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Alan M. Michelson, M.D., Ph.D.


Principal Investigator thumbnail image

Alan M. Michelson
Senior Investigator

P: +1 301 451 8041
F: +1 301 496 9985

Full Publications Listing

Integrative analysis of the zinc finger transcription factor Lame duck in the Drosophila myogenic gene regulatory network.
Busser BW, Huang D, Rogacki KR, Lane EA, Shokri L, Ni T, Gamble CE, Gisselbrecht SS, Zhu J, Bulyk ML, Ovcharenko I, Michelson AM.
Proc. Natl. Acad. Sci. U.S.A. 2012 Nov 26.
[Text Abstract on PubMed]

Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway.
Ahmad SM, Tansey TR, Busser BW, Nolte MT, Jeffries N, Gisselbrecht SS, Rusan NM, Michelson AM.
Dev. Cell. 2012 Jul 17;23(1):97-111.
[Text Abstract on PubMed]

Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead transcription factors.
Zhu X, Ahmad SM, Aboukhalil A, Busser BW, Kim Y, Tansey TR, Haimovich A, Jeffries N, Bulyk ML, Michelson AM.
Development. 2012 Apr;139(8):1457-66.
[Text Abstract on PubMed]

Molecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity.
Busser BW, Shokri L, Jaeger SA, Gisselbrecht SS, Singhania A, Berger MF, Zhou B, Bulyk ML, Michelson AM.
Development. 2012 Mar;139(6):1164-74.
[Text Abstract on PubMed]

A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis.
Busser BW, Taher L, Kim Y, Tansey T, Bloom MJ, Ovcharenko I, Michelson AM.
PLoS Genet. 2012;8(3):e1002531.
[Text Abstract on PubMed]

Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo.
Enriquez J, Boukhatmi H, Dubois L, Philippakis AA, Bulyk ML, Michelson AM, Crozatier M, Vincent A.
Development. 2010 Feb;137(3):457-66.
[Text Abstract on PubMed]

Developmental biology. From genetic association to genetic switch.
Michelson AM.
Science. 2008 Dec 19;322(5909):1803-4.
[Text Abstract on PubMed]

Toward a systems-level understanding of developmental regulatory networks.
Busser BW, Bulyk ML, Michelson AM.
Curr. Opin. Genet. Dev. 2008 Dec;18(6):521-9.
[Text Abstract on PubMed]

A genomic approach to myoblast fusion in Drosophila.
Estrada B, Michelson AM.
Methods Mol. Biol. 2008;475:299-314.
[Text Abstract on PubMed]

The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo.
Estrada B, Gisselbrecht SS, Michelson AM.
Development. 2007 Dec;134(24):4469-78.
[Text Abstract on PubMed]

The MARVEL domain protein, Singles Bar, is required for progression past the pre-fusion complex stage of myoblast fusion.
Estrada B, Maeland AD, Gisselbrecht SS, Bloor JW, Brown NH, Michelson AM.
Dev. Biol. 2007 Jul 15;307(2):328-39.
[Text Abstract on PubMed]

Expression-guided in silico evaluation of candidate cis regulatory codes for Drosophila muscle founder cells.
Philippakis AA, Busser BW, Gisselbrecht SS, He FS, Estrada B, Michelson AM, Bulyk ML.
PLoS Comput. Biol. 2006 May;2(5):e53.
[Text Abstract on PubMed]

An integrated strategy for analyzing the unique developmental programs of different myoblast subtypes.
Estrada B, Choe SE, Gisselbrecht SS, Michaud S, Raj L, Busser BW, Halfon MS, Church GM, Michelson AM.
PLoS Genet. 2006 Feb;2(2):e16.
[Text Abstract on PubMed]

Biological code breaking in the 21st century.
Michelson AM, Bulyk ML.
Mol. Syst. Biol. 2006;2:2006.0018.
[Text Abstract on PubMed]

Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset.
Choe SE, Boutros M, Michelson AM, Church GM, Halfon MS.
Genome Biol. 2005;6(2):R16.
[Text Abstract on PubMed]

Running interference for hedgehog signaling.
Michelson AM.
Sci. STKE. 2003 Jul 22;2003(192):PE30.
[Text Abstract on PubMed]

