)30223-9/abstract. DOI: https://doi.org/10.1016/j.jaci.2018.02.001.
Wang Z, Pianosi P, Keogh K, et al. The Diagnostic Accuracy of Fractional Exhaled Nitric Oxide Testing in Asthma: A Systematic Review and Meta-analysesexternal link. Mayo Clinic Proceedings. ePub ahead of print. DOI: http://dx.doi.org/10.1016/j.mayocp.2017.11.012.
Lin SY, Azar A, Suarez-Cuervo C, Diette GB, Brigham E, Rice J, Ramanathan M Jr, Robinson KA. Role of sublingual immunotherapy in the treatment of asthma: An updated systematic review. Int Forum Allergy Rhinol. 2018 Jun 9. doi: 10.1002/alr.22152. [Epub ahead of print] PubMed PMID: 29885036.