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Stewart Levine, M.D.

Publications


Principal Investigator thumbnail image

Stewart Levine
Senior Investigator

P: +1 301 402 1448
F: +1 301 451 5633
levines@nhlbi.nih.gov


Full Publications Listing

Apolipoprotein A-I attenuates ovalbumin-induced neutrophilic airway inflammation via a granulocyte colony-stimulating factor-dependent mechanism.
Dai C, Yao X, Keeran KJ, Zywicke GJ, Qu X, Yu ZX, Dagur PK, McCoy JP, Remaley AT, Levine SJ.
Am. J. Respir. Cell Mol. Biol. 2012 Aug;47(2):186-95.
[Text Abstract on PubMed]

Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in mice.
Yao X, Dai C, Fredriksson K, Lam J, Gao M, Keeran KJ, Nugent GZ, Qu X, Yu ZX, Jeffries N, Lin J, Kaler M, Shamburek R, Costello R, Csako G, Dahl M, Nordestgaard BG, Remaley AT, Levine SJ.
Am. J. Physiol. Lung Cell Mol. Physiol. 2012 Jan 15;302(2):L206-15.
[Text Abstract on PubMed]

Paradoxical effects of rapamycin on experimental house dust mite-induced asthma.
Fredriksson K, Fielhaber JA, Lam JK, Yao X, Meyer KS, Keeran KJ, Zywicke GJ, Qu X, Yu ZX, Moss J, Kristof AS, Levine SJ.
PLoS ONE. 2012;7(5):e33984.
[Text Abstract on PubMed]

Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis.
Vaisman BL, Demosky SJ, Stonik JA, Ghias M, Knapper CL, Sampson ML, Dai C, Levine SJ, Remaley AT.
J. Lipid Res. 2012 Jan;53(1):158-67.
[Text Abstract on PubMed]

Achieving symptom control in patients with moderate asthma.
Weir NA, Levine SJ.
Clin Med Insights Circ Respir Pulm Med. 2012;6:1-11.
[Text Abstract on PubMed]

Apolipoprotein mimetic peptides: a new approach for the treatment of asthma.
Yao X, Vitek MP, Remaley AT, Levine SJ.
Front Pharmacol. 2012;3:37.
[Text Abstract on PubMed]

A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages.
Qi HY, Daniels MP, Liu Y, Chen LY, Alsaaty S, Levine SJ, Shelhamer JH.
J. Immunol. 2011 Nov 15;187(10):5286-92.
[Text Abstract on PubMed]

New kids on the block: the emerging role of apolipoproteins in the pathogenesis and treatment of asthma.
Yao X, Remaley AT, Levine SJ.
Chest. 2011 Oct;140(4):1048-54.
[Text Abstract on PubMed]

Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses.
Yu M, Levine SJ.
Cytokine Growth Factor Rev. 2011 Apr;22(2):63-72.
[Text Abstract on PubMed]

Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways.
Yu M, Lam J, Rada B, Leto TL, Levine SJ.
J. Immunol. 2011 Jan 15;186(2):1180-8.
[Text Abstract on PubMed]

5A, an apolipoprotein A-I mimetic peptide, attenuates the induction of house dust mite-induced asthma.
Yao X, Dai C, Fredriksson K, Dagur PK, McCoy JP, Qu X, Yu ZX, Keeran KJ, Zywicke GJ, Amar MJ, Remaley AT, Levine SJ.
J. Immunol. 2011 Jan 1;186(1):576-83.
[Text Abstract on PubMed]

Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway.
Yao X, Fredriksson K, Yu ZX, Xu X, Raghavachari N, Keeran KJ, Zywicke GJ, Kwak M, Amar MJ, Remaley AT, Levine SJ.
Am. J. Respir. Crit. Care Med. 2010 Nov 15;182(10):1228-38.
[Text Abstract on PubMed]

Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes.
Levine SJ, Wenzel SE.
Ann. Intern. Med. 2010 Feb 16;152(4):232-7.
[Text Abstract on PubMed]

Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ.
Biochem. Biophys. Res. Commun. 2009 Jan 16;378(3):433-8.
[Text Abstract on PubMed]

cAMP-dependent protein kinase A (PKA) signaling induces TNFR1 exosome-like vesicle release via anchoring of PKA regulatory subunit RIIbeta to BIG2.
Islam A, Jones H, Hiroi T, Lam J, Zhang J, Moss J, Vaughan M, Levine SJ.
J. Biol. Chem. 2008 Sep 12;283(37):25364-71.
[Text Abstract on PubMed]

An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release.
Adamik B, Islam A, Rouhani FN, Hawari FI, Zhang J, Levine SJ.
Biochem. Biophys. Res. Commun. 2008 Jul 4;371(3):505-9.
[Text Abstract on PubMed]

Molecular mechanisms of soluble cytokine receptor generation.
Levine SJ.
J. Biol. Chem. 2008 May 23;283(21):14177-81.
[Text Abstract on PubMed]

