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Clare M. Waterman, Ph.D.


Principal Investigator thumbnail image

Clare M. Waterman
NIH Distinguished Investigator

P: +1 301 435 2949

Full Publications Listing

Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover.
Chen Y, Pasapera AM, Koretsky AP, Waterman CM.
Proc Natl Acad Sci U S A..
[Text Abstract on PubMed]

Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration.
Plotnikov SV, Pasapera AM, Sabass B, Waterman CM.
Cell. 2012 Dec 21;151(7):1513-27.
[Text Abstract on PubMed]

Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior.
Fischer RS, Myers KA, Gardel ML, Waterman CM.
Nat Protoc. 2012 Nov;7(11):2056-66.
[Text Abstract on PubMed]

Advances in light-based imaging of three-dimensional cellular ultrastructure.
Kanchanawong P, Waterman CM.
Curr. Opin. Cell Biol. 2012 Feb;24(1):125-33.
[Text Abstract on PubMed]

Isolation of focal adhesion proteins for biochemical and proteomic analysis.
Kuo JC, Han X, Yates, Waterman CM.
Methods Mol. Biol. 2012;757:297-323.
[Text Abstract on PubMed]

Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells.
Nishimura Y, Applegate K, Davidson MW, Danuser G, Waterman CM.
PLoS ONE. 2012;7(7):e41413.
[Text Abstract on PubMed]

Microscopy in 3D: a biologist's toolbox.
Fischer RS, Wu Y, Kanchanawong P, Shroff H, Waterman CM.
Trends Cell Biol. 2011 Dec;21(12):682-91.
[Text Abstract on PubMed]

Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.
Li CC, Kuo JC, Waterman CM, Kiyama R, Moss J, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 2011 Nov 29;108(48):19228-33.
[Text Abstract on PubMed]

Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (ß-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction.
Valdes JL, Tang J, McDermott MI, Kuo JC, Zimmerman SP, Wincovitch SM, Waterman CM, Milgram SL, Playford MP.
J. Biol. Chem. 2011 Nov 11;286(45):39403-16.
[Text Abstract on PubMed]

How we discovered fluorescent speckle microscopy.
Salmon ED, Waterman CM.
Mol. Biol. Cell. 2011 Nov;22(21):3940-2.
[Text Abstract on PubMed]

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.
Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM.
J. Cell Biol. 2011 Jun 27;193(7):1289-303.
[Text Abstract on PubMed]

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ß-Pix in negative regulation of focal adhesion maturation.
Kuo JC, Han X, Hsiao CT, Yates, Waterman CM.
Nat. Cell Biol. 2011 Apr;13(4):383-93.
[Text Abstract on PubMed]

Distinct ECM mechanosensing pathways regulate microtubule dynamics to control endothelial cell branching morphogenesis.
Myers KA, Applegate KT, Danuser G, Fischer RS, Waterman CM.
J. Cell Biol. 2011 Jan 24;192(2):321-34.
[Text Abstract on PubMed]

Adhesive F-actin waves: a novel integrin-mediated adhesion complex coupled to ventral actin polymerization.
Case LB, Waterman CM.
PLoS ONE. 2011;6(11):e26631.
[Text Abstract on PubMed]

Nanoscale architecture of integrin-based cell adhesions.
Kanchanawong P, Shtengel G, Pasapera AM, Ramko EB, Davidson MW, Hess HF, Waterman CM.
Nature. 2010 Nov 25;468(7323):580-4.
[Text Abstract on PubMed]

A zyxin-mediated mechanism for actin stress fiber maintenance and repair.
Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC.
Dev. Cell. 2010 Sep 14;19(3):365-76.
[Text Abstract on PubMed]

Protrusion and actin assembly are coupled to the organization of lamellar contractile structures.
Lim JI, Sabouri-Ghomi M, Machacek M, Waterman CM, Danuser G.
Exp. Cell Res. 2010 Aug 1;316(13):2027-41.
[Text Abstract on PubMed]

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation.
Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD, Waterman CM.
J. Cell Biol. 2010 Mar 22;188(6):877-90.
[Text Abstract on PubMed]

