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Keir C. Neuman, Ph.D.


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Keir C. Neuman

P: +1 301 496 3376
F: +1 301 402 3404

Full Publications Listing

Role of the Water-Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV.
Aldred KJ, Breland EJ, Vlčková V, Strub MP, Neuman KC, Kerns RJ, Osheroff N.
Biochemistry. 2014 Aug 21.
[Text Abstract on PubMed]

Tethered-bead, immune sandwich assay.
Silver J, Li Z, Neuman K.
Biosens Bioelectron. 2014 Jul 11;63C:117-123.
[Text Abstract on PubMed]

A propagating ATPase gradient drives transport of surface-confined cellular cargo.
Vecchiarelli AG, Neuman KC, Mizuuchi K.
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4880-5.
[Text Abstract on PubMed]

Wide-field in vivo background free imaging by selective magnetic modulation of nanodiamond fluorescence.
Sarkar SK, Bumb A, Wu X, Sochacki KA, Kellman P, Brechbiel MW, Neuman KC.
Biomed Opt Express. 2014 Apr 1;5(4):1190-202.
[Text Abstract on PubMed]

Poisoning of mitochondrial topoisomerase I by lamellarin D.
Khiati S, Seol Y, Agama K, Rosa ID, Agrawal S, Fesen K, Zhang H, Neuman KC, Pommier Y.
Mol Pharmacol. 2014 Aug ;86(2):193-9.
[Text Abstract on PubMed]

The tail that wags the dog: topoisomerase IV ParC C-terminal domain controls strand passage activity through multipartite topology-dependent interactions with DNA.
Neuman KC.
J Mol Biol. 2013 Sep 9;425(17):3025-8.
[Text Abstract on PubMed]

Silica encapsulation of fluorescent nanodiamonds for colloidal stability and facile surface functionalization.
Bumb A, Sarkar SK, Billington N, Brechbiel MW, Neuman KC.
J Am Chem Soc. 2013 May 29;135(21):7815-8.
[Text Abstract on PubMed]

SnapShot: Force Spectroscopy and Single-Molecule Manipulation.
Seol Y, Neuman KC.
Cell. 2013 May 23;153(5):1168-1168.e1.
[Text Abstract on PubMed]

Chiral Discrimination and Writhe-dependent Relaxation Mechanism of Human Topoisomerase IIα.
Seol Y, Gentry AC, Osheroff N, Neuman KC.
J Biol Chem. 2013 May 10;288(19):13695-703.
[Text Abstract on PubMed]

SnapShot: single-molecule fluorescence.
Sarkar SK, Bumb A, Mills M, Neuman KC.
Cell. 2013 Jun 6;153(6):1408-1408.e1.
[Text Abstract on PubMed]

Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification.
Seol Y, Hardin AH, Strub MP, Charvin G, Neuman KC.
Nucleic Acids Res..
[Text Abstract on PubMed]

A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity.
Seol Y, Zhang H, Pommier Y, Neuman KC.
Proc. Natl. Acad. Sci. U.S.A. 2012 Oct 2;109(40):16125-30.
[Text Abstract on PubMed]

Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis.
He J, Cooper HM, Reyes A, Di Re M, Sembongi H, Litwin TR, Gao J, Neuman KC, Fearnley IM, Spinazzola A, Walker JE, Holt IJ.
Nucleic Acids Res. 2012 Jul;40(13):6109-21.
[Text Abstract on PubMed]

Single-molecule tracking of collagenase on native type I collagen fibrils reveals degradation mechanism.
Sarkar SK, Marmer B, Goldberg G, Neuman KC.
Curr. Biol. 2012 Jun 19;22(12):1047-56.
[Text Abstract on PubMed]

Quantitative characterization of fluorophores in multi-component nanoprobes by single-molecule fluorescence.
Bumb A, Sarkar SK, Wu XS, Brechbiel MW, Neuman KC.
Biomed Opt Express. 2011 Oct 1;2(10):2761-9.
[Text Abstract on PubMed]

Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification.
Hardin AH, Sarkar SK, Seol Y, Liou GF, Osheroff N, Neuman KC.
Nucleic Acids Res. 2011 Jul;39(13):5729-43.
[Text Abstract on PubMed]

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
Pitts SL, Liou GF, Mitchenall LA, Burgin AB, Maxwell A, Neuman KC, Osheroff N.
Nucleic Acids Res. 2011 Jun;39(11):4808-17.
[Text Abstract on PubMed]