Circulating TNFR1 exosome-like vesicles partition with the LDL fraction of human plasma.
Zhang J, Hawari FI, Shamburek RD, Adamik B, Kaler M, Islam A, Liao DW, Rouhani FN, Ingham M, Levine SJ.
Biochem. Biophys. Res. Commun. 2008 Feb 8;366(2):579-84.
[Text Abstract on PubMed]

Lymphatics in lung disease.
El-Chemaly S, Levine SJ, Moss J.
Ann. N. Y. Acad. Sci. 2008;1131:195-202.
[Text Abstract on PubMed]

Proteomics of lung cell biology and pulmonary disease.
Levine SJ.
Expert Rev Respir Med. 2007 Oct;1(2):255-69.
[Text Abstract on PubMed]

The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles.
Islam A, Shen X, Hiroi T, Moss J, Vaughan M, Levine SJ.
J. Biol. Chem. 2007 Mar 30;282(13):9591-9.
[Text Abstract on PubMed]

Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex.
Islam A, Adamik B, Hawari FI, Ma G, Rouhani FN, Zhang J, Levine SJ.
J. Biol. Chem. 2006 Mar 10;281(10):6860-73.
[Text Abstract on PubMed]

Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation.
Rouhani FN, Meitin CA, Kaler M, Miskinis-Hilligoss D, Stylianou M, Levine SJ.
Respir Med. 2005 Sep;99(9):1175-82.
[Text Abstract on PubMed]

Proteasome inhibition induces TNFR1 shedding from human airway epithelial (NCI-H292) cells.
Levine SJ, Adamik B, Hawari FI, Islam A, Yu ZX, Liao DW, Zhang J, Cui X, Rouhani FN.
Am. J. Physiol. Lung Cell Mol. Physiol. 2005 Aug;289(2):L233-43.
[Text Abstract on PubMed]

Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch.
Buckley CA, Rouhani FN, Kaler M, Adamik B, Hawari FI, Levine SJ.
Am. J. Physiol. Lung Cell Mol. Physiol. 2005 Jun;288(6):L1132-8.
[Text Abstract on PubMed]

Mechanisms of soluble cytokine receptor generation.
Levine SJ.
J. Immunol. 2004 Nov 1;173(9):5343-8.
[Text Abstract on PubMed]

Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors.
Hawari FI, Rouhani FN, Cui X, Yu ZX, Buckley C, Kaler M, Levine SJ.
Proc. Natl. Acad. Sci. U.S.A. 2004 Feb 3;101(5):1297-302.
[Text Abstract on PubMed]

Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding.
Cui X, Rouhani FN, Hawari F, Levine SJ.
J. Immunol. 2003 Dec 15;171(12):6814-9.
[Text Abstract on PubMed]

An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding.
Cui X, Rouhani FN, Hawari F, Levine SJ.
J. Biol. Chem. 2003 Aug 1;278(31):28677-85.
[Text Abstract on PubMed]

Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding.
Cui X, Hawari F, Alsaaty S, Lawrence M, Combs CA, Geng W, Rouhani FN, Miskinis D, Levine SJ.
J. Clin. Invest. 2002 Aug;110(4):515-26.
[Text Abstract on PubMed]

Fas-mediated alveolar epithelial cell apoptosis in acute lung injury: friend or foe?
Levine SJ.
Crit. Care Med. 2002 Jul;30(7):1667-8.
[Text Abstract on PubMed]

Polymorphisms in candidate asthma genes.
Nanavaty U, Goldstein AD, Levine SJ.
Am. J. Med. Sci. 2001 Jan;321(1):11-6.
[Text Abstract on PubMed]

Pneumocystis carinii pneumonia in patients without HIV infection.
Russian DA, Levine SJ.
Am. J. Med. Sci. 2001 Jan;321(1):56-65.
[Text Abstract on PubMed]

Tumor necrosis factor-alpha stimulates human Clara cell secretory protein production by human airway epithelial cells.
Yao XL, Levine SJ, Cowan MJ, Logun C, Shelhamer JH.
Am. J. Respir. Cell Mol. Biol. 1998 Oct;19(4):629-35.
[Text Abstract on PubMed]

The major surface glycoprotein of Pneumocystis carinii induces release and gene expression of interleukin-8 and tumor necrosis factor alpha in monocytes.
Benfield TL, Lundgren B, Levine SJ, Kronborg G, Shelhamer JH, Lundgren JD.
Infect. Immun. 1997 Nov;65(11):4790-4.
[Text Abstract on PubMed]

Antisense inhibition of 85-kDa cPLA2 blocks arachidonic acid release from airway epithelial cells.
Wu T, Levine SJ, Cowan M, Logun C, Angus CW, Shelhamer JH.
Am. J. Physiol. 1997 Aug;273(2 Pt 1):L331-8.
[Text Abstract on PubMed]

Acute respiratory failure in the HIV-seropositive patient.
Cowan MJ, Shelhamer JH, Levine SJ.
Crit Care Clin. 1997 Jul;13(3):523-52.
[Text Abstract on PubMed]

Extracellular release of the type I intracellular IL-1 receptor antagonist from human airway epithelial cells: differential effects of IL-4, IL-13, IFN-gamma, and corticosteroids.
Levine SJ, Wu T, Shelhamer JH.
J. Immunol. 1997 Jun 15;158(12):5949-57.
[Text Abstract on PubMed]

