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Lance R. Pohl, Pharm.D., Ph.D.

Publications


Principal Investigator thumbnail image

Lance R. Pohl
Senior Investigator

P: +1 301 451 1097
F: +1 301 480 4852
pohll@nih.gov


Full Publications Listing

Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice.
Proctor WR, Chakraborty M, Chea LS, Morrison JC, Berkson JD, Semple K, Bourdi M, Pohl LR.
Hepatology. 2013 May 1;57(5):2026-36.
[Text Abstract on PubMed]

Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice.
Ryan PM, Bourdi M, Korrapati MC, Proctor WR, Vasquez RA, Yee SB, Quinn TD, Chakraborty M, Pohl LR.
Chem. Res. Toxicol. 2012 Jan 13;25(1):83-93.
[Text Abstract on PubMed]

SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.
Lu Z, Bourdi M, Li JH, Aponte AM, Chen Y, Lombard DB, Gucek M, Pohl LR, Sack MN.
EMBO Rep. 2011 Aug;12(8):840-6.
[Text Abstract on PubMed]

Mispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury.
Bourdi M, Davies JS, Pohl LR.
Chem. Res. Toxicol. 2011 Jun 20;24(6):794-6.
[Text Abstract on PubMed]

Pathologic role of stressed-induced glucocorticoids in drug-induced liver injury in mice.
Masson MJ, Collins LA, Carpenter LD, Graf ML, Ryan PM, Bourdi M, Pohl LR.
Biochem. Biophys. Res. Commun. 2010 Jul 2;397(3):453-8.
[Text Abstract on PubMed]

The role of cytokines in the mechanism of adverse drug reactions.
Masson MJ, Collins LA, Pohl LR.
Handb Exp Pharmacol. 2010(196):195-231.
[Text Abstract on PubMed]

Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury.
Bourdi M, Korrapati MC, Chakraborty M, Yee SB, Pohl LR.
Biochem. Biophys. Res. Commun. 2008 Sep 12;374(1):6-10.
[Text Abstract on PubMed]

Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide.
Masson MJ, Carpenter LD, Graf ML, Pohl LR.
Hepatology. 2008 Sep;48(3):889-97.
[Text Abstract on PubMed]

Lamotrigine extended-release as adjunctive therapy for partial seizures.
Naritoku DK, Warnock CR, Messenheimer JA, Borgohain R, Evers S, Guekht AB, Karlov VA, Lee BI, Pohl LR.
Neurology. 2007 Oct 16;69(16):1610-8.
[Text Abstract on PubMed]

Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminophen-induced liver disease.
Yee SB, Bourdi M, Masson MJ, Pohl LR.
Chem. Res. Toxicol. 2007 May;20(5):734-44.
[Text Abstract on PubMed]

Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.
Bourdi M, Eiras DP, Holt MP, Webster MR, Reilly TP, Welch KD, Pohl LR.
Chem. Res. Toxicol. 2007 Feb;20(2):208-16.
[Text Abstract on PubMed]

Lymphocyte loss and immunosuppression following acetaminophen-induced hepatotoxicity in mice as a potential mechanism of tolerance.
Masson MJ, Peterson RA, Chung CJ, Graf ML, Carpenter LD, Ambroso JL, Krull DL, Sciarrotta J, Pohl LR.
Chem. Res. Toxicol. 2007 Jan;20(1):20-6.
[Text Abstract on PubMed]

Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice.
Welch KD, Reilly TP, Bourdi M, Hays T, Pise-Masison CA, Radonovich MF, Brady JN, Dix DJ, Pohl LR.
Chem. Res. Toxicol. 2006 Feb;19(2):223-33.
[Text Abstract on PubMed]

Proteomic identification of potential susceptibility factors in drug-induced liver disease.
Welch KD, Wen B, Goodlett DR, Yi EC, Lee H, Reilly TP, Nelson SD, Pohl LR.
Chem. Res. Toxicol. 2005 Jun;18(6):924-33.
[Text Abstract on PubMed]

Tolerogenic role of Kupffer cells in immune-mediated adverse drug reactions.
Ju C, Pohl LR.
Toxicology. 2005 Apr 15;209(2):109-12.
[Text Abstract on PubMed]

Tolerogenic role of Kupffer cells in allergic reactions.
Ju C, McCoy JP, Chung CJ, Graf ML, Pohl LR.
Chem. Res. Toxicol. 2003 Dec;16(12):1514-9.
[Text Abstract on PubMed]

Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease.
Masubuchi Y, Bourdi M, Reilly TP, Graf ML, George JW, Pohl LR.
Biochem. Biophys. Res. Commun. 2003 Apr 25;304(1):207-12.
[Text Abstract on PubMed]

Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice.
Ju C, Reilly TP, Bourdi M, Radonovich MF, Brady JN, George JW, Pohl LR.
Chem. Res. Toxicol. 2002 Dec;15(12):1504-13.
[Text Abstract on PubMed]

Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness.
Bourdi M, Reilly TP, Elkahloun AG, George JW, Pohl LR.
Biochem. Biophys. Res. Commun. 2002 Jun 7;294(2):225-30.
[Text Abstract on PubMed]

Subcellular localization of trifluoroacetylated liver proteins in association with hepatitis following isoflurane.
Njoku DB, Shrestha S, Soloway R, Duray PR, Tsokos M, Abu-Asab MS, Pohl LR, West AB.
Anesthesiology. 2002 Mar;96(3):757-61.
[Text Abstract on PubMed]

Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists.
Njoku DB, Greenberg RS, Bourdi M, Borkowf CB, Dake EM, Martin JL, Pohl LR.
Anesth. Analg. 2002 Feb;94(2):243-9, table of contents.
[Text Abstract on PubMed]

Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase.
Bourdi M, Masubuchi Y, Reilly TP, Amouzadeh HR, Martin JL, George JW, Shah AG, Pohl LR.
Hepatology. 2002 Feb;35(2):289-98.
[Text Abstract on PubMed]

A protective role for cyclooxygenase-2 in drug-induced liver injury in mice.
Reilly TP, Brady JN, Marchick MR, Bourdi M, George JW, Radonovich MF, Pise-Masison CA, Pohl LR.
Chem. Res. Toxicol. 2001 Dec;14(12):1620-8.
[Text Abstract on PubMed]

Immunohistochemical detection of protein adducts of 2,4-dinitrochlorobenzene in antigen presenting cells and lymphocytes after oral administration to mice: lack of a role of Kupffer cells in oral tolerance.
Ju C, Pohl LR.
Chem. Res. Toxicol. 2001 Sep;14(9):1209-17.
[Text Abstract on PubMed]

Fatal hepatitis associated with isoflurane exposure and CYP2A6 autoantibodies.
Martin JL, Keegan MT, Vasdev GM, Nyberg SL, Bourdi M, Pohl LR, Plevak DJ.
Anesthesiology. 2001 Aug;95(2):551-3.
[Text Abstract on PubMed]

Halothane-induced liver injury in outbred guinea pigs: role of trifluoroacetylated protein adducts in animal susceptibility.
Bourdi M, Amouzadeh HR, Rushmore TH, Martin JL, Pohl LR.
Chem. Res. Toxicol. 2001 Apr;14(4):362-70.
[Text Abstract on PubMed]

Expression profiling of acetaminophen liver toxicity in mice using microarray technology.
Reilly TP, Bourdi M, Brady JN, Pise-Masison CA, Radonovich MF, George JW, Pohl LR.
Biochem. Biophys. Res. Commun. 2001 Mar 23;282(1):321-8.
[Text Abstract on PubMed]

Drug enterocyte adducts: possible causal factor for diclofenac enteropathy in rats.
Atchison CR, West AB, Balakumaran A, Hargus SJ, Pohl LR, Daiker DH, Aronson JF, Hoffmann WE, Shipp BK, Treinen-Moslen M.
Gastroenterology. 2000 Dec;119(6):1537-47.
[Text Abstract on PubMed]

Renal cysteine conjugate beta-lyase and compound A nephrotoxicity: minimal evidence for an association.
Njoku DB, Martin JL, Pohl LR.
Anesthesiology. 1999 Mar;90(3):921-2.
[Text Abstract on PubMed]

Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.
Chem. Res. Toxicol. 1999 Feb;12(2):214-22.
[Text Abstract on PubMed]

Immunochemical evidence against the involvement of cysteine conjugate beta-lyase in compound A nephrotoxicity in rats.
Njoku DB, Pohl LR, Sokoloski EA, Marchick MR, Borkowf CB, Martin JL.
Anesthesiology. 1999 Feb;90(2):458-69.
[Text Abstract on PubMed]

Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions.
Ware JA, Graf ML, Martin BM, Lustberg LR, Pohl LR.
Chem. Res. Toxicol. 1998 Mar;11(3):164-71.
[Text Abstract on PubMed]

Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons.
Hoet P, Graf ML, Bourdi M, Pohl LR, Duray PH, Chen W, Peter RM, Nelson SD, Verlinden N, Lison D.
Lancet. 1997 Aug 23;350(9077):556-9.
[Text Abstract on PubMed]

Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins.
Cribb AE, Pohl LR, Spielberg SP, Leeder JS.
J. Pharmacol. Exp. Ther. 1997 Aug;282(2):1064-71.
[Text Abstract on PubMed]

Cytochrome P4502C11 is a target of diclofenac covalent binding in rats.
Shen S, Hargus SJ, Martin BM, Pohl LR.
Chem. Res. Toxicol. 1997 Apr;10(4):420-3.
[Text Abstract on PubMed]

