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CARe: Candidate-gene Association Resource

Program Description

The NHLBI initiated the Candidate gene Association Resource (CARe) to create a shared genotype/phenotype resource for analyses of the association of genotypes with phenotypes relevant to the mission of the NHLBI. The resource comprises nine cohort studies funded by the NHLBI including: Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Cleveland Family Study (CFS), Coronary Artery Risk Development in Young Adults (CARDIA), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Multi-Ethnic Study of Atherosclerosis (MESA), and the Sleep Heart Health Study (SHHS). A database of genotype and phenotype data was created that includes records for approximately 41,000 study participants with approximately 50,000 SNPs from more than 2,000 selected candidate genes. In addition, a genome wide association study using a 1,000K SNP Chip was conducted on approximately 8,900 African American participants drawn from five CARe cohorts: ARIC, CARDIA, CFS, JHS, and MESA. Data from individual cohorts is available to approved investigators through dbGaP. A single contract award was made to the Broad Institute for they genotyping and bioinformatics center; Dr. Stacey Gabriel is the Principal Investigator.

The NHLBI Program Officer for CARe is George J. Papanicolaou, Ph.D.

Related Websites:

CARe Page at the Broad Instituteimage of external icon

NCBI BioProject Page: NHLBI SNP Health Association Resource (CARe)

Projects

  • ARIC - Atherosclerosis Risk in Communities
  • CARDIA - Coronary Artery Risk Development in Young Adults
  • CFS - Cleveland Family Study
  • CHS - Cardiovascular Health Study
  • FHS - Framingham Heart Study
  • JHS - Jackson Heart Study
  • MESA - Multi-Ethnic Study of Atherosclerosis
  • SHHS - Sleep Heart Health Study

Program Start and End Date

April 2006 to March 2011

Original Funding Announcement (FOA)

Documents

Last Updated September 2011

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