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Vincent Manganiello, M.D., Ph.D.

Publications


Principal Investigator thumbnail image

Vincent Manganiello
Senior Investigator

P: +1 301 496 1770
F: +1 301 402 1610
manganiv@nhlbi.nih.gov


Full Publications Listing

Cyclic nucleotide phosphodiesterase 3 signaling complexes.
Ahmad F, Degerman E, Manganiello VC.
Horm. Metab. Res. 2012 Nov;44(12):930.
[Text Abstract on PubMed]

Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins.
Begum N, Hockman S, Manganiello VC.
J. Biol. Chem. 2011 Jul 22;286(29):26238-49.
[Text Abstract on PubMed]

Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes.
Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, Strålfors P, Degerman E, Manganiello VC.
Biochem. J. 2009 Dec 15;424(3):399-410.
[Text Abstract on PubMed]

Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis.
Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O, Degerman E.
Cell. Signal. 2009 May;21(5):760-6.
[Text Abstract on PubMed]

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.
Puxeddu E, Uhart M, Li CC, Ahmad F, Pacheco-Rodriguez G, Manganiello VC, Moss J, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 2009 Apr 14;106(15):6158-63.
[Text Abstract on PubMed]

Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.
Berger K, Lindh R, Wierup N, Zmuda-Trzebiatowska E, Lindqvist A, Manganiello VC, Degerman E.
PLoS ONE. 2009;4(3):e4671.
[Text Abstract on PubMed]

Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus.
Liu H, Manganiello V, Waleh N, Clyman RI.
Pediatr. Res. 2008 Nov;64(5):477-81.
[Text Abstract on PubMed]

Role of phosphodiesterase type 3A and 3B in regulating platelet and cardiac function using subtype-selective knockout mice.
Sun B, Li H, Shakur Y, Hensley J, Hockman S, Kambayashi J, Manganiello VC, Liu Y.
Cell. Signal. 2007 Aug;19(8):1765-71.
[Text Abstract on PubMed]

Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.
Walz HA, Wierup N, Vikman J, Manganiello VC, Degerman E, Eliasson L, Holst LS.
Cell. Signal. 2007 Jul;19(7):1505-13.
[Text Abstract on PubMed]

Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB.
Ahmad F, Lindh R, Tang Y, Weston M, Degerman E, Manganiello VC.
Biochem. J. 2007 Jun 1;404(2):257-68.
[Text Abstract on PubMed]

Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B.
Lindh R, Ahmad F, Resjö S, James P, Yang JS, Fales HM, Manganiello V, Degerman E.
Biochim. Biophys. Acta. 2007 Apr;1773(4):584-92.
[Text Abstract on PubMed]

Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes.
Oknianska A, Zmuda-Trzebiatowska E, Manganiello V, Degerman E.
Biochem. Biophys. Res. Commun. 2007 Feb 23;353(4):1080-5.
[Text Abstract on PubMed]

Foxp3-dependent programme of regulatory T-cell differentiation.
Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, Beavo JA, Rudensky AY.
Nature. 2007 Feb 15;445(7129):771-5.
[Text Abstract on PubMed]

Novel mechanisms of the regulation of protein kinase B in adipocytes; implications for protein kinase A, Epac, phosphodiesterases 3 and 4.
Zmuda-Trzebiatowska E, Manganiello V, Degerman E.
Cell. Signal. 2007 Jan;19(1):81-6.
[Text Abstract on PubMed]

Re-discovering PDE3 inhibitors--new opportunities for a long neglected target.
Thompson PE, Manganiello V, Degerman E.
Curr Top Med Chem. 2007;7(4):421-36.
[Text Abstract on PubMed]

Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice.
Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC.
J. Clin. Invest. 2006 Dec;116(12):3240-51.
[Text Abstract on PubMed]

Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes.
Nilsson R, Ahmad F, Swärd K, Andersson U, Weston M, Manganiello V, Degerman E.
Cell. Signal. 2006 Oct;18(10):1713-21.
[Text Abstract on PubMed]

Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes.
Liu H, Tang JR, Choi YH, Napolitano M, Hockman S, Taira M, Degerman E, Manganiello VC.
J. Biol. Chem. 2006 Jul 28;281(30):21096-113.
[Text Abstract on PubMed]

Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.
Kim H, Pennisi PA, Gavrilova O, Pack S, Jou W, Setser-Portas J, East-Palmer J, Tang Y, Manganiello VC, Leroith D.
Am. J. Physiol. Endocrinol. Metab. 2006 Jun;290(6):E1227-36.
[Text Abstract on PubMed]

Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.
Walz HA, Härndahl L, Wierup N, Zmuda-Trzebiatowska E, Svennelid F, Manganiello VC, Ploug T, Sundler F, Degerman E, Ahrén B, Holst LS.
J. Endocrinol. 2006 Jun;189(3):629-41.
[Text Abstract on PubMed]

Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.
Zmuda-Trzebiatowska E, Oknianska A, Manganiello V, Degerman E.
Cell. Signal. 2006 Mar;18(3):382-90.
[Text Abstract on PubMed]

Expression of cyclic nucleotide phosphodiesterase 3A in isolated rat submandibular acini.
Shimizu K, Murata T, Hiramoto K, Sugiyama T, Nakagawa T, Manganiello VC, Tagawa T.
Arch. Oral Biol. 2006 Feb;51(2):83-8.
[Text Abstract on PubMed]

Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to cAMP hydrolytic activity in subcellular fractions of human myocardium.
Hambleton R, Krall J, Tikishvili E, Honeggar M, Ahmad F, Manganiello VC, Movsesian MA.
J. Biol. Chem. 2005 Nov 25;280(47):39168-74.
[Text Abstract on PubMed]

Effects of the human immunodeficiency virus-protease inhibitor, ritonavir, on basal and catecholamine-stimulated lipolysis.
Adler-Wailes DC, Liu H, Ahmad F, Feng N, Londos C, Manganiello V, Yanovski JA.
J. Clin. Endocrinol. Metab. 2005 Jun;90(6):3251-61.
[Text Abstract on PubMed]

Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B.
Ahmad F, Härndahl L, Tang Y, Holst LS, Manganiello VC.
Methods Mol. Biol. 2005;307:93-107.
[Text Abstract on PubMed]

Identification of promoter elements in 5'-flanking region of murine cyclic nucleotide phosphodiesterase 3B gene.
Liu H, Tang JR, Degerman E, Manganiello VC.
Methods Mol. Biol. 2005;307:109-24.
[Text Abstract on PubMed]

Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice.
Degerman E, Manganiello V, Holst JJ, Ahrén B.
Eur. J. Pharmacol. 2004 Sep 13;498(1-3):319-23.
[Text Abstract on PubMed]

Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility.
Masciarelli S, Horner K, Liu C, Park SH, Hinckley M, Hockman S, Nedachi T, Jin C, Conti M, Manganiello V.
J. Clin. Invest. 2004 Jul;114(2):196-205.
[Text Abstract on PubMed]

Emergence and success of PDE5 inhibitors as effective therapy for erectile dysfunction.
Manganiello V.
Int. J. Impot. Res. 2004 Jun;16 Suppl 1:S1-3.
[Text Abstract on PubMed]

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.
Härndahl L, Wierup N, Enerbäck S, Mulder H, Manganiello VC, Sundler F, Degerman E, Ahrén B, Holst LS.
J. Biol. Chem. 2004 Apr 9;279(15):15214-22.
[Text Abstract on PubMed]

Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes.
Akesson L, Ahrén B, Manganiello VC, Holst LS, Edgren G, Degerman E.
Endocrinology. 2003 Dec;144(12):5293-9.
[Text Abstract on PubMed]

Cyclic nucleotide phosphodiesterase 5 and sildenafil: promises realized.
Manganiello V.
Mol. Pharmacol. 2003 Jun;63(6):1209-11.
[Text Abstract on PubMed]

Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition.
Narita M, Murata T, Shimizu K, Sugiyama T, Nakagawa T, Manganiello VC, Tagawa T.
Anticancer Drugs. 2003 Jun;14(5):377-81.
[Text Abstract on PubMed]

Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.
Osawa H, Niiya T, Onuma H, Murakami A, Ochi M, Nishimiya T, Ogura T, Kato K, Shimizu I, Fujii Y, Ohashi J, Yamada K, Liang SJ, Manganiello VC, Fujita-Yamaguchi Y, Makino H.
Mol. Genet. Metab. 2003 May;79(1):43-51.
[Text Abstract on PubMed]

Cyclic adenosine 3',5'-monophosphate regulation of corticotropin-releasing hormone promoter activity in AtT-20 cells and in a transformed hypothalamic cell line.
Nikodemova M, Kasckow J, Liu H, Manganiello V, Aguilera G.
Endocrinology. 2003 Apr;144(4):1292-300.
[Text Abstract on PubMed]

[Morphologic and functional abnormalities of the cardiovascular system in patients with hepatic cirrhosis].
Piscione F, Manganiello V, Viola O, Chiariello M.
Ital Heart J Suppl. 2003 Feb;4(2):85-95.
[Text Abstract on PubMed]

Effect of the phosphodiesterase 4 inhibitor, rolipram, on retinoic acid-increased alkaline phosphatase activity in the mouse fibroblastic C3H10T1/2 cell line.
Murata T, Sugatani T, Shimizu K, Manganiello VC, Tagawa T.
Arch. Oral Biol. 2003 Jan;48(1):63-7.
[Text Abstract on PubMed]

Characterization of phosphodiesterase 3 in human malignant melanoma cell line.
Murata T, Shimizu K, Narita M, Manganiello VC, Tagawa T.
Anticancer Res. 2002 Nov-Dec;22(6A):3171-4.
[Text Abstract on PubMed]

Isoforms of cyclic nucleotide phosphodiesterase PDE3A in cardiac myocytes.
Wechsler J, Choi YH, Krall J, Ahmad F, Manganiello VC, Movsesian MA.
J. Biol. Chem. 2002 Oct 11;277(41):38072-8.
[Text Abstract on PubMed]

Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin.
Härndahl L, Jing XJ, Ivarsson R, Degerman E, Ahrén B, Manganiello VC, Renström E, Holst LS.
J. Biol. Chem. 2002 Oct 4;277(40):37446-55.
[Text Abstract on PubMed]

Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP.
Zhang HH, Halbleib M, Ahmad F, Manganiello VC, Greenberg AS.
Diabetes. 2002 Oct;51(10):2929-35.
[Text Abstract on PubMed]

Expression and role of phosphodiesterase 3 in human squamous cell carcinoma KB cells.
Shimizu K, Murata T, Okumura K, Manganiello VC, Tagawa T.
Anticancer Drugs. 2002 Sep;13(8):875-80.
[Text Abstract on PubMed]

Short-term regulation of PDE4 activity.
Manganiello V.
Br. J. Pharmacol. 2002 Jun;136(3):339-40.
[Text Abstract on PubMed]

Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes.
Resjö S, Göransson O, Härndahl L, Zolnierowicz S, Manganiello V, Degerman E.
Cell. Signal. 2002 Mar;14(3):231-8.
[Text Abstract on PubMed]

C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.
Mei J, Holst LS, Landström TR, Holm C, Brindley D, Manganiello V, Degerman E.
Diabetes. 2002 Mar;51(3):631-7.
[Text Abstract on PubMed]

Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes.
Göransson O, Resjö S, Rönnstrand L, Manganiello V, Degerman E.
Cell. Signal. 2002 Feb;14(2):175-82.
[Text Abstract on PubMed]

Expression of phosphodiesterase 3 in rat submandibular gland cell lines.
Murata T, Sugatani T, Manganiello VC, Shimizu K, Tagawa T.
Arch. Oral Biol. 2001 May;46(5):453-7.
[Text Abstract on PubMed]

Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family.
Shakur Y, Holst LS, Landstrom TR, Movsesian M, Degerman E, Manganiello V.
Prog. Nucleic Acid Res. Mol. Biol. 2001;66:241-77.
[Text Abstract on PubMed]

Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes.
Choi YH, Ekholm D, Krall J, Ahmad F, Degerman E, Manganiello VC, Movsesian MA.
Biochem. J. 2001 Jan 1;353(Pt 1):41-50.
[Text Abstract on PubMed]

Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland.
Murata T, Sugatani T, Shimizu K, Manganiello VC, Tagawa T.
Anticancer Drugs. 2001 Jan;12(1):79-83.
[Text Abstract on PubMed]

Methods to study phosphorylation and activation of the hormone-sensitive adipocyte phosphodiesterase type 3B in rat adipocytes.
Degerman E, Resjö S, Landström TR, Manganiello V.
Methods Mol. Biol. 2001;155:167-80.
[Text Abstract on PubMed]

Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum.
Shakur Y, Takeda K, Kenan Y, Yu ZX, Rena G, Brandt D, Houslay MD, Degerman E, Ferrans VJ, Manganiello VC.
J. Biol. Chem. 2000 Dec 8;275(49):38749-61.
[Text Abstract on PubMed]

Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells.
Ahmad F, Cong LN, Stenson Holst L, Wang LM, Rahn Landstrom T, Pierce JH, Quon MJ, Degerman E, Manganiello VC.
J. Immunol. 2000 May 1;164(9):4678-88.
[Text Abstract on PubMed]

Functions of the N-terminal region of cyclic nucleotide phosphodiesterase 3 (PDE 3) isoforms.
Kenan Y, Murata T, Shakur Y, Degerman E, Manganiello VC.
J. Biol. Chem. 2000 Apr 21;275(16):12331-8.
[Text Abstract on PubMed]

Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor.
Rondinone CM, Carvalho E, Rahn T, Manganiello VC, Degerman E, Smith UP.
J. Biol. Chem. 2000 Apr 7;275(14):10093-8.
[Text Abstract on PubMed]

Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP.
Rahn Landström T, Mei J, Karlsson M, Manganiello V, Degerman E.
Biochem. J. 2000 Mar 1;346 Pt 2:337-43.
[Text Abstract on PubMed]

Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene.
Kasuya J, Liang SJ, Goko H, Park SH, Kato K, Xu ZD, Hockman S, Manganiello VC, Fujita-Yamaguchi Y.
Biochem. Biophys. Res. Commun. 2000 Feb 24;268(3):827-34.
[Text Abstract on PubMed]

Cyclic nucleotide phosphodiesterases (PDE) 3 and 4 in normal, malignant, and HTLV-I transformed human lymphocytes.
Ekholm D, Mulloy JC, Gao G, Degerman E, Franchini G, Manganiello VC.
Biochem. Pharmacol. 1999 Sep 15;58(6):935-50.
[Text Abstract on PubMed]

Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A.
Resjö S, Oknianska A, Zolnierowicz S, Manganiello V, Degerman E.
Biochem. J. 1999 Aug 1;341 ( Pt 3):839-45.
[Text Abstract on PubMed]

Cyclic nucleotide phosphodiesterases (PDEs): diverse regulators of cyclic nucleotide signals and inviting molecular targets for novel therapeutic agents.
Manganiello VC, Degerman E.
Thromb. Haemost. 1999 Aug;82(2):407-11.
[Text Abstract on PubMed]

Evidence for the presence of several phosphodiesterase isoforms in brown adipose tissue of Zucker rats: modulation of PDE2 by the fa gene expression.
Coudray C, Charon C, Komas N, Mory G, Diot-Dupuy F, Manganiello V, Ferre P, Bazin R.
FEBS Lett. 1999 Jul 30;456(1):207-10.
[Text Abstract on PubMed]

Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes.
Castan I, Wijkander J, Manganiello V, Degerman E.
Biochem. J. 1999 Apr 15;339 ( Pt 2):281-9.
[Text Abstract on PubMed]

IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells.
Ahmad F, Gao G, Wang LM, Landstrom TR, Degerman E, Pierce JH, Manganiello VC.
J. Immunol. 1999 Apr 15;162(8):4864-75.
[Text Abstract on PubMed]

Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I.
Holst LS, Mulder H, Manganiello V, Sundler F, Ahrén B, Holm C, Degerman E.
Biochem. Biophys. Res. Commun. 1998 Sep 8;250(1):181-6.
[Text Abstract on PubMed]

Insulin-induced translocation of protein kinase B to the plasma membrane in rat adipocytes.
Göransson O, Wijkander J, Manganiello V, Degerman E.
Biochem. Biophys. Res. Commun. 1998 May 8;246(1):249-54.
[Text Abstract on PubMed]

Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase.
Wijkander J, Landström TR, Manganiello V, Belfrage P, Degerman E.
Endocrinology. 1998 Jan;139(1):219-27.
[Text Abstract on PubMed]

Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B.
Degerman E, Landström TR, Wijkander J, Holst LS, Ahmad F, Belfrage P, Manganiello V.
Methods. 1998 Jan;14(1):43-53.
[Text Abstract on PubMed]

Cyclic nucleotide PDE-3. Quantitation of PDE-3A and -3B mRNAs in rat tissues by RNase protection assay.
Nagaoka T, Shirakawa T, Kasuya J, Balon TW, Manganiello VC, Fujita-Yamaguchi Y.
Cell Biochem. Biophys. 1998;29(1-2):49-66.
[Text Abstract on PubMed]

Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3).
He R, Komas N, Ekholm D, Murata T, Taira M, Hockman S, Degerman E, Manganiello VC.
Cell Biochem. Biophys. 1998;29(1-2):89-111.
[Text Abstract on PubMed]

Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. Membrane translocation in response to peroxovanadate.
Wijkander J, Holst LS, Rahn T, Resjö S, Castan I, Manganiello V, Belfrage P, Degerman E.
J. Biol. Chem. 1997 Aug 22;272(34):21520-6.
[Text Abstract on PubMed]

Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein.
Ekholm D, Hemmer B, Gao G, Vergelli M, Martin R, Manganiello V.
J. Immunol. 1997 Aug 1;159(3):1520-9.
[Text Abstract on PubMed]

Protein kinase A-dependent activation of PDE4 (cAMP-specific cyclic nucleotide phosphodiesterase) in cultured bovine vascular smooth muscle cells.
Ekholm D, Belfrage P, Manganiello V, Degerman E.
Biochim. Biophys. Acta. 1997 Mar 27;1356(1):64-70.
[Text Abstract on PubMed]

Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3).
Degerman E, Belfrage P, Manganiello VC.
J. Biol. Chem. 1997 Mar 14;272(11):6823-6.
[Text Abstract on PubMed]

Regulation of hormone-sensitive lipase activity in adipose tissue.
Holm C, Langin D, Manganiello V, Belfrage P, Degerman E.
Meth. Enzymol. 1997;286:45-67.
[Text Abstract on PubMed]

cGMP-inhibited phosphodiesterases (PDE3 gene family).
Degerman E, Belfrage P, Manganiello VC.
Biochem. Soc. Trans. 1996 Nov;24(4):1010-4.
[Text Abstract on PubMed]

Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family.
Miki T, Taira M, Hockman S, Shimada F, Lieman J, Napolitano M, Ward D, Taira M, Makino H, Manganiello VC.
Genomics. 1996 Sep 15;36(3):476-85.
[Text Abstract on PubMed]

