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Neal Young, M.D.

Publications


Principal Investigator thumbnail image

Neal Young
Senior Investigator

P: +1 301 496 5093
F: +1 301 496 8396
youngns@mail.nih.gov


Full Publications Listing

Absence of SBDS mutations in sporadic paediatric acute myeloid leukaemia.
Aalbers AM, Calado RT, Young NS, Zwaan CM, Kajigaya S, Baruchel A, Geleijns K, de Haas V, Kaspers GJ, Reinhardt D, Trka J, Kuijpers TW, Pieters R, van der Velden VH, van den Heuvel-Eibrink MM.
Br. J. Haematol. 2012 Nov 28.
[Text Abstract on PubMed]

Effect of anticoagulants on multiplexed measurement of cytokine/chemokines in healthy subjects.
Biancotto A, Feng X, Langweiler M, Young NS, McCoy JP.
Cytokine. 2012 Nov;60(2):438-46.
[Text Abstract on PubMed]

Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation.
Peffault de Latour R, Calado RT, Busson M, Abrams J, Adoui N, Robin M, Larghero J, Dhedin N, Xhaard A, Clave E, Charron D, Toubert A, Loiseau P, Socié G, Young NS.
Blood. 2012 Oct 18;120(16):3353-9.
[Text Abstract on PubMed]

Interphase Chromosome Flow-FISH.
Keyvanfar K, Weed J, Swamy P, Kajigaya S, Calado RT, Young NS.
Blood. 2012 Oct 11;120(15):e54-9.
[Text Abstract on PubMed]

How I treat acquired aplastic anemia.
Scheinberg P, Young NS.
Blood. 2012 Aug 9;120(6):1185-96.
[Text Abstract on PubMed]

Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na.
Olnes MJ, Shenoy A, Weinstein B, Pfannes L, Loeliger K, Tucker Z, Tian X, Kwak M, Wilhelm F, Yong AS, Maric I, Maniar M, Scheinberg P, Groopman J, Young NS, Sloand EM.
Leuk. Res. 2012 Aug;36(8):982-9.
[Text Abstract on PubMed]

Damage control and its costs: BM failure in Fanconi anemia stems from overactive p53/p21.
Dumitriu B, Young NS.
Cell Stem Cell. 2012 Jul 6;11(1):7-8.
[Text Abstract on PubMed]

Eltrombopag and improved hematopoiesis in refractory aplastic anemia.
Olnes MJ, Scheinberg P, Calvo KR, Desmond R, Tang Y, Dumitriu B, Parikh AR, Soto S, Biancotto A, Feng X, Lozier J, Wu CO, Young NS, Dunbar CE.
N. Engl. J. Med. 2012 Jul 5;367(1):11-9.
[Text Abstract on PubMed]

Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.
Calado RT, Cooper JN, Padilla-Nash HM, Sloand EM, Wu CO, Scheinberg P, Ried T, Young NS.
Leukemia. 2012 Apr;26(4):700-7.
[Text Abstract on PubMed]

Bone marrow failure and the new telomere diseases: practice and research.
Young NS.
Hematology. 2012 Apr;17 Suppl 1:S18-21.
[Text Abstract on PubMed]

Human telomere disease due to disruption of the CCAAT box of the TERC promoter.
Aalbers AM, Kajigaya S, van den Heuvel-Eibrink MM, van der Velden VH, Calado RT, Young NS.
Blood. 2012 Mar 29;119(13):3060-3.
[Text Abstract on PubMed]

Effects of granulocyte-colony-stimulating factor on Monosomy 7 aneuploidy in healthy hematopoietic stem cell and granulocyte donors.
Olnes MJ, Poon A, Miranda SJ, Pfannes L, Tucker Z, Loeliger K, Padilla-Nash H, Yau YY, Ried T, Leitman SF, Young NS, Sloand EM.
Transfusion. 2012 Mar;52(3):537-41.
[Text Abstract on PubMed]

Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia.
Scheinberg P, Nunez O, Weinstein B, Scheinberg P, Wu CO, Young NS.
Blood. 2012 Jan 12;119(2):345-54.
[Text Abstract on PubMed]

Safety and immunogenicity of a candidate parvovirus B19 vaccine.
Bernstein DI, El Sahly HM, Keitel WA, Wolff M, Simone G, Segawa C, Wong S, Shelly D, Young NS, Dempsey W.
Vaccine. 2011 Oct 6;29(43):7357-63.
[Text Abstract on PubMed]

Horse versus rabbit antithymocyte globulin in acquired aplastic anemia.
Scheinberg P, Nunez O, Weinstein B, Scheinberg P, Biancotto A, Wu CO, Young NS.
N. Engl. J. Med. 2011 Aug 4;365(5):430-8.
[Text Abstract on PubMed]

MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.
Erie AJ, Samsel L, Takaku T, Desierto MJ, Keyvanfar K, McCoy JP, Young NS, Chen J.
Exp. Hematol. 2011 Aug;39(8):837-49.
[Text Abstract on PubMed]

Natural history of pulmonary fibrosis in two subjects with the same telomerase mutation.
El-Chemaly S, Ziegler SG, Calado RT, Wilson KA, Wu HP, Haughey M, Peterson NR, Young NS, Gahl WA, Moss J, Gochuico BR.
Chest. 2011 May;139(5):1203-9.
[Text Abstract on PubMed]

Constitutional telomerase mutations are genetic risk factors for cirrhosis.
Calado RT, Brudno J, Mehta P, Kovacs JJ, Wu C, Zago MA, Chanock SJ, Boyer TD, Young NS.
Hepatology. 2011 May;53(5):1600-7.
[Text Abstract on PubMed]

Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes.
Feng X, Scheinberg P, Wu CO, Samsel L, Nunez O, Prince C, Ganetzky RD, McCoy, Maciejewski JP, Young NS.
Haematologica. 2011 Apr;96(4):602-6.
[Text Abstract on PubMed]

Decreased infection-related mortality and improved survival in severe aplastic anemia in the past two decades.
Valdez JM, Scheinberg P, Nunez O, Wu CO, Young NS, Walsh TJ.
Clin. Infect. Dis. 2011 Mar 15;52(6):726-35.
[Text Abstract on PubMed]

T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy.
Sloand EM, Melenhorst JJ, Tucker ZC, Pfannes L, Brenchley JM, Yong A, Visconte V, Wu C, Gostick E, Scheinberg P, Olnes MJ, Douek DC, Price DA, Barrett AJ, Young NS.
Blood. 2011 Mar 3;117(9):2691-9.
[Text Abstract on PubMed]

Optimization of therapy for severe aplastic anemia based on clinical, biologic, and treatment response parameters: conclusions of an international working group on severe aplastic anemia convened by the Blood and Marrow Transplant Clinical Trials Network, March 2010.
Pulsipher MA, Young NS, Tolar J, Risitano AM, Deeg HJ, Anderlini P, Calado R, Kojima S, Eapen M, Harris R, Scheinberg P, Savage S, Maciejewski JP, Tiu RV, DiFronzo N, Horowitz MM, Antin JH.
Biol. Blood Marrow Transplant. 2011 Mar;17(3):291-9.
[Text Abstract on PubMed]

Alemtuzumab treatment of intermediate-1 myelodysplasia patients is associated with sustained improvement in blood counts and cytogenetic remissions.
Sloand EM, Olnes MJ, Shenoy A, Weinstein B, Boss C, Loeliger K, Wu CO, More K, Barrett AJ, Scheinberg P, Young NS.
J. Clin. Oncol. 2010 Dec 10;28(35):5166-73.
[Text Abstract on PubMed]

Codon optimization of human parvovirus B19 capsid genes greatly increases their expression in nonpermissive cells.
Zhi N, Wan Z, Liu X, Wong S, Kim DJ, Young NS, Kajigaya S.
J. Virol. 2010 Dec;84(24):13059-62.
[Text Abstract on PubMed]

Th17 immune responses contribute to the pathophysiology of aplastic anemia.
de Latour RP, Visconte V, Takaku T, Wu C, Erie AJ, Sarcon AK, Desierto MJ, Scheinberg P, Keyvanfar K, Nunez O, Chen J, Young NS.
Blood. 2010 Nov 18;116(20):4175-84.
[Text Abstract on PubMed]

Establishment of an erythroid cell line from primary CD36+ erythroid progenitor cells.
Wong S, Keyvanfar K, Wan Z, Kajigaya S, Young NS, Zhi N.
Exp. Hematol. 2010 Nov;38(11):994-1005.e1-2.
[Text Abstract on PubMed]

Hematopoiesis in 3 dimensions: human and murine bone marrow architecture visualized by confocal microscopy.
Takaku T, Malide D, Chen J, Calado RT, Kajigaya S, Young NS.
Blood. 2010 Oct 14;116(15):e41-55.
[Text Abstract on PubMed]

Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors.
Wan Z, Zhi N, Wong S, Keyvanfar K, Liu D, Raghavachari N, Munson PJ, Su S, Malide D, Kajigaya S, Young NS.
J. Clin. Invest. 2010 Oct;120(10):3530-44.
[Text Abstract on PubMed]

Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.
Scheinberg P, Cooper JN, Sloand EM, Wu CO, Calado RT, Young NS.
JAMA. 2010 Sep 22;304(12):1358-64.
[Text Abstract on PubMed]

Should irradiated blood products be given routinely to all patients with aplastic anaemia undergoing immunosuppressive therapy with antithymocyte globulin (ATG)? A survey from the European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party.
Marsh J, Socie G, Tichelli A, Schrezenmeier H, Hochsmann B, Risitano AM, Fuehrer M, Bekassy AN, Korthof ET, Locasciulli A, Ljungman P, Bacigalupo A, Camitta B, Young NS, Passweg J, European Group for Blood and Marrow Transplantation (EBMT) Severe Aplastic Anaemia Working Party.
Br. J. Haematol. 2010 Aug;150(3):377-9.
[Text Abstract on PubMed]

Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.
Scheinberg P, Marte M, Nunez O, Young NS.
Haematologica. 2010 Jul;95(7):1075-80.
[Text Abstract on PubMed]

Telomere length is inherited with resetting of the telomere set-point.
Chiang YJ, Calado RT, Hathcock KS, Lansdorp PM, Young NS, Hodes RJ.
Proc. Natl. Acad. Sci. U.S.A. 2010 Jun 1;107(22):10148-53.
[Text Abstract on PubMed]

Neutrophil count in African Americans: lowering the target cutoff to initiate or resume chemotherapy?
Hsieh MM, Tisdale JF, Rodgers GP, Young NS, Trimble EL, Little RF.
J. Clin. Oncol. 2010 Apr 1;28(10):1633-7.
[Text Abstract on PubMed]

Long-term follow-up of patients with moderate aplastic anemia and pure red cell aplasia treated with daclizumab.
Sloand EM, Olnes MJ, Weinstein B, Wu C, Maciejewski J, Scheinberg P, Young NS.
Haematologica. 2010 Mar;95(3):382-7.
[Text Abstract on PubMed]

Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells.
Visconte V, Raghavachari N, Liu D, Keyvanfar K, Desierto MJ, Chen J, Young NS.
Haematologica. 2010 Feb;95(2):214-23.
[Text Abstract on PubMed]

The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure.
Tang Y, Desierto MJ, Chen J, Young NS.
Blood. 2010 Jan 21;115(3):541-8.
[Text Abstract on PubMed]

Aplastic anemia: pathophysiology and treatment.
Young NS, Bacigalupo A, Marsh JC.
Biol. Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S119-25.
[Text Abstract on PubMed]

Telomere biology and telomere diseases: implications for practice and research.
Young NS.
Hematology Am Soc Hematol Educ Program. 2010;2010:30-5.
[Text Abstract on PubMed]

Telomere diseases.
Calado RT, Young NS.
N. Engl. J. Med. 2009 Dec 10;361(24):2353-65.
[Text Abstract on PubMed]

Granulocyte transfusions in severe aplastic anemia: an eleven-year experience.
Quillen K, Wong E, Scheinberg P, Young NS, Walsh TJ, Wu CO, Leitman SF.
Haematologica. 2009 Dec;94(12):1661-8.
[Text Abstract on PubMed]

Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations.
Calado RT, Regal JA, Kajigaya S, Young NS.
Eur. J. Clin. Invest. 2009 Nov;39(11):1025-32.
[Text Abstract on PubMed]

Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppression.
Palmore TN, Shah NL, Loomba R, Borg BB, Lopatin U, Feld JJ, Khokhar F, Lutchman G, Kleiner DE, Young NS, Childs R, Barrett AJ, Liang TJ, Hoofnagle JH, Heller T.
Clin. Gastroenterol. Hepatol. 2009 Oct;7(10):1130-7.
[Text Abstract on PubMed]

Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.
Calado RT, Yewdell WT, Wilkerson KL, Regal JA, Kajigaya S, Stratakis CA, Young NS.
Blood. 2009 Sep 10;114(11):2236-43.
[Text Abstract on PubMed]

Dyskeratosis congenita: the first NIH clinical research workshop.
Savage SA, Dokal I, Armanios M, Aubert G, Cowen EW, Domingo DL, Giri N, Greene MH, Orchard PJ, Tolar J, Tsilou E, Van Waes C, Wong JM, Young NS, Alter BP.
Pediatr Blood Cancer. 2009 Sep;53(3):520-3.
[Text Abstract on PubMed]

Interleukin-23 receptor (IL-23R) gene polymorphisms in acquired aplastic anemia.
Takaku T, Calado RT, Kajigaya S, Young NS.
Ann. Hematol. 2009 Jul;88(7):653-7.
[Text Abstract on PubMed]

Infections in patients with aplastic anemia.
Valdez JM, Scheinberg P, Young NS, Walsh TJ.
Semin. Hematol. 2009 Jul;46(3):269-76.
[Text Abstract on PubMed]

Role of perforin-mediated cell apoptosis in murine models of infusion-induced bone marrow failure.
Sarcon AK, Desierto MJ, Zhou W, Visconte V, Gibellini F, Chen J, Young NS.
Exp. Hematol. 2009 Apr;37(4):477-86.
[Text Abstract on PubMed]

Lymphocytes with aberrant expression of Fas or Fas ligand attenuate immune bone marrow failure in a mouse model.
Omokaro SO, Desierto MJ, Eckhaus MA, Ellison FM, Chen J, Young NS.
J. Immunol. 2009 Mar 15;182(6):3414-22.
[Text Abstract on PubMed]

Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study.
Scheinberg P, Wu CO, Nunez O, Scheinberg P, Boss C, Sloand EM, Young NS.
Haematologica. 2009 Mar;94(3):348-54.
[Text Abstract on PubMed]

Expansion of haematopoietic stem cells from normal donors and bone marrow failure patients by recombinant hoxb4.
Tang Y, Chen J, Young NS.
Br. J. Haematol. 2009 Feb;144(4):603-12.
[Text Abstract on PubMed]

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia.
Calado RT, Regal JA, Hills M, Yewdell WT, Dalmazzo LF, Zago MA, Lansdorp PM, Hogge D, Chanock SJ, Estey EH, Falcão RP, Young NS.
Proc. Natl. Acad. Sci. U.S.A. 2009 Jan 27;106(4):1187-92.
[Text Abstract on PubMed]

Paroxysmal nocturnal hemoglobinuria and myelodysplastic syndromes: clonal expansion of PIG-A-mutant hematopoietic cells in bone marrow failure.
Young NS.
Haematologica. 2009 Jan;94(1):3-7.
[Text Abstract on PubMed]

Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia.
Scheinberg P, Wu CO, Nunez O, Young NS.
Br. J. Haematol. 2009 Jan;144(2):206-16.
[Text Abstract on PubMed]

The management of paroxysmal nocturnal hemoglobinuria: recent advances in diagnosis and treatment and new hope for patients.
Young NS, Meyers G, Schrezenmeier H, Hillmen P, Hill A.
Semin. Hematol. 2009 Jan;46(1 Suppl 1):S1-S16.
[Text Abstract on PubMed]

A spectrum of severe familial liver disorders associate with telomerase mutations.
Calado RT, Regal JA, Kleiner DE, Schrump DS, Peterson NR, Pons V, Chanock SJ, Lansdorp PM, Young NS.
PLoS ONE. 2009;4(11):e7926.
[Text Abstract on PubMed]

Long-term outcome of pediatric patients with severe aplastic anemia treated with antithymocyte globulin and cyclosporine.
Scheinberg P, Wu CO, Nunez O, Young NS.
J. Pediatr. 2008 Dec;153(6):814-9.
[Text Abstract on PubMed]

Increased soluble urokinase plasminogen activator receptor (suPAR) is associated with thrombosis and inhibition of plasmin generation in paroxysmal nocturnal hemoglobinuria (PNH) patients.
Sloand EM, Pfannes L, Scheinberg P, More K, Wu CO, Horne M, Young NS.
Exp. Hematol. 2008 Dec;36(12):1616-24.
[Text Abstract on PubMed]

Why current publication practices may distort science.
Young NS, Ioannidis JP, Al-Ubaydli O.
PLoS Med. 2008 Oct 7;5(10):e201.
[Text Abstract on PubMed]

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice.
Chen J, Ellison FM, Keyvanfar K, Omokaro SO, Desierto MJ, Eckhaus MA, Young NS.
Exp. Hematol. 2008 Oct;36(10):1236-43.
[Text Abstract on PubMed]

Human B19 erythrovirus in vitro replication: what's new?
Pillet S, Fichelson S, Morinet F, Young NS, Zhi N, Wong S.
J. Virol. 2008 Sep;82(17):8951-3.
[Text Abstract on PubMed]

Eculizumab, a terminal complement inhibitor, improves anaemia in patients with paroxysmal nocturnal haemoglobinuria.
Schubert J, Hillmen P, Röth A, Young NS, Elebute MO, Szer J, Gianfaldoni G, Socié G, Browne P, Geller R, Rother RP, Muus P, TRIUMPH Study Investigators.
Br. J. Haematol. 2008 Jun;142(2):263-72.
[Text Abstract on PubMed]

VP1u phospholipase activity is critical for infectivity of full-length parvovirus B19 genomic clones.
Filippone C, Zhi N, Wong S, Lu J, Kajigaya S, Gallinella G, Kakkola L, Söderlund-Venermo M, Young NS, Brown KE.
Virology. 2008 May 10;374(2):444-52.
[Text Abstract on PubMed]

Telomere maintenance and human bone marrow failure.
Calado RT, Young NS.
Blood. 2008 May 1;111(9):4446-55.
[Text Abstract on PubMed]

Aplastic anemia.
Young NS, Scheinberg P, Calado RT.
Curr. Opin. Hematol. 2008 May;15(3):162-8.
[Text Abstract on PubMed]

Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro.
Feng X, Kajigaya S, Solomou EE, Keyvanfar K, Xu X, Raghavachari N, Munson PJ, Herndon TM, Chen J, Young NS.
Blood. 2008 Apr 1;111(7):3675-83.
[Text Abstract on PubMed]

The epidemiology of acquired aplastic anemia.
Young NS, Kaufman DW.
Haematologica. 2008 Apr;93(4):489-92.
[Text Abstract on PubMed]

Ex vivo-generated CD36+ erythroid progenitors are highly permissive to human parvovirus B19 replication.
Wong S, Zhi N, Filippone C, Keyvanfar K, Kajigaya S, Brown KE, Young NS.
J. Virol. 2008 Mar;82(5):2470-6.
[Text Abstract on PubMed]

Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria.
Brodsky RA, Young NS, Antonioli E, Risitano AM, Schrezenmeier H, Schubert J, Gaya A, Coyle L, de Castro C, Fu CL, Maciejewski JP, Bessler M, Kroon HA, Rother RP, Hillmen P.
Blood. 2008 Feb 15;111(4):1840-7.
[Text Abstract on PubMed]

Patient-specific transfusion-related acute lung injury.
Muniz M, Sheldon S, Schuller RM, Young NS, Klein HG, Leitman SF, Stroncek DF.
Vox Sang. 2008 Jan;94(1):70-3.
[Text Abstract on PubMed]

Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size.
Baerlocher GM, Sloand EM, Young NS, Lansdorp PM.
Exp. Hematol. 2007 Dec;35(12):1777-81.
[Text Abstract on PubMed]

Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria.
Hillmen P, Muus P, Dührsen U, Risitano AM, Schubert J, Luzzatto L, Schrezenmeier H, Szer J, Brodsky RA, Hill A, Socié G, Bessler M, Rollins SA, Bell L, Rother RP, Young NS.
Blood. 2007 Dec 1;110(12):4123-8.
[Text Abstract on PubMed]

Multiple antigenic peptides as vaccine platform for the induction of humoral responses against dengue-2 virus.
Amexis G, Young NS.
Viral Immunol. 2007 Dec;20(4):657-63.
[Text Abstract on PubMed]

Mitochondrial DNA sequence heterogeneity of single CD34+ cells after nonmyeloablative allogeneic stem cell transplantation.
Yao YG, Childs RW, Kajigaya S, McCoy, Young NS.
Stem Cells. 2007 Oct;25(10):2670-6.
[Text Abstract on PubMed]

Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia.
Solomou EE, Rezvani K, Mielke S, Malide D, Keyvanfar K, Visconte V, Kajigaya S, Barrett AJ, Young NS.
Blood. 2007 Sep 1;110(5):1603-6.
[Text Abstract on PubMed]

Mutations in the SBDS gene in acquired aplastic anemia.
Calado RT, Graf SA, Wilkerson KL, Kajigaya S, Ancliff PJ, Dror Y, Chanock SJ, Lansdorp PM, Young NS.
Blood. 2007 Aug 15;110(4):1141-6.
[Text Abstract on PubMed]

Cytokine gene polymorphisms in acquired bone marrow failure.
Gidvani V, Ramkissoon S, Sloand EM, Young NS.
Am. J. Hematol. 2007 Aug;82(8):721-4.
[Text Abstract on PubMed]

Mobilization, collection, and immunomagnetic selection of peripheral blood CD34 cells in recovered aplastic anemia patients.
Sloand EM, Read EJ, Scheinberg P, Tang Y, More K, Leitman SF, Maciejewski J, Young NS.
Transfusion. 2007 Jul;47(7):1250-3.
[Text Abstract on PubMed]

Decreased TCR zeta-chain expression in T cells from patients with acquired aplastic anaemia.
Solomou EE, Wong S, Visconte V, Gibellini F, Young NS.
Br. J. Haematol. 2007 Jul;138(1):72-6.
[Text Abstract on PubMed]

Perforin gene mutations in patients with acquired aplastic anemia.
Solomou EE, Gibellini F, Stewart B, Malide D, Berg M, Visconte V, Green S, Childs R, Chanock SJ, Young NS.
Blood. 2007 Jun 15;109(12):5234-7.
[Text Abstract on PubMed]

RMRP mutations in hematological disorders.
Graf SA, Calado RT, Kajigaya S, Young NS.
Clin. Genet. 2007 May;71(5):468-70.
[Text Abstract on PubMed]

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia.
Scheinberg P, Fischer SH, Li L, Nunez O, Wu CO, Sloand EM, Cohen JI, Young NS, John Barrett A.
Blood. 2007 Apr 15;109(8):3219-24.
[Text Abstract on PubMed]

PTPN22 620W allele is not associated with aplastic anemia.
Graf SA, Calado RT, Young NS.
Am. J. Hematol. 2007 Apr;82(4):291-2.
[Text Abstract on PubMed]

Minor antigen h60-mediated aplastic anemia is ameliorated by immunosuppression and the infusion of regulatory T cells.
Chen J, Ellison FM, Eckhaus MA, Smith AL, Keyvanfar K, Calado RT, Young NS.
J. Immunol. 2007 Apr 1;178(7):4159-68.
[Text Abstract on PubMed]

CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins.
Sloand EM, Pfannes L, Chen G, Shah S, Solomou EE, Barrett J, Young NS.
Blood. 2007 Mar 15;109(6):2399-405.
[Text Abstract on PubMed]

Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background.
Yao YG, Ellison FM, McCoy JP, Chen J, Young NS.
Hum. Mol. Genet. 2007 Feb 1;16(3):286-94.
[Text Abstract on PubMed]

Mitochondrial DNA sequence variation in single cells from leukemia patients.
Yao YG, Ogasawara Y, Kajigaya S, Molldrem JJ, Falcão RP, Pintão MC, McCoy, Rizzatti EG, Young NS.
Blood. 2007 Jan 15;109(2):756-62.
[Text Abstract on PubMed]

Functional characterization of natural telomerase mutations found in patients with hematologic disorders.
Xin ZT, Beauchamp AD, Calado RT, Bradford JW, Regal JA, Shenoy A, Liang Y, Lansdorp PM, Young NS, Ly H.
Blood. 2007 Jan 15;109(2):524-32.
[Text Abstract on PubMed]

External contamination in single cell mtDNA analysis.
Yao YG, Bandelt HJ, Young NS.
PLoS ONE. 2007;2(8):e681.
[Text Abstract on PubMed]

Hematologic manifestations and diagnosis of parvovirus B19 infections.
Young NS.
Clin Adv Hematol Oncol. 2006 Dec;4(12):908-10.
[Text Abstract on PubMed]

Current concepts in the pathophysiology and treatment of aplastic anemia.
Young NS, Calado RT, Scheinberg P.
Blood. 2006 Oct 15;108(8):2509-19.
[Text Abstract on PubMed]