Mechanical integration of actin and adhesion dynamics in cell migration.
Gardel ML, Schneider IC, Aratyn-Schaus Y, Waterman CM.
Annu. Rev. Cell Dev. Biol. 2010;26:315-33.
[Text Abstract on PubMed]

Epidermal growth factor-induced contraction regulates paxillin phosphorylation to temporally separate traction generation from de-adhesion.
Schneider IC, Hays CK, Waterman CM.
Mol. Biol. Cell. 2009 Jul;20(13):3155-67.
[Text Abstract on PubMed]

Interferometric fluorescent super-resolution microscopy resolves 3D cellular ultrastructure.
Shtengel G, Galbraith JA, Galbraith CG, Lippincott-Schwartz J, Gillette JM, Manley S, Sougrat R, Waterman CM, Kanchanawong P, Davidson MW, Fetter RD, Hess HF.
Proc. Natl. Acad. Sci. U.S.A. 2009 Mar 3;106(9):3125-30.
[Text Abstract on PubMed]

Local cortical tension by myosin II guides 3D endothelial cell branching.
Fischer RS, Gardel M, Ma X, Adelstein RS, Waterman CM.
Curr. Biol. 2009 Feb 10;19(3):260-5.
[Text Abstract on PubMed]

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed.
Gardel ML, Sabass B, Ji L, Danuser G, Schwarz US, Waterman CM.
J. Cell Biol. 2008 Dec 15;183(6):999-1005.
[Text Abstract on PubMed]

CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether.
Kim Y, Heuser JE, Waterman CM, Cleveland DW.
J. Cell Biol. 2008 May 5;181(3):411-9.
[Text Abstract on PubMed]

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD.
J. Cell Biol. 2008 Jan 14;180(1):187-203.
[Text Abstract on PubMed]

High resolution traction force microscopy based on experimental and computational advances.
Sabass B, Gardel ML, Waterman CM, Schwarz US.
Biophys. J. 2008 Jan 1;94(1):207-20.
[Text Abstract on PubMed]

Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks.
Delorme V, Machacek M, DerMardirossian C, Anderson KL, Wittmann T, Hanein D, Waterman-Storer C, Danuser G, Bokoch GM.
Dev. Cell. 2007 Nov;13(5):646-62.
[Text Abstract on PubMed]

mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration.
Gupton SL, Eisenmann K, Alberts AS, Waterman-Storer CM.
J. Cell. Sci. 2007 Oct 1;120(Pt 19):3475-87.
[Text Abstract on PubMed]

SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis.
Yarar D, Waterman-Storer CM, Schmid SL.
Dev. Cell. 2007 Jul;13(1):43-56.
[Text Abstract on PubMed]

Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases.
Grande-García A, Echarri A, de Rooij J, Alderson NB, Waterman-Storer CM, Valdivielso JM, del Pozo MA.
J. Cell Biol. 2007 May 21;177(4):683-94.
[Text Abstract on PubMed]

Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability.
Kroboth K, Newton IP, Kita K, Dikovskaya D, Zumbrunn J, Waterman-Storer CM, Näthke IS.
Mol. Biol. Cell. 2007 Mar;18(3):910-8.
[Text Abstract on PubMed]

Differential transmission of actin motion within focal adhesions.
Hu K, Ji L, Applegate KT, Danuser G, Waterman-Storer CM.
Science. 2007 Jan 5;315(5808):111-5.
[Text Abstract on PubMed]

Decreased polarity and increased random motility in PtK1 epithelial cells correlate with inhibition of endosomal recycling.
Prigozhina NL, Waterman-Storer CM.
J. Cell. Sci. 2006 Sep 1;119(Pt 17):3571-82.
[Text Abstract on PubMed]

Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration.
Gupton SL, Waterman-Storer CM.
Cell. 2006 Jun 30;125(7):1361-74.
[Text Abstract on PubMed]

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.
Kita K, Wittmann T, Näthke IS, Waterman-Storer CM.
Mol. Biol. Cell. 2006 May;17(5):2331-45.
[Text Abstract on PubMed]