Expression and activity of low Km, cGMP-inhibited cAMP phosphodiesterase in cardiac and skeletal muscle.
Movsesian MA, Komas N, Krall J, Manganiello VC.
Biochem. Biophys. Res. Commun. 1996 Aug 23;225(3):1058-62.
[Text Abstract on PubMed]

Characterization of two recombinant PDE3 (cGMP-inhibited cyclic nucleotide phosphodiesterase) isoforms, RcGIP1 and HcGIP2, expressed in NIH 3006 murine fibroblasts and Sf9 insect cells.
Leroy MJ, Degerman E, Taira M, Murata T, Wang LH, Movsesian MA, Meacci E, Manganiello VC.
Biochemistry. 1996 Aug 6;35(31):10194-202.
[Text Abstract on PubMed]

Differential expression of cGMP-inhibited cyclic nucleotide phosphodiesterases in human hepatoma cell lines.
Murata T, Taira M, Manganiello VC.
FEBS Lett. 1996 Jul 15;390(1):29-33.
[Text Abstract on PubMed]

Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol.
Rahn T, Rönnstrand L, Leroy MJ, Wernstedt C, Tornqvist H, Manganiello VC, Belfrage P, Degerman E.
J. Biol. Chem. 1996 May 10;271(19):11575-80.
[Text Abstract on PubMed]

Type III cyclic nucleotide phosphodiesterases and insulin action.
Manganiello VC, Degerman E, Taira M, Kono T, Belfrage P.
Curr. Top. Cell. Regul. 1996;34:63-100.
[Text Abstract on PubMed]

Insulin stimulates hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase in rat brown adipose cells.
Omatsu-Kanbe M, Cushman SW, Manganiello VC, Taira M.
FEBS Lett. 1995 Oct 30;374(2):187-91.
[Text Abstract on PubMed]

Diversity in cyclic nucleotide phosphodiesterase isoenzyme families.
Manganiello VC, Murata T, Taira M, Belfrage P, Degerman E.
Arch. Biochem. Biophys. 1995 Sep 10;322(1):1-13.
[Text Abstract on PubMed]

Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family).
Manganiello VC, Taira M, Degerman E, Belfrage P.
Cell. Signal. 1995 Jul;7(5):445-55.
[Text Abstract on PubMed]

Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin.
Eriksson H, Ridderstråle M, Degerman E, Ekholm D, Smith CJ, Manganiello VC, Belfrage P, Tornqvist H.
Biochim. Biophys. Acta. 1995 Apr 6;1266(1):101-7.
[Text Abstract on PubMed]

Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases.
Reinhardt RR, Chin E, Zhou J, Taira M, Murata T, Manganiello VC, Bondy CA.
J. Clin. Invest. 1995 Apr;95(4):1528-38.
[Text Abstract on PubMed]

A novel insulin secretagogue is a phosphodiesterase inhibitor.
Leibowitz MD, Biswas C, Brady EJ, Conti M, Cullinan CA, Hayes NS, Manganiello VC, Saperstein R, Wang LH, Zafian PT.
Diabetes. 1995 Jan;44(1):67-74.
[Text Abstract on PubMed]

Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studies using the selective inhibitor wortmannin.
Rahn T, Ridderstråle M, Tornqvist H, Manganiello V, Fredrikson G, Belfrage P, Degerman E.
FEBS Lett. 1994 Aug 22;350(2-3):314-8.
[Text Abstract on PubMed]

Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.
Rascón A, Degerman E, Taira M, Meacci E, Smith CJ, Manganiello V, Belfrage P, Tornqvist H.
J. Biol. Chem. 1994 Apr 22;269(16):11962-6.
[Text Abstract on PubMed]

Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase.
Degerman E, Moos, Rascón A, Vasta V, Meacci E, Smith CJ, Lindgren S, Andersson KE, Belfrage P, Manganiello V.
Biochim. Biophys. Acta. 1994 Apr 13;1205(2):189-98.
[Text Abstract on PubMed]

Roles of ATP in insulin actions.
Makino H, Manganiello VC, Kono T.
Annu. Rev. Physiol. 1994;56:273-95.
[Text Abstract on PubMed]

Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.
Taira M, Hockman SC, Calvo JC, Taira M, Belfrage P, Manganiello VC.
J. Biol. Chem. 1993 Sep 5;268(25):18573-9.
[Text Abstract on PubMed]

Stimulation by insulin of a serine kinase in human platelets that phosphorylates and activates the cGMP-inhibited cAMP phosphodiesterase.
López-Aparicio P, Belfrage P, Manganiello VC, Kono T, Degerman E.
Biochem. Biophys. Res. Commun. 1993 Jun 30;193(3):1137-44.
[Text Abstract on PubMed]

Cytosolic and sarcoplasmic reticulum-associated low Km, cGMP-inhibited cAMP phosphodiesterase in mammalian myocardium.
Smith CJ, Krall J, Manganiello VC, Movsesian MA.
Biochem. Biophys. Res. Commun. 1993 Jan 29;190(2):516-21.
[Text Abstract on PubMed]

Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets.
López-Aparicio P, Rascón A, Manganiello VC, Andersson KE, Belfrage P, Degerman E.
Biochem. Biophys. Res. Commun. 1992 Jul 15;186(1):517-23.
[Text Abstract on PubMed]

Purification and characterization of guanosine 3',5'-monophosphate-inhibited low K(m) adenosine 3',5'-monophosphate phosphodiesterase from human placental cytosolic fractions.
LeBon TR, Kasuya J, Paxton RJ, Belfrage P, Hockman S, Manganiello VC, Fujita Yamaguchi Y.
Endocrinology. 1992 Jun;130(6):3265-74.
[Text Abstract on PubMed]

Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.
Meacci E, Taira M, Moos, Smith CJ, Movsesian MA, Degerman E, Belfrage P, Manganiello V.
Proc. Natl. Acad. Sci. U.S.A. 1992 May 1;89(9):3721-5.
[Text Abstract on PubMed]

Insulin and isoproterenol induce phosphorylation of the particulate cyclic GMP-inhibited, low Km cyclic AMP phosphodiesterase (cGI PDE) in 3T3-L1 adipocytes.
Vasta V, Smith CJ, Calvo J, Belfrage P, Manganiello VC.
Biochem. Biophys. Res. Commun. 1992 Mar 31;183(3):1070-5.
[Text Abstract on PubMed]