Brief report: no evidence for parvovirus B19 or hepatitis E virus as a cause of acute liver failure.
Lee WM, Brown KE, Young NS, Dawson GJ, Schlauder GG, Gutierrez RA, Fontana R, Rossaro L, Davern T, Lalani E, Acute Liver Failure Study Group.
Dig. Dis. Sci. 2006 Oct;51(10):1712-5.
[Text Abstract on PubMed]

Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor.
Sloand EM, Yong AS, Ramkissoon S, Solomou E, Bruno TC, Kim S, Fuhrer M, Kajigaya S, Barrett AJ, Young NS.
Proc. Natl. Acad. Sci. U.S.A. 2006 Sep 26;103(39):14483-8.
[Text Abstract on PubMed]

The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.
Hillmen P, Young NS, Schubert J, Brodsky RA, Socié G, Muus P, Röth A, Szer J, Elebute MO, Nakamura R, Browne P, Risitano AM, Hill A, Schrezenmeier H, Fu CL, Maciejewski J, Rollins SA, Mojcik CF, Rother RP, Luzzatto L.
N. Engl. J. Med. 2006 Sep 21;355(12):1233-43.
[Text Abstract on PubMed]

Parvovirus B19 empty capsids as antigen carriers for presentation of antigenic determinants of dengue 2 virus.
Amexis G, Young NS.
J. Infect. Dis. 2006 Sep 15;194(6):790-4.
[Text Abstract on PubMed]

Treatment of severe aplastic anaemia with combined immunosuppression: anti-thymocyte globulin, ciclosporin and mycophenolate mofetil.
Scheinberg P, Nunez O, Wu C, Young NS.
Br. J. Haematol. 2006 Jun;133(6):606-11.
[Text Abstract on PubMed]

Retreatment with rabbit anti-thymocyte globulin and ciclosporin for patients with relapsed or refractory severe aplastic anaemia.
Scheinberg P, Nunez O, Young NS.
Br. J. Haematol. 2006 Jun;133(6):622-7.
[Text Abstract on PubMed]

T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia.
Solomou EE, Keyvanfar K, Young NS.
Blood. 2006 May 15;107(10):3983-91.
[Text Abstract on PubMed]

Hematopoietic-specific microRNA expression in human cells.
Ramkissoon SH, Mainwaring LA, Ogasawara Y, Keyvanfar K, McCoy, Sloand EM, Kajigaya S, Young NS.
Leuk. Res. 2006 May;30(5):643-7.
[Text Abstract on PubMed]

Overcoming graft rejection in heavily transfused and allo-immunised patients with bone marrow failure syndromes using fludarabine-based haematopoietic cell transplantation.
Srinivasan R, Takahashi Y, McCoy JP, Espinoza-Delgado I, Dorrance C, Igarashi T, Lundqvist A, Barrett AJ, Young NS, Geller N, Childs RW.
Br. J. Haematol. 2006 May;133(3):305-14.
[Text Abstract on PubMed]

Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemia.
Savage SA, Calado RT, Xin ZT, Ly H, Young NS, Chanock SJ.
Exp. Hematol. 2006 May;34(5):664-71.
[Text Abstract on PubMed]

Recombinant viral-like particles of parvovirus B19 as antigen carriers of anthrax protective antigen.
Ogasawara Y, Amexis G, Yamaguchi H, Kajigaya S, Leppla SH, Young NS.
In Vivo. 2006 May-Jun;20(3):319-24.
[Text Abstract on PubMed]

The epidemiology of aplastic anemia in Thailand.
Issaragrisil S, Kaufman DW, Anderson T, Chansung K, Leaverton PE, Shapiro S, Young NS.
Blood. 2006 Feb 15;107(4):1299-307.
[Text Abstract on PubMed]

Brief communication: Successful treatment of pure red-cell aplasia with an anti-interleukin-2 receptor antibody (daclizumab).
Sloand EM, Scheinberg P, Maciejewski J, Young NS.
Ann. Intern. Med. 2006 Feb 7;144(3):181-5.
[Text Abstract on PubMed]

Nonisotopic detection of microRNA using digoxigenin labeled RNA probes.
Ramkissoon SH, Mainwaring LA, Sloand EM, Young NS, Kajigaya S.
Mol. Cell. Probes. 2006 Feb;20(1):1-4.
[Text Abstract on PubMed]

Interferon-gamma-induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles.
Zeng W, Miyazato A, Chen G, Kajigaya S, Young NS, Maciejewski JP.
Blood. 2006 Jan 1;107(1):167-75.
[Text Abstract on PubMed]

Relative incidence of agranulocytosis and aplastic anemia.
Kaufman DW, Kelly JP, Issaragrisil S, Laporte JR, Anderson T, Levy M, Shapiro S, Young NS.
Am. J. Hematol. 2006 Jan;81(1):65-7.
[Text Abstract on PubMed]

Pathophysiologic mechanisms in acquired aplastic anemia.
Young NS.
Hematology Am Soc Hematol Educ Program. 2006:72-7.
[Text Abstract on PubMed]

Mitochondrial DNA spectra of single human CD34+ cells, T cells, B cells, and granulocytes.
Ogasawara Y, Nakayama K, Tarnowka M, McCoy, Kajigaya S, Levin BC, Young NS.
Blood. 2005 Nov 1;106(9):3271-84.
[Text Abstract on PubMed]

Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome.
Sloand EM, Mainwaring L, Fuhrer M, Ramkissoon S, Risitano AM, Keyvanafar K, Lu J, Basu A, Barrett AJ, Young NS.
Blood. 2005 Aug 1;106(3):841-51.
[Text Abstract on PubMed]

Defective stromal cell function in a mouse model of infusion-induced bone marrow failure.
Chen J, Brandt JS, Ellison FM, Calado RT, Young NS.
Exp. Hematol. 2005 Aug;33(8):901-8.
[Text Abstract on PubMed]

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.
Yamaguchi H, Calado RT, Ly H, Kajigaya S, Baerlocher GM, Chanock SJ, Lansdorp PM, Young NS.
N. Engl. J. Med. 2005 Apr 7;352(14):1413-24.
[Text Abstract on PubMed]

Functional characterization of telomerase RNA variants found in patients with hematologic disorders.
Ly H, Calado RT, Allard P, Baerlocher GM, Lansdorp PM, Young NS, Parslow TG.
Blood. 2005 Mar 15;105(6):2332-9.
[Text Abstract on PubMed]

Paroxysmal nocturnal hemoglobinuria: current issues in pathophysiology and treatment.
Young NS.
Curr. Hematol. Rep. 2005 Mar;4(2):103-9.
[Text Abstract on PubMed]

Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities.
Chen G, Zeng W, Miyazato A, Billings E, Maciejewski JP, Kajigaya S, Sloand EM, Young NS.
Blood. 2004 Dec 15;104(13):4210-8.
[Text Abstract on PubMed]

Transfer of glycosylphosphatidylinositol-anchored proteins to deficient cells after erythrocyte transfusion in paroxysmal nocturnal hemoglobinuria.
Sloand EM, Mainwaring L, Keyvanfar K, Chen J, Maciejewski J, Klein HG, Young NS.
Blood. 2004 Dec 1;104(12):3782-8.
[Text Abstract on PubMed]

A mouse model of lymphocyte infusion-induced bone marrow failure.
Bloom ML, Wolk AG, Simon-Stoos KL, Bard JS, Chen J, Young NS.
Exp. Hematol. 2004 Dec;32(12):1163-72.
[Text Abstract on PubMed]

Bystander destruction of hematopoietic progenitor and stem cells in a mouse model of infusion-induced bone marrow failure.
Chen J, Lipovsky K, Ellison FM, Calado RT, Young NS.
Blood. 2004 Sep 15;104(6):1671-8.
[Text Abstract on PubMed]

Transcript profile of CD4+ and CD8+ T cells from the bone marrow of acquired aplastic anemia patients.
Zeng W, Kajigaya S, Chen G, Risitano AM, Nunez O, Young NS.
Exp. Hematol. 2004 Sep;32(9):806-14.
[Text Abstract on PubMed]

Centrosome amplification and aneuploidy in bone marrow failure patients.
Kearns WG, Yamaguchi H, Young NS, Liu JM.
Genes Chromosomes Cancer. 2004 Aug;40(4):329-33.
[Text Abstract on PubMed]

Genomic instability in bone marrow failure syndromes.
Kearns WG, Sutton JF, Maciejewski JP, Young NS, Liu JM.
Am. J. Hematol. 2004 Jul;76(3):220-4.
[Text Abstract on PubMed]

In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing.
Risitano AM, Maciejewski JP, Green S, Plasilova M, Zeng W, Young NS.
Lancet. 2004 Jul 24-30;364(9431):355-64.
[Text Abstract on PubMed]

Analysis of T-cell repertoire in hepatitis-associated aplastic anemia.
Lu J, Basu A, Melenhorst JJ, Young NS, Brown KE.
Blood. 2004 Jun 15;103(12):4588-93.
[Text Abstract on PubMed]

Mitochondrial DNA sequence heterogeneity in circulating normal human CD34 cells and granulocytes.
Shin MG, Kajigaya S, Tarnowka M, McCoy, Levin BC, Young NS.
Blood. 2004 Jun 15;103(12):4466-77.
[Text Abstract on PubMed]

Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria.
Simak J, Holada K, Risitano AM, Zivny JH, Young NS, Vostal JG.
Br. J. Haematol. 2004 Jun;125(6):804-13.
[Text Abstract on PubMed]

Frequent HPRT mutations in paroxysmal nocturnal haemoglobinuria reflect T cell clonal expansion, not genomic instability.
Chen G, Zeng W, Green S, Young NS.
Br. J. Haematol. 2004 May;125(3):383-91.
[Text Abstract on PubMed]

In vitro and in vivo evidence of PNH cell sensitivity to immune attack after nonmyeloablative allogeneic hematopoietic cell transplantation.
Takahashi Y, McCoy, Carvallo C, Rivera C, Igarashi T, Srinivasan R, Young NS, Childs RW.
Blood. 2004 Feb 15;103(4):1383-90.
[Text Abstract on PubMed]

Parvovirus B19.
Young NS, Brown KE.
N. Engl. J. Med. 2004 Feb 5;350(6):586-97.
[Text Abstract on PubMed]

Increased risk for aplastic anemia and myelodysplastic syndrome in individuals lacking glutathione S-transferase genes.
Sutton JF, Stacey M, Kearns WG, Rieg TS, Young NS, Liu JM.
Pediatr Blood Cancer. 2004 Feb;42(2):122-6.
[Text Abstract on PubMed]

Marked mitochondrial DNA sequence heterogeneity in single CD34+ cell clones from normal adult bone marrow.
Shin MG, Kajigaya S, McCoy, Levin BC, Young NS.
Blood. 2004 Jan 15;103(2):553-61.
[Text Abstract on PubMed]

Gene expression profiling in CD34 cells to identify differences between aplastic anemia patients and healthy volunteers.
Zeng W, Chen G, Kajigaya S, Nunez O, Charrow A, Billings EM, Young NS.
Blood. 2004 Jan 1;103(1):325-32.
[Text Abstract on PubMed]

Is there a direct effect of antithymocyte globulin on hematopoiesis?
Chen G, Kook H, Zeng W, Young NS, Maciejewski JP.
Hematol. J. 2004;5(3):255-61.
[Text Abstract on PubMed]

Recombinant humanized anti-IL-2 receptor antibody (daclizumab) produces responses in patients with moderate aplastic anemia.
Maciejewski JP, Sloand EM, Nunez O, Boss C, Young NS.
Blood. 2003 Nov 15;102(10):3584-6.
[Text Abstract on PubMed]

Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis.
Umemura T, Tanaka E, Ostapowicz G, Brown KE, Heringlake S, Tassopoulos NC, Wang RY, Yeo AE, Shih JW, Orii K, Young NS, Hatzakis A, Manns MP, Lee WM, Kiyosawa K, Alter HJ.
J. Infect. Dis. 2003 Nov 15;188(10):1545-52.
[Text Abstract on PubMed]

Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA.
Fogarty PF, Yamaguchi H, Wiestner A, Baerlocher GM, Sloand E, Zeng WS, Read EJ, Lansdorp PM, Young NS.
Lancet. 2003 Nov 15;362(9396):1628-30.
[Text Abstract on PubMed]

The graft-versus-leukemia effect of nonmyeloablative stem cell allografts may not be sufficient to cure chronic myelogenous leukemia.
Sloand E, Childs RW, Solomon S, Greene A, Young NS, Barrett AJ.
Bone Marrow Transplant. 2003 Nov;32(9):897-901.
[Text Abstract on PubMed]

