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Nehal Mehta, M.D., M.S.C.E., F.A.H.A.

Publications


Principal Investigator thumbnail image

Nehal Mehta
Lasker Clinical Research Scholar

P: +1 301 827 0483
F: +1 301 451 7093
nehal.mehta@nih.gov


Full Publications Listing

Candidate Gene Association Study of Coronary Artery Calcification in Chronic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort Study.
Ferguson JF, Matthews GJ, Townsend RR, Raj DS, Kanetsky PA, Budoff M, Fischer MJ, Rosas SE, Kanthety R, Rahman M, Master SR, Qasim A, Li M, Mehta NN, Shen H, Mitchell BD, O'Connell JR, Shuldiner AR, Ho WK, Young R, Rasheed A, Danesh J, He J, Kusek JW, Ojo AO, Flack J, Go AS, Gadegbeku CA, Wright JT, Saleheen D, Feldman HI, Rader DJ, Foulkes AS, Reilly MP.
J Am Coll Cardiol. 2013 May 30.
[Text Abstract on PubMed]

Algid malaria treated with early goal-directed therapy.
Gaieski DF, Goldman JD, Holtzman DL, Shoff WH, Shepherd SM, Mehta N, Goyal M.
Am J Emerg Med. 2013 Jan;31(1):263.e5-263.e10.
[Text Abstract on PubMed]

Prevalence and treatment patterns of psoriatic arthritis in the UK.
Ogdie A, Langan S, Love T, Haynes K, Shin D, Seminara N, Mehta NN, Troxel A, Choi H, Gelfand JM.
Rheumatology (Oxford). 2013 Mar ;52(3):568-75.
[Text Abstract on PubMed]

Race and gender variation in response to evoked inflammation.
Ferguson JF, Patel PN, Shah RY, Mulvey CK, Gadi R, Nijjar PS, Usman HM, Mehta NN, Shah R, Master SR, Propert KJ, Reilly MP.
J Transl Med. 2013 01 ;11:63.
[Text Abstract on PubMed]

Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines.
Bose S, Krishnamoorthy P, Varanasi A, Nair J, Schutta M, Braunstein S, Iqbal N, Schwartz S, St Clair C, Master SR, Rader DJ, Reilly MP, Mehta NN.
Obesity (Silver Spring). 2013 Jan ;21(1):E118-23.
[Text Abstract on PubMed]

Adipose genes down-regulated during experimental endotoxemia are also suppressed in obesity.
Shah R, Hinkle CC, Haris L, Shah R, Mehta NN, Putt ME, Reilly MP.
J. Clin. Endocrinol. Metab. 2012 Nov;97(11):E2152-9.
[Text Abstract on PubMed]

The impact of psoriasis on 10-year Framingham risk.
Mehta NN, Krishnamoorthy P, Yu Y, Khan O, Raper A, Van Voorhees A, Troxel AB, Gelfand JM.
J. Am. Acad. Dermatol. 2012 Oct;67(4):796-8.
[Text Abstract on PubMed]

Vitamin D, metabolic dyslipidemia, and metabolic syndrome in rheumatoid arthritis.
Baker JF, Mehta NN, Baker DG, Toedter G, Shults J, Von Feldt JM, Leonard MB.
Am. J. Med. 2012 Oct;125(10):1036.e9-1036.e15.
[Text Abstract on PubMed]

Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis.
Mehta NN, Li R, Krishnamoorthy P, Yu Y, Farver W, Rodrigues A, Raper A, Wilcox M, Baer A, DerOhannesian S, Wolfe M, Reilly MP, Rader DJ, VanVoorhees A, Gelfand JM.
Atherosclerosis. 2012 Sep;224(1):218-21.
[Text Abstract on PubMed]

Peroxisome Proliferator-Activated Receptor-a Agonism With Fenofibrate Does Not Suppress Inflammatory Responses to Evoked Endotoxemia.
Mulvey CK, Ferguson JF, Tabita-Martinez J, Kong S, Shah RY, Patel PN, Master SR, Usman MH, Propert KJ, Shah R, Mehta NN, Reilly MP.
J Am Heart Assoc. 2012 Aug;1(4):e002923.
[Text Abstract on PubMed]