Purification and properties of the cGMP-inhibited cAMP phosphodiesterase from bovine aortic smooth muscle.
Rascón A, Lindgren S, Stavenow L, Belfrage P, Andersson KE, Manganiello VC, Degerman E.
Biochim. Biophys. Acta. 1992 Mar 16;1134(2):149-56.
[Text Abstract on PubMed]

Mechanisms for activation of the rat adipocyte particulate cyclic-GMP-inhibited cyclic AMP phosphodiesterase and its importance in the antilipolytic action of insulin.
Manganiello VC, Degerman E, Smith CJ, Vasta V, Tornqvist H, Belfrage P.
Adv. Second Messenger Phosphoprotein Res. 1992;25:147-64.
[Text Abstract on PubMed]

Selection of cDNAs for phosphodiesterases that hydrolyze guanosine 3';5'-monophosphate in Escherichia coli.
Van Lookeren Campagne MM, Villalba-Díaz F, Meacci E, Manganiello VC, Kessin RH.
Second Messengers Phosphoproteins. 1992-1993;14(3):127-37.
[Text Abstract on PubMed]

Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation.
Smith CJ, Vasta V, Degerman E, Belfrage P, Manganiello VC.
J. Biol. Chem. 1991 Jul 15;266(20):13385-90.
[Text Abstract on PubMed]

Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta.
Lindgren S, Rascón A, Andersson KE, Manganiello V, Degerman E.
Biochem. Pharmacol. 1991 Jul 15;42(3):545-52.
[Text Abstract on PubMed]

Sarcoplasmic reticulum-associated cyclic adenosine 5'-monophosphate phosphodiesterase activity in normal and failing human hearts.
Movsesian MA, Smith CJ, Krall J, Bristow MR, Manganiello VC.
J. Clin. Invest. 1991 Jul;88(1):15-9.
[Text Abstract on PubMed]

Comparison of putative cGMP-binding regions in bovine brain and cardiac cGMP-stimulated phosphodiesterases.
Tanaka T, Hockman S, Moos, Taira M, Meacci E, Murashima S, Manganiello VC.
Second Messengers Phosphoproteins. 1991;13(2-3):87-98.
[Text Abstract on PubMed]

Molecular mechanisms involved in the antilipolytic action of insulin: phosphorylation and activation of a particulate adipocyte cAMP phosphodiesterase.
Manganiello VC, Smith CJ, Degerman E, Vasta V, Tornqvist H, Belfrage P.
Adv. Exp. Med. Biol. 1991;293:239-48.
[Text Abstract on PubMed]

Characterization of particulate cyclic nucleotide phosphodiesterases from bovine brain: purification of a distinct cGMP-stimulated isoenzyme.
Murashima S, Tanaka T, Hockman S, Manganiello V.
Biochemistry. 1990 Jun 5;29(22):5285-92.
[Text Abstract on PubMed]

Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation.
Degerman E, Smith CJ, Tornqvist H, Vasta V, Belfrage P, Manganiello VC.
Proc. Natl. Acad. Sci. U.S.A. 1990 Jan;87(2):533-7.
[Text Abstract on PubMed]

Relaxant effects of the selective phosphodiesterase inhibitors milrinone and OPC 3911 on isolated human mesenteric vessels.
Lindgren S, Andersson KE, Belfrage P, Degerman E, Manganiello VC.
Pharmacol. Toxicol. 1989 May;64(5):440-5.
[Text Abstract on PubMed]

Role of hormone-sensitive low Km cAMP phosphodiesterase in regulation of cAMP-dependent protein kinase and lipolysis in rat adipocytes.
Smith CJ, Manganiello VC.
Mol. Pharmacol. 1989 Mar;35(3):381-6.
[Text Abstract on PubMed]

Effects of nitroprusside and nitroglycerin on cGMP content and PGI2 formation in aorta and vena cava.
Tsai SC, Adamik R, Manganiello VC, Moss J.
Biochem. Pharmacol. 1989 Jan 1;38(1):61-5.
[Text Abstract on PubMed]

Mechanism of enhanced sensitivity to bradykinin in pertussis toxin-treated fibroblasts: toxin increases bradykinin-stimulated prostaglandin formation.
Moss J, Hom BE, Hewlett EL, Tsai SC, Adamik R, Halpern JL, Price SR, Manganiello VC.
Mol. Pharmacol. 1988 Sep;34(3):279-85.
[Text Abstract on PubMed]

Selective inhibitors of specific phosphodiesterases in intact adipocytes.
Manganiello V, Degerman E, Elks M.
Meth. Enzymol. 1988;159:504-20.
[Text Abstract on PubMed]

Assay of cyclic nucleotide phosphodiesterase using radiolabeled and fluorescent substrates.
Kincaid RL, Manganiello VC.
Meth. Enzymol. 1988;159:457-70.
[Text Abstract on PubMed]

Purification, properties and polyclonal antibodies for the particulate, low Km cAMP phosphodiesterase from bovine adipose tissue.
Degerman E, Manganiello VC, Newman AH, Rice KC, Belfrage P.
Second Messengers Phosphoproteins. 1988;12(4):171-82.
[Text Abstract on PubMed]

Analysis of the kinetics of cyclic AMP hydrolysis by the cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.
Wada H, Manganiello VC, Osborne.
J. Biol. Chem. 1987 Oct 15;262(29):13938-45.
[Text Abstract on PubMed]

Effects of pH on allosteric and catalytic properties of the guanosine cyclic 3',5'-phosphate stimulated cyclic nucleotide phosphodiesterase from calf liver.
Wada H, Osborne, Manganiello VC.
Biochemistry. 1987 Oct 6;26(20):6565-70.
[Text Abstract on PubMed]

Subcellular localization and biological function of specific cyclic nucleotide phosphodiesterases.
Manganiello VC.
J. Mol. Cell. Cardiol. 1987 Oct;19(10):1037-40.
[Text Abstract on PubMed]

Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand.
Degerman E, Belfrage P, Newman AH, Rice KC, Manganiello VC.
J. Biol. Chem. 1987 Apr 25;262(12):5797-807.
[Text Abstract on PubMed]

Effects of temperature on allosteric and catalytic properties of the cGMP-stimulated cyclic nucleotide phosphodiesterase from calf liver.
Wada H, Osborne, Manganiello VC.
J. Biol. Chem. 1987 Apr 15;262(11):5139-44.
[Text Abstract on PubMed]

