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Trans-Agency Coagulopathy in Trauma Workshop
The Trans-Agency Coagulopathy in Trauma Workshop was convened on April 5 - 7, 2010 to identify the critical barriers to discovery of new approaches for the diagnosis and management of coagulopathy, and to develop recommendations about the direction of future research. The Workshop format emphasized cross-disciplinary discussions to identify the challenges and limitations in the current practice of coagulopathy diagnosis and treatment, gaps in the state of knowledge of coagulation and coagulopathy biology, and solutions to rapidly advance the research to develop new diagnosis and treatment measures.
More than 130 experts representing the National Institutes of Health (NIH), Department of Defense (DoD), Centers for Disease Control and Prevention (CDC), U.S. Food and Drug Administration (FDA), Department of Veterans Affairs, academia, and industry attended the Workshop. Countries represented at the Workshop included Australia, Canada, Israel, the United Kingdom, and the United States.
Dr. Susan Shurin, NHLBI Acting Director, welcomed all participants and emphasized the importance of working jointly and collaboratively to address the biological and translational research opportunities in the area of Trauma-Induced Coagulopathy (TIC). Dr. Keith Hoots, Director, Division of Blood Disease and Resources (DBDR), NHLBI and Dr. Joseph Palma, Senior Scientific and Medical Advisor to the U.S. Army Medical Research and Materiel Command (USAMRMC) and The Surgeon General, welcomed all attendees and reviewed the Workshop goals. Dr. Kenneth Mann, Chair of the Workshop, commended the NHLBI and USAMRMC for organizing the Workshop in a display of true intergovernmental cooperation. He provided an overview of trauma and coagulopathy, highlighting his and others' research on developing better procedures for the diagnosis of and therapeutic intervention in hemorrhagic and thrombotic diseases. He noted that there needs to be (1) an opportunity in both the military and civilian communities to document the natural history of coagulopathy in trauma; (2) the development of the clinical ability to rapidly assess the coagulation status of an individual who has experienced trauma; (3) the establishment of laboratory tools to guide therapeutic interventions intervention; and (4) short and long term outcomes surveillance following acute intervention.
The first day of the Workshop consisted of a series of 16 presentations by scientists who are studying various aspects of coagulopathy in trauma (See Meeting Agenda , (87KB)) and the application of systems biology approaches. A broad array of research topics was covered, including basic coagulation biology, stochastic modeling of blood coagulation, and the clinical management of coagulopathy after trauma.
On the second day of the meeting, participants divided into four topic-related Working Groups: Biology, -Omics, Animal Models, and Diagnostics/Biomarkers.
During the Integration Session that followed on the third day of the meeting, the Workshop Chair, Working Group Co-Chairs, and Workshop organizers (NHLBI and DoD) met to synthesize information generated by the Working Groups and formulate the findings and recommendations.
Members of the workshop identified the need for actionable research or product-oriented research that integrates basic, preclinical, and clinical studies. Meeting participants subsequently developed four broad objectives:
Members recommended that the four broad objectives be addressed in a parallel, not sequentially, except when a model or product developed under one objective is required for the achievement of another objective.
A consensus view reflected the high enthusiasm of panelists for new research and suggested two parallel approaches to stimulating the science that would accomplish the four broad objectives related to TIC:
The group felt that major research efforts from both large integrated research groups and individual investigators are critical to overcome the barriers to discovery and translation of new approaches for the diagnosis and management of TIC.
View the detailed summary , (90KB) of the workshop discussions and recommendations.
Participating Institute and Organizations
Andrei Kindzelski, MD, (301) 435-0070, firstname.lastname@example.org
Last Updated September 2011