HLA-DR4 predicts haematological response to cyclosporine in T-large granular lymphocyte lymphoproliferative disorders.
Battiwalla M, Melenhorst J, Saunthararajah Y, Nakamura R, Molldrem J, Young NS, Barrett AJ.
Br. J. Haematol. 2003 Nov;123(3):449-53.
[Text Abstract on PubMed]

Cytogenetic abnormalities in paroxysmal nocturnal haemoglobinuria usually occur in haematopoietic cells that are glycosylphosphatidylinositol-anchored protein (GPI-AP) positive.
Sloand EM, Fuhrer M, Keyvanfar K, Mainwaring L, Maciejewski J, Wang Y, Johnson S, Barrett AJ, Young NS.
Br. J. Haematol. 2003 Oct;123(1):173-6.
[Text Abstract on PubMed]

Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome.
Yamaguchi H, Baerlocher GM, Lansdorp PM, Chanock SJ, Nunez O, Sloand E, Young NS.
Blood. 2003 Aug 1;102(3):916-8.
[Text Abstract on PubMed]

Prevalence of parvovirus B19 in liver tissue: no association with fulminant hepatitis or hepatitis-associated aplastic anemia.
Wong S, Young NS, Brown KE.
J. Infect. Dis. 2003 May 15;187(10):1581-6.
[Text Abstract on PubMed]

Cyclosporine is required to prevent severe acute GVHD following T-cell-depleted peripheral blood stem cell transplantation.
Solomon SR, Nakamura R, Read EJ, Leitman SF, Carter C, Childs R, Dunbar CE, Young NS, Barrett AJ.
Bone Marrow Transplant. 2003 May;31(9):783-8.
[Text Abstract on PubMed]

Genetic and transcriptional analysis of spindle checkpoint genes in bone marrow failure patients.
Yamaguchi H, Aridgides LJ, Zeng W, Osgood C, Young NS, Liu JM.
Blood Cells Mol. Dis. 2003 May-Jun;30(3):307-11.
[Text Abstract on PubMed]

Mitochondrial DNA mutations in patients with myelodysplastic syndromes.
Shin MG, Kajigaya S, Levin BC, Young NS.
Blood. 2003 Apr 15;101(8):3118-25.
[Text Abstract on PubMed]

Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome.
Rosenfeld S, Follmann D, Nunez O, Young NS.
JAMA. 2003 Mar 5;289(9):1130-5.
[Text Abstract on PubMed]

Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1.
Ballou WR, Reed JL, Noble W, Young NS, Koenig S.
J. Infect. Dis. 2003 Feb 15;187(4):675-8.
[Text Abstract on PubMed]

CD34+ cells from paroxysmal nocturnal hemoglobinuria (PNH) patients are deficient in surface expression of cellular prion protein (PrPc).
Risitano AM, Holada K, Chen G, Simak J, Vostal JG, Young NS, Maciejewski JP.
Exp. Hematol. 2003 Jan;31(1):65-72.
[Text Abstract on PubMed]

Late complications following treatment for severe aplastic anemia (SAA) with high-dose cyclophosphamide (Cy): follow-up of a randomized trial.
Tisdale JF, Maciejewski JP, Nuñez O, Rosenfeld SJ, Young NS.
Blood. 2002 Dec 15;100(13):4668-70.
[Text Abstract on PubMed]

Fas-mediated apoptosis is important in regulating cell replication and death in trisomy 8 hematopoietic cells but not in cells with other cytogenetic abnormalities.
Sloand EM, Kim S, Fuhrer M, Risitano AM, Nakamura R, Maciejewski JP, Barrett AJ, Young NS.
Blood. 2002 Dec 15;100(13):4427-32.
[Text Abstract on PubMed]

Selective reduction of natural killer T cells in the bone marrow of aplastic anaemia.
Zeng W, Maciejewski JP, Chen G, Risitano AM, Kirby M, Kajigaya S, Young NS.
Br. J. Haematol. 2002 Dec;119(3):803-9.
[Text Abstract on PubMed]

High-dose cyclophosphamide for treatment of aplastic anemia.
Young NS, Tisdale JF.
Ann. Intern. Med. 2002 Sep 17;137(6):549-50; author reply 549-50.
[Text Abstract on PubMed]

HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome.
Saunthararajah Y, Nakamura R, Nam JM, Robyn J, Loberiza F, Maciejewski JP, Simonis T, Molldrem J, Young NS, Barrett AJ.
Blood. 2002 Sep 1;100(5):1570-4.
[Text Abstract on PubMed]

Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia.
Sloand E, Kim S, Maciejewski JP, Tisdale J, Follmann D, Young NS.
Blood. 2002 Aug 15;100(4):1185-91.
[Text Abstract on PubMed]

Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes.
Molldrem JJ, Leifer E, Bahceci E, Saunthararajah Y, Rivera M, Dunbar C, Liu J, Nakamura R, Young NS, Barrett AJ.
Ann. Intern. Med. 2002 Aug 6;137(3):156-63.
[Text Abstract on PubMed]

Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro.
Nagakura S, Ishihara S, Dunn DE, Nishimura J, Kawaguchi T, Horikawa K, Hidaka M, Kagimoto T, Eto N, Mitsuya H, Kinoshita T, Young NS, Nakakuma H.
Blood. 2002 Aug 1;100(3):1031-7.
[Text Abstract on PubMed]

Immune pathophysiology of aplastic anemia.
Maciejewski JP, Risitano A, Kook H, Zeng W, Chen G, Young NS.
Int. J. Hematol. 2002 Aug;76 Suppl 1:207-14.
[Text Abstract on PubMed]

The relationship of aplastic anemia and PNH.
Young NS, Maciejewski JP, Sloand E, Chen G, Zeng W, Risitano A, Miyazato A.
Int. J. Hematol. 2002 Aug;76 Suppl 2:168-72.
[Text Abstract on PubMed]

Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry.
Risitano AM, Kook H, Zeng W, Chen G, Young NS, Maciejewski JP.
Blood. 2002 Jul 1;100(1):178-83.
[Text Abstract on PubMed]

Activated platelets of patients with paroxysmal nocturnal hemoglobinuria express cellular prion protein.
Holada K, Simak J, Risitano AM, Maciejewski J, Young NS, Vostal JG.
Blood. 2002 Jul 1;100(1):341-3.
[Text Abstract on PubMed]

Superior growth of glycophosphatidy linositol-anchored protein-deficient progenitor cells in vitro is due to the higher apoptotic rate of progenitors with normal phenotype in vivo.
Chen G, Kirby M, Zeng W, Young NS, Maciejewski JP.
Exp. Hematol. 2002 Jul;30(7):774-82.
[Text Abstract on PubMed]

Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens.
Kook H, Risitano AM, Zeng W, Wlodarski M, Lottemann C, Nakamura R, Barrett J, Young NS, Maciejewski JP.
Blood. 2002 May 15;99(10):3668-75.
[Text Abstract on PubMed]

Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia.
Maciejewski JP, Risitano A, Sloand EM, Nunez O, Young NS.
Blood. 2002 May 1;99(9):3129-35.
[Text Abstract on PubMed]

Acquired aplastic anemia.
Young NS.
Ann. Intern. Med. 2002 Apr 2;136(7):534-46.
[Text Abstract on PubMed]

A pilot study of the recombinant soluble human tumour necrosis factor receptor (p75)-Fc fusion protein in patients with myelodysplastic syndrome.
Maciejewski JP, Risitano AM, Sloand EM, Wisch L, Geller N, Barrett JA, Young NS, Ristiano AM.
Br. J. Haematol. 2002 Apr;117(1):119-26.
[Text Abstract on PubMed]

Immunosuppressive treatment of acquired aplastic anemia and immune-mediated bone marrow failure syndromes.
Young NS.
Int. J. Hematol. 2002 Feb;75(2):129-40.
[Text Abstract on PubMed]

Myelodysplastic syndromes.
Greenberg PL, Young NS, Gattermann N.
Hematology Am Soc Hematol Educ Program. 2002:136-61.
[Text Abstract on PubMed]

Increased frequency of HLA-DR2 in patients with paroxysmal nocturnal hemoglobinuria and the PNH/aplastic anemia syndrome.
Maciejewski JP, Follmann D, Nakamura R, Saunthararajah Y, Rivera CE, Simonis T, Brown KE, Barrett JA, Young NS.
Blood. 2001 Dec 15;98(13):3513-9.
[Text Abstract on PubMed]

Relationship between bone marrow failure syndromes and the presence of glycophosphatidyl inositol-anchored protein-deficient clones.
Maciejewski JP, Rivera C, Kook H, Dunn D, Young NS.
Br. J. Haematol. 2001 Dec;115(4):1015-22.
[Text Abstract on PubMed]

Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia.
Kook H, Zeng W, Guibin C, Kirby M, Young NS, Maciejewski JP.
Exp. Hematol. 2001 Nov;29(11):1270-7.
[Text Abstract on PubMed]

Oral manifestations in patients with aplastic anemia.
Brennan MT, Sankar V, Baccaglini L, Pillemer SR, Kingman A, Nunez O, Young NS, Atkinson JC.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Nov;92(5):503-8.
[Text Abstract on PubMed]

Transplant dose of CD34(+) and CD3(+) cells predicts outcome in patients with haematological malignancies undergoing T cell-depleted peripheral blood stem cell transplants with delayed donor lymphocyte add-back.
Nakamura R, Bahceci E, Read EJ, Leitman SF, Carter CS, Childs R, Dunbar CE, Gress R, Altemus R, Young NS, Barrett AJ.
Br. J. Haematol. 2001 Oct;115(1):95-104.
[Text Abstract on PubMed]

Limited heterogeneity of T cell receptor BV usage in aplastic anemia.
Zeng W, Maciejewski JP, Chen G, Young NS.
J. Clin. Invest. 2001 Sep;108(5):765-73.
[Text Abstract on PubMed]

Telomere length in leukocyte subpopulations of patients with aplastic anemia.
Brümmendorf TH, Maciejewski JP, Mak J, Young NS, Lansdorp PM.
Blood. 2001 Feb 15;97(4):895-900.
[Text Abstract on PubMed]

Parvovirus B19: implications for transfusion medicine. Summary of a workshop.
Brown KE, Young NS, Alving BM, Barbosa LH.
Transfusion. 2001 Jan;41(1):130-5.
[Text Abstract on PubMed]

Coincident myelodysplastic syndrome and T-cell large granular lymphocytic disease: clinical and pathophysiological features.
Saunthararajah Y, Molldrem JL, Rivera M, Williams A, Stetler-Stevenson M, Sorbara L, Young NS, Barrett JA.
Br. J. Haematol. 2001 Jan;112(1):195-200.
[Text Abstract on PubMed]

Sino-orbital-cerebral aspergillosis in immunocompromised pediatric patients.
Robinson MR, Fine HF, Ross ML, Mont EK, Bryant-Greenwood PK, Hertle RW, Tisdale JF, Young NS, Zeichner SL, Van Waes C, Whitcup SM, Walsh TJ.
Pediatr. Infect. Dis. J. 2000 Dec;19(12):1197-203.
[Text Abstract on PubMed]

High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial.
Tisdale JF, Dunn DE, Geller N, Plante M, Nunez O, Dunbar CE, Barrett AJ, Walsh TJ, Rosenfeld SJ, Young NS.
Lancet. 2000 Nov 4;356(9241):1554-9.
[Text Abstract on PubMed]

Sustained long-term hematologic recovery despite a marked quantitative defect in the stem cell compartment of patients with aplastic anemia after immunosuppressive therapy.
Maciejewski JP, Kim S, Sloand E, Selleri C, Young NS.
Am. J. Hematol. 2000 Oct;65(2):123-31.
[Text Abstract on PubMed]

Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.
Childs R, Chernoff A, Contentin N, Bahceci E, Schrump D, Leitman S, Read EJ, Tisdale J, Dunbar C, Linehan WM, Young NS, Barrett AJ.
N. Engl. J. Med. 2000 Sep 14;343(11):750-8.
[Text Abstract on PubMed]

Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?".
Young NS, Maciejewski JP.
J. Clin. Invest. 2000 Sep;106(5):637-41.
[Text Abstract on PubMed]

Sequencing and characterization of A-2 plaque virus: A new member of the Picornaviridae family.
Liu Z, Donahue RE, Young NS, Brown KE.
Virology. 2000 Jun 20;272(1):168-76.
[Text Abstract on PubMed]

Pharmacologic doses of granulocyte colony-stimulating factor affect cytokine production by lymphocytes in vitro and in vivo.
Sloand EM, Kim S, Maciejewski JP, Van Rhee F, Chaudhuri A, Barrett J, Young NS.
Blood. 2000 Apr 1;95(7):2269-74.
[Text Abstract on PubMed]