Quantitative fluorescent speckle microscopy of cytoskeleton dynamics.
Danuser G, Waterman-Storer CM.
Annu Rev Biophys Biomol Struct. 2006;35:361-87.
[Text Abstract on PubMed]

Periodic patterns of actin turnover in lamellipodia and lamellae of migrating epithelial cells analyzed by quantitative Fluorescent Speckle Microscopy.
Ponti A, Matov A, Adams M, Gupton S, Waterman-Storer CM, Danuser G.
Biophys. J. 2005 Nov;89(5):3456-69.
[Text Abstract on PubMed]

Integrin-dependent actomyosin contraction regulates epithelial cell scattering.
de Rooij J, Kerstens A, Danuser G, Schwartz MA, Waterman-Storer CM.
J. Cell Biol. 2005 Oct 10;171(1):153-64.
[Text Abstract on PubMed]

Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells.
Wittmann T, Waterman-Storer CM.
J. Cell Biol. 2005 Jun 20;169(6):929-39.
[Text Abstract on PubMed]

The effects of collapsing factors on F-actin content and microtubule distribution of Helisoma growth cones.
Torreano PJ, Waterman-Storer CM, Cohan CS.
Cell Motil. Cytoskeleton. 2005 Mar;60(3):166-79.
[Text Abstract on PubMed]

Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin.
Gupton SL, Anderson KL, Kole TP, Fischer RS, Ponti A, Hitchcock-DeGregori SE, Danuser G, Fowler VM, Wirtz D, Hanein D, Waterman-Storer CM.
J. Cell Biol. 2005 Feb 14;168(4):619-31.
[Text Abstract on PubMed]

A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis.
Yarar D, Waterman-Storer CM, Schmid SL.
Mol. Biol. Cell. 2005 Feb;16(2):964-75.
[Text Abstract on PubMed]

Signal analysis of total internal reflection fluorescent speckle microscopy (TIR-FSM) and wide-field epi-fluorescence FSM of the actin cytoskeleton and focal adhesions in living cells.
Adams MC, Matov A, Yarar D, Gupton SL, Danuser G, Waterman-Storer CM.
J Microsc. 2004 Nov;216(Pt 2):138-52.
[Text Abstract on PubMed]

Two distinct actin networks drive the protrusion of migrating cells.
Ponti A, Machacek M, Gupton SL, Waterman-Storer CM, Danuser G.
Science. 2004 Sep 17;305(5691):1782-6.
[Text Abstract on PubMed]

Simultaneous mapping of filamentous actin flow and turnover in migrating cells by quantitative fluorescent speckle microscopy.
Vallotton P, Gupton SL, Waterman-Storer CM, Danuser G.
Proc. Natl. Acad. Sci. U.S.A. 2004 Jun 29;101(26):9660-5.
[Text Abstract on PubMed]

Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.
Wittmann T, Bokoch GM, Waterman-Storer CM.
J. Biol. Chem. 2004 Feb 13;279(7):6196-203.
[Text Abstract on PubMed]

Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motility.
Prigozhina NL, Waterman-Storer CM.
Curr. Biol. 2004 Jan 20;14(2):88-98.
[Text Abstract on PubMed]

Modulation of Rac localization and function by dynamin.
Schlunck G, Damke H, Kiosses WB, Rusk N, Symons MH, Waterman-Storer CM, Schmid SL, Schwartz MA.
Mol. Biol. Cell. 2004 Jan;15(1):256-67.
[Text Abstract on PubMed]

Quantitative fluorescent speckle microscopy: where it came from and where it is going.
Danuser G, Waterman-Storer CM.
J Microsc. 2003 Sep;211(Pt 3):191-207.
[Text Abstract on PubMed]

Recovery, visualization, and analysis of actin and tubulin polymer flow in live cells: a fluorescent speckle microscopy study.
Vallotton P, Ponti A, Waterman-Storer CM, Salmon ED, Danuser G.
Biophys. J. 2003 Aug;85(2):1289-306.
[Text Abstract on PubMed]

