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Rodney L. Levine, Ph.D., M.D.

Publications


Principal Investigator thumbnail image

Rodney L. Levine
Senior Investigator

P: +1 301 496 2310
F: +1 301 451 5460
rlevine@nih.gov


Full Publications Listing

Methionine oxidation and reduction in proteins.
Kim G, Weiss SJ, Levine RL.
Biochim Biophys Acta. 2013 May 3.
[Text Abstract on PubMed]

Stereospecific oxidation of calmodulin by methionine sulfoxide reductase A.
Lim JC, Kim G, Levine RL.
Free Radic Biol Med. 2013 Apr 11;61C:257-264.
[Text Abstract on PubMed]

Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates.
Maltsev AS, Chen J, Levine RL, Bax A.
J Am Chem Soc. 2013 Feb 27;135(8):2943-6.
[Text Abstract on PubMed]

Regulation of the actin-activated MgATPase activity of Acanthamoeba myosin II by phosphorylation of serine 639 in motor domain loop 2.
Liu X, Lee DY, Cai S, Yu S, Shu S, Levine RL, Korn ED.
Proc. Natl. Acad. Sci. U.S.A. 2013 Jan 2;110(1):E23-32.
[Text Abstract on PubMed]

Quantification of protein carbonylation.
Wehr NB, Levine RL.
Methods Mol Biol. 2013 01 ;965:265-81.
[Text Abstract on PubMed]

Wanted and wanting: antibody against methionine sulfoxide.
Wehr NB, Levine RL.
Free Radic. Biol. Med. 2012 Sep 15;53(6):1222-5.
[Text Abstract on PubMed]

Characterization and solution structure of mouse myristoylated methionine sulfoxide reductase A.
Lim JC, Gruschus JM, Ghesquière B, Kim G, Piszczek G, Tjandra N, Levine RL.
J. Biol. Chem. 2012 Jul 20;287(30):25589-95.
[Text Abstract on PubMed]

A low pKa cysteine at the active site of mouse methionine sulfoxide reductase A.
Lim JC, Gruschus JM, Kim G, Berlett BS, Tjandra N, Levine RL.
J. Biol. Chem. 2012 Jul 20;287(30):25596-601.
[Text Abstract on PubMed]

Methionine sulfoxide reductase contributes to meeting dietary methionine requirements.
Zhao H, Kim G, Levine RL.
Arch. Biochem. Biophys. 2012 Jun 1;522(1):37-43.
[Text Abstract on PubMed]

Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-?2.
Mitterberger MC, Kim G, Rostek U, Levine RL, Zwerschke W.
Exp. Cell Res. 2012 May 1;318(8):877-86.
[Text Abstract on PubMed]

Quantitation of protein carbonylation by dot blot.
Wehr NB, Levine RL.
Anal. Biochem. 2012 Apr 15;423(2):241-5.
[Text Abstract on PubMed]

Myristoylated methionine sulfoxide reductase A protects the heart from ischemia-reperfusion injury.
Zhao H, Sun J, Deschamps AM, Kim G, Liu C, Murphy E, Levine RL.
Am. J. Physiol. Heart Circ. Physiol. 2011 Oct;301(4):H1513-8.
[Text Abstract on PubMed]

Iron regulatory protein 2 turnover through a nonproteasomal pathway.
Chang AH, Jeong J, Levine RL.
J. Biol. Chem. 2011 Jul 8;286(27):23698-707.
[Text Abstract on PubMed]

Methionine sulfoxide reductase A is a stereospecific methionine oxidase.
Lim JC, You Z, Kim G, Levine RL.
Proc. Natl. Acad. Sci. U.S.A. 2011 Jun 28;108(26):10472-7.
[Text Abstract on PubMed]

Group B Streptococcus, phospholipids and pulmonary hypertension.
Curtis J, Kim G, Wehr NB, Levine RL.
J Perinatol. 2011 Apr;31 Suppl 1:S24-8.
[Text Abstract on PubMed]

Deuteration of Escherichia coli enzyme I(Ntr) alters its stability.
Piszczek G, Lee JC, Tjandra N, Lee CR, Seok YJ, Levine RL, Peterkofsky A.
Arch. Biochem. Biophys. 2011 Mar 15;507(2):332-42.
[Text Abstract on PubMed]

Transgenic mice overexpressing methionine sulfoxide reductase A: characterization of embryonic fibroblasts.
Zhao H, Kim G, Liu C, Levine RL.
Free Radic. Biol. Med. 2010 Aug 15;49(4):641-8.
[Text Abstract on PubMed]

Oxidative stress causes reversible changes in mitochondrial permeability and structure.
Cole NB, Daniels MP, Levine RL, Kim G.
Exp. Gerontol. 2010 Aug;45(7-8):596-602.
[Text Abstract on PubMed]

Dual sites of protein initiation control the localization and myristoylation of methionine sulfoxide reductase A.
Kim G, Cole NB, Lim JC, Zhao H, Levine RL.
J. Biol. Chem. 2010 Jun 4;285(23):18085-94.
[Text Abstract on PubMed]