Exploring genetic regulatory networks in metazoan development: methods and models.
Halfon MS, Michelson AM.
Physiol. Genomics. 2002 Sep 3;10(3):131-43.
[Text Abstract on PubMed]

New fluorescent protein reporters for use with the Drosophila Gal4 expression system and for vital detection of balancer chromosomes.
Halfon MS, Gisselbrecht S, Lu J, Estrada B, Keshishian H, Michelson AM.
Genesis. 2002 Sep-Oct;34(1-2):135-8.
[Text Abstract on PubMed]

Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model.
Halfon MS, Grad Y, Church GM, Michelson AM.
Genome Res. 2002 Jul;12(7):1019-28.
[Text Abstract on PubMed]

Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm.
Carmena A, Buff E, Halfon MS, Gisselbrecht S, Jiménez F, Baylies MK, Michelson AM.
Dev. Biol. 2002 Apr 15;244(2):226-42.
[Text Abstract on PubMed]

Deciphering genetic regulatory codes: a challenge for functional genomics.
Michelson AM.
Proc. Natl. Acad. Sci. U.S.A. 2002 Jan 22;99(2):546-8.
[Text Abstract on PubMed]

rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion.
Rau A, Buttgereit D, Holz A, Fetter R, Doberstein SK, Paululat A, Staudt N, Skeath J, Michelson AM, Renkawitz-Pohl R.
Development. 2001 Dec;128(24):5061-73.
[Text Abstract on PubMed]

Invertebrate myogenesis: looking back to the future of muscle development.
Baylies MK, Michelson AM.
Curr. Opin. Genet. Dev. 2001 Aug;11(4):431-9.
[Text Abstract on PubMed]

Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors.
Halfon MS, Carmena A, Gisselbrecht S, Sackerson CM, Jiménez F, Baylies MK, Michelson AM.
Cell. 2000 Sep 29;103(1):63-74.
[Text Abstract on PubMed]

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development.
Lin X, Buff EM, Perrimon N, Michelson AM.
Development. 1999 Sep;126(17):3715-23.
[Text Abstract on PubMed]

Regulation of Pax6 expression is conserved between mice and flies.
Xu PX, Zhang X, Heaney S, Yoon A, Michelson AM, Maas RL.
Development. 1999 Jan;126(2):383-95.
[Text Abstract on PubMed]

Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm.
Carmena A, Gisselbrecht S, Harrison J, Jiménez F, Michelson AM.
Genes Dev. 1998 Dec 15;12(24):3910-22.
[Text Abstract on PubMed]

Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila.
Michelson AM, Gisselbrecht S, Buff E, Skeath JB.
Development. 1998 Nov;125(22):4379-89.
[Text Abstract on PubMed]

Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors.
Buff E, Carmena A, Gisselbrecht S, Jiménez F, Michelson AM.
Development. 1998 Jun;125(11):2075-86.
[Text Abstract on PubMed]

Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm.
Michelson AM, Gisselbrecht S, Zhou Y, Baek KH, Buff EM.
Dev. Genet. 1998;22(3):212-29.
[Text Abstract on PubMed]

heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo.
Gisselbrecht S, Skeath JB, Doe CQ, Michelson AM.
Genes Dev. 1996 Dec 1;10(23):3003-17.
[Text Abstract on PubMed]

A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila.
Rehorn KP, Thelen H, Michelson AM, Reuter R.
Development. 1996 Dec;122(12):4023-31.
[Text Abstract on PubMed]

A new turn (or two) for twist.
Michelson AM.
Science. 1996 Jun 7;272(5267):1449-50.
[Text Abstract on PubMed]

Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development.
Rushton E, Drysdale R, Abmayr SM, Michelson AM, Bate M.
Development. 1995 Jul;121(7):1979-88.
[Text Abstract on PubMed]

Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm.
Michelson AM.
Development. 1994 Apr;120(4):755-68.
[Text Abstract on PubMed]

A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster.
Winick J, Abel T, Leonard MW, Michelson AM, Chardon-Loriaux I, Holmgren RA, Maniatis T, Engel JD.
Development. 1993 Dec;119(4):1055-65.
[Text Abstract on PubMed]