GB virus C/Hepatitis G virus infection is frequent in American children and young adults.
Handa A, Jubran RF, Dickstein B, Boylan A, Luban NL, Young NS, Brown KE.
Clin. Infect. Dis. 2000 Mar;30(3):569-71.
[Text Abstract on PubMed]

Prevalence of the newly described human circovirus, TTV, in United States blood donors.
Handa A, Dickstein B, Young NS, Brown KE.
Transfusion. 2000 Feb;40(2):245-51.
[Text Abstract on PubMed]

CD34+ cell dose predicts relapse and survival after T-cell-depleted HLA-identical haematopoietic stem cell transplantation (HSCT) for haematological malignancies.
Bahçeci E, Read EJ, Leitman S, Childs R, Dunbar C, Young NS, Barrett AJ.
Br. J. Haematol. 2000 Feb;108(2):408-14.
[Text Abstract on PubMed]

Clinical and laboratory evidence for a trilineage haematopoietic defect in patients with refractory Diamond-Blackfan anaemia.
Giri N, Kang E, Tisdale JF, Follman D, Rivera M, Schwartz GN, Kim S, Young NS, Rick ME, Dunbar CE.
Br. J. Haematol. 2000 Jan;108(1):167-75.
[Text Abstract on PubMed]

Introduction: acquired aplastic anemia.
Young NS.
Semin. Hematol. 2000 Jan;37(1):2.
[Text Abstract on PubMed]

Hematopoietic cell destruction by immune mechanisms in acquired aplastic anemia.
Young NS.
Semin. Hematol. 2000 Jan;37(1):3-14.
[Text Abstract on PubMed]

Epidemiology and pathology of erythroviruses.
Brown KE, Young NS.
Contrib Microbiol. 2000;4:107-22.
[Text Abstract on PubMed]

New Insights into the Pathophysiology of Acquired Cytopenias.
Young NS, Abkowitz JL, Luzzatto L.
Hematology Am Soc Hematol Educ Program. 2000:18-38.
[Text Abstract on PubMed]

Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses.
Childs R, Clave E, Contentin N, Jayasekera D, Hensel N, Leitman S, Read EJ, Carter C, Bahceci E, Young NS, Barrett AJ.
Blood. 1999 Nov 1;94(9):3234-41.
[Text Abstract on PubMed]

Paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure syndromes.
Dunn DE, Tanawattanacharoen P, Boccuni P, Nagakura S, Green SW, Kirby MR, Kumar MS, Rosenfeld S, Young NS.
Ann. Intern. Med. 1999 Sep 21;131(6):401-8.
[Text Abstract on PubMed]

Engraftment of hematopoietic progenitor cells transduced with the Fanconi anemia group C gene (FANCC).
Liu JM, Kim S, Read EJ, Futaki M, Dokal I, Carter CS, Leitman SF, Pensiero M, Young NS, Walsh CE.
Hum. Gene Ther. 1999 Sep 20;10(14):2337-46.
[Text Abstract on PubMed]

Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo.
Sloand EM, Kumar PN, Kim S, Chaudhuri A, Weichold FF, Young NS.
Blood. 1999 Aug 1;94(3):1021-7.
[Text Abstract on PubMed]

Acquired aplastic anemia.
Young NS.
JAMA. 1999 Jul 21;282(3):271-8.
[Text Abstract on PubMed]

Regional patterns in the incidence of aplastic anemia in Thailand. The Aplastic Anemia Study Group.
Issaragrisil S, Leaverton PE, Chansung K, Thamprasit T, Porapakham Y, Vannasaeng S, Piankijagum A, Kaufman DW, Anderson TE, Shapiro S, Young NS.
Am. J. Hematol. 1999 Jul;61(3):164-8.
[Text Abstract on PubMed]

Expression of interferon-gamma by stromal cells inhibits murine long-term repopulating hematopoietic stem cell activity.
Yu JM, Emmons RV, Hanazono Y, Sellers S, Young NS, Dunbar CE.
Exp. Hematol. 1999 May;27(5):895-903.
[Text Abstract on PubMed]

Research directions in paroxysmal nocturnal hemoglobinuria.
Dunn DE, Ware RE, Parker CJ, Mishoe HO, Young NS.
Immunol. Today. 1999 Apr;20(4):168-71.
[Text Abstract on PubMed]

Agranulocytosis in Bangkok, Thailand: a predominantly drug-induced disease with an unusually low incidence. Aplastic Anemia Study Group.
Shapiro S, Issaragrisil S, Kaufman DW, Anderson T, Chansung K, Thamprasit T, Sirijirachai J, Piankijagum A, Porapakkham Y, Vannasaeng S, Leaverton PE, Young NS.
Am. J. Trop. Med. Hyg. 1999 Apr;60(4):573-7.
[Text Abstract on PubMed]

Quantitative analysis of neutralizing immune responses to human parvovirus B19 using a novel reverse transcriptase-polymerase chain reaction-based assay.
Bostic JR, Brown KE, Young NS, Koenig S.
J. Infect. Dis. 1999 Mar;179(3):619-26.
[Text Abstract on PubMed]

Generation of neutralizing human monoclonal antibodies against parvovirus B19 proteins.
Gigler A, Dorsch S, Hemauer A, Williams C, Kim S, Young NS, Zolla-Pazner S, Wolf H, Gorny MK, Modrow S.
J. Virol. 1999 Mar;73(3):1974-9.
[Text Abstract on PubMed]

Correction of the PNH defect by GPI-anchored protein transfer.
Sloand EM, Maciejewski JP, Dunn D, Moss J, Brewer B, Kirby M, Young NS.
Blood. 1998 Dec 1;92(11):4439-45.
[Text Abstract on PubMed]

Inhibition of interleukin-1beta-converting enzyme in human hematopoietic progenitor cells results in blockade of cytokine-mediated apoptosis and expansion of their proliferative potential.
Sloand EM, Young NS, Sato T, Kim S, Maciejewski JP.
Exp. Hematol. 1998 Oct;26(11):1093-9.
[Text Abstract on PubMed]

Measurement of secondary colony formation after 5 weeks in long-term cultures in patients with myelodysplastic syndrome.
Sato T, Kim S, Selleri C, Young NS, Maciejewski JP.
Leukemia. 1998 Aug;12(8):1187-94.
[Text Abstract on PubMed]

T cell-depleted bone marrow transplantation and delayed T cell add-back to control acute GVHD and conserve a graft-versus-leukemia effect.
Barrett AJ, Mavroudis D, Tisdale J, Molldrem J, Clave E, Dunbar C, Cottler-Fox M, Phang S, Carter C, Okunnieff P, Young NS, Read EJ.
Bone Marrow Transplant. 1998 Mar;21(6):543-51.
[Text Abstract on PubMed]

Neither human immunodeficiency virus-1 (HIV-1) nor HIV-2 infects most-primitive human hematopoietic stem cells as assessed in long-term bone marrow cultures.
Weichold FF, Zella D, Barabitskaja O, Maciejewski JP, Dunn DE, Sloand EM, Young NS.
Blood. 1998 Feb 1;91(3):907-15.
[Text Abstract on PubMed]

The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection.
Sloand EM, Maciejewski JP, Sato T, Bruny J, Kumar P, Kim S, Weichold FF, Young NS.
J. Clin. Invest. 1998 Jan 1;101(1):195-201.
[Text Abstract on PubMed]

Inhibition of interferon regulatory factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3.
Sato T, Selleri C, Young NS, Maciejewski JP.
Blood. 1997 Dec 15;90(12):4749-58.
[Text Abstract on PubMed]

Induction of nitric oxide synthase is involved in the mechanism of Fas-mediated apoptosis in haemopoietic cells.
Selleri C, Sato T, Raiola AM, Rotoli B, Young NS, Maciejewski JP.
Br. J. Haematol. 1997 Dec;99(3):481-9.
[Text Abstract on PubMed]

Antithymocyte globulin for patients with myelodysplastic syndrome.
Molldrem JJ, Caples M, Mavroudis D, Plante M, Young NS, Barrett AJ.
Br. J. Haematol. 1997 Dec;99(3):699-705.
[Text Abstract on PubMed]

Secondary colony formation after long-term bone marrow culture using peripheral blood and bone marrow of HIV-infected patients.
Sloand EM, Young NS, Sato T, Kumar P, Kim S, Weichold FF, Maciejewski JP.
AIDS. 1997 Nov;11(13):1547-53.
[Text Abstract on PubMed]

Retroviral mediated gene transfer of the Fanconi anemia complementation group C gene to hematopoietic progenitors of group C patients.
Liu JM, Young NS, Walsh CE, Cottler-Fox M, Carter C, Dunbar C, Barrett AJ, Emmons R.
Hum. Gene Ther. 1997 Sep 20;8(14):1715-30.
[Text Abstract on PubMed]

Aplastic anemia in rural Thailand: its association with grain farming and agricultural pesticide exposure. Aplastic Anemia Study Group.
Issaragrisil S, Chansung K, Kaufman DW, Sirijirachai J, Thamprasit T, Young NS.
Am J Public Health. 1997 Sep;87(9):1551-4.
[Text Abstract on PubMed]

Clinical relevance of parvovirus B19 as a cause of anemia in patients with human immunodeficiency virus infection.
Abkowitz JL, Brown KE, Wood RW, Kovach NL, Green SW, Young NS.
J. Infect. Dis. 1997 Jul;176(1):269-73.
[Text Abstract on PubMed]

Low drug attributability of aplastic anemia in Thailand. The Aplastic Anemia Study Group.
Issaragrisil S, Kaufman DW, Anderson T, Chansung K, Thamprasit T, Sirijirachai J, Piankijagum A, Porapakkham Y, Vannasaeng S, Leaverton PE, Shapiro S, Young NS.
Blood. 1997 Jun 1;89(11):4034-9.
[Text Abstract on PubMed]

Use of household pesticides and the risk of aplastic anaemia in Thailand. The Aplastic Anemia Study Group.
Kaufman DW, Issaragrisil S, Anderson T, Chansung K, Thamprasit T, Sirijirachai J, Piankijagum A, Porapakkham Y, Vannasaeng S, Leaverton PE, Shapiro S, Young NS.
Int J Epidemiol. 1997 Jun;26(3):643-50.
[Text Abstract on PubMed]

The pathophysiology of acquired aplastic anemia.
Young NS, Maciejewski J.
N. Engl. J. Med. 1997 May 8;336(19):1365-72.
[Text Abstract on PubMed]

Association of seropositivity for hepatitis viruses and aplastic anemia in Thailand.
Issaragrisil S, Kaufman D, Thongput A, Chansung K, Thamprasit T, Piankijagum A, Anderson T, Shapiro S, Leaverton P, Young NS.
Hepatology. 1997 May;25(5):1255-7.
[Text Abstract on PubMed]

Expression and modulation of cellular receptors for interferon-gamma, tumour necrosis factor, and Fas on human bone marrow CD34+ cells.
Sato T, Selleri C, Anderson S, Young NS, Maciejewski JP.
Br. J. Haematol. 1997 May;97(2):356-65.
[Text Abstract on PubMed]

[Hypoproliferative disorders of stem cells].
Rosse WF, Young NS, Góngora-Biachi R.
Rev. Invest. Clin. 1997 May;49 Suppl 1:83-8.
[Text Abstract on PubMed]

Hepatitis-associated aplastic anemia.
Brown KE, Tisdale J, Barrett AJ, Dunbar CE, Young NS.
N. Engl. J. Med. 1997 Apr 10;336(15):1059-64.
[Text Abstract on PubMed]

Paroxysmal nocturnal hemoglobinuria: new insights from murine Pig-a-deficient hematopoiesis.
Devetten MP, Liu JM, Ling V, Weichold FF, Yu J, Medof ME, Young NS, Dunn DE.
Proc. Assoc. Am. Physicians. 1997 Mar;109(2):99-110.
[Text Abstract on PubMed]

Impaired hematopoiesis in paroxysmal nocturnal hemoglobinuria/aplastic anemia is not associated with a selective proliferative defect in the glycosylphosphatidylinositol-anchored protein-deficient clone.
Maciejewski JP, Sloand EM, Sato T, Anderson S, Young NS.
Blood. 1997 Feb 15;89(4):1173-81.
[Text Abstract on PubMed]

Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication.
Sloand EM, Young NS, Kumar P, Weichold FF, Sato T, Maciejewski JP.
Blood. 1997 Feb 15;89(4):1357-63.
[Text Abstract on PubMed]

Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia.
Selleri C, Sato T, Del Vecchio L, Luciano L, Barrett AJ, Rotoli B, Young NS, Maciejewski JP.
Blood. 1997 Feb 1;89(3):957-64.
[Text Abstract on PubMed]

High prevalence of GB virus C/hepatitis G virus in healthy persons in Ho Chi Minh City, Vietnam.
Brown KE, Wong S, Buu M, Binh TV, Be TV, Young NS.
J. Infect. Dis. 1997 Feb;175(2):450-3.
[Text Abstract on PubMed]