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.
Guyot N, Bergsson G, Butler MW, Greene CM, Weldon S, Kessler E, Levine RL, O'Neill SJ, Taggart CC, McElvaney NG.
Biol. Chem. 2010 Jun;391(6):705-16.
[Text Abstract on PubMed]

Characterization of a covalent polysulfane bridge in copper-zinc superoxide dismutase .
You Z, Cao X, Taylor AB, Hart PJ, Levine RL.
Biochemistry. 2010 Feb 16;49(6):1191-8.
[Text Abstract on PubMed]

Small-molecule antioxidant proteome-shields in Deinococcus radiodurans.
Daly MJ, Gaidamakova EK, Matrosova VY, Kiang JG, Fukumoto R, Lee DY, Wehr NB, Viteri GA, Berlett BS, Levine RL.
PLoS ONE. 2010;5(9):e12570.
[Text Abstract on PubMed]

Earl R. Stadtman.
Levine RL, Bohr VA.
Mech. Ageing Dev. 2010 Jan;131(1):1.
[Text Abstract on PubMed]

Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation.
Weldon S, McNally P, McElvaney NG, Elborn JS, McAuley DF, Wartelle J, Belaaouaj A, Levine RL, Taggart CC.
J. Immunol. 2009 Dec 15;183(12):8148-56.
[Text Abstract on PubMed]

ADP-ribosylation of human defensin HNP-1 results in the replacement of the modified arginine with the noncoded amino acid ornithine.
Stevens LA, Levine RL, Gochuico BR, Moss J.
Proc. Natl. Acad. Sci. U.S.A. 2009 Nov 24;106(47):19796-800.
[Text Abstract on PubMed]

Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span.
Salmon AB, Pérez VI, Bokov A, Jernigan A, Kim G, Zhao H, Levine RL, Richardson A.
FASEB J. 2009 Oct;23(10):3601-8.
[Text Abstract on PubMed]

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin.
Klamt F, Zdanov S, Levine RL, Pariser A, Zhang Y, Zhang B, Yu LR, Veenstra TD, Shacter E.
Nat. Cell Biol. 2009 Oct;11(10):1241-6.
[Text Abstract on PubMed]

Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au-Se adduct.
Jackson-Rosario S, Cowart D, Myers A, Tarrien R, Levine RL, Scott RA, Self WT.
J. Biol. Inorg. Chem. 2009 May;14(4):507-19.
[Text Abstract on PubMed]

Methionine in proteins defends against oxidative stress.
Luo S, Levine RL.
FASEB J. 2009 Feb;23(2):464-72.
[Text Abstract on PubMed]

Buffer modulation of menadione-induced oxidative stress in Saccharomyces cerevisiae.
Lushchak OV, Bayliak MM, Korobova OV, Levine RL, Lushchak VI.
Redox Rep. 2009;14(5):214-20.
[Text Abstract on PubMed]

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.
Guyot N, Butler MW, McNally P, Weldon S, Greene CM, Levine RL, O'Neill SJ, Taggart CC, McElvaney NG.
J. Biol. Chem. 2008 Nov 21;283(47):32377-85.
[Text Abstract on PubMed]

Mitochondrial NADH fluorescence is enhanced by complex I binding.
Blinova K, Levine RL, Boja ES, Griffiths GL, Shi ZD, Ruddy B, Balaban RS.
Biochemistry. 2008 Sep 9;47(36):9636-45.
[Text Abstract on PubMed]

Lon protease promotes survival of Escherichia coli during anaerobic glucose starvation.
Luo S, McNeill M, Myers TG, Hohman RJ, Levine RL.
Arch. Microbiol. 2008 Feb;189(2):181-5.
[Text Abstract on PubMed]

Metal-catalyzed oxidation of the Werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions.
Harrigan JA, Piotrowski J, Di Noto L, Levine RL, Bohr VA.
J. Biol. Chem. 2007 Dec 14;282(50):36403-11.
[Text Abstract on PubMed]

Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes.
Curtis C, Landis GN, Folk D, Wehr NB, Hoe N, Waskar M, Abdueva D, Skvortsov D, Ford D, Luu A, Badrinath A, Levine RL, Bradley TJ, Tavaré S, Tower J.
Genome Biol. 2007;8(12):R262.
[Text Abstract on PubMed]

Phosphorylation of actin Tyr-53 inhibits filament nucleation and elongation and destabilizes filaments.
Liu X, Shu S, Hong MS, Levine RL, Korn ED.
Proc. Natl. Acad. Sci. U.S.A. 2006 Sep 12;103(37):13694-9.
[Text Abstract on PubMed]

ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.
Paone G, Stevens LA, Levine RL, Bourgeois C, Steagall WK, Gochuico BR, Moss J.
J. Biol. Chem. 2006 Jun 23;281(25):17054-60.
[Text Abstract on PubMed]

Quantitation of protein on gels and blots by infrared fluorescence of Coomassie blue and Fast Green.
Luo S, Wehr NB, Levine RL.
Anal. Biochem. 2006 Mar 15;350(2):233-8.
[Text Abstract on PubMed]

