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Imaging Probe Development Center


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Imaging Probe Development Center
Rolf Swenson, Ph.D.

Full Publications Listing

The N-acetyl-binding pocket of N-acetylglucosaminyltransferases also accommodates a sugar analog with a chemical handle at C2.
Pasek M, Ramakrishnan B, Boeggeman E, Mercer N, Dulcey AE, Griffiths GL, Qasba PK.
Glycobiology. 2012 Mar ;22(3):379-88.
[Text Abstract on PubMed]

Synthesis of ApoSense compound [18F]2-(5-(dimethylamino)naphthalene-1-sulfonamido)-2-(fluoromethyl)butanoic acid ([18F]NST732) by nucleophilic ring opening of an aziridine precursor.
Basuli F, Wu H, Shi ZD, Teng B, Li C, Sulima A, Bate A, Young P, McMillan M, Griffiths GL.
Nucl Med Biol. 2012 Jul ;39(5):687-96.
[Text Abstract on PubMed]

In vivo fluorescence lifetime imaging monitors binding of specific probes to cancer biomarkers.
Ardeshirpour Y, Chernomordik V, Zielinski R, Capala J, Griffiths G, Vasalatiy O, Smirnov AV, Knutson JR, Lyakhov I, Achilefu S, Gandjbakhche A, Hassan M.
PLoS ONE. 2012;7(2):e31881.
[Text Abstract on PubMed]

68Ga-DOTA-affibody molecule for in vivo assessment of HER2/neu expression with PET.
Kramer-Marek G, Shenoy N, Seidel J, Griffiths GL, Choyke P, Capala J.
Eur J Nucl Med Mol Imaging. 2011 Nov ;38(11):1967-76.
[Text Abstract on PubMed]

Improved synthesis of UDP-2-(2-ketopropyl)galactose and a first synthesis of UDP-2-(2-ketopropyl)glucose for the site-specific linking of biomolecules via modified glycan residues using glycosyltransferases.
Dulcey AE, Qasba PK, Lamb J, Griffiths GL.
Tetrahedron. 2011 Mar 18;67(11):2013-2017.
[Text Abstract on PubMed]

Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
Goldsborough AS, Handley MD, Dulcey AE, Pluchino KM, Kannan P, Brimacombe KR, Hall MD, Griffiths G, Gottesman MM.
J Med Chem. 2011 Jul 28;54(14):4987-97.
[Text Abstract on PubMed]

Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm.
Ardeshirpour Y, Chernomordik V, Capala J, Hassan M, Zielinsky R, Griffiths G, Achilefu S, Smith P, Gandjbakhche A.
Technol Cancer Res Treat. 2011 Dec ;10(6):549-60.
[Text Abstract on PubMed]

Rh-I-UEA-1 polymerized liposomes target and image adenomatous polyps in the APC(Min/+) mouse using optical colonography.
Roney CA, Xu B, Xie J, Yuan S, Wierwille J, Chen CW, Chen Y, Griffiths GL, Summers RM.
Mol Imaging. 2011 Aug ;10(4):305-16.
[Text Abstract on PubMed]

Development of a MR-visible compound for tracing neuroanatomical connections in vivo.
Wu CW, Vasalatiy O, Liu N, Wu H, Cheal S, Chen DY, Koretsky AP, Griffiths GL, Tootell RB, Ungerleider LG.
Neuron. 2011 Apr 28;70(2):229-43.
[Text Abstract on PubMed]

Near-infrared fluorescence lifetime pH-sensitive probes.
Berezin MY, Guo K, Akers W, Northdurft RE, Culver JP, Teng B, Vasalatiy O, Barbacow K, Gandjbakhche A, Griffiths GL, Achilefu S.
Biophys J. 2011 Apr 20;100(8):2063-72.
[Text Abstract on PubMed]

Syntheses of meta-[F]Fluorobenzaldehyde and meta-[F]Fluorobenzylbromide from Phenyl(3-Formylphenyl) Iodonium Salt Precursors.
Basuli F, Wu H, Griffiths GL.
J Labelled Comp Radiopharm. 2011 Apr ;54(4):224-228.
[Text Abstract on PubMed]

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.
Zhu X, Owen JS, Wilson MD, Li H, Griffiths GL, Thomas MJ, Hiltbold EM, Fessler MB, Parks JS.
J Lipid Res. 2010 Nov ;51(11):3196-206.
[Text Abstract on PubMed]

Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging.
Guo K, Berezin MY, Zheng J, Akers W, Lin F, Teng B, Vasalatiy O, Gandjbakhche A, Griffiths GL, Achilefu S.
Chem Commun (Camb). 2010 Jun 7;46(21):3705-7.
[Text Abstract on PubMed]

Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging.
Yuan S, Roney CA, Wierwille J, Chen CW, Xu B, Griffiths G, Jiang J, Ma H, Cable A, Summers RM, Chen Y.
Phys Med Biol. 2010 Jan 7;55(1):191-206.
[Text Abstract on PubMed]

Formation of a mast cell synapse: Fc epsilon RI membrane dynamics upon binding mobile or immobilized ligands on surfaces.
Carroll-Portillo A, Spendier K, Pfeiffer J, Griffiths G, Li H, Lidke KA, Oliver JM, Lidke DS, Thomas JL, Wilson BS, Timlin JA.
J Immunol. 2010 Feb 1;184(3):1328-38.
[Text Abstract on PubMed]

Dyslipidemia induces opposing effects on intrapulmonary and extrapulmonary host defense through divergent TLR response phenotypes.
Madenspacher JH, Draper DW, Smoak KA, Li H, Griffiths GL, Suratt BT, Wilson MD, Rudel LL, Fessler MB.
J Immunol. 2010 Aug 1;185(3):1660-9.
[Text Abstract on PubMed]

An improved synthesis of a fluorescent gabapentin-choline conjugate for single molecule detection.
Wu H, Kaur G, Griffiths GL.
Tetrahedron Lett. 2009 May 6;50(18):2100-2102.
[Text Abstract on PubMed]

Synthesis and pharmacological characterization of [(125)I]MRS1898, a high-affinity, selective radioligand for the rat A(3) adenosine receptor.
Gao ZG, Teng B, Wu H, Joshi BV, Griffiths GL, Jacobson KA.
Purinergic Signal. 2009 Mar ;5(1):31-7.
[Text Abstract on PubMed]

Determining molecular mass distributions and compositions of functionalized dendrimer nanoparticles.
Sousa AA, Aronova MA, Wu H, Sarin H, Griffiths G, Leapman RD.
Nanomedicine (Lond). 2009 Jun ;4(4):391-9.
[Text Abstract on PubMed]

Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye.
Berezin MY, Guo K, Teng B, Edwards WB, Anderson CJ, Vasalatiy O, Gandjbakhche A, Griffiths GL, Achilefu S.
J Am Chem Soc. 2009 Jul 8;131(26):9198-200.
[Text Abstract on PubMed]

A new resorufin-based alpha-glucosidase assay for high-throughput screening.
Motabar O, Shi ZD, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W.
Anal Biochem. 2009 Jul 1;390(1):79-84.
[Text Abstract on PubMed]

Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins.
Taguchi Y, Shi ZD, Ruddy B, Dorward DW, Greene L, Baron GS.
Mol. Biol. Cell. 2009 Jan;20(1):233-44.
[Text Abstract on PubMed]

Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase.
Shi ZD, Motabar O, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W.
Anal Bioanal Chem. 2009 Aug ;394(7):1903-9.
[Text Abstract on PubMed]

Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors.
Sarin H, Kanevsky AS, Wu H, Sousa AA, Wilson CM, Aronova MA, Griffiths GL, Leapman RD, Vo HQ.
J Transl Med. 2009 01 ;7:51.
[Text Abstract on PubMed]

Mitochondrial NADH fluorescence is enhanced by complex I binding.
Blinova K, Levine RL, Boja ES, Griffiths GL, Shi ZD, Ruddy B, Balaban RS.
Biochemistry. 2008 Sep 9;47(36):9636-45.
[Text Abstract on PubMed]

Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent.
Hyodo F, Chuang KH, Goloshevsky AG, Sulima A, Griffiths GL, Mitchell JB, Koretsky AP, Krishna MC.
J Cereb Blood Flow Metab. 2008 Jun ;28(6):1165-74.
[Text Abstract on PubMed]

The imaging probe development center and the production of molecular imaging probes.
Griffiths GL.
Curr Chem Genomics. 2008 01 ;1:65-9.
[Text Abstract on PubMed]

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells.
Sarin H, Kanevsky AS, Wu H, Brimacombe KR, Fung SH, Sousa AA, Auh S, Wilson CM, Sharma K, Aronova MA, Leapman RD, Griffiths GL, Hall MD.
J Transl Med. 2008 01 ;6:80.
[Text Abstract on PubMed]

Imaging Probe Development Center: a National Institutes of Health core synthesis resource for imaging probes.
Shi ZD, Wu H, Ruddy B, Griffiths GL.
J Biomed Opt. 2007 01 ;12(5):051502.
[Text Abstract on PubMed]