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Nico Tjandra, Ph.D.

Publications


Principal Investigator thumbnail image

Nico Tjandra
Senior Investigator

P: +1 301 402 3029
F: +1 301 402 3405
tjandran@nhlbi.nih.gov


Full Publications Listing

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.
Snyder GA, Cirl C, Jiang J, Chen K, Waldhuber A, Smith P, Römmler F, Snyder N, Fresquez T, Dürr S, Tjandra N, Miethke T, Xiao TS.
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6985-90.
[Text Abstract on PubMed]

Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.
Ma J, Edlich F, Bermejo GA, Norris KL, Youle RJ, Tjandra N.
Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20901-6.
[Text Abstract on PubMed]

The maturational refolding of the ß-hairpin motif of equine infectious anemia virus capsid protein extends its helix a1 at capsid assembly locus.
Chen K, Piszczek G, Carter C, Tjandra N.
J. Biol. Chem. 2012 Nov 26.
[Text Abstract on PubMed]

Parameterization of solvent-protein interaction and its use on NMR protein structure determination.
Wang Y, Schwieters CD, Tjandra N.
J. Magn. Reson. 2012 Aug;221:76-84.
[Text Abstract on PubMed]

Characterization and solution structure of mouse myristoylated methionine sulfoxide reductase A.
Lim JC, Gruschus JM, Ghesquière B, Kim G, Piszczek G, Tjandra N, Levine RL.
J. Biol. Chem. 2012 Jul 20;287(30):25589-95.
[Text Abstract on PubMed]

A low pKa cysteine at the active site of mouse methionine sulfoxide reductase A.
Lim JC, Gruschus JM, Kim G, Berlett BS, Tjandra N, Levine RL.
J. Biol. Chem. 2012 Jul 20;287(30):25596-601.
[Text Abstract on PubMed]

On the mechanism of aC polymer formation in fibrin.
Tsurupa G, Pechik I, Litvinov RI, Hantgan RR, Tjandra N, Weisel JW, Medved L.
Biochemistry. 2012 Mar 27;51(12):2526-38.
[Text Abstract on PubMed]

Temperature dependence of molecular interactions involved in defining stability of glutamine binding protein and its complex with L-glutamine.
Pistolesi S, Tjandra N.
Biochemistry. 2012 Jan 17;51(2):643-52.
[Text Abstract on PubMed]

The use of residual dipolar coupling in studying proteins by NMR.
Chen K, Tjandra N.
Top Curr Chem. 2012;326:47-67.
[Text Abstract on PubMed]

Water proton spin saturation affects measured protein backbone 15N spin relaxation rates.
Chen K, Tjandra N.
J. Magn. Reson. 2011 Dec;213(1):151-7.
[Text Abstract on PubMed]

Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings.
Maciejewski M, Tjandra N, Barlow PN.
Biochemistry. 2011 Sep 27;50(38):8138-49.
[Text Abstract on PubMed]

Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3.
Zhou Z, Feng H, Zhou BR, Ghirlando R, Hu K, Zwolak A, Miller Jenkins LM, Xiao H, Tjandra N, Wu C, Bai Y.
Nature. 2011 Apr 14;472(7342):234-7.
[Text Abstract on PubMed]

Phosphoinositides direct equine infectious anemia virus gag trafficking and release.
Fernandes F, Chen K, Ehrlich LS, Jin J, Chen MH, Medina GN, Symons M, Montelaro R, Donaldson J, Tjandra N, Carter CA.
Traffic. 2011 Apr;12(4):438-51.
[Text Abstract on PubMed]

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.
Edlich F, Banerjee S, Suzuki M, Cleland MM, Arnoult D, Wang C, Neutzner A, Tjandra N, Youle RJ.
Cell. 2011 Apr 1;145(1):104-16.
[Text Abstract on PubMed]

Deuteration of Escherichia coli enzyme I(Ntr) alters its stability.
Piszczek G, Lee JC, Tjandra N, Lee CR, Seok YJ, Levine RL, Peterkofsky A.
Arch. Biochem. Biophys. 2011 Mar 15;507(2):332-42.
[Text Abstract on PubMed]