Fixation of nitrogen in an electrospray mass spectrometer.
Levine RL.
Rapid Commun. Mass Spectrom. 2006;20(12):1828-30.
[Text Abstract on PubMed]

Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis.
Di Noto L, Whitson LJ, Cao X, Hart PJ, Levine RL.
J. Biol. Chem. 2005 Dec 2;280(48):39907-13.
[Text Abstract on PubMed]

Mutation of the adenylylated tyrosine of glutamine synthetase alters its catalytic properties.
Luo S, Kim G, Levine RL.
Biochemistry. 2005 Jul 12;44(27):9441-6.
[Text Abstract on PubMed]

Molecular determinants of S-glutathionylation of carbonic anhydrase 3.
Kim G, Levine RL.
Antioxid. Redox Signal. 2005 Jul-Aug;7(7-8):849-54.
[Text Abstract on PubMed]

Commentary on "Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death" by D.A. Bota, J.K. Ngo, and K.J.A. Davies.
Levine RL.
Free Radic. Biol. Med. 2005 Jun 1;38(11):1445-6.
[Text Abstract on PubMed]

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence.
Zhao H, Joseph J, Fales HM, Sokoloski EA, Levine RL, Vasquez-Vivar J, Kalyanaraman B.
Proc. Natl. Acad. Sci. U.S.A. 2005 Apr 19;102(16):5727-32.
[Text Abstract on PubMed]

Metal-catalyzed oxidation of alpha-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments.
Cole NB, Murphy DD, Lebowitz J, Di Noto L, Levine RL, Nussbaum RL.
J. Biol. Chem. 2005 Mar 11;280(10):9678-90.
[Text Abstract on PubMed]

Methionine oxidation and aging.
Stadtman ER, Van Remmen H, Richardson A, Wehr NB, Levine RL.
Biochim. Biophys. Acta. 2005 Jan 17;1703(2):135-40.
[Text Abstract on PubMed]

Oxidation of methionine residues in the prion protein by hydrogen peroxide.
Requena JR, Dimitrova MN, Legname G, Teijeira S, Prusiner SB, Levine RL.
Arch. Biochem. Biophys. 2004 Dec 15;432(2):188-95.
[Text Abstract on PubMed]

Carbonic anhydrase III is not required in the mouse for normal growth, development, and life span.
Kim G, Lee TH, Wetzel P, Geers C, Robinson MA, Myers TG, Owens JW, Wehr NB, Eckhaus MW, Gros G, Wynshaw-Boris A, Levine RL.
Mol. Cell. Biol. 2004 Nov;24(22):9942-7.
[Text Abstract on PubMed]

Identification of a heme-sensing domain in iron regulatory protein 2.
Jeong J, Rouault TA, Levine RL.
J. Biol. Chem. 2004 Oct 29;279(44):45450-4.
[Text Abstract on PubMed]

Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.
Zhao M, Boja ES, Hoodbhoy T, Nawrocki J, Kaufman JB, Kresge N, Ghirlando R, Shiloach J, Pannell L, Levine RL, Fales HM, Dean J.
Biochemistry. 2004 Sep 28;43(38):12090-104.
[Text Abstract on PubMed]

High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA.
Zhang Z, Dmitrieva NI, Park JH, Levine RL, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2004 Jun 22;101(25):9491-6.
[Text Abstract on PubMed]

Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice.
Browne SE, Roberts, Dennery PA, Doctrow SR, Beal MF, Barlow C, Levine RL.
Free Radic. Biol. Med. 2004 Apr 1;36(7):938-42.
[Text Abstract on PubMed]

Free radical-mediated oxidation of free amino acids and amino acid residues in proteins.
Stadtman ER, Levine RL.
Amino Acids. 2003 Dec;25(3-4):207-18.
[Text Abstract on PubMed]

Recent advances in the analysis of oxidized proteins.
Requena JR, Levine RL, Stadtman ER.
Amino Acids. 2003 Dec;25(3-4):221-6.
[Text Abstract on PubMed]

Oxidation of methionine residues of proteins: biological consequences.
Stadtman ER, Moskovitz J, Levine RL.
Antioxid. Redox Signal. 2003 Oct;5(5):577-82.
[Text Abstract on PubMed]

The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.
Bourdon E, Kang DK, Ghosh MC, Drake SK, Wey J, Levine RL, Rouault TA.
Blood Cells Mol. Dis. 2003 Sep-Oct;31(2):247-55.
[Text Abstract on PubMed]

Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins.
Taggart CC, Greene CM, Smith SG, Levine RL, McCray, O'Neill S, McElvaney NG.
J. Immunol. 2003 Jul 15;171(2):931-7.
[Text Abstract on PubMed]

Group B streptococcal phospholipid causes pulmonary hypertension.
Curtis J, Kim G, Wehr NB, Levine RL.
Proc. Natl. Acad. Sci. U.S.A. 2003 Apr 29;100(9):5087-90.
[Text Abstract on PubMed]

Iron regulatory protein 2 as iron sensor. Iron-dependent oxidative modification of cysteine.
Kang DK, Jeong J, Drake SK, Wehr NB, Rouault TA, Levine RL.
J. Biol. Chem. 2003 Apr 25;278(17):14857-64.
[Text Abstract on PubMed]

