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Warren J. Leonard, M.D.

Publications


Principal Investigator thumbnail image

Warren J. Leonard
NIH Distinguished Investigator

P: +1 301 496 0098
F: +1 301 402 0971
wjl@helix.nih.gov


Full Publications Listing

Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis.
Ishigame H, Zenewicz LA, Sanjabi S, Licona-Limón P, Nakayama M, Leonard WJ, Flavell RA.
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6961-6.
[Text Abstract on PubMed]

The Cytokines IL-21 and GM-CSF Have Opposing Regulatory Roles in the Apoptosis of Conventional Dendritic Cells.
Wan CK, Oh J, Li P, West EE, Wong EA, Andraski AB, Spolski R, Yu ZX, He J, Kelsall BL, Leonard WJ.
Immunity. 2013 Feb 26.
[Text Abstract on PubMed]

A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis.
Usategui A, Criado G, Izquierdo E, Del Rey MJ, Carreira PE, Ortiz P, Leonard WJ, Pablos JL.
Ann Rheum Dis. 2013 Feb 14.
[Text Abstract on PubMed]

Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice.
Horikawa M, Weimer ET, DiLillo DJ, Venturi GM, Spolski R, Leonard WJ, Heise MT, Tedder TF.
J Immunol. 2013 Feb 1;190(3):1158-68.
[Text Abstract on PubMed]

Enhanced T cell lymphoma in NOD.Stat5b transgenic mice is caused by hyperactivation of Stat5b in CD8+ thymocytes.
Chen B, Yi B, Mao R, Liu H, Wang J, Sharma A, Peiper S, Leonard WJ, She JX.
PLoS One. 2013 01 ;8(2):e56600.
[Text Abstract on PubMed]

Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells.
Rasheed MA, Latner DR, Aubert RD, Gourley T, Spolski R, Davis CW, Langley WA, Ha SJ, Ye L, Sarkar S, Kalia V, Konieczny BT, Leonard WJ, Ahmed R.
J Virol. 2013 Jul ;87(13):7737-46.
[Text Abstract on PubMed]

IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection.
Schmitz I, Schneider C, Fröhlich A, Frebel H, Christ D, Leonard WJ, Sparwasser T, Oxenius A, Freigang S, Kopf M.
PLoS Pathog. 2013 May ;9(5):e1003362.
[Text Abstract on PubMed]

Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy.
Liao W, Lin JX, Leonard WJ.
Immunity. 2013 Jan 24;38(1):13-25.
[Text Abstract on PubMed]

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC.
Nat. Immunol. 2012 Dec;13(12):1187-95.
[Text Abstract on PubMed]

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.
Yoshizaki A, Miyagaki T, DiLillo DJ, Matsushita T, Horikawa M, Kountikov EI, Spolski R, Poe JC, Leonard WJ, Tedder TF.
Nature. 2012 Nov 8;491(7423):264-8.
[Text Abstract on PubMed]

BATF-JUN is critical for IRF4-mediated transcription in T cells.
Li P, Spolski R, Liao W, Wang L, Murphy TL, Murphy KM, Leonard WJ.
Nature. 2012 Oct 25;490(7421):543-6.
[Text Abstract on PubMed]

Compensatory dendritic cell development mediated by BATF-IRF interactions.
Tussiwand R, Lee WL, Murphy TL, Mashayekhi M, Wumesh KC, Albring JC, Satpathy AT, Rotondo JA, Edelson BT, Kretzer NM, Wu X, Weiss LA, Glasmacher E, Li P, Liao W, Behnke M, Lam SS, Aurthur CT, Leonard WJ, Singh H, Stallings CL, Sibley LD, Schreiber RD, Murphy KM.
Nature. 2012 Oct 25;490(7421):502-7.
[Text Abstract on PubMed]

Th17 cell-derived IL-17 is dispensable for B cell antibody production.
Shibui A, Shimura E, Nambu A, Yamaguchi S, Leonard WJ, Okumura K, Sugano S, Sudo K, Nakae S.
Cytokine. 2012 Jul;59(1):108-14.
[Text Abstract on PubMed]