Molecular basis for barbed end uncapping by CARMIL homology domain 3 of mouse CARMIL-1.
Zwolak A, Uruno T, Piszczek G, Hammer, Tjandra N.
J. Biol. Chem. 2010 Sep 10;285(37):29014-26.
[Text Abstract on PubMed]

Structural basis for capping protein sequestration by myotrophin (V-1).
Zwolak A, Fujiwara I, Hammer, Tjandra N.
J. Biol. Chem. 2010 Aug 13;285(33):25767-81.
[Text Abstract on PubMed]

A practical implementation of cross-spectrum in protein backbone resonance assignment.
Chen K, Delaglio F, Tjandra N.
J. Magn. Reson. 2010 Apr;203(2):208-12.
[Text Abstract on PubMed]

Ligand-free open-closed transitions of periplasmic binding proteins: the case of glutamine-binding protein.
Bermejo GA, Strub MP, Ho C, Tjandra N.
Biochemistry. 2010 Mar 9;49(9):1893-902.
[Text Abstract on PubMed]

Structure, stability, and interaction of the fibrin(ogen) alphaC-domains.
Tsurupa G, Hantgan RR, Burton RA, Pechik I, Tjandra N, Medved L.
Biochemistry. 2009 Dec 29;48(51):12191-201.
[Text Abstract on PubMed]

Characterization of the N-terminal tail domain of histone H3 in condensed nucleosome arrays by hydrogen exchange and NMR.
Kato H, Gruschus J, Ghirlando R, Tjandra N, Bai Y.
J. Am. Chem. Soc. 2009 Oct 28;131(42):15104-5.
[Text Abstract on PubMed]

15N-1H scalar coupling perturbation: an additional probe for measuring structural changes due to ligand binding.
Ma J, Gruschus JM, Tjandra N.
J. Am. Chem. Soc. 2009 Jul 29;131(29):9884-5.
[Text Abstract on PubMed]

Determination of the solution-bound conformation of an amino acid binding protein by NMR paramagnetic relaxation enhancement: use of a single flexible paramagnetic probe with improved estimation of its sampling space.
Bermejo GA, Strub MP, Ho C, Tjandra N.
J. Am. Chem. Soc. 2009 Jul 15;131(27):9532-7.
[Text Abstract on PubMed]

Direct measurements of protein backbone 15N spin relaxation rates from peak line-width using a fully-relaxed Accordion 3D HNCO experiment.
Chen K, Tjandra N.
J. Magn. Reson. 2009 Mar;197(1):71-6.
[Text Abstract on PubMed]

Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase.
Yang Y, Wang X, Hawkins CA, Chen K, Vaynberg J, Mao X, Tu Y, Zuo X, Wang J, Wang YX, Wu C, Tjandra N, Qin J.
J. Biol. Chem. 2009 Feb 27;284(9):5836-44.
[Text Abstract on PubMed]

Weak alignment of biomacromolecules in collagen gels: an alternative way to yield residual dipolar couplings for NMR measurements.
Ma J, Goldberg GI, Tjandra N.
J. Am. Chem. Soc. 2008 Dec 3;130(48):16148-9.
[Text Abstract on PubMed]

BAX activation is initiated at a novel interaction site.
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD.
Nature. 2008 Oct 23;455(7216):1076-81.
[Text Abstract on PubMed]

Extended model free approach to analyze correlation functions of multidomain proteins in the presence of motional coupling.
Chen K, Tjandra N.
J. Am. Chem. Soc. 2008 Sep 24;130(38):12745-51.
[Text Abstract on PubMed]

Solution NMR structure of selenium-binding protein from Methanococcus vannielii.
Suzuki M, Lee DY, Inyamah N, Stadtman TC, Tjandra N.
J. Biol. Chem. 2008 Sep 19;283(38):25936-43.
[Text Abstract on PubMed]