Single-molecule measurements of topoisomerase activity with magnetic tweezers.
Seol Y, Neuman KC.
Methods Mol. Biol. 2011;778:229-41.
[Text Abstract on PubMed]

Magnetic tweezers for single-molecule manipulation.
Seol Y, Neuman KC.
Methods Mol. Biol. 2011;783:265-93.
[Text Abstract on PubMed]

Evolutionary twist on topoisomerases: conversion of gyrase to topoisomerase IV.
Neuman KC.
Proc. Natl. Acad. Sci. U.S.A. 2010 Dec 28;107(52):22363-4.
[Text Abstract on PubMed]

Single-molecule measurements of DNA topology and topoisomerases.
Neuman KC.
J. Biol. Chem. 2010 Jun 18;285(25):18967-71.
[Text Abstract on PubMed]

Mechanisms of chiral discrimination by topoisomerase IV.
Neuman KC, Charvin G, Bensimon D, Croquette V.
Proc. Natl. Acad. Sci. U.S.A. 2009 Apr 28;106(17):6986-91.
[Text Abstract on PubMed]

Mutational analysis of the helicase-like domain of Thermotoga maritima reverse gyrase.
Bouthier de la Tour C, Amrani L, Cossard R, Neuman KC, Serre MC, Duguet M.
J. Biol. Chem. 2008 Oct 10;283(41):27395-402.
[Text Abstract on PubMed]

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy.
Neuman KC, Nagy A.
Nat. Methods. 2008 Jun;5(6):491-505.
[Text Abstract on PubMed]

Pulling on the nascent RNA during transcription does not alter kinetics of elongation or ubiquitous pausing.
Dalal RV, Larson MH, Neuman KC, Gelles J, Landick R, Block SM.
Mol. Cell. 2006 Jul 21;23(2):231-9.
[Text Abstract on PubMed]

Sequence-resolved detection of pausing by single RNA polymerase molecules.
Herbert KM, La Porta A, Wong BJ, Mooney RA, Neuman KC, Landick R, Block SM.
Cell. 2006 Jun 16;125(6):1083-94.
[Text Abstract on PubMed]

Statistical determination of the step size of molecular motors.
Neuman KC, Saleh OA, Lionnet T, Lia G, Allemand JF, Bensimon D, Croquette V.
J Phys Condens Matter. 2005 Nov 30;17(47):S3811-20.
[Text Abstract on PubMed]

Measurement of the effective focal shift in an optical trap.
Neuman KC, Abbondanzieri EA, Block SM.
Opt Lett. 2005 Jun 1;30(11):1318-20.
[Text Abstract on PubMed]

Simultaneous, coincident optical trapping and single-molecule fluorescence.
Lang MJ, Fordyce PM, Engh AM, Neuman KC, Block SM.
Nat. Methods. 2004 Nov;1(2):133-9.
[Text Abstract on PubMed]

Optical trapping.
Neuman KC, Block SM.
Rev Sci Instrum. 2004 Sep;75(9):2787-809.
[Text Abstract on PubMed]

Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking.
Neuman KC, Abbondanzieri EA, Landick R, Gelles J, Block SM.
Cell. 2003 Nov 14;115(4):437-47.
[Text Abstract on PubMed]

Characterization of photodamage to Escherichia coli in optical traps.
Neuman KC, Chadd EH, Liou GF, Bergman K, Block SM.
Biophys. J. 1999 Nov;77(5):2856-63.
[Text Abstract on PubMed]

Nonlamellar phases induced by the interaction of gramicidin S with lipid bilayers. A possible relationship to membrane-disrupting activity.
Prenner EJ, Lewis RN, Neuman KC, Gruner SM, Kondejewski LH, Hodges RS, McElhaney RN.
Biochemistry. 1997 Jun 24;36(25):7906-16.
[Text Abstract on PubMed]

Role of lipid polymorphism in pulmonary surfactant.
Perkins WR, Dause RB, Parente RA, Minchey SR, Neuman KC, Gruner SM, Taraschi TF, Janoff AS.
Science. 1996 Jul 19;273(5273):330-2.
[Text Abstract on PubMed]

High-order harmonic generation in atom clusters.
Donnelly, Ditmire, Neuman, Perry, Falcone.
Phys. Rev. Lett. 1996 Apr 1;76(14):2472-2475.
[Text Abstract on PubMed]