Selective protein covalent binding and target organ toxicity.
Cohen SD, Pumford NR, Khairallah EA, Boekelheide K, Pohl LR, Amouzadeh HR, Hinson JA.
Toxicol. Appl. Pharmacol. 1997 Mar;143(1):1-12.
[Text Abstract on PubMed]

UDP-glucose:glycoprotein glucosyltransferase associates with endoplasmic reticulum chaperones and its activity is decreased in vivo by the inhalation anesthetic halothane.
Amouzadeh HR, Bourdi M, Martin JL, Martin BM, Pohl LR.
Chem. Res. Toxicol. 1997 Jan;10(1):59-63.
[Text Abstract on PubMed]

Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.
Bourdi M, Chen W, Peter RM, Martin JL, Buters JT, Nelson SD, Pohl LR.
Chem. Res. Toxicol. 1996 Oct-Nov;9(7):1159-66.
[Text Abstract on PubMed]

Mechanisms, chemical structures and drug metabolism.
Pohl LR, Pumford NR, Martin JL.
Eur J Haematol Suppl. 1996;60:98-104.
[Text Abstract on PubMed]

Covalent modification of rat liver dipeptidyl peptidase IV (CD26) by the nonsteroidal anti-inflammatory drug diclofenac.
Hargus SJ, Martin BM, George JW, Pohl LR.
Chem. Res. Toxicol. 1995 Dec;8(8):993-6.
[Text Abstract on PubMed]

cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase.
Bourdi M, Demady D, Martin JL, Jabbour SK, Martin BM, George JW, Pohl LR.
Arch. Biochem. Biophys. 1995 Nov 10;323(2):397-403.
[Text Abstract on PubMed]

Hepatotoxicity after desflurane anesthesia.
Martin JL, Plevak DJ, Flannery KD, Charlton M, Poterucha JJ, Humphreys CE, Derfus G, Pohl LR.
Anesthesiology. 1995 Nov;83(5):1125-9.
[Text Abstract on PubMed]

Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes.
Amouzadeh HR, Pohl LR.
Hepatology. 1995 Sep;22(3):936-43.
[Text Abstract on PubMed]

Stereoselective metabolism of halothane enantiomers to trifluoroacetylated liver proteins.
Martin JL, Meinwald J, Radford P, Liu Z, Graf ML, Pohl LR.
Drug Metab. Rev. 1995;27(1-2):179-89.
[Text Abstract on PubMed]

Immunochemical methods of studying the mechanism of diclofenac-induced hepatitis.
Pohl LR, Martin JL, Hargus SJ.
Arthritis Rheum. 1994 Oct;37(10):1557.
[Text Abstract on PubMed]

Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac.
Hargus SJ, Amouzedeh HR, Pumford NR, Myers TG, McCoy SC, Pohl LR.
Chem. Res. Toxicol. 1994 Jul-Aug;7(4):575-82.
[Text Abstract on PubMed]

Immunochemical methods of studying the mechanism of diclofenac-induced hepatitis [corrected].
Pohl LR, Martin JL, Hargus SJ.
Arthritis Rheum. 1994 Jul;37(7):1112.
[Text Abstract on PubMed]

Characteristics of a purified dog hepatic microsomal N,O-acyltransferase.
Sone T, Zukowski K, Land SJ, King CM, Martin BM, Pohl LR, Wang CY.
Carcinogenesis. 1994 Apr;15(4):595-9.
[Text Abstract on PubMed]

An immunochemical approach of identifying and characterizing protein targets of toxic reactive metabolites.
Pohl LR.
Chem. Res. Toxicol. 1993 Nov-Dec;6(6):786-93.
[Text Abstract on PubMed]

Association of anti-58 kDa endoplasmic reticulum antibodies with halothane hepatitis.
Martin JL, Reed GF, Pohl LR.
Biochem. Pharmacol. 1993 Oct 5;46(7):1247-50.
[Text Abstract on PubMed]

Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase.
Martin JL, Kenna JG, Martin BM, Thomassen D, Reed GF, Pohl LR.
Hepatology. 1993 Oct;18(4):858-63.
[Text Abstract on PubMed]

Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72.
Pumford NR, Martin BM, Thomassen D, Burris JA, Kenna JG, Martin JL, Pohl LR.
Chem. Res. Toxicol. 1993 Sep-Oct;6(5):609-15.
[Text Abstract on PubMed]

Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac.
Pumford NR, Myers TG, Davila JC, Highet RJ, Pohl LR.
Chem. Res. Toxicol. 1993 Mar-Apr;6(2):147-50.
[Text Abstract on PubMed]

Immunohistochemical localization of carboxylesterase in the nasal mucosa of rats.
Olson MJ, Martin JL, LaRosa AC, Brady AN, Pohl LR.
J. Histochem. Cytochem. 1993 Feb;41(2):307-11.
[Text Abstract on PubMed]