Solution NMR characterizations of oligomerization and dynamics of equine infectious anemia virus matrix protein and its interaction with PIP2.
Chen K, Bachtiar I, Piszczek G, Bouamr F, Carter C, Tjandra N.
Biochemistry. 2008 Feb 19;47(7):1928-37.
[Text Abstract on PubMed]

Top-down approach in protein RDC data analysis: de novo estimation of the alignment tensor.
Chen K, Tjandra N.
J. Biomol. NMR. 2007 Aug;38(4):303-13.
[Text Abstract on PubMed]

NMR solution structure, stability, and interaction of the recombinant bovine fibrinogen alphaC-domain fragment.
Burton RA, Tsurupa G, Hantgan RR, Tjandra N, Medved L.
Biochemistry. 2007 Jul 24;46(29):8550-60.
[Text Abstract on PubMed]

Refinement of protein structure against non-redundant carbonyl 13C NMR relaxation.
Tjandra N, Suzuki M, Chang SL.
J. Biomol. NMR. 2007 Jul;38(3):243-53.
[Text Abstract on PubMed]

Residue-specific 13C' CSA tensor principal components for ubiquitin: correlation between tensor components and hydrogen bonding.
Burton RA, Tjandra N.
J. Am. Chem. Soc. 2007 Feb 7;129(5):1321-6.
[Text Abstract on PubMed]

On the accurate measurement of amide one-bond 15N-1H couplings in proteins: effects of cross-correlated relaxation, selective pulses and dynamic frequency shifts.
de Alba E, Tjandra N.
J. Magn. Reson. 2006 Nov;183(1):160-5.
[Text Abstract on PubMed]

Determination of the residue-specific 15N CSA tensor principal components using multiple alignment media.
Burton RA, Tjandra N.
J. Biomol. NMR. 2006 Aug;35(4):249-59.
[Text Abstract on PubMed]

Interference between cross-correlated relaxation and the measurement of scalar and dipolar couplings by Quantitative J.
de Alba E, Tjandra N.
J. Biomol. NMR. 2006 May;35(1):1-16.
[Text Abstract on PubMed]

Identification of an ordered compact structure within the recombinant bovine fibrinogen alphaC-domain fragment by NMR.
Burton RA, Tsurupa G, Medved L, Tjandra N.
Biochemistry. 2006 Feb 21;45(7):2257-66.
[Text Abstract on PubMed]

Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.
Suzuki M, Neutzner A, Tjandra N, Youle RJ.
J. Biol. Chem. 2005 Jun 3;280(22):21444-52.
[Text Abstract on PubMed]

Temperature dependence of protein backbone motion from carbonyl 13C and amide 15N NMR relaxation.
Chang SL, Tjandra N.
J. Magn. Reson. 2005 May;174(1):43-53.
[Text Abstract on PubMed]

Solution structure of human saposin C in a detergent environment.
Hawkins CA, de Alba E, Tjandra N.
J. Mol. Biol. 2005 Mar 11;346(5):1381-92.
[Text Abstract on PubMed]

Structural and dynamics studies of the D54A mutant of human T cell leukemia virus-1 capsid protein.
Bouamr F, Cornilescu CC, Goff SP, Tjandra N, Carter CA.
J. Biol. Chem. 2005 Feb 25;280(8):6792-801.
[Text Abstract on PubMed]

Structural basis for redox regulation of Yap1 transcription factor localization.
Wood MJ, Storz G, Tjandra N.
Nature. 2004 Aug 19;430(7002):917-21.
[Text Abstract on PubMed]

Structural studies on the Ca2+-binding domain of human nucleobindin (calnuc).
de Alba E, Tjandra N.
Biochemistry. 2004 Aug 10;43(31):10039-49.
[Text Abstract on PubMed]

Completely automated, highly error-tolerant macromolecular structure determination from multidimensional nuclear overhauser enhancement spectra and chemical shift assignments.
Kuszewski J, Schwieters CD, Garrett DS, Byrd RA, Tjandra N, Clore GM.
J. Am. Chem. Soc. 2004 May 26;126(20):6258-73.
[Text Abstract on PubMed]

