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Dan Kastner

Dan Kastner photoChief, Laboratory of Clinical Investigation, NIAMS


Dr. Dan Kastner is the Chief of the Laboratory of Clinical Investigation in the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Clinical Director of NIAMS, and Deputy Director for Intramural Clinical Research at the NIH. His laboratory has a long-standing interest in human genetic disorders of inflammation. He led an international consortium that identified the gene causing familial Mediterranean fever in 1997, and his group subsequently discovered that mutations in the p55 tumor necrosis factor receptor cause a dominantly inherited periodic fever syndrome that they named TRAPS (the TNF receptor-associated periodic syndrome).

Based on these findings, Dr. Kastner proposed the term "autoinflammatory" to describe the family of diseases characterized by seemingly unprovoked episodes of inflammation, without high titer autoantibodies or antigen-specific T-cells, which are now known to be disorders of the innate immune system. His group has gone on to identify the genetic basis of NOMID (neonatal onset multisystem inflammatory disease), and has recently described a new syndrome, DIRA, in which there is a genetic deficiency of the IL-1 receptor antagonist. Recent work from the Kastner laboratory has also focused on genetically complex disorders. His group established the association of STAT4 polymorphisms with several autoimmune diseases, and is currently studying the genetics of Beh?et?s disease.

Last Updated July 2010

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