Direct detection of potential selenium delivery proteins by using an Escherichia coli strain unable to incorporate selenium from selenite into proteins.
Lacourciere GM, Levine RL, Stadtman TC.
Proc. Natl. Acad. Sci. U.S.A. 2002 Jul 9;99(14):9150-3.
[Text Abstract on PubMed]

ADP ribosylation of human neutrophil peptide-1 regulates its biological properties.
Paone G, Wada A, Stevens LA, Matin A, Hirayama T, Levine RL, Moss J.
Proc. Natl. Acad. Sci. U.S.A. 2002 Jun 11;99(12):8231-5.
[Text Abstract on PubMed]

Carbonyl modified proteins in cellular regulation, aging, and disease.
Levine RL.
Free Radic. Biol. Med. 2002 May 1;32(9):790-6.
[Text Abstract on PubMed]

Cyclic oxidation and reduction of protein methionine residues is an important antioxidant mechanism.
Stadtman ER, Moskovitz J, Berlett BS, Levine RL.
Mol. Cell. Biochem. 2002 May-Jun;234-235(1-2):3-9.
[Text Abstract on PubMed]

Why have cells selected reactive oxygen species to regulate cell signaling events?
Stadtman ER, Levine RL.
Hum Exp Toxicol. 2002 Feb;21(2):83.
[Text Abstract on PubMed]

Induction of apoptosis by chemotherapeutic drugs without generation of reactive oxygen species.
Sentürker S, Tschirret-Guth R, Morrow J, Levine R, Shacter E.
Arch. Biochem. Biophys. 2002 Jan 15;397(2):262-72.
[Text Abstract on PubMed]

Assessment of skin carbonyl content as a noninvasive measure of biological age.
Richert S, Wehr NB, Stadtman ER, Levine RL.
Arch. Biochem. Biophys. 2002 Jan 15;397(2):430-2.
[Text Abstract on PubMed]

Detection and affinity purification of oxidant-sensitive proteins using biotinylated glutathione ethyl ester.
Sullivan DM, Levine RL, Finkel T.
Meth. Enzymol. 2002;353:101-13.
[Text Abstract on PubMed]

Reversible oxidation of HIV-2 protease.
Davis DA, Newcomb FM, Moskovitz J, Fales HM, Levine RL, Yarchoan R.
Meth. Enzymol. 2002;348:249-59.
[Text Abstract on PubMed]

Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation.
Drake SK, Bourdon E, Wehr NB, Levine RL, Backlund PS, Yergey AL, Rouault TA.
Dev. Neurosci. 2002;24(2-3):114-24.
[Text Abstract on PubMed]

Selectivity of protein oxidative damage during aging in Drosophila melanogaster.
Das N, Levine RL, Orr WC, Sohal RS.
Biochem. J. 2001 Nov 15;360(Pt 1):209-16.
[Text Abstract on PubMed]

Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor.
Taggart CC, Lowe GJ, Greene CM, Mulgrew AT, O'Neill SJ, Levine RL, McElvaney NG.
J. Biol. Chem. 2001 Sep 7;276(36):33345-52.
[Text Abstract on PubMed]

Oxidative modification of proteins during aging.
Levine RL, Stadtman ER.
Exp. Gerontol. 2001 Sep;36(9):1495-502.
[Text Abstract on PubMed]

Copper-catalyzed oxidation of the recombinant SHa(29-231) prion protein.
Requena JR, Groth D, Legname G, Stadtman ER, Prusiner SB, Levine RL.
Proc. Natl. Acad. Sci. U.S.A. 2001 Jun 19;98(13):7170-5.
[Text Abstract on PubMed]

Nucleotide sequence and structure of the mouse carbonic anhydrase III gene.
Kim G, Lee T, Wynshaw-Boris A, Levine RL.
Gene. 2001 Mar 7;265(1-2):37-44.
[Text Abstract on PubMed]

Antioxidant activity of Ferrozine-iron-amino acid complexes.
Berlett BS, Levine RL, Chock PB, Chevion M, Stadtman ER.
Proc. Natl. Acad. Sci. U.S.A. 2001 Jan 16;98(2):451-6.
[Text Abstract on PubMed]

Thioredoxin converts the Syrian hamster (29-231) recombinant prion protein to an insoluble form.
Requena JR, Levine RL.
Free Radic. Biol. Med. 2001 Jan 15;30(2):141-7.
[Text Abstract on PubMed]

Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins.
Requena JR, Chao CC, Levine RL, Stadtman ER.
Proc. Natl. Acad. Sci. U.S.A. 2001 Jan 2;98(1):69-74.
[Text Abstract on PubMed]

Use of isosbestic point wavelength shifts to estimate the fraction of a precursor that is converted to a given product.
Berlett BS, Levine RL, Stadtman ER.
Anal. Biochem. 2000 Dec 15;287(2):329-33.
[Text Abstract on PubMed]

Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation.
Levine RL, Moskovitz J, Stadtman ER.
IUBMB Life. 2000 Oct-Nov;50(4-5):301-7.
[Text Abstract on PubMed]