Autoimmunity and its treatment in aplastic anemia.
Young NS.
Ann. Intern. Med. 1997 Jan 15;126(2):166-8.
[Text Abstract on PubMed]

Parvovirus B19 in human disease.
Brown KE, Young NS.
Annu. Rev. Med. 1997;48:59-67.
[Text Abstract on PubMed]

A new syndrome of familial aplastic anemia and chronic liver disease.
Qazilbash MH, Liu JM, Vlachos A, Fruchtman S, Messner H, Zipursky A, Alter BP, Young NS.
Acta Haematol. 1997;97(3):164-7.
[Text Abstract on PubMed]

Human parvovirus B19 infections in infants and children.
Brown KE, Young NS.
Adv Pediatr Infect Dis. 1997;13:101-26.
[Text Abstract on PubMed]

Gene marking and gene therapy directed at primary hematopoietic cells.
Dunbar CE, Young NS.
Curr. Opin. Hematol. 1996 Nov;3(6):430-7.
[Text Abstract on PubMed]

A severe and consistent deficit in marrow and circulating primitive hematopoietic cells (long-term culture-initiating cells) in acquired aplastic anemia.
Maciejewski JP, Selleri C, Sato T, Anderson S, Young NS.
Blood. 1996 Sep 15;88(6):1983-91.
[Text Abstract on PubMed]

Analysis of the expression of glycosylphosphatidylinositol anchored proteins on platelets from patients with paroxysmal nocturnal hemoglobinuria.
Maciejewski JP, Young NS, Yu M, Anderson SM, Sloand EM.
Thromb. Res. 1996 Sep 15;83(6):433-47.
[Text Abstract on PubMed]

Cryo-electron microscopy studies of empty capsids of human parvovirus B19 complexed with its cellular receptor.
Chipman PR, Agbandje-McKenna M, Kajigaya S, Brown KE, Young NS, Baker TS, Rossmann MG.
Proc. Natl. Acad. Sci. U.S.A. 1996 Jul 23;93(15):7502-6.
[Text Abstract on PubMed]

A knock-out model of paroxysmal nocturnal hemoglobinuria: Pig-a(-) hematopoiesis is reconstituted following intercellular transfer of GPI-anchored proteins.
Dunn DE, Yu J, Nagarajan S, Devetten M, Weichold FF, Medof ME, Young NS, Liu JM.
Proc. Natl. Acad. Sci. U.S.A. 1996 Jul 23;93(15):7938-43.
[Text Abstract on PubMed]

Nucleotide sequencing and generation of an infectious clone of adeno-associated virus 3.
Muramatsu S, Mizukami H, Young NS, Brown KE.
Virology. 1996 Jul 1;221(1):208-17.
[Text Abstract on PubMed]

Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction.
Emmons RV, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR.
Blood. 1996 May 15;87(10):4068-71.
[Text Abstract on PubMed]

Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition.
Selleri C, Maciejewski JP, Sato T, Young NS.
Blood. 1996 May 15;87(10):4149-57.
[Text Abstract on PubMed]

Parvovirus infection and its treatment.
Young NS.
Clin. Exp. Immunol. 1996 May;104 Suppl 1:26-30.
[Text Abstract on PubMed]

Adeno-associated virus type 2 binds to a 150-kilodalton cell membrane glycoprotein.
Mizukami H, Young NS, Brown KE.
Virology. 1996 Mar 1;217(1):124-30.
[Text Abstract on PubMed]

Parvoviruses and bone marrow failure.
Brown KE, Young NS.
Stem Cells. 1996 Mar;14(2):151-63.
[Text Abstract on PubMed]

Drug-related blood dyscrasias. Introduction.
Young NS.
Eur J Haematol Suppl. 1996;60:6-8.
[Text Abstract on PubMed]

Drugs in the aetiology of agranulocytosis and aplastic anaemia.
Kaufman DW, Kelly JP, Jurgelon JM, Anderson T, Issaragrisil S, Wiholm BE, Young NS, Leaverton P, Levy M, Shapiro S.
Eur J Haematol Suppl. 1996;60:23-30.
[Text Abstract on PubMed]

Immune pathophysiology of acquired aplastic anaemia.
Young NS.
Eur J Haematol Suppl. 1996;60:55-9.
[Text Abstract on PubMed]

Genetic defects underlying paroxysmal nocturnal hemoglobinuria that arises out of aplastic anemia.
Nagarajan S, Brodsky RA, Young NS, Medof ME.
Blood. 1995 Dec 15;86(12):4656-61.
[Text Abstract on PubMed]

Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death.
Selleri C, Sato T, Anderson S, Young NS, Maciejewski JP.
J. Cell. Physiol. 1995 Dec;165(3):538-46.
[Text Abstract on PubMed]

Pancytopenia secondary to parvovirus B19 infection in a child with acute lymphoblastic leukemia, mimicking leukemic relapse.
Smith TJ, Cullen JW, Peck SD, Brown KE, Young NS.
Am. J. Hematol. 1995 Nov;50(3):226-7.
[Text Abstract on PubMed]

Hematopoietic inhibition by interferon-gamma is partially mediated through interferon regulatory factor-1.
Sato T, Selleri C, Young NS, Maciejewski JP.
Blood. 1995 Nov 1;86(9):3373-80.
[Text Abstract on PubMed]

Modest truncation of the major capsid protein abrogates B19 parvovirus capsid formation.
Kawase M, Momoeda M, Young NS, Kajigaya S.
J. Virol. 1995 Oct;69(10):6567-71.
[Text Abstract on PubMed]

Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anaemia.
Maciejewski JP, Selleri C, Sato T, Anderson S, Young NS.
Br. J. Haematol. 1995 Sep;91(1):245-52.
[Text Abstract on PubMed]

Parvovirus B19 infection and hematopoiesis.
Brown KE, Young NS.
Blood Rev. 1995 Sep;9(3):176-82.
[Text Abstract on PubMed]

Most of the VP1 unique region of B19 parvovirus is on the capsid surface.
Kawase M, Momoeda M, Young NS, Kajigaya S.
Virology. 1995 Aug 20;211(2):359-66.
[Text Abstract on PubMed]

Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha.
Maciejewski JP, Selleri C, Sato T, Cho HJ, Keefer LK, Nathan CF, Young NS.
J. Clin. Invest. 1995 Aug;96(2):1085-92.
[Text Abstract on PubMed]

Aplastic anaemia.
Young NS.
Lancet. 1995 Jul 22;346(8969):228-32.
[Text Abstract on PubMed]

Goose parvovirus--an autonomous member of the dependovirus genus?
Brown KE, Green SW, Young NS.
Virology. 1995 Jul 10;210(2):283-91.
[Text Abstract on PubMed]

Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro.
Maciejewski JP, Weichold FF, Young NS, Cara A, Zella D, Reitz, Gallo RC.
Nat. Med. 1995 Jul;1(7):667-73.
[Text Abstract on PubMed]

The treatment of severe acquired aplastic anemia.
Young NS, Barrett AJ.
Blood. 1995 Jun 15;85(12):3367-77.
[Text Abstract on PubMed]

Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro.
Maciejewski J, Selleri C, Anderson S, Young NS.
Blood. 1995 Jun 1;85(11):3183-90.
[Text Abstract on PubMed]

Human parvovirus B19 can infect cynomolgus monkey marrow cells in tissue culture.
Gallinella G, Anderson SM, Young NS, Brown KE.
J. Virol. 1995 Jun;69(6):3897-9.
[Text Abstract on PubMed]

Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for severe acquired aplastic anemia.
Rosenfeld SJ, Kimball J, Vining D, Young NS.
Blood. 1995 Jun 1;85(11):3058-65.
[Text Abstract on PubMed]

Purification of functional recombinant YY1 expressed in Sf9 insect cells.
Momoeda M, Kawase M, Young NS, Kajigaya S.
Protein Expr. Purif. 1995 Apr;6(2):169-75.
[Text Abstract on PubMed]

Viruses, virulence and pathogenicity.
Hibbs J, Young NS.
Baillieres Clin. Haematol. 1995 Mar;8(1):1-23.
[Text Abstract on PubMed]

B19 parvovirus.
Young NS.
Baillieres Clin. Haematol. 1995 Mar;8(1):25-56.
[Text Abstract on PubMed]

Peptides derived from the unique region of B19 parvovirus minor capsid protein elicit neutralizing antibodies in rabbits.
Anderson S, Momoeda M, Kawase M, Kajigaya S, Young NS.
Virology. 1995 Jan 10;206(1):626-32.
[Text Abstract on PubMed]

Fanconi anemia and novel strategies for therapy.
Liu JM, Buchwald M, Walsh CE, Young NS.
Blood. 1994 Dec 15;84(12):3995-4007.
[Text Abstract on PubMed]

In situ hybridisation and in situ polymerase chain reaction detection of parvovirus B19 DNA within cells.
Gallinella G, Young NS, Brown KE.
J. Virol. Methods. 1994 Dec;50(1-3):67-74.
[Text Abstract on PubMed]

Lack of evidence for parvovirus B19 viraemia in children with chronic neutropenia.
Hartman KR, Brown KE, Green SW, Young NS.
Br. J. Haematol. 1994 Dec;88(4):895-6.
[Text Abstract on PubMed]

A putative nucleoside triphosphate-binding domain in the nonstructural protein of B19 parvovirus is required for cytotoxicity.
Momoeda M, Wong S, Kawase M, Young NS, Kajigaya S.
J. Virol. 1994 Dec;68(12):8443-6.
[Text Abstract on PubMed]

HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-alpha.
Maciejewski JP, Weichold FF, Young NS.
J. Immunol. 1994 Nov 1;153(9):4303-10.
[Text Abstract on PubMed]

Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells.
Miller JL, Donahue RE, Sellers SE, Samulski RJ, Young NS, Nienhuis AW.
Proc. Natl. Acad. Sci. U.S.A. 1994 Oct 11;91(21):10183-7.
[Text Abstract on PubMed]

Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure.
Maciejewski JP, Hibbs JR, Anderson S, Katevas P, Young NS.
Exp. Hematol. 1994 Oct;22(11):1102-10.
[Text Abstract on PubMed]

Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector.
Walsh CE, Nienhuis AW, Samulski RJ, Brown MG, Miller JL, Young NS, Liu JM.
J. Clin. Invest. 1994 Oct;94(4):1440-8.
[Text Abstract on PubMed]

Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major.
Brittenham GM, Griffith PM, Nienhuis AW, McLaren CE, Young NS, Tucker EE, Allen CJ, Farrell DE, Harris JW.
N. Engl. J. Med. 1994 Sep 1;331(9):567-73.
[Text Abstract on PubMed]

Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells.
Goodman S, Xiao X, Donahue RE, Moulton A, Miller J, Walsh C, Young NS, Samulski RJ, Nienhuis AW.
Blood. 1994 Sep 1;84(5):1492-500.
[Text Abstract on PubMed]

Parvovirus particles as platforms for protein presentation.
Miyamura K, Kajigaya S, Momoeda M, Smith-Gill SJ, Young NS.
Proc. Natl. Acad. Sci. U.S.A. 1994 Aug 30;91(18):8507-11.
[Text Abstract on PubMed]

The structure of human parvovirus B19 at 8 A resolution.
Agbandje M, Kajigaya S, McKenna R, Young NS, Rossmann MG.
Virology. 1994 Aug 15;203(1):106-15.
[Text Abstract on PubMed]

Parvovirus B19 as a cause of acquired chronic pure red cell aplasia.
Frickhofen N, Chen ZJ, Young NS, Cohen BJ, Heimpel H, Abkowitz JL.
Br. J. Haematol. 1994 Aug;87(4):818-24.
[Text Abstract on PubMed]

Acquired sideroblastic anaemia following progesterone therapy.
Brodsky RA, Hasegawa S, Fibach E, Dunbar CE, Young NS, Rodgers GP.
Br. J. Haematol. 1994 Aug;87(4):859-62.
[Text Abstract on PubMed]

A functionally active retrovirus vector for gene therapy in Fanconi anemia group C.
Walsh CE, Grompe M, Vanin E, Buchwald M, Young NS, Nienhuis AW, Liu JM.
Blood. 1994 Jul 15;84(2):453-9.
[Text Abstract on PubMed]

Formation of empty B19 parvovirus capsids by the truncated minor capsid protein.
Wong S, Momoeda M, Field A, Kajigaya S, Young NS.
J. Virol. 1994 Jul;68(7):4690-4.
[Text Abstract on PubMed]

Phenotypic and functional analysis of bone marrow progenitor cell compartment in bone marrow failure.
Maciejewski JP, Anderson S, Katevas P, Young NS.
Br. J. Haematol. 1994 Jun;87(2):227-34.
[Text Abstract on PubMed]

Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen).
Brown KE, Hibbs JR, Gallinella G, Anderson SM, Lehman ED, McCarthy P, Young NS.
N. Engl. J. Med. 1994 Apr 28;330(17):1192-6.
[Text Abstract on PubMed]

Congenital anaemia after transplacental B19 parvovirus infection.
Brown KE, Green SW, Antunez de Mayolo J, Bellanti JA, Smith SD, Smith TJ, Young NS.
Lancet. 1994 Apr 9;343(8902):895-6.
[Text Abstract on PubMed]

gamma-Interferon gene expression in the bone marrow of patients with aplastic anemia.
Nisticò A, Young NS.
Ann. Intern. Med. 1994 Mar 15;120(6):463-9.
[Text Abstract on PubMed]

Agranulocytosis.
Young NS.
JAMA. 1994 Mar 23-30;271(12):935-8.
[Text Abstract on PubMed]

Molecular, cellular and clinical aspects of parvovirus B19 infection.
Brown KE, Young NS, Liu JM.
Crit. Rev. Oncol. Hematol. 1994 Feb;16(1):1-31.
[Text Abstract on PubMed]

Subunit interaction in B19 parvovirus empty capsids.
Rosenfeld SJ, Young NS, Alling D, Ayub J, Saxinger C.
Arch. Virol. 1994;136(1-2):9-18.
[Text Abstract on PubMed]

Antibody capture haemadherence tests for parvovirus B19-specific IgM and IgG.
Hilfenhaus S, Cohen BJ, Bates C, Kajigaya S, Young NS, Zambon M, Mortimer PP.
J. Virol. Methods. 1993 Nov;45(1):27-37.
[Text Abstract on PubMed]

Erythrocyte P antigen: cellular receptor for B19 parvovirus.
Brown KE, Anderson SM, Young NS.
Science. 1993 Oct 1;262(5130):114-7.
[Text Abstract on PubMed]

A trial of recombinant human superoxide dismutase in patients with Fanconi anaemia.
Liu JM, Auerbach AD, Anderson SM, Green SW, Young NS.
Br. J. Haematol. 1993 Oct;85(2):406-8.
[Text Abstract on PubMed]

Infection of mononucleated phagocytes with human cytomegalovirus.
Maciejewski JP, Bruening EE, Donahue RE, Sellers SE, Carter C, Young NS, St Jeor S.
Virology. 1993 Aug;195(2):327-36.
[Text Abstract on PubMed]

Neutralizing linear epitopes of B19 parvovirus cluster in the VP1 unique and VP1-VP2 junction regions.
Saikawa T, Anderson S, Momoeda M, Kajigaya S, Young NS.
J. Virol. 1993 Jun;67(6):3004-9.
[Text Abstract on PubMed]

Early and late gene expression in UT-7 cells infected with B19 parvovirus.
Shimomura S, Wong S, Brown KE, Komatsu N, Kajigaya S, Young NS.
Virology. 1993 May;194(1):149-56.
[Text Abstract on PubMed]

Candidate recombinant vaccine for human B19 parvovirus.
Bansal GP, Hatfield JA, Dunn FE, Kramer AA, Brady F, Riggin CH, Collett MS, Yoshimoto K, Kajigaya S, Young NS.
J. Infect. Dis. 1993 May;167(5):1034-44.
[Text Abstract on PubMed]

Successful surgical management of neutropenic enterocolitis in two patients with severe aplastic anemia. Case reports and review of the literature.
Weinberger M, Hollingsworth H, Feuerstein IM, Young NS, Pizzo PA.
Arch. Intern. Med. 1993 Jan 11;153(1):107-13.
[Text Abstract on PubMed]

Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major.
Brittenham GM, Cohen AR, McLaren CE, Martin MB, Griffith PM, Nienhuis AW, Young NS, Allen CJ, Farrell DE, Harris JW.
Am. J. Hematol. 1993 Jan;42(1):81-5.
[Text Abstract on PubMed]

Expression of stem cell inhibitor (SCI) gene in patients with bone marrow failure.
Maciejewski JP, Liu JM, Green SW, Walsh CE, Plumb M, Pragnell IB, Young NS.
Exp. Hematol. 1992 Oct;20(9):1112-7.
[Text Abstract on PubMed]

Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector.
Walsh CE, Liu JM, Xiao X, Young NS, Nienhuis AW, Samulski RJ.
Proc. Natl. Acad. Sci. U.S.A. 1992 Aug 1;89(15):7257-61.
[Text Abstract on PubMed]

A block in full-length transcript maturation in cells nonpermissive for B19 parvovirus.
Liu JM, Green SW, Shimada T, Young NS.
J. Virol. 1992 Aug;66(8):4686-92.
[Text Abstract on PubMed]

Infection of hematopoietic progenitor cells by human cytomegalovirus.
Maciejewski JP, Bruening EE, Donahue RE, Mocarski ES, Young NS, St Jeor SC.
Blood. 1992 Jul 1;80(1):170-8.
[Text Abstract on PubMed]

Unique region of the minor capsid protein of human parvovirus B19 is exposed on the virion surface.
Rosenfeld SJ, Yoshimoto K, Kajigaya S, Anderson S, Young NS, Field A, Warrener P, Bansal G, Collett MS.
J. Clin. Invest. 1992 Jun;89(6):2023-9.
[Text Abstract on PubMed]

Nosocomial human parvovirus B19 infection: lack of transmission from a chronically infected patient to hospital staff.
Koziol DE, Kurtzman G, Ayub J, Young NS, Henderson DK.
Infect Control Hosp Epidemiol. 1992 Jun;13(6):343-8.
[Text Abstract on PubMed]

Parvovirus B19 infection and bone marrow transplantation.
Frickhofen N, Arnold R, Hertenstein B, Wiesneth M, Young NS.
Ann. Hematol. 1992 Jun;64 Suppl:A121-4.
[Text Abstract on PubMed]

High prevalence of hepatitis C viremia among aplastic anemia patients and controls from Thailand.
Hibbs JR, Issaragrisil S, Young NS.
Am. J. Trop. Med. Hyg. 1992 May;46(5):564-70.
[Text Abstract on PubMed]

Aplastic anemia and viral hepatitis. Non-A, Non-B, Non-C?
Hibbs JR, Frickhofen N, Rosenfeld SJ, Feinstone SM, Kojima S, Bacigalupo A, Locasciulli A, Tzakis AG, Alter HJ, Young NS.
JAMA. 1992 Apr 15;267(15):2051-4.
[Text Abstract on PubMed]

Viruses and the blood.
Hibbs JR, Young NS.
Baillieres Clin. Haematol. 1992 Apr;5(2):245-71.
[Text Abstract on PubMed]

A trial of recombinant human interleukin-1 in patients with severe refractory aplastic anaemia.
Walsh CE, Liu JM, Anderson SM, Rossio JL, Nienhuis AW, Young NS.
Br. J. Haematol. 1992 Jan;80(1):106-10.
[Text Abstract on PubMed]

Patterns of infection in patients with aplastic anemia and the emergence of Aspergillus as a major cause of death.
Weinberger M, Elattar I, Marshall D, Steinberg SM, Redner RL, Young NS, Pizzo PA.
Medicine (Baltimore). 1992 Jan;71(1):24-43.
[Text Abstract on PubMed]

First continuous propagation of B19 parvovirus in a cell line.
Shimomura S, Komatsu N, Frickhofen N, Anderson S, Kajigaya S, Young NS.
Blood. 1992 Jan 1;79(1):18-24.
[Text Abstract on PubMed]

A second neutralizing epitope of B19 parvovirus implicates the spike region in the immune response.
Yoshimoto K, Rosenfeld S, Frickhofen N, Kennedy D, Hills R, Kajigaya S, Young NS.
J. Virol. 1991 Dec;65(12):7056-60.
[Text Abstract on PubMed]

A rapid method of sample preparation for detection of DNA viruses in human serum by polymerase chain reaction.
Frickhofen N, Young NS.
J. Virol. Methods. 1991 Nov;35(1):65-72.
[Text Abstract on PubMed]

Upstream sequences within the terminal hairpin positively regulate the P6 promoter of B19 parvovirus.
Liu JM, Green SW, Hao YS, McDonagh KT, Young NS, Shimada T.
Virology. 1991 Nov;185(1):39-47.
[Text Abstract on PubMed]

Fanconi anemia presenting unexpectedly in an adult kindred with no dysmorphic features.
Liu JM, Auerbach AD, Young NS.
Am. J. Med. 1991 Nov;91(5):555-7.
[Text Abstract on PubMed]

Human parvovirus B19 specific IgG, IgA, and IgM antibodies and DNA in serum specimens from persons with erythema infectiosum.
Erdman DD, Usher MJ, Tsou C, Caul EO, Gary GW, Kajigaya S, Young NS, Anderson LJ.
J. Med. Virol. 1991 Oct;35(2):110-5.
[Text Abstract on PubMed]

Treatment of Diamond-Blackfan anaemia with haematopoietic growth factors, granulocyte-macrophage colony stimulating factor and interleukin 3: sustained remissions following IL-3.
Dunbar CE, Smith DA, Kimball J, Garrison L, Nienhuis AW, Young NS.
Br. J. Haematol. 1991 Oct;79(2):316-21.
[Text Abstract on PubMed]

Preliminary X-ray crystallographic investigation of human parvovirus B19.
Agbandje M, McKenna R, Rossmann MG, Kajigaya S, Young NS.
Virology. 1991 Sep;184(1):170-4.
[Text Abstract on PubMed]

Viruses and bone marrow failure.
Rosenfeld SJ, Young NS.
Blood Rev. 1991 Jun;5(2):71-7.
[Text Abstract on PubMed]

Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions.
Kajigaya S, Fujii H, Field A, Anderson S, Rosenfeld S, Anderson LJ, Shimada T, Young NS.
Proc. Natl. Acad. Sci. U.S.A. 1991 Jun 1;88(11):4646-50.
[Text Abstract on PubMed]

Incidence of aplastic anemia in Bangkok. The Aplastic Anemia Study Group.
Issaragrisil S, Sriratanasatavorn C, Piankijagum A, Vannasaeng S, Porapakkham Y, Leaverton PE, Kaufman DW, Anderson TE, Shapiro S, Young NS.
Blood. 1991 May 15;77(10):2166-8.
[Text Abstract on PubMed]

Indiscriminate activity from the B19 parvovirus p6 promoter in nonpermissive cells.
Liu JM, Fujii H, Green SW, Komatsu N, Young NS, Shimada T.
Virology. 1991 May;182(1):361-4.
[Text Abstract on PubMed]

Viruses and bone marrow failure.
Young NS, Rosenfeld S, Antunez-de-Mayolo J, Hibbs J, Liu J, Maciejewski J, St Jeor S, Shimomura S, Kajigaya S.
Schweiz Med Wochenschr Suppl. 1991;43:28-32.
[Text Abstract on PubMed]

Polymerase chain reaction for detection of parvovirus B19 in immunodeficient patients with anemia.
Frickhofen N, Young NS.
Behring Inst. Mitt. 1990 Aug(85):46-54.
[Text Abstract on PubMed]

Flaviviruses and bone marrow failure.
Young NS.
JAMA. 1990 Jun 13;263(22):3065-8.
[Text Abstract on PubMed]

Different haematopoietic growth factors have different capacity in overcoming the in vitro interferon gamma-induced suppression of bone marrow progenitor cells.
Zoumbos NC, Baranski B, Young NS.
Eur. J. Haematol. 1990 May;44(5):282-90.
[Text Abstract on PubMed]

Hematopoietic growth factors: a summary of their biology in tissue culture, animals, and clinical trials.
Young NS.
Prog. Clin. Biol. Res. 1990;337:539-49.
[Text Abstract on PubMed]

Etiologic mechanisms of hematopoietic failure.
Frickhofen N, Liu JM, Young NS.
Am J Pediatr Hematol Oncol. 1990 Winter;12(4):385-95.
[Text Abstract on PubMed]

Persistent parvovirus B19 infections in humans.
Frickhofen N, Young NS.
Microb. Pathog. 1989 Nov;7(5):319-27.
[Text Abstract on PubMed]

Immune response to B19 parvovirus and an antibody defect in persistent viral infection.
Kurtzman GJ, Cohen BJ, Field AM, Oseas R, Blaese RM, Young NS.
J. Clin. Invest. 1989 Oct;84(4):1114-23.
[Text Abstract on PubMed]

A genetically engineered cell line that produces empty capsids of B19 (human) parvovirus.
Kajigaya S, Shimada T, Fujita S, Young NS.
Proc. Natl. Acad. Sci. U.S.A. 1989 Oct;86(19):7601-5.
[Text Abstract on PubMed]

