R01 HL42257 - John Sullivan - University of Massachusetts, Boston, MA
This project is a continuation of a collaboration with the New England Area Hemophilia Clinic in a long-term study to understand the pathogenesis of HIV infection in individuals with hemophilia. The sample collection and data analysis obtained from this 10-year study provide valuable resources.
This grant is being supported from 1988 to 1997.
Studies show that individuals with normal CD4 counts despite more than ten years of infection with HIV-1 have remarkably low viral binders in circulation and maintain activated viral antigen expression. Also studies suggest that infection with nef-defective, attenuated forms of HIV-1 may be responsible for the lack of disease progression in some individuals.
R01 HL43512 - George Gjerset - Puget Sound Blood Center, Seattle, WA
This was a prospective study of HIV infection in treated hemophiliacs and their spouses. The investigators examined the course of HIV infection and important cofactors involved in its pathophysiology.
This grant was supported from 1990 to 1995.
Follow-up of 78 anti-HIV positive subjects has shown that the actuarial rate of AIDS is 7.9 percent per year with a median time to AIDS of 9 years since enrollment. In contrast, time to CD4 <200 is longer, with a rate of 3 percent per year. All but one of the subjects with AIDS to date have first developed CD4 <200. The older age group fared poorly while the younger age group (15-30) had the most favorable outcome.