The use of stable isotopes to identify reactive metabolites and target macromolecules associated with toxicities of halogenated hydrocarbon compounds.
Osawa Y, Highet RJ, Pohl LR.
Xenobiotica. 1992 Sep-Oct;22(9-10):1147-56.
[Text Abstract on PubMed]

Pentahaloethane-based chlorofluorocarbon substitutes and halothane: correlation of in vivo hepatic protein trifluoroacetylation and urinary trifluoroacetic acid excretion with calculated enthalpies of activation.
Harris JW, Jones JP, Martin JL, LaRosa AC, Olson MJ, Pohl LR, Anders MW.
Chem. Res. Toxicol. 1992 Sep-Oct;5(5):720-5.
[Text Abstract on PubMed]

The topography of trifluoroacetylated protein antigens in liver microsomal fractions from halothane treated rats.
Kenna JG, Martin JL, Pohl LR.
Biochem. Pharmacol. 1992 Aug 18;44(4):621-9.
[Text Abstract on PubMed]

The calcium-binding protein calreticulin is covalently modified in rat liver by a reactive metabolite of the inhalation anesthetic halothane.
Butler LE, Thomassen D, Martin JL, Martin BM, Kenna JG, Pohl LR.
Chem. Res. Toxicol. 1992 May-Jun;5(3):406-10.
[Text Abstract on PubMed]

Halothane hepatitis 28 years after primary exposure.
Martin JL, Dubbink DA, Plevak DJ, Peronne A, Taswell HF, Hay EJ, Pumford NR, Pohl LR.
Anesth. Analg. 1992 Apr;74(4):605-8.
[Text Abstract on PubMed]

Detection of cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts.
Hayden PJ, Ichimura T, McCann DJ, Pohl LR, Stevens JL.
J. Biol. Chem. 1991 Oct 5;266(28):18415-8.
[Text Abstract on PubMed]

A metabolite of halothane covalently binds to an endoplasmic reticulum protein that is highly homologous to phosphatidylinositol-specific phospholipase C-alpha but has no activity.
Martin JL, Pumford NR, LaRosa AC, Martin BM, Gonzaga HM, Beaven MA, Pohl LR.
Biochem. Biophys. Res. Commun. 1991 Jul 31;178(2):679-85.
[Text Abstract on PubMed]

Characterization by NMR of the heme-myoglobin adduct formed during the reductive metabolism of BrCCl3. Covalent bonding of the proximal histidine to the ring I vinyl group.
Osawa Y, Highet RJ, Bax A, Pohl LR.
J. Biol. Chem. 1991 Feb 15;266(5):3208-14.
[Text Abstract on PubMed]

Tissue acylation by the chlorofluorocarbon substitute 2,2-dichloro-1,1,1-trifluoroethane.
Harris JW, Pohl LR, Martin JL, Anders MW.
Proc. Natl. Acad. Sci. U.S.A. 1991 Feb 15;88(4):1407-10.
[Text Abstract on PubMed]

Cloning and sequencing of a human liver carboxylesterase isoenzyme.
Long RM, Calabrese MR, Martin BM, Pohl LR.
Life Sci. 1991;48(11):PL43-9.
[Text Abstract on PubMed]

Hapten carrier conjugates associated with halothane hepatitis.
Pohl LR, Thomassen D, Pumford NR, Butler LE, Satoh H, Ferrans VJ, Perrone A, Martin BM, Martin JL.
Adv. Exp. Med. Biol. 1991;283:111-20.
[Text Abstract on PubMed]

Drug-induced allergic hepatitis.
Pohl LR.
Semin. Liver Dis. 1990 Nov;10(4):305-15.
[Text Abstract on PubMed]

Factors affecting the expression of trifluoroacetylated liver microsomal protein neoantigens in rats treated with halothane.
Kenna JG, Martin JL, Satoh H, Pohl LR.
Drug Metab. Dispos. 1990 Sep-Oct;18(5):788-93.
[Text Abstract on PubMed]

Metabolism-based covalent bonding of the heme prosthetic group to its apoprotein during the reductive debromination of BrCCl3 by myoglobin.
Osawa Y, Martin BM, Griffin PR, Yates, Shabanowitz J, Hunt DF, Murphy AC, Chen L, Cotter RJ, Pohl LR.
J. Biol. Chem. 1990 Jun 25;265(18):10340-6.
[Text Abstract on PubMed]

Antibody assays for the detection of patients sensitized to halothane.
Martin JL, Kenna JG, Pohl LR.
Anesth. Analg. 1990 Feb;70(2):154-9.
[Text Abstract on PubMed]

Involvement of the carboxyl-terminal propeptide of beta-glucuronidase in its compartmentalization within the endoplasmic reticulum as determined by a synthetic peptide approach.
Medda S, Chemelli RM, Martin JL, Pohl LR, Swank RT.
J. Biol. Chem. 1989 Sep 25;264(27):15824-8.
[Text Abstract on PubMed]