Identification of oxidant-sensitive proteins: TNF-alpha induces protein glutathiolation.
Sullivan DM, Wehr NB, Fergusson MM, Levine RL, Finkel T.
Biochemistry. 2000 Sep 12;39(36):11121-8.
[Text Abstract on PubMed]

Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity.
Taggart C, Cervantes-Laurean D, Kim G, McElvaney NG, Wehr N, Moss J, Levine RL.
J. Biol. Chem. 2000 Sep 1;275(35):27258-65.
[Text Abstract on PubMed]

MDP-1: A novel eukaryotic magnesium-dependent phosphatase.
Selengut JD, Levine RL.
Biochemistry. 2000 Jul 18;39(28):8315-24.
[Text Abstract on PubMed]

Effects of aging and hyperoxia on oxidative damage to cytochrome c in the housefly, Musca domestica.
Yan LJ, Levine RL, Sohal RS.
Free Radic. Biol. Med. 2000 Jul 1;29(1):90-7.
[Text Abstract on PubMed]

Carbonic anhydrase III: the phosphatase activity is extrinsic.
Kim G, Selengut J, Levine RL.
Arch. Biochem. Biophys. 2000 May 15;377(2):334-40.
[Text Abstract on PubMed]

Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity.
Lee SR, Bar-Noy S, Kwon J, Levine RL, Stadtman TC, Rhee SG.
Proc. Natl. Acad. Sci. U.S.A. 2000 Mar 14;97(6):2521-6.
[Text Abstract on PubMed]

HIV-2 protease is inactivated after oxidation at the dimer interface and activity can be partly restored with methionine sulphoxide reductase.
Davis DA, Newcomb FM, Moskovitz J, Wingfield PT, Stahl SJ, Kaufman J, Fales HM, Levine RL, Yarchoan R.
Biochem. J. 2000 Mar 1;346 Pt 2:305-11.
[Text Abstract on PubMed]

Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns.
Arking R, Burde V, Graves K, Hari R, Feldman E, Zeevi A, Soliman S, Saraiya A, Buck S, Vettraino J, Sathrasala K, Wehr N, Levine RL.
Exp. Gerontol. 2000 Mar;35(2):167-85.
[Text Abstract on PubMed]

Protein oxidation.
Stadtman ER, Levine RL.
Ann. N. Y. Acad. Sci. 2000;899:191-208.
[Text Abstract on PubMed]

Determination of carbonyl groups in oxidized proteins.
Levine RL, Wehr N, Williams JA, Stadtman ER, Shacter E.
Methods Mol. Biol. 2000;99:15-24.
[Text Abstract on PubMed]

Modification of the ADP-ribosyltransferase and NAD glycohydrolase activities of a mammalian transferase (ADP-ribosyltransferase 5) by auto-ADP-ribosylation.
Weng B, Thompson WC, Kim HJ, Levine RL, Moss J.
J. Biol. Chem. 1999 Nov 5;274(45):31797-803.
[Text Abstract on PubMed]

Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs.
Barlow C, Dennery PA, Shigenaga MK, Smith MA, Morrow JD, Roberts, Wynshaw-Boris A, Levine RL.
Proc. Natl. Acad. Sci. U.S.A. 1999 Aug 17;96(17):9915-9.
[Text Abstract on PubMed]

Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate dehydrogenase.
Rivera-Nieves J, Thompson WC, Levine RL, Moss J.
J. Biol. Chem. 1999 Jul 9;274(28):19525-31.
[Text Abstract on PubMed]

Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation.
Tien M, Berlett BS, Levine RL, Chock PB, Stadtman ER.
Proc. Natl. Acad. Sci. U.S.A. 1999 Jul 6;96(14):7809-14.
[Text Abstract on PubMed]

Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants.
Chen W, Yewdell JW, Levine RL, Bennink JR.
J. Exp. Med. 1999 Jun 7;189(11):1757-64.
[Text Abstract on PubMed]

Oxidation of cellular proteins by beta-amyloid peptide.
Stadtman ER, Levine RL.
Neurobiol. Aging. 1999 May-Jun;20(3):331-3; discussion 339-42.
[Text Abstract on PubMed]

Methionine residues may protect proteins from critical oxidative damage.
Levine RL, Berlett BS, Moskovitz J, Mosoni L, Stadtman ER.
Mech. Ageing Dev. 1999 Mar 15;107(3):323-32.
[Text Abstract on PubMed]

Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver.
Lee SR, Kim JR, Kwon KS, Yoon HW, Levine RL, Ginsburg A, Rhee SG.
J. Biol. Chem. 1999 Feb 19;274(8):4722-34.
[Text Abstract on PubMed]

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins.
Iwai K, Drake SK, Wehr NB, Weissman AM, LaVaute T, Minato N, Klausner RD, Levine RL, Rouault TA.
Proc. Natl. Acad. Sci. U.S.A. 1998 Apr 28;95(9):4924-8.
[Text Abstract on PubMed]

Oxidative stress and aging.
Levine RL.
Aging (Milano). 1998 Apr;10(2):151.
[Text Abstract on PubMed]