Cd14 SNPs regulate the innate immune response.
Liu HH, Hu Y, Zheng M, Suhoski MM, Engleman EG, Dill DL, Hudnall M, Wang J, Spolski R, Leonard WJ, Peltz G.
Mol. Immunol. 2012 Jun;51(2):112-27.
[Text Abstract on PubMed]

Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function.
Lin JX, Li P, Liu D, Jin HT, He J, Ata Ur Rasheed M, Rochman Y, Wang L, Cui K, Liu C, Kelsall BL, Ahmed R, Leonard WJ.
Immunity. 2012 Apr 20;36(4):586-99.
[Text Abstract on PubMed]

Unusual timing of CD127 expression by mouse uterine natural killer cells.
Zhang J, Chen Z, Fritz JH, Rochman Y, Leonard WJ, Gommerman JL, Plumb AW, Abraham N, Croy BA.
J. Leukoc. Biol. 2012 Mar;91(3):417-26.
[Text Abstract on PubMed]

IL-21 promotes the pathologic immune response to pneumovirus infection.
Spolski R, Wang L, Wan CK, Bonville CA, Domachowske JB, Kim HP, Yu Z, Leonard WJ.
J. Immunol. 2012 Feb 15;188(4):1924-32.
[Text Abstract on PubMed]

Induction of thymic stromal lymphopoietin production by xylene and exacerbation of picryl chloride-induced allergic inflammation in mice.
Satou N, Ishihara K, Hiratsuka M, Tanaka H, Endo Y, Saito S, Iwakura Y, Leonard WJ, Hirasawa N.
Int. Arch. Allergy Immunol. 2012;157(2):194-201.
[Text Abstract on PubMed]

Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells.
Meguro A, Ozaki K, Hatanaka K, Oh I, Sudo K, Ohmori T, Matsu H, Tatara R, Sato K, Sakata Y, Nakae S, Leonard WJ, Ozawa K.
Bone Marrow Transplant. 2011 Dec;46(12):1557-65.
[Text Abstract on PubMed]

IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response.
Petrelli A, Carvello M, Vergani A, Lee KM, Tezza S, Du M, Kleffel S, Chengwen L, Mfarrej BG, Hwu P, Secchi A, Leonard WJ, Young D, Sayegh MH, Markmann JF, Zajac AJ, Fiorina P.
Diabetes. 2011 Dec;60(12):3223-34.
[Text Abstract on PubMed]

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation.
Liao W, Lin JX, Leonard WJ.
Curr. Opin. Immunol. 2011 Oct;23(5):598-604.
[Text Abstract on PubMed]

Thymic stromal lymphopoietin is produced by dendritic cells.
Kashyap M, Rochman Y, Spolski R, Samsel L, Leonard WJ.
J. Immunol. 2011 Aug 1;187(3):1207-11.
[Text Abstract on PubMed]

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL.
Hanash AM, Kappel LW, Yim NL, Nejat RA, Goldberg GL, Smith OM, Rao UK, Dykstra L, Na IK, Holland AM, Dudakov JA, Liu C, Murphy GF, Leonard WJ, Heller G, van den Brink MR.
Blood. 2011 Jul 14;118(2):446-55.
[Text Abstract on PubMed]

p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.
Elf S, Blevins D, Jin L, Chung TW, Williams IR, Lee BH, Lin JX, Leonard WJ, Taunton J, Khoury HJ, Kang S.
Blood. 2011 Jun 23;117(25):6885-94.
[Text Abstract on PubMed]

IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.
Oh MH, Oh SY, Yu J, Myers AC, Leonard WJ, Liu YJ, Zhu Z, Zheng T.
J. Immunol. 2011 Jun 15;186(12):7232-42.
[Text Abstract on PubMed]

Key role for IL-21 in experimental autoimmune uveitis.
Wang L, Yu CR, Kim HP, Liao W, Telford WG, Egwuagu CE, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 2011 Jun 7;108(23):9542-7.
[Text Abstract on PubMed]

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.
Liao W, Lin JX, Wang L, Li P, Leonard WJ.
Nat. Immunol. 2011 Jun;12(6):551-9.
[Text Abstract on PubMed]

Role of thymic stromal lymphopoietin (TSLP) in palifermin-mediated immune modulation and protection from acute murine graft-versus-host disease.
Ellison CA, Lissitsyn YV, Packiasamy JA, Leonard WJ, Gartner JG.
J. Clin. Immunol. 2011 Jun;31(3):406-13.
[Text Abstract on PubMed]