Effect of N6-(L-2-phenylisopropyl)adenosine and insulin on cAMP metabolism in 3T3-L1 adipocytes.
Elks ML, Jackson M, Manganiello VC, Vaughan M.
Am. J. Physiol. 1987 Mar;252(3 Pt 1):C342-8.
[Text Abstract on PubMed]

Effects of atrial natriuretic factor on cyclic guanosine monophosphate and cyclic adenosine monophosphate accumulation in microdissected nephron segments from rats.
Nonoguchi H, Knepper MA, Manganiello VC.
J. Clin. Invest. 1987 Feb;79(2):500-7.
[Text Abstract on PubMed]

Phorbol 12-myristate 13-acetate and vasopressin potentiate the effect of corticotropin-releasing factor on cyclic AMP production in rat anterior pituitary cells. Mechanisms of action.
Abou-Samra AB, Harwood JP, Manganiello VC, Catt KJ, Aguilera G.
J. Biol. Chem. 1987 Jan 25;262(3):1129-36.
[Text Abstract on PubMed]

Effects of nitroprusside on the bradykinin responsiveness of human fibroblasts.
Tsai SC, Adamik R, Hom BE, Manganiello VC, Moss J.
Mol. Pharmacol. 1986 Sep;30(3):274-8.
[Text Abstract on PubMed]

Hormonal regulation of adipocyte particulate "low Km" cAMP phosphodiesterase.
Manganiello VC, Smith CJ, Newman AH, Rice K, Degerman E, Belfrage P.
J Cyclic Nucleotide Protein Phosphor Res. 1986-1987;11(7):497-511.
[Text Abstract on PubMed]

Effects of thyroid hormone on regulation of lipolysis and adenosine 3',5'-monophosphate metabolism in 3T3-L1 adipocytes.
Elks ML, Manganiello VC.
Endocrinology. 1985 Sep;117(3):947-53.
[Text Abstract on PubMed]

A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes.
Elks ML, Manganiello VC.
J. Cell. Physiol. 1985 Aug;124(2):191-8.
[Text Abstract on PubMed]

Antilipolytic action of insulin: role of cAMP phosphodiesterase activation.
Elks ML, Manganiello VC.
Endocrinology. 1985 May;116(5):2119-21.
[Text Abstract on PubMed]

Effect of bradykinin on prostaglandin production by human skin fibroblasts in culture.
Jelsema CL, Moss J, Manganiello VC.
Meth. Enzymol. 1985;109:480-503.
[Text Abstract on PubMed]

Selective effects of phosphodiesterase inhibitors on different phosphodiesterases, adenosine 3',5'-monophosphate metabolism, and lipolysis in 3T3-L1 adipocytes.
Elks ML, Manganiello VC.
Endocrinology. 1984 Oct;115(4):1262-8.
[Text Abstract on PubMed]

Effect of dexamethasone on adenosine 3',5'-monophosphate content and phosphodiesterase activities in 3T3-L1 adipocytes.
Elks ML, Manganiello VC, Vaughan M.
Endocrinology. 1984 Oct;115(4):1350-6.
[Text Abstract on PubMed]

Autoregulation of bradykinin receptors and bradykinin-induced prostacyclin formation in human fibroblasts.
Roscher AA, Manganiello VC, Jelsema CL, Moss J.
J. Clin. Invest. 1984 Aug;74(2):552-8.
[Text Abstract on PubMed]

Purification and properties of calmodulin-stimulated phosphodiesterase from mammalian brain.
Kincaid RL, Manganiello VC, Odya CE, Osborne, Stith-Coleman IE, Danello MA, Vaughan M.
J. Biol. Chem. 1984 Apr 25;259(8):5158-66.
[Text Abstract on PubMed]

Effects of fatty acids on activity of cGMP-stimulated cyclic nucleotide phosphodiesterase from calf liver.
Yamamoto T, Yamamoto S, Manganiello VC, Vaughan M.
Arch. Biochem. Biophys. 1984 Feb 15;229(1):81-9.
[Text Abstract on PubMed]

Selective inhibition of two soluble adenosine cyclic 3',5'-phosphate phosphodiesterases partially purified from calf liver.
Yamamoto T, Lieberman F, Osborne, Manganiello VC, Vaughan M, Hidaka H.
Biochemistry. 1984 Feb 14;23(4):670-5.
[Text Abstract on PubMed]

Regulation of specific forms of cyclic nucleotide phosphodiesterases in cultured cells.
Manganiello VC, Yamamoto T, Elks M, Lin MC, Vaughan M.
Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;16:291-301.
[Text Abstract on PubMed]

Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.
Yamamoto T, Yamamoto S, Osborne, Manganiello VC, Vaughan M, Hidaka H.
J. Biol. Chem. 1983 Dec 10;258(23):14173-7.
[Text Abstract on PubMed]

Regulation of activity of purified guanylate cyclase from liver that is unresponsive to nitric oxide.
Tsai SC, Adamik R, Manganiello VC, Vaughan M.
Biochem. J. 1983 Dec 1;215(3):447-55.
[Text Abstract on PubMed]

Selective regulation by pertussis toxin of insulin-induced activation of particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes.
Elks ML, Watkins PA, Manganiello VC, Moss J, Hewlett E, Vaughan M.
Biochem. Biophys. Res. Commun. 1983 Oct 31;116(2):593-8.
[Text Abstract on PubMed]

Purification and characterization of cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from calf liver. Effects of divalent cations on activity.
Yamamoto T, Manganiello VC, Vaughan M.
J. Biol. Chem. 1983 Oct 25;258(20):12526-33.
[Text Abstract on PubMed]

Receptors for bradykinin in intact cultured human fibroblasts. Identification and characterization by direct binding study.
Roscher AA, Manganiello VC, Jelsema CL, Moss J.
J. Clin. Invest. 1983 Aug;72(2):626-35.
[Text Abstract on PubMed]

Ca2+-independent cyclic GMP phosphodiesterases from rat liver and HTC hepatoma cells.
Strewler GJ, Danello MA, Manganiello VC, Vaughan M.
Biochem. J. 1983 Aug 1;213(2):379-86.
[Text Abstract on PubMed]

Hormone-sensitive particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes. Regulation of responsiveness by dexamethasone.
Elks ML, Manganiello VC, Vaughan M.
J. Biol. Chem. 1983 Jul 25;258(14):8582-7.
[Text Abstract on PubMed]

Bradykinin stimulates phospholipid methylation, calcium influx, prostaglandin formation, and cAMP accumulation in human fibroblasts.
Bareis DL, Manganiello VC, Hirata F, Vaughan M, Axelrod J.
Proc. Natl. Acad. Sci. U.S.A. 1983 May;80(9):2514-8.
[Text Abstract on PubMed]