A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body.
Abel T, Michelson AM, Maniatis T.
Development. 1993 Nov;119(3):623-33.
[Text Abstract on PubMed]

A role for the Drosophila neurogenic genes in mesoderm differentiation.
Corbin V, Michelson AM, Abmayr SM, Neel V, Alcamo E, Maniatis T, Young MW.
Cell. 1991 Oct 18;67(2):311-23.
[Text Abstract on PubMed]

Expression of a MyoD family member prefigures muscle pattern in Drosophila embryos.
Michelson AM, Abmayr SM, Bate M, Arias AM, Maniatis T.
Genes Dev. 1990 Dec;4(12A):2086-97.
[Text Abstract on PubMed]

Clonal analysis using recombinant DNA probes from the X-chromosome.
Vogelstein B, Fearon ER, Hamilton SR, Preisinger AC, Willard HF, Michelson AM, Riggs AD, Orkin SH.
Cancer Res. 1987 Sep 15;47(18):4806-13.
[Text Abstract on PubMed]

An alpha-globin gene initiation codon mutation in a black family with HbH disease.
Olivieri NF, Chang LS, Poon AO, Michelson AM, Orkin SH.
Blood. 1987 Sep;70(3):729-32.
[Text Abstract on PubMed]

Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.
Michelson AM, Blake CC, Evans ST, Orkin SH.
Proc. Natl. Acad. Sci. U.S.A. 1985 Oct;82(20):6965-9.
[Text Abstract on PubMed]

The human phosphoglycerate kinase multigene family. HLA-associated sequences and an X-linked locus containing a processed pseudogene and its functional counterpart.
Michelson AM, Bruns GA, Morton CC, Orkin SH.
J. Biol. Chem. 1985 Jun 10;260(11):6982-92.
[Text Abstract on PubMed]

Effects of glucose 6-phosphate and hemin on activation of heme-regulated eIF-2 alpha kinase in gel-filtered reticulocyte lysates.
Michelson AM, Ernst V, Levin DH, London IM.
J. Biol. Chem. 1984 Jul 10;259(13):8529-33.
[Text Abstract on PubMed]

Restriction site polymorphism in the phosphoglycerate kinase gene on the X chromosome.
Hutz MH, Michelson AM, Antonarakis SE, Orkin SH, Kazazian.
Hum. Genet. 1984;66(2-3):217-9.
[Text Abstract on PubMed]

Boundaries of gene conversion within the duplicated human alpha-globin genes. Concerted evolution by segmental recombination.
Michelson AM, Orkin SH.
J. Biol. Chem. 1983 Dec 25;258(24):15245-54.
[Text Abstract on PubMed]

Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.
Michelson AM, Markham AF, Orkin SH.
Proc. Natl. Acad. Sci. U.S.A. 1983 Jan;80(2):472-6.
[Text Abstract on PubMed]

Characterization of the homopolymer tailing reaction catalyzed by terminal deoxynucleotidyl transferase. Implications for the cloning of cDNA.
Michelson AM, Orkin SH.
J. Biol. Chem. 1982 Dec 25;257(24):14773-82.
[Text Abstract on PubMed]

The 3' untranslated regions of the duplicated human alpha-globin genes are unexpectedly divergent.
Michelson AM, Orkin SH.
Cell. 1980 Nov;22(2 Pt 2):371-7.
[Text Abstract on PubMed]

Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia.
Orkin SH, Michelson A.
Nature. 1980 Jul 31;286(5772):538-40.
[Text Abstract on PubMed]

Cloning and direct examination of a structurally abnormal human beta 0-thalassemia globin gene.
Orkin SH, Kolodner R, Michelson A, Husson R.
Proc. Natl. Acad. Sci. U.S.A. 1980 Jun;77(6):3558-62.
[Text Abstract on PubMed]

Loss of chloramphenicol production in strains of Streptomyces species 3022alpha treated with acriflavine and ethidium bromide.
Michelson AM, Vining LC.
Can. J. Microbiol. 1978 Jun;24(6):662-9.
[Text Abstract on PubMed]