Residual dipolar couplings in NMR structure analysis.
Lipsitz RS, Tjandra N.
Annu Rev Biophys Biomol Struct. 2004;33:387-413.
[Text Abstract on PubMed]

Residual dipolar couplings in protein structure determination.
de Alba E, Tjandra N.
Methods Mol. Biol. 2004;278:89-106.
[Text Abstract on PubMed]

Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles.
de Alba E, Weiler S, Tjandra N.
Biochemistry. 2003 Dec 23;42(50):14729-40.
[Text Abstract on PubMed]

The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle.
Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N.
J. Mol. Biol. 2003 Nov 28;334(3):445-58.
[Text Abstract on PubMed]

Specific non-native hydrophobic interactions in a hidden folding intermediate: implications for protein folding.
Feng H, Takei J, Lipsitz R, Tjandra N, Bai Y.
Biochemistry. 2003 Nov 4;42(43):12461-5.
[Text Abstract on PubMed]

Temperature dependence of domain motions of calmodulin probed by NMR relaxation at multiple fields.
Chang SL, Szabo A, Tjandra N.
J. Am. Chem. Soc. 2003 Sep 17;125(37):11379-84.
[Text Abstract on PubMed]

15N chemical shift anisotropy in protein structure refinement and comparison with NH residual dipolar couplings.
Lipsitz RS, Tjandra N.
J. Magn. Reson. 2003 Sep;164(1):171-6.
[Text Abstract on PubMed]

Overall structure and sugar dynamics of a DNA dodecamer from homo- and heteronuclear dipolar couplings and 31P chemical shift anisotropy.
Wu Z, Delaglio F, Tjandra N, Zhurkin VB, Bax A.
J. Biomol. NMR. 2003 Aug;26(4):297-315.
[Text Abstract on PubMed]

Backbone (15)N relaxation analysis of the N-terminal domain of the HTLV-I capsid protein and comparison with the capsid protein of HIV-1.
Cornilescu CC, Bouamr F, Carter C, Tjandra N.
Protein Sci. 2003 May;12(5):973-81.
[Text Abstract on PubMed]

The Xplor-NIH NMR molecular structure determination package.
Schwieters CD, Kuszewski JJ, Tjandra N, Clore GM.
J. Magn. Reson. 2003 Jan;160(1):65-73.
[Text Abstract on PubMed]

Hydrogen bonding in high-resolution protein structures: a new method to assess NMR protein geometry.
Lipsitz RS, Sharma Y, Brooks BR, Tjandra N.
J. Am. Chem. Soc. 2002 Sep 4;124(35):10621-6.
[Text Abstract on PubMed]

An ab initio study of amide proton shift tensor dependence on local protein structure.
Sharma Y, Kwon OY, Brooks B, Tjandra N.
J. Am. Chem. Soc. 2002 Jan 16;124(2):327-35.
[Text Abstract on PubMed]

Analysis of NMR relaxation data of biomolecules with slow domain motions using wobble-in-a-cone approximation.
Chang SL, Tjandra N.
J. Am. Chem. Soc. 2001 Nov 21;123(46):11484-5.
[Text Abstract on PubMed]

Carbonyl CSA restraints from solution NMR for protein structure refinement.
Lipsitz RS, Tjandra N.
J. Am. Chem. Soc. 2001 Nov 7;123(44):11065-6.
[Text Abstract on PubMed]

Analysis of slow interdomain motion of macromolecules using NMR relaxation data.
Baber JL, Szabo A, Tjandra N.
J. Am. Chem. Soc. 2001 May 2;123(17):3953-9.
[Text Abstract on PubMed]

31P chemical shift anisotropy as an aid in determining nucleic acid structure in liquid crystals.
Wu Z, Tjandra N, Bax A.
J. Am. Chem. Soc. 2001 Apr 18;123(15):3617-8.
[Text Abstract on PubMed]