Carbon dioxide stimulates peroxynitrite-mediated nitration of tyrosine residues and inhibits oxidation of methionine residues of glutamine synthetase: both modifications mimic effects of adenylylation.
Berlett BS, Levine RL, Stadtman ER.
Proc. Natl. Acad. Sci. U.S.A. 1998 Mar 17;95(6):2784-9.
[Text Abstract on PubMed]

Oxidative damage during aging targets mitochondrial aconitase.
Yan LJ, Levine RL, Sohal RS.
Proc. Natl. Acad. Sci. U.S.A. 1997 Oct 14;94(21):11168-72.
[Text Abstract on PubMed]

Modification of proteins in endothelial cell death during oxidative stress.
Ciolino HP, Levine RL.
Free Radic. Biol. Med. 1997;22(7):1277-82.
[Text Abstract on PubMed]

Methionine residues as endogenous antioxidants in proteins.
Levine RL, Mosoni L, Berlett BS, Stadtman ER.
Proc. Natl. Acad. Sci. U.S.A. 1996 Dec 24;93(26):15036-40.
[Text Abstract on PubMed]

Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90.
Conconi M, Szweda LI, Levine RL, Stadtman ER, Friguet B.
Arch. Biochem. Biophys. 1996 Jul 15;331(2):232-40.
[Text Abstract on PubMed]

The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation.
Cabiscol E, Levine RL.
Proc. Natl. Acad. Sci. U.S.A. 1996 Apr 30;93(9):4170-4.
[Text Abstract on PubMed]

Comparison of the effects of ozone on the modification of amino acid residues in glutamine synthetase and bovine serum albumin.
Berlett BS, Levine RL, Stadtman ER.
J. Biol. Chem. 1996 Feb 23;271(8):4177-82.
[Text Abstract on PubMed]

Regulation of HIV-1 protease activity through cysteine modification.
Davis DA, Dorsey K, Wingfield PT, Stahl SJ, Kaufman J, Fales HM, Levine RL.
Biochemistry. 1996 Feb 20;35(7):2482-8.
[Text Abstract on PubMed]

Determination of 2-oxohistidine by amino acid analysis.
Lewisch SA, Levine RL.
Anal. Biochem. 1995 Nov 1;231(2):440-6.
[Text Abstract on PubMed]

Inhibition of the human immunodeficiency virus-1 protease and human immunodeficiency virus-1 replication by bathocuproine disulfonic acid Cu1+.
Davis DA, Branca AA, Pallenberg AJ, Marschner TM, Patt LM, Chatlynne LG, Humphrey RW, Yarchoan R, Levine RL.
Arch. Biochem. Biophys. 1995 Sep 10;322(1):127-34.
[Text Abstract on PubMed]

Carbonic anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during aging.
Cabiscol E, Levine RL.
J. Biol. Chem. 1995 Jun 16;270(24):14742-7.
[Text Abstract on PubMed]

Aging of the liver: proteolysis of oxidatively modified glutamine synthetase.
Sahakian JA, Szweda LI, Friguet B, Kitani K, Levine RL.
Arch. Biochem. Biophys. 1995 Apr 20;318(2):411-7.
[Text Abstract on PubMed]

Oxidative modification of fibrinogen inhibits thrombin-catalyzed clot formation.
Shacter E, Williams JA, Levine RL.
Free Radic. Biol. Med. 1995 Apr;18(4):815-21.
[Text Abstract on PubMed]

Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay.
Shacter E, Williams JA, Lim M, Levine RL.
Free Radic. Biol. Med. 1994 Nov;17(5):429-37.
[Text Abstract on PubMed]

Reactivity of cysteine-67 of the human immunodeficiency virus-1 protease: studies on a peptide spanning residues 59 to 75.
D'Ettorre C, Levine RL.
Arch. Biochem. Biophys. 1994 Aug 15;313(1):71-6.
[Text Abstract on PubMed]

Oxidation of proteins in neonatal lungs.
Gladstone, Levine RL.
Pediatrics. 1994 May;93(5):764-8.
[Text Abstract on PubMed]

Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers.
Reddy VY, Desorchers PE, Pizzo SV, Gonias SL, Sahakian JA, Levine RL, Weiss SJ.
J. Biol. Chem. 1994 Feb 11;269(6):4683-91.
[Text Abstract on PubMed]

Carbonyl assays for determination of oxidatively modified proteins.
Levine RL, Williams JA, Stadtman ER, Shacter E.
Meth. Enzymol. 1994;233:346-57.
[Text Abstract on PubMed]

Ischemia: from acidosis to oxidation.
Levine RL.
FASEB J. 1993 Oct;7(13):1242-6.
[Text Abstract on PubMed]

Reactivity of cysteine residues in the protease from human immunodeficiency virus: identification of a surface-exposed region which affects enzyme function.
Karlström AR, Shames BD, Levine RL.
Arch. Biochem. Biophys. 1993 Jul;304(1):163-9.
[Text Abstract on PubMed]

Oxidation of the active site of glutamine synthetase: conversion of arginine-344 to gamma-glutamyl semialdehyde.
Climent I, Levine RL.
Arch. Biochem. Biophys. 1991 Sep;289(2):371-5.
[Text Abstract on PubMed]