Underdiagnosis and undertreatment of cardiovascular risk factors in patients with moderate to severe psoriasis.
Kimball AB, Szapary P, Mrowietz U, Reich K, Langley RG, You Y, Hsu MC, Yeilding N, Rader DJ, Mehta NN.
J. Am. Acad. Dermatol. 2012 Jul;67(1):76-85.
[Text Abstract on PubMed]

Inflammation modulates human HDL composition and function in vivo.
de la Llera Moya M, McGillicuddy FC, Hinkle CC, Byrne M, Joshi MR, Nguyen V, Tabita-Martinez J, Wolfe ML, Badellino K, Pruscino L, Mehta NN, Asztalos BF, Reilly MP.
Atherosclerosis. 2012 Jun;222(2):390-4.
[Text Abstract on PubMed]

Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom.
Langan SM, Seminara NM, Shin DB, Troxel AB, Kimmel SE, Mehta NN, Margolis DJ, Gelfand JM.
J. Invest. Dermatol. 2012 Mar;132(3 Pt 1):556-62.
[Text Abstract on PubMed]

Translational studies of lipoprotein-associated phospholipase A2 in inflammation and atherosclerosis.
Ferguson JF, Hinkle CC, Mehta NN, Bagheri R, Derohannessian SL, Shah R, Mucksavage MI, Bradfield JP, Hakonarson H, Wang X, Master SR, Rader DJ, Li M, Reilly MP.
J. Am. Coll. Cardiol. 2012 Feb 21;59(8):764-72.
[Text Abstract on PubMed]

Monocyte mayhem: do subtypes modulate distinct atherosclerosis phenotypes?
Mehta NN, Reilly MP.
Circ Cardiovasc Genet. 2012 Feb 1;5(1):7-9.
[Text Abstract on PubMed]

The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake.
Mehta NN.
Circ Cardiovasc Genet. 2012 Feb 1;5(1):148-50.
[Text Abstract on PubMed]

Quantification of atherosclerotic plaque activity and vascular inflammation using [18-F] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT).
Mehta NN, Torigian DA, Gelfand JM, Saboury B, Alavi A.
J Vis Exp. 2012(63):e3777.
[Text Abstract on PubMed]

A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial.
Mehta NN, Heffron SP, Patel PN, Ferguson J, Shah RD, Hinkle CC, Krishnamoorthy P, Shah R, Tabita-Martinez J, Terembula K, Master SR, Rickels MR, Reilly MP.
J Transl Med. 2012;10:124.
[Text Abstract on PubMed]

Dysglycemia but not lipids is associated with abnormal urinary albumin excretion in diabetic kidney disease: a report from the Kidney Early Evaluation Program (KEEP).
Bose S, Bomback AS, Mehta NN, Chen SC, Li S, Whaley-Connell A, Benjamin J, McCullough PA, null null.
BMC Nephrol. 2012 01 ;13:104.
[Text Abstract on PubMed]

Introducing the cardiovascular, metabolic and lipoprotein translation section of Journal of Translational Medicine.
Mehta NN.
J Transl Med. 2012 01 ;10:203.
[Text Abstract on PubMed]

Aortic vascular inflammation in psoriasis is associated with HDL particle size and concentration: a pilot study.
Yu Y, Sheth N, Krishnamoorthy P, Saboury B, Raper A, Baer A, Ochotony R, Doveikis J, Derohannessian S, Voorhees AS, Torigian DA, Alavi A, Gelfand JM, Mehta NN.
Am J Cardiovasc Dis. 2012 01 ;2(4):285-92.
[Text Abstract on PubMed]

Systemic and vascular inflammation in patients with moderate to severe psoriasis as measured by [18F]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT): a pilot study.
Mehta NN, Yu Y, Saboury B, Foroughi N, Krishnamoorthy P, Raper A, Baer A, Antigua J, Van Voorhees AS, Torigian DA, Alavi A, Gelfand JM.
Arch Dermatol. 2011 Sep;147(9):1031-9.
[Text Abstract on PubMed]

Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
IBC 50K CAD Consortium.
PLoS Genet. 2011 Sep;7(9):e1002260.
[Text Abstract on PubMed]

A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease.
Mehta NN.
Circ Cardiovasc Genet. 2011 Aug 1;4(4):465-6.
[Text Abstract on PubMed]

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.
Wild PS, Zeller T, Schillert A, Szymczak S, Sinning CR, Deiseroth A, Schnabel RB, Lubos E, Keller T, Eleftheriadis MS, Bickel C, Rupprecht HJ, Wilde S, Rossmann H, Diemert P, Cupples LA, Perret C, Erdmann J, Stark K, Kleber ME, Epstein SE, Voight BF, Kuulasmaa K, Li M, Schäfer AS, Klopp N, Braund PS, Sager HB, Demissie S, Proust C, König IR, Wichmann HE, Reinhard W, Hoffmann MM, Virtamo J, Burnett MS, Siscovick D, Wiklund PG, Qu L, El Mokthari NE, Thompson JR, Peters A, Smith AV, Yon E, Baumert J, Hengstenberg C, März W, Amouyel P, Devaney J, Schwartz SM, Saarela O, Mehta NN, Rubin D, Silander K, Hall AS, Ferrieres J, Harris TB, Melander O, Kee F, Hakonarson H, Schrezenmeir J, Gudnason V, Elosua R, Arveiler D, Evans A, Rader DJ, Illig T, Schreiber S, Bis JC, Altshuler D, Kavousi M, Witteman JC, Uitterlinden AG, Hofman A, Folsom AR, Barbalic M, Boerwinkle E, Kathiresan S, Reilly MP, O'Donnell CJ, Samani NJ, Schunkert H, Cambien F, Lackner KJ, Tiret L, Salomaa V, Munzel T, Ziegler A, Blankenberg S.
Circ Cardiovasc Genet. 2011 Aug 1;4(4):403-12.
[Text Abstract on PubMed]

Attributable risk estimate of severe psoriasis on major cardiovascular events.
Mehta NN, Yu Y, Pinnelas R, Krishnamoorthy P, Shin DB, Troxel AB, Gelfand JM.
Am. J. Med. 2011 Aug;124(8):775.e1-6.
[Text Abstract on PubMed]

Fluorescent green plaques: light at the end of the catheter?
Mehta NN, Rader DJ.
Cell Metab. 2011 Jul 6;14(1):7-8.
[Text Abstract on PubMed]

Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women.
Qasim AN, Martin SS, Mehta NN, Wolfe ML, Park J, Schwartz S, Schutta M, Iqbal N, Reilly MP.
Int. J. Cardiol. 2011 Jul 1;150(1):17-21.
[Text Abstract on PubMed]

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
Mehta NN.
Circ Cardiovasc Genet. 2011 Jun;4(3):327-9.
[Text Abstract on PubMed]

Psoriasis and cardiovascular risk: strength in numbers, part II.
Gelfand JM, Mehta NN, Langan SM.
J. Invest. Dermatol. 2011 May;131(5):1007-10.
[Text Abstract on PubMed]

Fractalkine is a novel human adipochemokine associated with type 2 diabetes.
Shah R, Hinkle CC, Ferguson JF, Mehta NN, Li M, Qu L, Lu Y, Putt ME, Ahima RS, Reilly MP.
Diabetes. 2011 May;60(5):1512-8.
[Text Abstract on PubMed]

Detection and global quantification of cardiovascular molecular calcification by fluoro18-fluoride positron emission tomography/computed tomography--a novel concept.
Beheshti M, Saboury B, Mehta NN, Torigian DA, Werner T, Mohler E, Wilensky R, Newberg AB, Basu S, Langsteger W, Alavi A.
Hell J Nucl Med. 2011 May-Aug;14(2):114-20.
[Text Abstract on PubMed]