Covalent bonding of the prosthetic heme to protein: a potential mechanism for the suicide inactivation or activation of hemoproteins.
Osawa Y, Pohl LR.
Chem. Res. Toxicol. 1989 May-Jun;2(3):131-41.
[Text Abstract on PubMed]

Drug-induced allergic hepatitis: does isaxonine fall into this category?
Pohl LR.
Hepatology. 1989 May;9(5):785-8.
[Text Abstract on PubMed]

Serum samples from patients with hepatic dysfunction following enflurane.
Martin JL, Pohl LR.
Anesthesiology. 1989 May;70(5):881.
[Text Abstract on PubMed]

Neoantigens associated with halothane hepatitis.
Pohl LR, Kenna JG, Satoh H, Christ D, Martin JL.
Drug Metab. Rev. 1989;20(2-4):203-17.
[Text Abstract on PubMed]

Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase.
Satoh H, Martin BM, Schulick AH, Christ DD, Kenna JG, Pohl LR.
Proc. Natl. Acad. Sci. U.S.A. 1989 Jan;86(1):322-6.
[Text Abstract on PubMed]

Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis.
Christ DD, Kenna JG, Kammerer W, Satoh H, Pohl LR.
Anesthesiology. 1988 Dec;69(6):833-8.
[Text Abstract on PubMed]

Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence for a multigene family.
Long RM, Satoh H, Martin BM, Kimura S, Gonzalez FJ, Pohl LR.
Biochem. Biophys. Res. Commun. 1988 Oct 31;156(2):866-73.
[Text Abstract on PubMed]

Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane.
Kenna JG, Satoh H, Christ DD, Pohl LR.
J. Pharmacol. Exp. Ther. 1988 Jun;245(3):1103-9.
[Text Abstract on PubMed]

Potential metabolic basis for enflurane hepatitis and the apparent cross-sensitization between enflurane and halothane.
Christ DD, Satoh H, Kenna JG, Pohl LR.
Drug Metab. Dispos. 1988 Jan-Feb;16(1):135-40.
[Text Abstract on PubMed]

The immunologic and metabolic basis of drug hypersensitivities.
Pohl LR, Satoh H, Christ DD, Kenna JG.
Annu. Rev. Pharmacol. Toxicol. 1988;28:367-87.
[Text Abstract on PubMed]

Inactivation of cytochrome P-450 by 2-isopropyl-4-pentenamide and other xenobiotics leads to heme-derived protein adducts.
Davies HW, Britt SG, Pohl LR.
Chem. Biol. Interact. 1986 Jun;58(3):345-52.
[Text Abstract on PubMed]

Activation of cytochrome P-450 heme in vivo.
Davies HW, Thomas PE, Pohl LR.
Adv. Exp. Med. Biol. 1986;197:253-61.
[Text Abstract on PubMed]

Investigation of the immunological basis of halothane-induced hepatotoxicity.
Satoh H, Gillette JR, Takemura T, Ferrans VJ, Jelenich SE, Kenna JG, Neuberger J, Pohl LR.
Adv. Exp. Med. Biol. 1986;197:657-73.
[Text Abstract on PubMed]

Carbon tetrachloride and 2-isopropyl-4-pentenamide-induced inactivation of cytochrome P-450 leads to heme-derived protein adducts.
Davies HW, Britt SG, Pohl LR.
Arch. Biochem. Biophys. 1986 Jan;244(1):387-92.
[Text Abstract on PubMed]

Immunochemical evidence of trifluoroacetylated cytochrome P-450 in the liver of halothane-treated rats.
Satoh H, Gillette JR, Davies HW, Schulick RD, Pohl LR.
Mol. Pharmacol. 1985 Nov;28(5):468-74.
[Text Abstract on PubMed]

Immunochemical identification of an irreversibly bound heme-derived adduct to cytochrome P-450 following CCl4 treatment of rats.
Davies HW, Satoh H, Schulick RD, Pohl LR.
Biochem. Pharmacol. 1985 Sep 1;34(17):3203-6.
[Text Abstract on PubMed]

Two-dimensional J-resolved nuclear magnetic resonance spectral study of two bromobenzene glutathione conjugates.
Ferretti JA, Highet RJ, Pohl LR, Monks TJ, Hinson JA.
Environ. Health Perspect. 1985 Sep;61:139-45.
[Text Abstract on PubMed]

Immunological studies on the mechanism of halothane-induced hepatotoxicity: immunohistochemical evidence of trifluoroacetylated hepatocytes.
Satoh H, Fukuda Y, Anderson DK, Ferrans VJ, Gillette JR, Pohl LR.
J. Pharmacol. Exp. Ther. 1985 Jun;233(3):857-62.
[Text Abstract on PubMed]