Conserved microtubule-actin interactions in cell movement and morphogenesis.
Rodriguez OC, Schaefer AW, Mandato CA, Forscher P, Bement WM, Waterman-Storer CM.
Nat. Cell Biol. 2003 Jul;5(7):599-609.
[Text Abstract on PubMed]

Regulation of leading edge microtubule and actin dynamics downstream of Rac1.
Wittmann T, Bokoch GM, Waterman-Storer CM.
J. Cell Biol. 2003 Jun 9;161(5):845-51.
[Text Abstract on PubMed]

Computational analysis of F-actin turnover in cortical actin meshworks using fluorescent speckle microscopy.
Ponti A, Vallotton P, Salmon WC, Waterman-Storer CM, Danuser G.
Biophys. J. 2003 May;84(5):3336-52.
[Text Abstract on PubMed]

A high-speed multispectral spinning-disk confocal microscope system for fluorescent speckle microscopy of living cells.
Adams MC, Salmon WC, Gupton SL, Cohan CS, Wittmann T, Prigozhina N, Waterman-Storer CM.
Methods. 2003 Jan;29(1):29-41.
[Text Abstract on PubMed]

Converging populations of f-actin promote breakage of associated microtubules to spatially regulate microtubule turnover in migrating cells.
Gupton SL, Salmon WC, Waterman-Storer CM.
Curr. Biol. 2002 Nov 19;12(22):1891-9.
[Text Abstract on PubMed]

New directions for fluorescent speckle microscopy.
Waterman-Storer CM, Danuser G.
Curr. Biol. 2002 Sep 17;12(18):R633-40.
[Text Abstract on PubMed]

Dual-wavelength fluorescent speckle microscopy reveals coupling of microtubule and actin movements in migrating cells.
Salmon WC, Adams MC, Waterman-Storer CM.
J. Cell Biol. 2002 Jul 8;158(1):31-7.
[Text Abstract on PubMed]

Focal loss of actin bundles causes microtubule redistribution and growth cone turning.
Zhou FQ, Waterman-Storer CM, Cohan CS.
J. Cell Biol. 2002 May 27;157(5):839-49.
[Text Abstract on PubMed]

Fluorescent speckle microscopy (FSM) of microtubules and actin in living cells.
Waterman-Storer C.
Curr Protoc Cell Biol. 2002 Feb;Chapter 4:Unit 4.10.
[Text Abstract on PubMed]

Cell motility: can Rho GTPases and microtubules point the way?
Wittmann T, Waterman-Storer CM.
J. Cell. Sci. 2001 Nov;114(Pt 21):3795-803.
[Text Abstract on PubMed]

Rapid dynamics of the microtubule binding of ensconsin in vivo.
Bulinski JC, Odde DJ, Howell BJ, Salmon TD, Waterman-Storer CM.
J. Cell. Sci. 2001 Nov;114(Pt 21):3885-97.
[Text Abstract on PubMed]

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly.
Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K.
Cell. 2001 Jan 12;104(1):95-106.
[Text Abstract on PubMed]

Microtubules remodel actomyosin networks in Xenopus egg extracts via two mechanisms of F-actin transport.
Waterman-Storer C, Duey DY, Weber KL, Keech J, Cheney RE, Salmon ED, Bement WM.
J. Cell Biol. 2000 Jul 24;150(2):361-76.
[Text Abstract on PubMed]

Feedback interactions between cell-cell adherens junctions and cytoskeletal dynamics in newt lung epithelial cells.
Waterman-Storer CM, Salmon WC, Salmon ED.
Mol. Biol. Cell. 2000 Jul;11(7):2471-83.
[Text Abstract on PubMed]

E-MAP-115 (ensconsin) associates dynamically with microtubules in vivo and is not a physiological modulator of microtubule dynamics.
Faire K, Waterman-Storer CM, Gruber D, Masson D, Salmon ED, Bulinski JC.
J. Cell. Sci. 1999 Dec;112 ( Pt 23):4243-55.
[Text Abstract on PubMed]

Fluorescent speckle microscopy of microtubules: how low can you go?
Waterman-Storer CM, Salmon ED.
FASEB J. 1999 Dec;13 Suppl 2:S225-30.
[Text Abstract on PubMed]