Copper inhibits the protease from human immunodeficiency virus 1 by both cysteine-dependent and cysteine-independent mechanisms.
Karlström AR, Levine RL.
Proc. Natl. Acad. Sci. U.S.A. 1991 Jul 1;88(13):5552-6.
[Text Abstract on PubMed]

A difference in mortality between two strains of jaundiced rats.
Stobie PE, Hansen CT, Hailey JR, Levine RL.
Pediatrics. 1991 Jan;87(1):88-93.
[Text Abstract on PubMed]

Inactivation of bacterial glutamine synthetase by ADP-ribosylation.
Moss J, Stanley SJ, Levine RL.
J. Biol. Chem. 1990 Dec 5;265(34):21056-60.
[Text Abstract on PubMed]

Human immunodeficiency viral protease is catalytically active as a fusion protein: characterization of the fusion and native enzymes produced in Escherichia coli.
Boutelje J, Karlström AR, Hartmanis MG, Holmgren E, Sjögren A, Levine RL.
Arch. Biochem. Biophys. 1990 Nov 15;283(1):141-9.
[Text Abstract on PubMed]

Metal-catalyzed oxidation of Escherichia coli glutamine synthetase: correlation of structural and functional changes.
Rivett AJ, Levine RL.
Arch. Biochem. Biophys. 1990 Apr;278(1):26-34.
[Text Abstract on PubMed]

Hydrogen peroxide mediates the oxidative inactivation of enzymes following the switch from anaerobic to aerobic metabolism in Klebsiella pneumoniae.
Chevalier M, Lin EC, Levine RL.
J. Biol. Chem. 1990 Jan 5;265(1):42-6.
[Text Abstract on PubMed]

Determination of carbonyl content in oxidatively modified proteins.
Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S, Stadtman ER.
Meth. Enzymol. 1990;186:464-78.
[Text Abstract on PubMed]

Derivatization of gamma-glutamyl semialdehyde residues in oxidized proteins by fluoresceinamine.
Climent I, Tsai L, Levine RL.
Anal. Biochem. 1989 Nov 1;182(2):226-32.
[Text Abstract on PubMed]

Determination of carbonyl groups in oxidatively modified proteins by reduction with tritiated sodium borohydride.
Lenz AG, Costabel U, Shaltiel S, Levine RL.
Anal. Biochem. 1989 Mar;177(2):419-25.
[Text Abstract on PubMed]

Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions.
Amici A, Levine RL, Tsai L, Stadtman ER.
J. Biol. Chem. 1989 Feb 25;264(6):3341-6.
[Text Abstract on PubMed]

Proteolysis induced by metal-catalyzed oxidation.
Levine RL.
Revis. Biol. Celular. 1989;21:347-60.
[Text Abstract on PubMed]

Modulation of the hydrophobicity of glutamine synthetase by mixed-function oxidation.
Cervera J, Levine RL.
FASEB J. 1988 Jul;2(10):2591-5.
[Text Abstract on PubMed]

Neonatal jaundice.
Levine RL.
Acta Paediatr Scand. 1988 Mar;77(2):177-82.
[Text Abstract on PubMed]

Oxidative modification of glutamine synthetase: covalent and conformational changes which control susceptibility to proteolysis.
Levine RL, Rivett AJ.
Basic Life Sci. 1988;49:541-4.
[Text Abstract on PubMed]

Implication of protein oxidation in protein turnover, aging, and oxygen toxicity.
Stadtman ER, Oliver CN, Levine RL, Fucci L, Rivett AJ.
Basic Life Sci. 1988;49:331-9.
[Text Abstract on PubMed]

Enhanced proteolytic susceptibility of oxidized proteins.
Rivett AJ, Levine RL.
Biochem. Soc. Trans. 1987 Oct;15(5):816-8.
[Text Abstract on PubMed]

A role of mixed-function oxidation reactions in the accumulation of altered enzyme forms during aging.
Oliver CN, Levine RL, Stadtman ER.
J Am Geriatr Soc. 1987 Oct;35(10):947-56.
[Text Abstract on PubMed]

Purification of a protease from Escherichia coli with specificity for oxidized glutamine synthetase.
Roseman JE, Levine RL.
J. Biol. Chem. 1987 Feb 15;262(5):2101-10.
[Text Abstract on PubMed]

Sequence of a peptide susceptible to mixed-function oxidation. Probable cation binding site in glutamine synthetase.
Farber JM, Levine RL.
J. Biol. Chem. 1986 Apr 5;261(10):4574-8.
[Text Abstract on PubMed]

Inactivation of glycerol dehydrogenase of Klebsiella pneumoniae and the role of divalent cations.
Johnson EA, Levine RL, Lin EC.
J. Bacteriol. 1985 Oct;164(1):479-83.
[Text Abstract on PubMed]

Clearance of bilirubin from rat brain after reversible osmotic opening of the blood-brain barrier.
Levine RL, Fredericks WR, Rapoport SI.
Pediatr. Res. 1985 Oct;19(10):1040-3.
[Text Abstract on PubMed]