Strain and sex differences in chloroform-induced nephrotoxicity. Different rates of metabolism of chloroform to phosgene by the mouse kidney.
Pohl LR, George JW, Satoh H.
Drug Metab. Dispos. 1984 May-Jun;12(3):304-8.
[Text Abstract on PubMed]

The mechanism of formation of o-bromophenol from bromobenzene.
Monks TJ, Lau SS, Pohl LR, Gillette JR.
Drug Metab. Dispos. 1984 Mar-Apr;12(2):193-8.
[Text Abstract on PubMed]

Reductive-oxygenation mechanism of metabolism of carbon tetrachloride to phosgene by cytochrome P-450.
Pohl LR, Schulick RD, Highet RJ, George JW.
Mol. Pharmacol. 1984 Mar;25(2):318-21.
[Text Abstract on PubMed]

Nephrotoxicity of chloroform: metabolism to phosgene by the mouse kidney.
Branchflower RV, Nunn DS, Highet RJ, Smith JH, Hook JB, Pohl LR.
Toxicol. Appl. Pharmacol. 1984 Jan;72(1):159-68.
[Text Abstract on PubMed]

Determination of toxic pathways of metabolism by deuterium substitution.
Pohl LR, Gillette JR.
Drug Metab. Rev. 1984-1985;15(7):1335-51.
[Text Abstract on PubMed]

Identification of dichloromethyl carbene as a metabolite of carbon tetrachloride.
Pohl LR, George JW.
Biochem. Biophys. Res. Commun. 1983 Dec 16;117(2):367-71.
[Text Abstract on PubMed]

Comparison of the effects of methyl-N-butyl ketone and phenobarbital on rat liver cytochromes P-450 and the metabolism of chloroform to phosgene.
Branchflower RV, Schulick RD, George JW, Pohl LR.
Toxicol. Appl. Pharmacol. 1983 Dec;71(3):414-21.
[Text Abstract on PubMed]

Reductive oxygenation of carbon tetrachloride: trichloromethylperoxyl radical as a possible intermediate in the conversion of carbon tetrachloride to electrophilic chlorine.
Mico BA, Pohl LR.
Arch. Biochem. Biophys. 1983 Sep;225(2):596-609.
[Text Abstract on PubMed]

Formation of electrophilic chlorine from carbon tetrachloride--involvement of cytochrome P-450.
Mico BA, Branchflower RV, Pohl LR.
Biochem. Pharmacol. 1983 Aug 1;32(15):2357-9.
[Text Abstract on PubMed]

A continuous-flow detector for cytochrome P-450 and cytochrome P-420.
Bonner RF, Bungay PM, Pohl LR, Branchflower RV.
Anal. Biochem. 1983 Jul 1;132(1):26-33.
[Text Abstract on PubMed]

A perspective on halothane-induced hepatotoxicity.
Pohl LR, Gillette JR.
Anesth. Analg. 1982 Oct;61(10):809-11.
[Text Abstract on PubMed]

A new pathway for the oxidative metabolism of chloramphenicol by rat liver microsomes.
Morris PL, Burke, George JW, Pohl LR.
Drug Metab. Dispos. 1982 Sep-Oct;10(5):439-45.
[Text Abstract on PubMed]

Stereoselective formation of bromobenzene glutathione conjugates.
Monks TJ, Pohl LR, Gillette JR, Hong M, Highet RJ, Ferretti JA, Hinson JA.
Chem. Biol. Interact. 1982 Aug;41(2):203-16.
[Text Abstract on PubMed]

Metabolism of carbon tetrachloride to electrophilic chlorine by liver microsomes: exclusion of cytochrome P-450 catalyzed chloroperoxidase reaction.
Mico BA, Pohl LR.
Biochem. Biophys. Res. Commun. 1982 Jul 16;107(1):27-31.
[Text Abstract on PubMed]

Bone marrow toxicity in vitro of chloramphenicol and its metabolites.
Gross BJ, Branchflower RV, Burke TR, Lees DE, Pohl LR.
Toxicol. Appl. Pharmacol. 1982 Jul;64(3):557-65.
[Text Abstract on PubMed]

Oxidation of carbon tetrachloride, bromotrichloromethane, and carbon tetrabromide by rat liver microsomes to electrophilic halogens.
Mico BA, Branchflower RV, Pohl LR, Pudzianowski AT, Loew GH.
Life Sci. 1982 Jan 11;30(2):131-7.
[Text Abstract on PubMed]

3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen.
Hinson JA, Monks TJ, Hong M, Highet RJ, Pohl LR.
Drug Metab. Dispos. 1982 Jan-Feb;10(1):47-50.
[Text Abstract on PubMed]

Investigation of the mechanism of the potentiation of chloroform-induced hepatotoxicity and nephrotoxicity by methyl n-butyl ketone.
Branchflower RV, Pohl LR.
Toxicol. Appl. Pharmacol. 1981 Dec;61(3):407-13.
[Text Abstract on PubMed]