Structural analysis of the N-terminal domain of the human T-cell leukemia virus capsid protein.
Cornilescu CC, Bouamr F, Yao X, Carter C, Tjandra N.
J. Mol. Biol. 2001 Mar 2;306(4):783-97.
[Text Abstract on PubMed]

Simple multidimensional NMR experiments to obtain different types of one-bond dipolar couplings simultaneously.
de Alba E, Suzuki M, Tjandra N.
J. Biomol. NMR. 2001 Jan;19(1):63-7.
[Text Abstract on PubMed]

Dipolar couplings in macromolecular structure determination.
Bax A, Kontaxis G, Tjandra N.
Meth. Enzymol. 2001;339:127-74.
[Text Abstract on PubMed]

Structure of Bax: coregulation of dimer formation and intracellular localization.
Suzuki M, Youle RJ, Tjandra N.
Cell. 2000 Nov 10;103(4):645-54.
[Text Abstract on PubMed]

Protein backbone (15)N relaxation rates as a tool for the diagnosis of structure quality.
de Alba E, Tjandra N.
J. Magn. Reson. 2000 Jun;144(2):367-71.
[Text Abstract on PubMed]

Chemical shift mapped DNA-binding sites and 15N relaxation analysis of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K.
Baber JL, Levens D, Libutti D, Tjandra N.
Biochemistry. 2000 May 23;39(20):6022-32.
[Text Abstract on PubMed]

Direct refinement against proton-proton dipolar couplings in NMR structure determination of macromolecules.
Tjandra N, Marquardt J, Clore GM.
J. Magn. Reson. 2000 Feb;142(2):393-6.
[Text Abstract on PubMed]

Establishing a degree of order: obtaining high-resolution NMR structures from molecular alignment.
Tjandra N.
Structure. 1999 Sep 15;7(9):R205-11.
[Text Abstract on PubMed]

Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling.
de Alba E, De Vries L, Farquhar MG, Tjandra N.
J. Mol. Biol. 1999 Aug 27;291(4):927-39.
[Text Abstract on PubMed]

High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor.
Baber JL, Libutti D, Levens D, Tjandra N.
J. Mol. Biol. 1999 Jun 18;289(4):949-62.
[Text Abstract on PubMed]

The use of dipolar couplings for determining the solution structure of rat apo-S100B(betabeta).
Drohat AC, Tjandra N, Baldisseri DM, Weber DJ.
Protein Sci. 1999 Apr;8(4):800-9.
[Text Abstract on PubMed]

Measurement of dipolar couplings for methylene and methyl sites in weakly oriented macromolecules and their use in structure determination.
Ottiger M, Delaglio F, Marquardt JL, Tjandra N, Bax A.
J. Magn. Reson. 1998 Oct;134(2):365-9.
[Text Abstract on PubMed]

Dynamical behavior of the HIV-1 nucleocapsid protein.
Lee BM, De Guzman RN, Turner BG, Tjandra N, Summers MF.
J. Mol. Biol. 1998 Jun 12;279(3):633-49.
[Text Abstract on PubMed]

Direct structure refinement against residual dipolar couplings in the presence of rhombicity of unknown magnitude.
Clore GM, Gronenborn AM, Tjandra N.
J. Magn. Reson. 1998 Mar;131(1):159-62.
[Text Abstract on PubMed]

Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium.
Tjandra N, Bax A.
Science. 1997 Nov 7;278(5340):1111-4.
[Text Abstract on PubMed]

High-resolution heteronuclear NMR of human ubiquitin in an aqueous liquid crystalline medium.
Bax A, Tjandra N.
J. Biomol. NMR. 1997 Oct;10(3):289-92.
[Text Abstract on PubMed]

Use of dipolar 1H-15N and 1H-13C couplings in the structure determination of magnetically oriented macromolecules in solution.
Tjandra N, Omichinski JG, Gronenborn AM, Clore GM, Bax A.
Nat. Struct. Biol. 1997 Sep;4(9):732-8.
[Text Abstract on PubMed]

