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James Taylor, M.D.


Principal Investigator thumbnail image

James Taylor
Assistant Clinical Investigator

P: +1 301 435 7895
F: +1 301 402 0190

Full Publications Listing

Hemodynamic predictors of mortality in adults with sickle cell disease.
Mehari A, Alam S, Tian X, Cuttica MJ, Barnett CF, Miles G, Xu D, Seamon C, Adams-Graves P, Castro OL, Minniti CP, Sachdev V, Taylor JG 6th, Kato GJ, Machado RF.
Am J Respir Crit Care Med. 2013 Apr 15;187(8):840-7.
[Text Abstract on PubMed]

Reduced sensitivity of the ferroportin Q248H mutant to physiologicconcentrations of hepcidin.
Nekhai S, Xu M, Foster A, Kasvosve I, Diaz S, Machado RF, Castro OL, Kato GJ, Taylor J, Gordeuk VR.
Haematologica. 2012 Oct 12.
[Text Abstract on PubMed]

Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.
Bae HT, Baldwin CT, Sebastiani P, Telen MJ, Ashley-Koch A, Garrett M, Hooper WC, Bean CJ, Debaun MR, Arking DE, Bhatnagar P, Casella JF, Keefer JR, Barron-Casella E, Gordeuk V, Kato GJ, Minniti C, Taylor J, Campbell A, Luchtman-Jones L, Hoppe C, Gladwin MT, Zhang Y, Steinberg MH.
Blood. 2012 Aug 30;120(9):1961-2.
[Text Abstract on PubMed]

Harnessing genomics to identify environmental determinants of heritable disease.
Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB.
Mutat. Res. 2012 Aug 28.
[Text Abstract on PubMed]

Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia.
Darbari DS, Onyekwere O, Nouraie M, Minniti CP, Luchtman-Jones L, Rana S, Sable C, Ensing G, Dham N, Campbell A, Arteta M, Gladwin MT, Castro O, Taylor, Kato GJ, Gordeuk V.
J. Pediatr. 2012 Feb;160(2):286-90.
[Text Abstract on PubMed]

Therapy-related acute myelogenous leukemia in a hydroxyurea-treated patient with sickle cell anemia.
Taylor JG, Darbari DS, Darari DS, Maric I, McIver Z, Arthur DC.
Ann. Intern. Med. 2011 Nov 15;155(10):722-4.
[Text Abstract on PubMed]

Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom.
Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Taylor, Hannoush H, Goldsmith JC, Gladwin MT, Gordeuk VR, Walk-PHASST Investigators.
Circulation. 2011 Sep 27;124(13):1452-60.
[Text Abstract on PubMed]

Transcriptome profiling and sequencing of differentiated human hematopoietic stem cells reveal lineage-specific expression and alternative splicing of genes.
Liu P, Barb J, Woodhouse K, Taylor JG 6th, Munson PJ, Raghavachari N.
Physiol Genomics. 2011 Oct 20;43(20):1117-34.
[Text Abstract on PubMed]

Laboratory and echocardiography markers in sickle cell patients with leg ulcers.
Minniti CP, Taylor, Hildesheim M, O'Neal P, Wilson J, Castro O, Gordeuk VR, Kato GJ.
Am. J. Hematol. 2011 Aug;86(8):705-8.
[Text Abstract on PubMed]

Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension.
Zorca S, Freeman L, Hildesheim M, Allen D, Remaley AT, Taylor, Kato GJ.
Br. J. Haematol. 2010 May;149(3):436-45.
[Text Abstract on PubMed]

Pleiotropic effects of intravascular haemolysis on vascular homeostasis.
Kato GJ, Taylor.
Br. J. Haematol. 2010 Mar;148(5):690-701.
[Text Abstract on PubMed]

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.
Taylor, Cheuk AT, Tsang PS, Chung JY, Song YK, Desai K, Yu Y, Chen QR, Shah K, Youngblood V, Fang J, Kim SY, Yeung C, Helman LJ, Mendoza A, Ngo V, Staudt LM, Wei JS, Khanna C, Catchpoole D, Qualman SJ, Hewitt SM, Merlino G, Chanock SJ, Khan J.
J. Clin. Invest. 2009 Nov;119(11):3395-407.
[Text Abstract on PubMed]

Improvement in hemolysis and pulmonary arterial systolic pressure in adult patients with sickle cell disease during treatment with hydroxyurea.
Olnes M, Chi A, Haney C, May R, Minniti C, Taylor, Kato GJ.
Am. J. Hematol. 2009 Aug;84(8):530-32.
[Text Abstract on PubMed]

Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
Kato GJ, Wang Z, Machado RF, Blackwelder WC, Taylor, Hazen SL.
Br. J. Haematol. 2009 May;145(4):506-13.
[Text Abstract on PubMed]

Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy.
Little JA, Hauser KP, Martyr SE, Harris A, Maric I, Morris CR, Suh JH, Taylor J, Castro O, Machado R, Kato G, Gladwin MT.
Eur. J. Haematol. 2009 Apr;82(4):315-21.
[Text Abstract on PubMed]

Transplant-associated Ochroconis gallopava infections.
Shoham S, Pic-Aluas L, Taylor J, Cortez K, Rinaldi MG, Shea Y, Walsh TJ.
Transpl Infect Dis. 2008 Dec;10(6):442-8.
[Text Abstract on PubMed]

Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease.
Darbari DS, Castro O, Taylor, Fasano R, Rehm J, Gordeuk VR, Minniti CP.
J Natl Med Assoc. 2008 Aug;100(8):948-51.
[Text Abstract on PubMed]

Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency.
Gordeuk VR, Sachdev V, Taylor JG, Gladwin MT, Kato G, Castro OL.
Am. J. Hematol. 2008 Jan;83(1):15-8.
[Text Abstract on PubMed]

Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease.
Taylor, Ackah D, Cobb C, Orr N, Percy MJ, Sachdev V, Machado R, Castro O, Kato GJ, Chanock SJ, Gladwin MT.
Am. J. Hematol. 2008 Jan;83(1):6-14.
[Text Abstract on PubMed]

Severe pulmonary hypertension in an adolescent with sickle cell disease.
Taylor, Woods GM, Machado R, Kato GJ, Gladwin MT.
Am. J. Hematol. 2008 Jan;83(1):71-2.
[Text Abstract on PubMed]

Sickle cell disease and pulmonary hypertension in Africa: a global perspective and review of epidemiology, pathophysiology, and management.
Aliyu ZY, Kato GJ, Taylor, Babadoko A, Mamman AI, Gordeuk VR, Gladwin MT.
Am. J. Hematol. 2008 Jan;83(1):63-70.
[Text Abstract on PubMed]

Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain.
Taylor, Nolan VG, Mendelsohn L, Kato GJ, Gladwin MT, Steinberg MH.
PLoS ONE. 2008;3(5):e2095.
[Text Abstract on PubMed]

A network model to predict the risk of death in sickle cell disease.
Sebastiani P, Nolan VG, Baldwin CT, Abad-Grau MM, Wang L, Adewoye AH, McMahon LC, Farrer LA, Taylor, Kato GJ, Gladwin MT, Steinberg MH.
Blood. 2007 Oct 1;110(7):2727-35.
[Text Abstract on PubMed]

Functional profiling of uncommon VCAM1 promoter polymorphisms prevalent in African American populations.
Idelman G, Taylor JG, Tongbai R, Chen RA, Haggerty CM, Bilke S, Chanock SJ, Gardner K.
Hum. Mutat. 2007 Aug;28(8):824-9.
[Text Abstract on PubMed]

Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review.
Little JA, McGowan VR, Kato GJ, Partovi KS, Feld JJ, Maric I, Martyr S, Taylor, Machado RF, Heller T, Castro O, Gladwin MT.
Haematologica. 2006 Aug;91(8):1076-83.
[Text Abstract on PubMed]

Cerebrovascular disease associated with sickle cell pulmonary hypertension.
Kato GJ, Hsieh M, Machado R, Taylor, Little J, Butman JA, Lehky T, Tisdale J, Gladwin MT.
Am. J. Hematol. 2006 Jul;81(7):503-10.
[Text Abstract on PubMed]

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.
Kato GJ, McGowan V, Machado RF, Little JA, Taylor, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris, Gladwin MT.
Blood. 2006 Mar 15;107(6):2279-85.
[Text Abstract on PubMed]

Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients.
Choi EH, Taylor JG, Foster CB, Walsh TJ, Anttila VJ, Ruutu T, Palotie A, Chanock SJ.
Med. Mycol. 2005 Jun;43(4):349-53.
[Text Abstract on PubMed]

Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection.
Bernig T, Taylor JG, Foster CB, Staats B, Yeager M, Chanock SJ.
Genes Immun. 2004 Sep;5(6):461-76.
[Text Abstract on PubMed]

Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2.
Eck P, Erichsen HC, Taylor JG, Yeager M, Hughes AL, Levine M, Chanock S.
Hum. Genet. 2004 Sep;115(4):285-94.
[Text Abstract on PubMed]

Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes.
Choi EH, Foster CB, Taylor JG, Erichsen HC, Chen RA, Walsh TJ, Anttila VJ, Ruutu T, Palotie A, Chanock SJ.
J. Infect. Dis. 2003 Apr 1;187(7):1153-6.
[Text Abstract on PubMed]

Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease.
Taylor, Tang DC, Savage SA, Leitman SF, Heller SI, Serjeant GR, Rodgers GP, Chanock SJ.
Blood. 2002 Dec 15;100(13):4303-9.
[Text Abstract on PubMed]

Using genetic variation to study immunomodulation.
Chanock S, Taylor.
Curr Opin Pharmacol. 2002 Aug;2(4):463-9.
[Text Abstract on PubMed]

Using genetic variation to study human disease.
Taylor JG, Choi EH, Foster CB, Chanock SJ.
Trends Mol Med. 2001 Nov;7(11):507-12.
[Text Abstract on PubMed]

Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S.
Agarwal A, Guindo A, Cissoko Y, Taylor JG, Coulibaly D, Koné A, Kayentao K, Djimde A, Plowe CV, Doumbo O, Wellems TE, Diallo D.
Blood. 2000 Oct 1;96(7):2358-63.
[Text Abstract on PubMed]

Toward quantitative genetic analysis of host and parasite traits in the manifestations of Plasmodium falciparum malaria.
Taylor JG, Ferdig MT, Su XZ, Wellems TE.
Curr. Opin. Genet. Dev. 2000 Jun;10(3):314-9.
[Text Abstract on PubMed]