The mission of the trans-NIH CHI is cooperative research based on advanced technologies in order to efficiently translate enhanced understanding of immune function and pathophysiology to the clinic. The Center is based on cooperative research, technologically driven with the goal of understanding human immunology, and addressing pathophysiologically-related human diseases. This initiative is translational, but this overused term is defined here as both directly resulting in improved therapy of immune-mediated diseases and deriving important and often unique biologic information from the study of ill human beings.
The mission statement has three major components:
- The Center is envisioned as a cooperative enterprise, with representatives form many NIH Institutes working together on focused projects with clear shared goals.
- The Center will provide specific technologies often unavailable to individual laboratories because of cost, complexity, and novelty, incorporated into three technology centers dedicated to:
- assays of immune cells and their products, mainly based on flow cytometry and other emerging multiplexed techniques;
- high-throughput systems technologies, involving the use of new methods for large scale examination of the genome, gene expression epigenetic modulation, as well as the proteome, lipidome, and metabolome, and the application of advanced biostatical and computer modeling methods for mining these diverse data to aid in understanding immune function and pathology;
- protocol development, with staff dedicated to the efficient translation to the clinic with appropriate ethical and regulatory requirements for human research.
- The Center's focus is human immunology, normal but especially pathologic, with an emphasis on shared pathophysiologic mechanisms that underlie disease. This includes recognized immunologially-mediated diseases, organ specific autoimmunity, and the role of inflammation in a wide variety of common diseases, including cancer, atherosclerosis, and neurologic degeneration.
Where CHI conducts their studies and research
Last Updated January 2014