Influence of the intestinal microflora on the elimination of warfarin in the rat.
Remmel RP, Pohl LR, Elmer GW.
Drug Metab. Dispos. 1981 Sep-Oct;9(5):410-4.
[Text Abstract on PubMed]

Acetaminophen-induced hepatotoxicity.
Hinson JA, Pohl LR, Monks TJ, Gillette JR.
Life Sci. 1981 Jul 13;29(2):107-16.
[Text Abstract on PubMed]

The formation of diglutathionyl dithiocarbonate as a metabolite of chloroform, bromotrichloromethane, and carbon tetrachloride.
Pohl LR, Branchflower RV, Highet RJ, Martin JL, Nunn DS, Monks TJ, George JW, Hinson JA.
Drug Metab. Dispos. 1981 Jul-Aug;9(4):334-9.
[Text Abstract on PubMed]

Mechanism of defluorination of enflurane. Identification of an organic metabolite in rat and man.
Burke, Branchflower RV, Lees DE, Pohl LR.
Drug Metab. Dispos. 1981 Jan-Feb;9(1):19-24.
[Text Abstract on PubMed]

Covalent binding of electrophilic metabolites to macromolecules.
Pohl LR, Branchflower RV.
Meth. Enzymol. 1981;77:43-50.
[Text Abstract on PubMed]

Formation of chemically reactive metabolites of phenacetin and acetaminophen.
Gillette JR, Nelson SD, Mulder GJ, Jollow DJ, Mitchell JR, Pohl LR, Hinson JA.
Adv. Exp. Med. Biol. 1981;136 Pt B:931-50.
[Text Abstract on PubMed]

Mechanism of metabolic activation of chloroform by rat liver microsomes.
Pohl LR, Martin JL, George JW.
Biochem. Pharmacol. 1980 Dec;29(24):3271-6.
[Text Abstract on PubMed]

Mechanism of glutathione-dependent dechlorination of chloramphenicol and thiamphenicol by cytosol of rat liver.
Martin JL, Gross BJ, Morris P, Pohl LR.
Drug Metab. Dispos. 1980 Nov-Dec;8(6):371-5.
[Text Abstract on PubMed]

3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen.
Hinson JA, Pohl LR, Monks TJ, Gillette JR, Guengerich FP.
Drug Metab. Dispos. 1980 Sep-Oct;8(5):289-94.
[Text Abstract on PubMed]

Comparison of the biotransformation and hepatotoxicity of halothane and deuterated halothane.
Sipes IG, Gandolfi AJ, Pohl LR, Krishna G, Brown.
J. Pharmacol. Exp. Ther. 1980 Sep;214(3):716-20.
[Text Abstract on PubMed]

Bioactivation and covalent binding of halothane in vitro: studies with [3H]- and [14C]halothane.
Gandolfi AJ, White RD, Sipes IG, Pohl LR.
J. Pharmacol. Exp. Ther. 1980 Sep;214(3):721-5.
[Text Abstract on PubMed]

Investigation of the mechanism of defluorination of enflurane in rat liver microsomes with specifically deuterated derivatives.
Burke, Martin JL, George JW, Pohl LR.
Biochem. Pharmacol. 1980 Jun 1;29(11):1623-6.
[Text Abstract on PubMed]

Glutathione-dependent dechlorination of chloramphenicol by cytosol of rat liver.
Martin JL, George JW, Pohl LR.
Drug Metab. Dispos. 1980 Mar-Apr;8(2):93-7.
[Text Abstract on PubMed]

Carbon-13 nuclear magnetic resonance studies of spironolactone and several related steroids.
Highet RJ, Burke TR, Trager WF, Pohl LR, Menard RH, Taburet AM, Gillette JR.
Steroids. 1980 Feb;35(2):119-32.
[Text Abstract on PubMed]

A simple high-pressure liquid chromatographic assay for the N-hydroxy derivatives of phenacetin, acetaminophen, 2-acetylaminofluorene, and other hydroxamic acids.
Hinson JA, Pohl LR, Gillette JR.
Anal. Biochem. 1980 Jan 15;101(2):462-7.
[Text Abstract on PubMed]

Differing degrees of coal-tar shampoo-induced mutagenesis in the Salmonella/liver test system in vitro.
Fysh JM, Andrews LS, Pohl LR, Nebert DW.
Pharmacology. 1980;20(1):1-8.
[Text Abstract on PubMed]

Specificity of the in vitro destruction of adrenal and hepatic microsomal steroid hydroxylases by thiosteroids.
Menard RH, Guenthner TM, Taburet AM, Kon H, Pohl LR, Gillette JR, Gelboin HV, Trager WF.
Mol. Pharmacol. 1979 Nov;16(3):997-1010.
[Text Abstract on PubMed]