Dengue virus, a flavivirus, propagates in human bone marrow progenitors and hematopoietic cell lines.
Nakao S, Lai CJ, Young NS.
Blood. 1989 Sep;74(4):1235-40.
[Text Abstract on PubMed]

Feline parvovirus propagates in cat bone marrow cultures and inhibits hematopoietic colony formation in vitro.
Kurtzman GJ, Platanias L, Lustig L, Frickhofen N, Young NS.
Blood. 1989 Jul;74(1):71-81.
[Text Abstract on PubMed]

Cyclosporine therapy of aplastic anaemia, congenital and acquired red cell aplasia.
Leonard EM, Raefsky E, Griffith P, Kimball J, Nienhuis AW, Young NS.
Br. J. Haematol. 1989 Jun;72(2):278-84.
[Text Abstract on PubMed]

The immune system as mediator of virus-associated bone marrow failure: B19 parvovirus and Epstein-Barr virus.
Young NS, Baranski B, Kurtzman G.
Ann. N. Y. Acad. Sci. 1989;554:75-80.
[Text Abstract on PubMed]

Antithymocyte globulin hypersensitivity in bone marrow failure patients.
Bielory L, Wright R, Nienhuis AW, Young NS, Kaliner MA.
JAMA. 1988 Dec 2;260(21):3164-7.
[Text Abstract on PubMed]

Persistent B19 parvovirus infection as a cause of severe chronic anaemia in children with acute lymphocytic leukaemia.
Kurtzman GJ, Cohen B, Meyers P, Amunullah A, Young NS.
Lancet. 1988 Nov 19;2(8621):1159-62.
[Text Abstract on PubMed]

Epstein-Barr virus in the bone marrow of patients with aplastic anemia.
Baranski B, Armstrong G, Truman JT, Quinnan, Straus SE, Young NS.
Ann. Intern. Med. 1988 Nov 1;109(9):695-704.
[Text Abstract on PubMed]

B19 parvovirus replicates in circulating cells of acutely infected patients.
Kurtzman GJ, Gascon P, Caras M, Cohen B, Young NS.
Blood. 1988 May;71(5):1448-54.
[Text Abstract on PubMed]

Autoimmune aspects of aplastic anemia.
Baranski BG, Young NS.
In Vivo. 1988 Jan-Feb;2(1):91-4.
[Text Abstract on PubMed]

Human serum sickness: a prospective analysis of 35 patients treated with equine anti-thymocyte globulin for bone marrow failure.
Bielory L, Gascon P, Lawley TJ, Young NS, Frank MM.
Medicine (Baltimore). 1988 Jan;67(1):40-57.
[Text Abstract on PubMed]

Chronic bone marrow failure due to persistent B19 parvovirus infection.
Kurtzman GJ, Ozawa K, Cohen B, Hanson G, Oseas R, Young NS.
N. Engl. J. Med. 1987 Jul 30;317(5):287-94.
[Text Abstract on PubMed]

Gamma interferon and aplastic anemia.
Young NS.
Blood. 1987 Jul;70(1):337-9.
[Text Abstract on PubMed]

Hematologic effects of immunotherapy with lymphokine-activated killer cells and recombinant interleukin-2 in cancer patients.
Ettinghausen SE, Moore JG, White DE, Platanias L, Young NS, Rosenberg SA.
Blood. 1987 Jun;69(6):1654-60.
[Text Abstract on PubMed]

Lymphocytes and lymphokines in aplastic anemia: pathogenic role and implications for pathogenesis.
Young NS, Leonard E, Platanias L.
Blood Cells. 1987;13(1-2):87-100.
[Text Abstract on PubMed]

The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease).
Chorba T, Coccia P, Holman RC, Tattersall P, Anderson LJ, Sudman J, Young NS, Kurczynski E, Saarinen UM, Moir R.
J. Infect. Dis. 1986 Sep;154(3):383-93.
[Text Abstract on PubMed]

Biological and immunological characterization of ATG and ALG.
Raefsky EL, Gascon P, Gratwohl A, Speck B, Young NS.
Blood. 1986 Sep;68(3):712-9.
[Text Abstract on PubMed]

Serum sickness and haematopoietic recovery with antithymocyte globulin in bone marrow failure patients.
Bielory L, Gascon P, Lawley TJ, Nienhuis A, Frank MM, Young NS.
Br. J. Haematol. 1986 Aug;63(4):729-36.
[Text Abstract on PubMed]

Human parvovirus B19-induced epidemic acute red cell aplasia in patients with hereditary hemolytic anemia.
Saarinen UM, Chorba TL, Tattersall P, Young NS, Anderson LJ, Palmer E, Coccia PF.
Blood. 1986 May;67(5):1411-7.
[Text Abstract on PubMed]

Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production.
Dover GJ, Humphries RK, Moore JG, Ley TJ, Young NS, Charache S, Nienhuis AW.
Blood. 1986 Mar;67(3):735-8.
[Text Abstract on PubMed]

Aplastic anaemia in the Orient.
Young NS, Issaragrasil S, Chieh CW, Takaku F.
Br. J. Haematol. 1986 Jan;62(1):1-6.
[Text Abstract on PubMed]

Studies of interferon as a regulator of hematopoietic cell proliferation.
Raefsky EL, Platanias LC, Zoumbos NC, Young NS.
J. Immunol. 1985 Oct;135(4):2507-12.
[Text Abstract on PubMed]

Decay-accelerating factor is present on paroxysmal nocturnal hemoglobinuria erythroid progenitors and lost during erythropoiesis in vitro.
Moore JG, Frank MM, Müller-Eberhard HJ, Young NS.
J. Exp. Med. 1985 Oct 1;162(4):1182-92.
[Text Abstract on PubMed]

Cutaneous manifestations of serum sickness in patients receiving antithymocyte globulin.
Bielory L, Yancey KB, Young NS, Frank MM, Lawley TJ.
J. Am. Acad. Dermatol. 1985 Sep;13(3):411-7.
[Text Abstract on PubMed]

A study of human serum sickness.
Lawley TJ, Bielory L, Gascon P, Yancey KB, Young NS, Frank MM.
J. Invest. Dermatol. 1985 Jul;85(1 Suppl):129s-132s.
[Text Abstract on PubMed]

5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin.
Humphries RK, Dover G, Young NS, Moore JG, Charache S, Ley T, Nienhuis AW.
J. Clin. Invest. 1985 Feb;75(2):547-57.
[Text Abstract on PubMed]

Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of antithymocyte globulin.
Gascon P, Zoumbos NC, Scala G, Djeu JY, Moore JG, Young NS.
Blood. 1985 Feb;65(2):407-13.
[Text Abstract on PubMed]

Circulating activated suppressor T lymphocytes in aplastic anemia.
Zoumbos NC, Gascón P, Djeu JY, Trost SR, Young NS.
N. Engl. J. Med. 1985 Jan 31;312(5):257-65.
[Text Abstract on PubMed]

Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe beta-thalassemia.
Nienhuis AW, Ley TJ, Humphries RK, Young NS, Dover G.
Ann. N. Y. Acad. Sci. 1985;445:198-211.
[Text Abstract on PubMed]

Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo.
Zoumbos NC, Gascon P, Djeu JY, Young NS.
Proc. Natl. Acad. Sci. U.S.A. 1985 Jan;82(1):188-92.
[Text Abstract on PubMed]

A prospective clinical and immunologic analysis of patients with serum sickness.
Lawley TJ, Bielory L, Gascon P, Yancey KB, Young NS, Frank MM.
N. Engl. J. Med. 1984 Nov 29;311(22):1407-13.
[Text Abstract on PubMed]

Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes in vitro.
Zoumbos NC, Djeu JY, Young NS.
J. Immunol. 1984 Aug;133(2):769-74.
[Text Abstract on PubMed]

Immunologic abnormalities in patients receiving multiple blood transfusions.
Gascón P, Zoumbos NC, Young NS.
Ann. Intern. Med. 1984 Feb;100(2):173-7.
[Text Abstract on PubMed]

The human parvovirus and in vitro hematopoietic colony formation.
Young NS, Moore JG, Humphries RK.
Prog. Clin. Biol. Res. 1984;148:129-39.
[Text Abstract on PubMed]

Characterization of a virus that causes transient aplastic crisis.
Young NS, Mortimer PP, Moore JG, Humphries RK.
J. Clin. Invest. 1984 Jan;73(1):224-30.
[Text Abstract on PubMed]

Human serum sickness.
Lawley TJ, Bielory L, Gascon P, Yancey KB, Young NS, Frank MM.
Trans. Assoc. Am. Physicians. 1984;97:49-55.
[Text Abstract on PubMed]

A human parvovirus-like virus inhibits haematopoietic colony formation in vitro.
Mortimer PP, Humphries RK, Moore JG, Purcell RH, Young NS.
Nature. 1983 Mar 31-Apr 6;302(5907):426-9.
[Text Abstract on PubMed]

5-azacytidine for beta thalassaemia?
Ley TJ, Anagnou NP, Young NS, Nienhuis AW, DeSimone J, Heller P.
Lancet. 1983 Feb 26;1(8322):467.
[Text Abstract on PubMed]

A trial of immunotherapy in aplastic anemia and pure red cell aplasia.
Young NS, Klein HG, Griffith P, Nienhuis AW.
J Clin Apher. 1983;1(2):95-103.
[Text Abstract on PubMed]

Anti-K562 monoclonal antibodies that recognize antigens on immature hematopoietic cells.
Young NS, Gallagher RE, Chen SP.
Prog. Clin. Biol. Res. 1983;134:293-304.
[Text Abstract on PubMed]

5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia.
Ley TJ, DeSimone J, Anagnou NP, Keller GH, Humphries RK, Turner PH, Young NS, Keller P, Nienhuis AW.
N. Engl. J. Med. 1982 Dec 9;307(24):1469-75.
[Text Abstract on PubMed]

Regulation of human globin gene expression in mouse erythroleukemia x human fibroblast hybrid cells.
Vembu D, Young NS, Willing M, Church E, Sanders-Haigh L, Anderson WF.
Somatic Cell Genet. 1982 Mar;8(2):163-78.
[Text Abstract on PubMed]

Anti-K562 cell monoclonal antibodies recognize hematopoietic progenitors.
Young NS, Hwang-Chen SP.
Proc. Natl. Acad. Sci. U.S.A. 1981 Nov;78(11):7073-7.
[Text Abstract on PubMed]

Reduced vitamin a levels of chicks fed anaerobically digested sewage sludge.
Kienholz EW, Young NS, Smith JL, Whiteman CA.
Poult. Sci. 1981 Apr;60(4):884-6.
[Text Abstract on PubMed]

Instrumentation.
Young NS.
Dent Hyg (Chic). 1980 Apr;54(4):186-96.
[Text Abstract on PubMed]

Hemoglobin switching in sheep: only the gamma gene is in the active conformation in fetal liver but all the beta and gamma genes are in the active conformation in bone marrow.
Young NS, Benz, Kantor JA, Kretschmer P, Nienhuis AW.
Proc. Natl. Acad. Sci. U.S.A. 1978 Dec;75(12):5884-8.
[Text Abstract on PubMed]

The NH2-terminal region of the sickle hemoglobin beta chain. II. Characterization of monospecific antibodies.
Young NS, Eastlake A, Schechter AN.
J. Biol. Chem. 1976 Oct 25;251(20):6431-8.
[Text Abstract on PubMed]

Antibodies to an NH2-terminal fragment of betaS globin. II. Specificity and isolation of antibodies for the sickle mutation.
Curd JG, Young NS, Schechter AN.
J. Biol. Chem. 1976 Mar 10;251(5):1290-5.
[Text Abstract on PubMed]

Urinary fibrin split products in lupus nephritis.
Zizic TM, Cwazka WF, Young NS, Stevens MB.
J. Rheumatol. 1976 Mar;3(1):43-9.
[Text Abstract on PubMed]

Isolation of antibodies specific to sickle hemoglobin by affinity chromatography using a synthetic peptide.
Young NS, Curd JG, Eastlake A, Furie B, Schechter AN.
Proc. Natl. Acad. Sci. U.S.A. 1975 Dec;72(12):4759-63.
[Text Abstract on PubMed]

An invertebrate coagulation system activated by endotoxin: evidence for enzymatic mediation.
Young NS, Levin J, Prendergast RA.
J. Clin. Invest. 1972 Jul;51(7):1790-7.
[Text Abstract on PubMed]

Gram-negative sepsis: detection of endotoxemia with the limulus test. With studies of associated changes in blood coagulation, serum lipids, and complement.
Levin J, Poore TE, Young NS, Margolis S, Zauber NP, Townes AS, Bell WR.
Ann. Intern. Med. 1972 Jan;76(1):1-7.
[Text Abstract on PubMed]