Regulation by bradykinin of its receptor and of receptor-mediated prostacyclin formation in cultured human fibroblasts.
Roscher AA, Manganiello VC, Jelsema CL, Moss J, Vaughan M.
Trans. Assoc. Am. Physicians. 1983;96:175-81.
[Text Abstract on PubMed]

Alterations in cyclic AMP phosphodiesterase activities during differentiation of 3T3-L1 cells.
Manganiello VC, Reed BC, Lieberman FS, Moss J, Lane MD, Vaughan M.
J Cyclic Nucleotide Protein Phosphor Res. 1983;9(2):143-54.
[Text Abstract on PubMed]

Calmodulin-activated cyclic nucleotide phosphodiesterase from brain. Changes in molecular size assessed by gel filtration and electrophoresis.
Kincaid RL, Manganiello VC, Vaughan M.
J. Biol. Chem. 1981 Nov 10;256(21):11345-50.
[Text Abstract on PubMed]

Calmodulin-activated cyclic nucleotide phosphodiesterase from brain. Relationship of subunit structure to activity assessed by radiation inactivation.
Kincaid RL, Kempner E, Manganiello VC, Osborne, Vaughan M.
J. Biol. Chem. 1981 Nov 10;256(21):11351-5.
[Text Abstract on PubMed]

Modification of calmodulin function by enzymatic carboxylic methylation.
Gagnon C, Kelly S, Manganiello V, Vaughan M, Odya C, Strittmatter W, Hoffman A, Hirata F.
Nature. 1981 Jun 11;291(5815):515-6.
[Text Abstract on PubMed]

Effects of d- and l-propranolol on the responsiveness of human fibroblasts to choleragen and prostaglandin E1.
Moss J, Manganiello VC, Hom BE, Nakaya S, Vaughan M.
Biochem. Pharmacol. 1981 Jun 1;30(11):1263-9.
[Text Abstract on PubMed]

Reversible inactivation of soluble liver guanylate cyclase by disulfides.
Tsai SC, Adamik R, Manganiello VC, Vaughan M.
Biochem. Biophys. Res. Commun. 1981 May 29;100(2):637-43.
[Text Abstract on PubMed]

Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases.
Hirata F, del Carmine R, Nelson CA, Axelrod J, Schiffmann E, Warabi A, De Blas AL, Nirenberg M, Manganiello V, Vaughan M, Kumagai S, Green I, Decker JL, Steinberg AD.
Proc. Natl. Acad. Sci. U.S.A. 1981 May;78(5):3190-4.
[Text Abstract on PubMed]

Regulation of cyclic nucleotide phosphodiesterase activity.
Vaughan M, Danello MA, Manganiello VC, Strewler GJ.
Adv Cyclic Nucleotide Res. 1981;14:263-71.
[Text Abstract on PubMed]

Products of reaction catalyzed by purified rat liver guanylate cyclase determined by 31p NMR spectroscopy.
Tsai SC, Shindo H, Manganiello VC, Adamik R, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 1980 Oct;77(10):5734-7.
[Text Abstract on PubMed]

Protein carboxyl-methylase modifies calmodulin function.
Gagnon C, Kelly S, Manganiello V, Vaughn M, Strittmatter W, Hoffman A, Hirata F.
Ann. N. Y. Acad. Sci. 1980;356:385-6.
[Text Abstract on PubMed]

Purification and characterization of phosphodiesterase activator from kidney. A lysosomal protease.
Strewler GJ, Manganiello VC.
J. Biol. Chem. 1979 Dec 10;254(23):11891-8.
[Text Abstract on PubMed]

Effects of spermine on activity and stability of calcium-dependent guanosine 3',5'-monophosphate phosphodiesterase.
Kincaid RL, Manganiello VC, Vaughan M.
J. Biol. Chem. 1979 Jun 25;254(12):4970-3.
[Text Abstract on PubMed]

Purification of guanylate cyclase from rat liver supernatant.
Tsai SC, Manganiello VC, Vaughan M.
J. Biol. Chem. 1978 Dec 10;253(23):8542-7.
[Text Abstract on PubMed]

Effects of chymotrypsin and a calcium-dependent protein activator on guanosine 3',5'-monophosphate phosphodiesterase from rat liver.
Moss J, Manganiello VC, Vaughan M.
Biochim. Biophys. Acta. 1978 Jul 3;541(3):279-87.
[Text Abstract on PubMed]

Activation of kidney guanylate cyclase by cobalt.
Tsai SC, Manganiello VC, Vaughan M.
Arch. Biochem. Biophys. 1978 Jul;189(1):155-60.
[Text Abstract on PubMed]

Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion.
Gallin JI, Sandler JA, Clyman RI, Manganiello VC, Vaughan M.
J. Immunol. 1978 Feb;120(2):492-6.
[Text Abstract on PubMed]

Phosphodiesterase activator from rat kidney cortex.
Strewler GJ, Manganiello VC, Vaughan M.
J. Biol. Chem. 1978 Jan 25;253(2):390-4.
[Text Abstract on PubMed]

Effect of serum on ganglioside uptake and choleragen responsiveness of transformed mouse fibroblasts.
Fishman PH, Bradley RM, Moss J, Manganiello VC.
J. Lipid Res. 1978 Jan;19(1):77-81.
[Text Abstract on PubMed]

Substrate and effector specificity of a guanosine 3':5'-monophosphate phosphodiesterase from rat liver.
Moss J, Manganiello VC, Vaughan M.
J. Biol. Chem. 1977 Aug 10;252(15):5211-5.
[Text Abstract on PubMed]

Synthesis and uptake of gangliosides by choleragen-responsive human fibroblasts.
Fishman PH, Moss J, Manganiello VC.
Biochemistry. 1977 May 3;16(9):1871-5.
[Text Abstract on PubMed]

Enzymatic and chemical oxidation of gangliosides in cultured cells: effects of choleragen.
Moss J, Manganiello VC, Fishman PH.
Biochemistry. 1977 May 3;16(9):1876-81.
[Text Abstract on PubMed]

Solubilization and characterization of hormone- responsive phosphodiesterase activity of rat fat cells.
Lovell-Smith CJ, Manganiello VC, Vaughan M.
Biochim. Biophys. Acta. 1977 Apr 27;497(2):447-58.
[Text Abstract on PubMed]