The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels.
Mehta NN, Li M, William D, Khera AV, DerOhannessian S, Qu L, Ferguson JF, McLaughlin C, Shaikh LH, Shah R, Patel PN, Bradfield JP, He J, Stylianou IM, Hakonarson H, Rader DJ, Reilly MP.
Eur. Heart J. 2011 Apr;32(8):963-71.
[Text Abstract on PubMed]

Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistance.
Martin SS, Qasim AN, Wolfe M, St Clair C, Schwartz S, Iqbal N, Schutta M, Bagheri R, Mehta NN, Rader DJ, Reilly MP.
Am. J. Cardiol. 2011 Feb 1;107(3):393-8.
[Text Abstract on PubMed]

Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus.
Mehta NN, Krishnamoorthy P, Martin SS, St Clair C, Schwartz S, Iqbal N, Braunstein S, Schutta M, Rader DJ, Reilly MP.
Am. J. Cardiol. 2011 Feb 1;107(3):406-11.
[Text Abstract on PubMed]

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Burnett MS, Devaney JM, Knouff CW, Thompson JR, Horne BD, Stewart AF, Assimes TL, Wild PS, Allayee H, Nitschke PL, Patel RS, Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Martinelli N, Girelli D, Quyyumi AA, Anderson JL, Erdmann J, Hall AS, Schunkert H, Quertermous T, Blankenberg S, Hazen SL, Roberts R, Kathiresan S, Samani NJ, Epstein SE, Rader DJ.
Lancet. 2011 Jan 29;377(9763):383-92.
[Text Abstract on PubMed]

Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes.
Qasim AN, Budharaju V, Mehta NN, St Clair C, Farouk S, Braunstein S, Schutta M, Iqbal N, Rader DJ, Reilly MP.
Clin. Endocrinol. (Oxf). 2011 Jan;74(1):44-50.
[Text Abstract on PubMed]

Quantitative angiography in South Asians reveals differences in vessel size and coronary artery disease severity compared to Caucasians.
Hasan RK, Ginwala NT, Shah RY, Kumbhani DJ, Wilensky RL, Mehta NN.
Am J Cardiovasc Dis. 2011;1(1):31-7.
[Text Abstract on PubMed]

Type 2 diabetes does not attenuate racial differences in coronary calcification.
Wade AN, Fedyna S, Mehta NN, St Clair C, Ginwala N, Krishna RK, Qasim AN, Braunstein S, Iqbal N, Schutta MH, Reilly MP.
Diabetes Res. Clin. Pract. 2011 Jan;91(1):101-7.
[Text Abstract on PubMed]

Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification.
Shen H, Bielak LF, Ferguson JF, Streeten EA, Yerges-Armstrong LM, Liu J, Post W, O'Connell JR, Hixson JE, Kardia SL, Sun YV, Jhun MA, Wang X, Mehta NN, Li M, Koller DL, Hakonarson H, Keating BJ, Rader DJ, Shuldiner AR, Peyser PA, Reilly MP, Mitchell BD.
Arterioscler. Thromb. Vasc. Biol. 2010 Dec;30(12):2648-54.
[Text Abstract on PubMed]

Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus.
Bagheri R, Qasim AN, Mehta NN, Terembula K, Kapoor S, Braunstein S, Schutta M, Iqbal N, Lehrke M, Reilly MP.
Am. J. Cardiol. 2010 Oct 15;106(8):1118-23.
[Text Abstract on PubMed]

CXCL12: a new player in coronary disease identified through human genetics.
Farouk SS, Rader DJ, Reilly MP, Mehta NN.
Trends Cardiovasc. Med. 2010 Aug;20(6):204-9.
[Text Abstract on PubMed]

Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database.
Mehta NN, Azfar RS, Shin DB, Neimann AL, Troxel AB, Gelfand JM.
Eur. Heart J. 2010 Apr;31(8):1000-6.
[Text Abstract on PubMed]

Psoriasis and cardiovascular risk: strength in numbers.
Gelfand JM, Azfar RS, Mehta NN.
J. Invest. Dermatol. 2010 Apr;130(4):919-22.
[Text Abstract on PubMed]

Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes.
Eraso LH, Ginwala N, Qasim AN, Mehta NN, Dlugash R, Kapoor S, Schwartz S, Schutta M, Iqbal N, Mohler, Reilly MP.
Diabetes Care. 2010 Feb;33(2):408-10.
[Text Abstract on PubMed]

Experimental endotoxemia induces adipose inflammation and insulin resistance in humans.
Mehta NN, McGillicuddy FC, Anderson PD, Hinkle CC, Shah R, Pruscino L, Tabita-Martinez J, Sellers KF, Rickels MR, Reilly MP.
Diabetes. 2010 Jan;59(1):172-81.
[Text Abstract on PubMed]

Gene profiling of human adipose tissue during evoked inflammation in vivo.
Shah R, Lu Y, Hinkle CC, McGillicuddy FC, Kim R, Hannenhalli S, Cappola TP, Heffron S, Wang X, Mehta NN, Putt M, Reilly MP.
Diabetes. 2009 Oct;58(10):2211-9.
[Text Abstract on PubMed]

Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites.
Martin SS, Qasim AN, Mehta NN, Wolfe M, Terembula K, Schwartz S, Iqbal N, Schutta M, Bagheri R, Reilly MP.
Diabetes. 2009 Aug;58(8):1887-92.
[Text Abstract on PubMed]

Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus.
Mehta NN, Sheetz M, Price K, Comiskey L, Amrutia S, Iqbal N, Mohler ER, Reilly MP.
Cardiovasc Drugs Ther. 2009 Feb;23(1):17-24.
[Text Abstract on PubMed]

Adipokines, insulin resistance, and coronary artery calcification.
Qasim A, Mehta NN, Tadesse MG, Wolfe ML, Rhodes T, Girman C, Reilly MP.
J. Am. Coll. Cardiol. 2008 Jul 15;52(3):231-6.
[Text Abstract on PubMed]

CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis.
Nolan A, Weiden M, Kelly A, Hoshino Y, Hoshino S, Mehta N, Gold JA.
Am. J. Respir. Crit. Care Med. 2008 Feb 1;177(3):301-8.
[Text Abstract on PubMed]

Innate immunity modulates adipokines in humans.
Anderson PD, Mehta NN, Wolfe ML, Hinkle CC, Pruscino L, Comiskey LL, Tabita-Martinez J, Sellers KF, Rickels MR, Ahima RS, Reilly MP.
J. Clin. Endocrinol. Metab. 2007 Jun;92(6):2272-9.
[Text Abstract on PubMed]

Purple glove syndrome following intravenous phenytoin administration.
Chokshi R, Openshaw J, Mehta NN, Mohler.
Vasc Med. 2007 Feb;12(1):29-31.
[Text Abstract on PubMed]

Atherosclerotic cardiovascular disease risk in the HAART-treated HIV-1 population.
Mehta N, Reilly M.
HIV Clin Trials. 2005 Jan-Feb;6(1):5-24.
[Text Abstract on PubMed]

Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis.
Reilly MP, Wolfe ML, Rhodes T, Girman C, Mehta N, Rader DJ.
Circulation. 2004 Aug 17;110(7):803-9.
[Text Abstract on PubMed]

Native aortic valve vegetative endocarditis with Cunninghamella.
Mehta NN, Romanelli J, Sutton MG.
Eur J Echocardiogr. 2004 Mar;5(2):156-8.
[Text Abstract on PubMed]

A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23.
Mehta N, Loria PM, Hobert O.
Genetics. 2004 Mar;166(3):1253-67.
[Text Abstract on PubMed]

Images in cardiovascular medicine. Pulmonary venous aneurysms in hereditary hemorrhagic telangiectasia detected by 3-dimensional magnetic resonance angiography.
Ferrari VA, Mehta NN, Soulen M, Roberts DA, St John Sutton M.
Circulation. 2003 Oct 28;108(17):e122-3.
[Text Abstract on PubMed]