Closed form of liganded glutamine-binding protein by rotational-echo double-resonance NMR.
Klug CA, Tasaki K, Tjandra N, Ho C, Schaefer J.
Biochemistry. 1997 Aug 5;36(31):9405-8.
[Text Abstract on PubMed]

Defining long range order in NMR structure determination from the dependence of heteronuclear relaxation times on rotational diffusion anisotropy.
Tjandra N, Garrett DS, Gronenborn AM, Bax A, Clore GM.
Nat. Struct. Biol. 1997 Jun;4(6):443-9.
[Text Abstract on PubMed]

Refined solution structure and backbone dynamics of HIV-1 Nef.
Grzesiek S, Bax A, Hu JS, Kaufman J, Palmer I, Stahl SJ, Tjandra N, Wingfield PT.
Protein Sci. 1997 Jun;6(6):1248-63.
[Text Abstract on PubMed]

Are proteins even floppier than we thought?
Bax A, Tjandra N.
Nat. Struct. Biol. 1997 Apr;4(4):254-6.
[Text Abstract on PubMed]

1H, 13C, and 15N NMR backbone assignments and chemical-shift-derived secondary structure of glutamine-binding protein of Escherichia coli.
Yu J, Simplaceanu V, Tjandra NL, Cottam PF, Lukin JA, Ho C.
J. Biomol. NMR. 1997 Feb;9(2):167-80.
[Text Abstract on PubMed]

Measurement of dipolar contributions to 1JCH splittings from magnetic-field dependence of J modulation in two-dimensional NMR spectra.
Tjandra N, Bax A.
J. Magn. Reson. 1997 Feb;124(2):512-5.
[Text Abstract on PubMed]

Anisotropic rotational diffusion of perdeuterated HIV protease from 15N NMR relaxation measurements at two magnetic fields.
Tjandra N, Wingfield P, Stahl S, Bax A.
J. Biomol. NMR. 1996 Oct;8(3):273-84.
[Text Abstract on PubMed]

Solution structure of calcium-free calmodulin.
Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A.
Nat. Struct. Biol. 1995 Sep;2(9):768-76.
[Text Abstract on PubMed]

Rotational dynamics of calcium-free calmodulin studied by 15N-NMR relaxation measurements.
Tjandra N, Kuboniwa H, Ren H, Bax A.
Eur. J. Biochem. 1995 Jun 15;230(3):1014-24.
[Text Abstract on PubMed]

An investigation of the ligand-binding site of the glutamine-binding protein of Escherichia coli using rotational-echo double-resonance NMR.
Hing AW, Tjandra N, Cottam PF, Schaefer J, Ho C.
Biochemistry. 1994 Jul 26;33(29):8651-61.
[Text Abstract on PubMed]

Structure and self assembly of a retrovirus (FeLV) proline rich neutralization domain.
Fontenot JD, Tjandra N, Ho C, Andrews PC, Montelaro RC.
J. Biomol. Struct. Dyn. 1994 Feb;11(4):821-36.
[Text Abstract on PubMed]

Biophysical characterization of one-, two-, and three-tandem repeats of human mucin (muc-1) protein core.
Fontenot JD, Tjandra N, Bu D, Ho C, Montelaro RC, Finn OJ.
Cancer Res. 1993 Nov 15;53(22):5386-94.
[Text Abstract on PubMed]

Multidimensional 1H and 15N NMR investigation of glutamine-binding protein of Escherichia coli.
Tjandra N, Simplaceanu V, Cottam PF, Ho C.
J. Biomol. NMR. 1992 Mar;2(2):149-60.
[Text Abstract on PubMed]

Slow motions in oriented phospholipid bilayers and effects of cholesterol or gramicidin. A 19F-NMR T1 rho study.
Peng ZY, Tjandra N, Simplaceanu V, Ho C.
Biophys. J. 1989 Nov;56(5):877-85.
[Text Abstract on PubMed]