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts.
Waterman-Storer CM, Worthylake RA, Liu BP, Burridge K, Salmon ED.
Nat. Cell Biol. 1999 May;1(1):45-50.
[Text Abstract on PubMed]

Positive feedback interactions between microtubule and actin dynamics during cell motility.
Waterman-Storer CM, Salmon E.
Curr. Opin. Cell Biol. 1999 Feb;11(1):61-7.
[Text Abstract on PubMed]

Fluorescent speckle microscopy of spindle microtubule assembly and motility in living cells.
Waterman-Storer C, Desai A, Salmon ED.
Methods Cell Biol. 1999;61:155-73.
[Text Abstract on PubMed]

Microtubules and microscopes: how the development of light microscopic imaging technologies has contributed to discoveries about microtubule dynamics in living cells.
Waterman-Storer CM.
Mol. Biol. Cell. 1998 Dec;9(12):3263-71.
[Text Abstract on PubMed]

Fluorescent speckle microscopy, a method to visualize the dynamics of protein assemblies in living cells.
Waterman-Storer CM, Desai A, Bulinski JC, Salmon ED.
Curr. Biol. 1998 Nov 5;8(22):1227-30.
[Text Abstract on PubMed]

How microtubules get fluorescent speckles.
Waterman-Storer CM, Salmon ED.
Biophys. J. 1998 Oct;75(4):2059-69.
[Text Abstract on PubMed]

Endoplasmic reticulum membrane tubules are distributed by microtubules in living cells using three distinct mechanisms.
Waterman-Storer CM, Salmon ED.
Curr. Biol. 1998 Jul 2;8(14):798-806.
[Text Abstract on PubMed]

A high-resolution multimode digital microscope system.
Salmon ED, Shaw SL, Waters J, Waterman-Storer CM, Maddox PS, Yeh E, Bloom K.
Methods Cell Biol. 1998;56:185-215.
[Text Abstract on PubMed]

Production and presentation of digital movies.
Waterman-Storer CM, Shaw SL, Salmon ED.
Trends Cell Biol. 1997 Dec;7(12):503-6.
[Text Abstract on PubMed]

The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport.
Waterman-Storer CM, Karki SB, Kuznetsov SA, Tabb JS, Weiss DG, Langford GM, Holzbaur EL.
Proc. Natl. Acad. Sci. U.S.A. 1997 Oct 28;94(22):12180-5.
[Text Abstract on PubMed]

Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase.
Xiong W, Parsons JT.
J. Cell Biol. 1997 Oct 20;139(2):529-39.
[Text Abstract on PubMed]

Microtubule dynamics: treadmilling comes around again.
Waterman-Storer CM, Salmon ED.
Curr. Biol. 1997 Jun 1;7(6):R369-72.
[Text Abstract on PubMed]

The product of the Drosophila gene, Glued, is the functional homologue of the p150Glued component of the vertebrate dynactin complex.
Waterman-Storer CM, Holzbaur EL.
J. Biol. Chem. 1996 Jan 12;271(2):1153-9.
[Text Abstract on PubMed]

Membrane/microtubule tip attachment complexes (TACs) allow the assembly dynamics of plus ends to push and pull membranes into tubulovesicular networks in interphase Xenopus egg extracts.
Waterman-Storer CM, Gregory J, Parsons SF, Salmon ED.
J. Cell Biol. 1995 Sep;130(5):1161-9.
[Text Abstract on PubMed]

The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).
Waterman-Storer CM, Karki S, Holzbaur EL.
Proc. Natl. Acad. Sci. U.S.A. 1995 Feb 28;92(5):1634-8.
[Text Abstract on PubMed]

Dynamics of organelles in the mitotic spindles of living cells: membrane and microtubule interactions.
Waterman-Storer CM, Sanger JW, Sanger JM.
Cell Motil. Cytoskeleton. 1993;26(1):19-39.
[Text Abstract on PubMed]

The cytoskeleton of skeletal muscle: is it affected by exercise? A brief review.
Waterman-Storer CM.
Med Sci Sports Exerc. 1991 Nov;23(11):1240-9.
[Text Abstract on PubMed]