Labeling of cysteine-containing peptides with 2-nitro-5-thiobenzoic acid.
Sliwkowski MX, Levine RL.
Anal. Biochem. 1985 Jun;147(2):369-73.
[Text Abstract on PubMed]

Covalent modification of proteins by mixed-function oxidation: recognition by intracellular proteases.
Rivett AJ, Roseman JE, Oliver CN, Levine RL, Stadtman ER.
Prog. Clin. Biol. Res. 1985;180:317-28.
[Text Abstract on PubMed]

Covalent modification of proteins by mixed function oxidation.
Levine RL.
Curr. Top. Cell. Regul. 1985;27:305-16.
[Text Abstract on PubMed]

Identification of amino acid phenylthiohydantoins by multicomponent analysis of ultraviolet spectra.
Levine RL, Lehrman SR.
J. Chromatogr. 1984 Apr 20;288(1):111-6.
[Text Abstract on PubMed]

Mixed-function oxidation of histidine residues.
Levine RL.
Meth. Enzymol. 1984;107:370-6.
[Text Abstract on PubMed]

Oxidative modification of glutamine synthetase. I. Inactivation is due to loss of one histidine residue.
Levine RL.
J. Biol. Chem. 1983 Oct 10;258(19):11823-7.
[Text Abstract on PubMed]

Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system.
Levine RL.
J. Biol. Chem. 1983 Oct 10;258(19):11828-33.
[Text Abstract on PubMed]

Base hydrolysis and amino acid analysis for phosphotyrosine in proteins.
Martensen TM, Levine RL.
Meth. Enzymol. 1983;99:402-5.
[Text Abstract on PubMed]

Quantitation of aromatic residues in proteins: model compounds for second-derivative spectroscopy.
Levine RL, Federici MM.
Biochemistry. 1982 May 25;21(11):2600-6.
[Text Abstract on PubMed]

Entry of bilirubin into the brain due to opening of the blood-brain barrier.
Levine RL, Fredericks WR, Rapoport SI.
Pediatrics. 1982 Mar;69(3):255-9.
[Text Abstract on PubMed]

Turnover of bacterial glutamine synthetase: oxidative inactivation precedes proteolysis.
Levine RL, Oliver CN, Fulks RM, Stadtman ER.
Proc. Natl. Acad. Sci. U.S.A. 1981 Apr;78(4):2120-4.
[Text Abstract on PubMed]

Pharmacology of furosemide in the premature newborn infant.
Peterson RG, Simmons MA, Rumack BH, Levine RL, Brooks JG.
J. Pediatr. 1980 Jul;97(1):139-43.
[Text Abstract on PubMed]

Bilirubin: worked out years ago?
Levine RL.
Pediatrics. 1979 Sep;64(3):380-5.
[Text Abstract on PubMed]

Low positioning of umbilical-artery catheters increases associated complications in newborn infants.
Mokrohisky ST, Levine RL, Blumhagen JD, Wesenberg RL, Simmons MA.
N. Engl. J. Med. 1978 Sep 14;299(11):561-4.
[Text Abstract on PubMed]

Warning: serious sequelae of temporal artery catheterization.
Simmons MA, Levine RL, Lubchenco LO, Guggenheim MA.
J. Pediatr. 1978 Feb;92(2):284.
[Text Abstract on PubMed]

Fluorescence-quenching studies of the binding of bilirubin to albumin.
Levine RL.
Clin. Chem. 1977 Dec;23(12):2292-301.
[Text Abstract on PubMed]

Perinatal influence on the hyperbilirubineamia of the newborn infant.
Stockman R, Sidiropoulos D, von Muralt G, Levine RL.
J. Pediatr. 1977 May;90(5):858-60.
[Text Abstract on PubMed]

Letter: "Albumin-titratable bilirubin" as an index to bilirubin binding.
Levine RL.
Clin. Chem. 1976 Apr;22(4):560-1.
[Text Abstract on PubMed]

Letter: Concentrations of serum iron in relation to infection in the neonate.
Levine RL, Lemons JA.
J. Pediatr. 1975 Aug;87(2):331-2.
[Text Abstract on PubMed]

Pyrmidine biosynthesis during development of rat cerebellum.
Weichsel, Hoogenraad NJ, Levine RL, Kretchmer N.
Pediatr. Res. 1972 Aug;6(8):682-6.
[Text Abstract on PubMed]

Regulation of activity of carbamoyl phosphate synthetase from mouse spleen.
Levine RL, Hoogenraad NJ, Kretchmer N.
Biochemistry. 1971 Sep 28;10(20):3694-9.
[Text Abstract on PubMed]

Copurification of carbamoyl phosphate synthetase and aspartate transcarbamoylase from mouse spleen.
Hoogenraad NJ, Levine RL, Kretchmer N.
Biochem. Biophys. Res. Commun. 1971 Aug 20;44(4):981-8.
[Text Abstract on PubMed]

Conversion of carbamoyl phosphate to hydroxyurea. An assay for carbamoylphosphate synthetase.
Levine RL, Kretchmer N.
Anal. Biochem. 1971 Aug;42(2):324-37.
[Text Abstract on PubMed]

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