Regulation of cyclic nucleotide phosphodiesterases in cultured hepatoma cells by dexamethasone and N6,O2'-dibutyryl adenosine 3':k'-monophosphate.
Ross PS, Manganiello VC, Vaughan M.
J. Biol. Chem. 1977 Feb 25;252(4):1448-52.
[Text Abstract on PubMed]

Oxygen: influence on cyclic nucleotides and calcium sequestration in the human umbilical artery.
Clyman RI, Manganiello VC, Vaughan M.
Chest. 1977 Feb;71(2 suppl):247-9.
[Text Abstract on PubMed]

Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A protomer: possible role in the activation of adenylate cyclase.
Moss J, Manganiello VC, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 1976 Dec;73(12):4424-7.
[Text Abstract on PubMed]

Effects of choleragen on hormonal responsiveness of adenylate cyclase in human fibroblasts and rat fat cells.
Manganiello VC, Lovell-Smith CJ, Vaughan M.
Biochim. Biophys. Acta. 1976 Nov 18;451(1):62-71.
[Text Abstract on PubMed]

Activation and inhibition of fat cell adenylate cyclase by fluoride.
Manganiello VC, Vaughan M.
J. Biol. Chem. 1976 Oct 25;251(20):6205-9.
[Text Abstract on PubMed]

Calcium uptake by subcellular fractions of human umbilical artery.
Clyman RI, Manganiello VC, Lovell-Smith CJ, Vaughan M.
Am. J. Physiol. 1976 Oct;231(4):1074-81.
[Text Abstract on PubMed]

Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness.
Moss J, Fishman PH, Manganiello VC, Vaughan M, Brady RO.
Proc. Natl. Acad. Sci. U.S.A. 1976 Apr;73(4):1034-7.
[Text Abstract on PubMed]

Stimulation of monocyte cGMP by leukocyte dialysates. An antigen-independent property of dialyzable transfer factor.
Sandler JA, Smith TK, Manganiello VC, Kirkpatrick CH.
J. Clin. Invest. 1975 Nov;56(5):1271-9.
[Text Abstract on PubMed]

Oxygen and cyclic nucleotides in human umbilical artery.
Clyman RI, Blacksin AS, Manganiello VC, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 1975 Oct;72(10):3883-7.
[Text Abstract on PubMed]

The role of calcium in regulation of cyclic nucleotide content in human umbilical artery.
Clyman RI, Blacksin AS, Sandler JA, Manganiello VC, Vaughan M.
J. Biol. Chem. 1975 Jun 25;250(12):4718-21.
[Text Abstract on PubMed]

Guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate content of human umbilical artery.
Clyman RI, Sandler JA, Manganiello VC, Vaughan M.
J. Clin. Invest. 1975 May;55(5):1020-5.
[Text Abstract on PubMed]

The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.
Sandler JA, Clyman RI, Manganiello VC, Vaughan M.
J. Clin. Invest. 1975 Feb;55(2):431-5.
[Text Abstract on PubMed]

Effects of prostaglandin E1 and isoproterenol on cyclic AMP content of human fibroblasts modified by time and cell density in subculture.
Manganiello VC, Breslow J.
Biochim. Biophys. Acta. 1974 Oct 8;362(3):509-20.
[Text Abstract on PubMed]

Effects of epinephrine, adrenocorticotrophic hormone, and theophylline on adenosine 3', 5'-monophosphate phosphodiesterase activity in fat cells.
Pawlson LG, Lovell-Smith CJ, Manganiello VC, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 1974 May;71(5):1639-42.
[Text Abstract on PubMed]

Guanosine cyclic 3',5'-monophosphate and guanylate cyclase activity in guinea pig lung: effects of acetylcholine and cholinesterase inhibitors.
Stoner JS, Manganiello VC, Vaughan M.
Mol. Pharmacol. 1974 Jan;10(1):155-61.
[Text Abstract on PubMed]

Effects of bradykinin and indomethacin on cyclic GMP and cyclic AMP in lung slices.
Stoner J, Manganiello VC, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 1973 Dec;70(12):3830-3.
[Text Abstract on PubMed]

An effect of insulin on cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in fat cells.
Manganiello V, Vaughan M.
J. Biol. Chem. 1973 Oct 25;248(20):7164-70.
[Text Abstract on PubMed]

Effect of thyroxine on the disaturated lecithin content of lung.
Mason RJ, Manganiello V, Vaughan M.
Am. Rev. Respir. Dis. 1972 Nov;106(5):767-8.
[Text Abstract on PubMed]

An effect of dexamethasone on adenosine 3',5'-monophosphate content and adenosine 3',5'-monophosphate phosphodiesterase activity of cultured hepatoma cells.
Manganiello V, Vaughan M.
J. Clin. Invest. 1972 Oct;51(10):2763-7.
[Text Abstract on PubMed]

Purification of hepatic microsomal membranes.
Weihing RR, Manganiello VC, Chiu R, Phillips AH.
Biochemistry. 1972 Aug 1;11(16):3128-35.
[Text Abstract on PubMed]

Selective loss of adipose cell responsiveness to glucagon with growth in the rat.
Manganiello V, Vaughan M.
J. Lipid Res. 1972 Jan;13(1):12-6.
[Text Abstract on PubMed]

The effect of polystyrene beads on cyclic 3',5'-adenosine monophosphate concentration in leukocytes.
Manganiello V, Evans WH, Stossel TP, Mason RJ, Vaughan M.
J. Clin. Invest. 1971 Dec;50(12):2741-4.
[Text Abstract on PubMed]

Effects of lipolytic and antilipolytic agents on cyclic 3',5'-adenosine monophosphate in fat cells.
Manganiello VC, Murad F, Vaughan M.
J. Biol. Chem. 1971 Apr 10;246(7):2195-202.
[Text Abstract on PubMed]

A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate.
Murad F, Manganiello V, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 1971 Apr;68(4):736-9.
[Text Abstract on PubMed]

Effects of guanosine 3',5'-monophosphate on glycerol production and accumulation of adenosine 3',5'-monophosphate by fat cells.
Murad F, Manganiello V, Vaughan M.
J. Biol. Chem. 1970 Jul 10;245(13):3352-60.
[Text Abstract on PubMed]

The relationship between ribosomes and the endoplasmic reticulum during protein synthesis.
Manganiello VC, Phillips AH.
J. Biol. Chem. 1965 Oct;240(10):3951-9.
[Text Abstract on PubMed]

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