Pneumocystis carinii.
Levine SJ.
Clin. Chest Med. 1996 Dec;17(4):665-95.
[Text Abstract on PubMed]

Corticosteroids induce intracellular interleukin-1 receptor antagonist type I expression by a human airway epithelial cell line.
Levine SJ, Benfield T, Shelhamer JH.
Am. J. Respir. Cell Mol. Biol. 1996 Aug;15(2):245-51.
[Text Abstract on PubMed]

Protein kinase C, interleukin-1 beta, and corticosteroids regulate shedding of the type I, 55 kDa TNF receptor from human airway epithelial cells.
Levine SJ, Logun C, Chopra DP, Rhim JS, Shelhamer JH.
Am. J. Respir. Cell Mol. Biol. 1996 Mar;14(3):254-61.
[Text Abstract on PubMed]

NIH conference. Airway inflammation.
Shelhamer JH, Levine SJ, Wu T, Jacoby DB, Kaliner MA, Rennard SI.
Ann. Intern. Med. 1995 Aug 15;123(4):288-304.
[Text Abstract on PubMed]

Bronchial epithelial cell-cytokine interactions in airway inflammation.
Levine SJ.
J. Investig. Med. 1995 Jun;43(3):241-9.
[Text Abstract on PubMed]

Tumor necrosis factor-alpha induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells.
Levine SJ, Larivée P, Logun C, Angus CW, Ognibene FP, Shelhamer JH.
Am. J. Respir. Cell Mol. Biol. 1995 Feb;12(2):196-204.
[Text Abstract on PubMed]

Platelet-activating factor induces airway mucin release via activation of protein kinase C: evidence for translocation of protein kinase C to membranes.
Larivée P, Levine SJ, Martinez A, Wu T, Logun C, Shelhamer JH.
Am. J. Respir. Cell Mol. Biol. 1994 Aug;11(2):199-205.
[Text Abstract on PubMed]

Interferon-gamma induces the synthesis and activation of cytosolic phospholipase A2.
Wu T, Levine SJ, Lawrence MG, Logun C, Angus CW, Shelhamer JH.
J. Clin. Invest. 1994 Feb;93(2):571-7.
[Text Abstract on PubMed]

Corticosteroids differentially regulate secretion of IL-6, IL-8, and G-CSF by a human bronchial epithelial cell line.
Levine SJ, Larivée P, Logun C, Angus CW, Shelhamer JH.
Am. J. Physiol. 1993 Oct;265(4 Pt 1):L360-8.
[Text Abstract on PubMed]

Approach to the immunocompromised host with pulmonary symptoms.
Dichter JR, Levine SJ, Shelhamer JH.
Hematol. Oncol. Clin. North Am. 1993 Aug;7(4):887-912.
[Text Abstract on PubMed]

Diagnosis of Pneumocystis carinii pneumonia by multiple lobe, site-directed bronchoalveolar lavage with immunofluorescent monoclonal antibody staining in human immunodeficiency virus-infected patients receiving aerosolized pentamidine chemoprophylaxis.
Levine SJ, Kennedy D, Shelhamer JH, Kovacs A, Feuerstein IM, Gill VJ, Stock F, Solomon D, Boylen CT, Masur H.
Am. Rev. Respir. Dis. 1992 Oct;146(4):838-43.
[Text Abstract on PubMed]

An approach to the diagnosis of pulmonary infections in immunosuppressed patients.
Levine SJ.
Semin Respir Infect. 1992 Jun;7(2):81-95.
[Text Abstract on PubMed]

Effect of aerosolized pentamidine prophylaxis on the diagnosis of Pneumocystis carinii pneumonia by induced sputum examination in patients infected with the human immunodeficiency virus.
Levine SJ, Masur H, Gill VJ, Feuerstein I, Suffredini AF, Brown D, Lane HC, Yarchoan R, Shelhamer JH, Ognibene FP.
Am. Rev. Respir. Dis. 1991 Oct;144(4):760-4.
[Text Abstract on PubMed]

Cardiopulmonary toxicity after liposomal amphotericin B infusion.
Levine SJ, Walsh TJ, Martinez A, Eichacker PQ, Lopez-Berestein G, Natanson C.
Ann. Intern. Med. 1991 Apr 15;114(8):664-6.
[Text Abstract on PubMed]

The incidence and significance of Staphylococcus aureus in respiratory cultures from patients infected with the human immunodeficiency virus.
Levine SJ, White DA, Fels AO.
Am. Rev. Respir. Dis. 1990 Jan;141(1):89-93.
[Text Abstract on PubMed]

Pneumocystis carinii.
Levine SJ, White DA.
Clin. Chest Med. 1988 Sep;9(3):395-423.
[Text Abstract on PubMed]

An abnormal chest radiograph in a patient with recurring high altitude pulmonary edema.
Levine SJ, White DA, Fels AO.
Chest. 1988 Sep;94(3):627-8.
[Text Abstract on PubMed]

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