Production of a dimer of 2-acetylaminofluorene during the sulfation of N-hydroxy-2-acetylaminofluorene in vitro.
Andrews LS, Pohl LR, Hinson JA, Fisk CL, Gillette JR.
Drug Metab. Dispos. 1979 Sep-Oct;7(5):296-300.
[Text Abstract on PubMed]

A new pathway of metabolism of chloramphenicol which influences the interpretation of its irreversible binding to protein in vivo.
Pohl LR, Reddy GB, Krishna G.
Biochem. Pharmacol. 1979 Aug 15;28(16):2433-40.
[Text Abstract on PubMed]

The use of high-pressure liquid chromatography in the preparation of tritium-labeled chloramphenicol and its analogs.
Martin JL, Taburet AM, Pohl LR.
Anal. Biochem. 1979 Jul 1;96(1):215-9.
[Text Abstract on PubMed]

N-Hydroxyacetaminophen: a microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen.
Hinson JA, Pohl LR, Gillette JR.
Life Sci. 1979 Jun 4;24(23):2133-8.
[Text Abstract on PubMed]

Deuterium isotope effect in in vivo bioactivation of chloroform to phosgene.
Pohl LR, George JW, Martin JL, Krishna G.
Biochem. Pharmacol. 1979;28(4):561-3.
[Text Abstract on PubMed]

Deuterium isotope effect in bioactivation and hepatotoxicity of chloroform.
Pohl LR, Krishna G.
Life Sci. 1978 Sep 11;23(10):1067-72.
[Text Abstract on PubMed]

Investigation of the mechanism of the metabolic activation of chloramphenicol by rat liver microsomes. Identification of a new metabolite.
Pohl LR, Nelson SD, Krishna G.
Biochem. Pharmacol. 1978 Feb 15;27(4):491-6.
[Text Abstract on PubMed]

Study of the mechanism of metabolic activation of chloramphenicol by rat liver microsomes.
Pohl LR, Krishna G.
Biochem. Pharmacol. 1978 Feb 1;27(3):335-41.
[Text Abstract on PubMed]

Phosgene: a metabolite of chloroform.
Pohl LR, Bhooshan B, Whittaker NF, Krishna G.
Biochem. Biophys. Res. Commun. 1977 Dec 7;79(3):684-91.
[Text Abstract on PubMed]

A prospective on covalent binding and toxicity.
Gillette JR, Pohl LR.
J Toxicol Environ Health. 1977 Mar;2(4):849-71.
[Text Abstract on PubMed]

Stereochemical biotransformation of warfarin as a probe of the homogeneity and mechanism of microsomal hydroxylases.
Pohl LR, Porter WR, Trager WF.
Biochem. Pharmacol. 1977 Jan 15;26(2):109-14.
[Text Abstract on PubMed]

Warfarin-stereochemical aspects of its metabolism by rat liver microsomes.
Pohl LR, Nelson SD, Porter WR, Trager WF, Fasco MJ, Baker FD, Fenton.
Biochem. Pharmacol. 1976 Oct 1;25(19):2153-62.
[Text Abstract on PubMed]

Warfarin: stereochemical aspects of its metabolism in vivo in the rat.
Pohl LR, Bales R, Trager WF.
Res. Commun. Chem. Pathol. Pharmacol. 1976 Oct;15(2):233-56.
[Text Abstract on PubMed]

The requirement of the gut flora in nitrobenzene-induced methemoglobinemia in rats.
Reddy BG, Pohl LR, Krishna G.
Biochem. Pharmacol. 1976 May 1;25(9):1119-22.
[Text Abstract on PubMed]

Primary and beta-secondary deuterium isotope effects in N-deethylation reactions.
Nelson SD, Pohl LR, Trager WF.
J. Med. Chem. 1975 Nov;18(11):1062-5.
[Text Abstract on PubMed]

Synthesis and thin-layer chromatographic ultraviolet, and mass spectral properties of the anticoagulant phenprocoumon and its monohydroxylated derivatives.
Pohl LR, Haddock R, Garland WA, Trager WF.
J. Med. Chem. 1975 May;18(5):513-9.
[Text Abstract on PubMed]

Biotransformation of phenprocoumon in the rat.
Pohl LR, Haddock RE, Trager WF.
J. Med. Chem. 1975 May;18(5):519-23.
[Text Abstract on PubMed]

The rapid identification of a new metabolite of warfarin via a chemical ionization mass spectrometry ion doublet technique.
Pohl LR, Nelson SD, Garland WA, Trager WF.
Biomed. Mass Spectrom. 1975 Feb;2(1):23-30.
[Text Abstract on PubMed]

A new chiral reagent for the determination of nantiomeric purity and absolute configuration of certain substituted -arylethylamines.
Pohl LR, Trager WF.
J. Med. Chem. 1973 May;16(5):475-9.
[Text Abstract on PubMed]

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