Thymic stromal lymphopoietin is a key mediator of breast cancer progression.
Olkhanud PB, Rochman Y, Bodogai M, Malchinkhuu E, Wejksza K, Xu M, Gress RE, Hesdorffer C, Leonard WJ, Biragyn A.
J. Immunol. 2011 May 15;186(10):5656-62.
[Text Abstract on PubMed]

Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.
Simard N, Konforte D, Tran AH, Esufali J, Leonard WJ, Paige CJ.
J. Immunol. 2011 May 1;186(9):5244-53.
[Text Abstract on PubMed]

IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.
Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL.
J. Clin. Invest. 2011 Mar;121(3):1154-62.
[Text Abstract on PubMed]

Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection.
Novy P, Huang X, Leonard WJ, Yang Y.
J. Immunol. 2011 Mar 1;186(5):2729-38.
[Text Abstract on PubMed]

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Rochman Y, Kashyap M, Robinson GW, Sakamoto K, Gomez-Rodriguez J, Wagner KU, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 2010 Nov 9;107(45):19455-60.
[Text Abstract on PubMed]

Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease.
Oh I, Ozaki K, Meguro A, Hatanaka K, Kadowaki M, Matsu H, Tatara R, Sato K, Iwakura Y, Nakae S, Sudo K, Teshima T, Leonard WJ, Ozawa K.
J. Immunol. 2010 Aug 1;185(3):1920-6.
[Text Abstract on PubMed]

IL-21 is critical for GVHD in a mouse model.
Meguro A, Ozaki K, Oh I, Hatanaka K, Matsu H, Tatara R, Sato K, Leonard WJ, Ozawa K.
Bone Marrow Transplant. 2010 Apr;45(4):723-9.
[Text Abstract on PubMed]

Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
Do JS, Fink PJ, Li L, Spolski R, Robinson J, Leonard WJ, Letterio JJ, Min B.
J. Immunol. 2010 Feb 15;184(4):1675-9.
[Text Abstract on PubMed]

NetPath: a public resource of curated signal transduction pathways.
Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A.
Genome Biol. 2010;11(1):R3.
[Text Abstract on PubMed]

IL-21 and T follicular helper cells.
Spolski R, Leonard WJ.
Int. Immunol. 2010 Jan;22(1):7-12.
[Text Abstract on PubMed]

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.
Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, Radtke F.
PLoS ONE. 2010;5(2):e9258.
[Text Abstract on PubMed]

IL-21 is an immune activator that also mediates suppression via IL-10.
Spolski R, Leonard WJ.
Crit. Rev. Immunol. 2010;30(6):559-70.
[Text Abstract on PubMed]

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.
Kwon H, Thierry-Mieg D, Thierry-Mieg J, Kim HP, Oh J, Tunyaplin C, Carotta S, Donovan CE, Goldman ML, Tailor P, Ozato K, Levy DE, Nutt SL, Calame K, Leonard WJ.
Immunity. 2009 Dec 18;31(6):941-52.
[Text Abstract on PubMed]

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.
Hinrichs CS, Borman ZA, Cassard L, Gattinoni L, Spolski R, Yu Z, Sanchez-Perez L, Muranski P, Kern SJ, Logun C, Palmer DC, Ji Y, Reger RN, Leonard WJ, Danner RL, Rosenberg SA, Restifo NP.
Proc. Natl. Acad. Sci. U.S.A. 2009 Oct 13;106(41):17469-74.
[Text Abstract on PubMed]

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.
Guo L, Wei G, Zhu J, Liao W, Leonard WJ, Zhao K, Paul W.
Proc. Natl. Acad. Sci. U.S.A. 2009 Aug 11;106(32):13463-8.
[Text Abstract on PubMed]

New insights into the regulation of T cells by gamma(c) family cytokines.
Rochman Y, Spolski R, Leonard WJ.
Nat. Rev. Immunol. 2009 Jul;9(7):480-90.
[Text Abstract on PubMed]

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities.
Eddahri F, Denanglaire S, Bureau F, Spolski R, Leonard WJ, Leo O, Andris F.
Blood. 2009 Mar 12;113(11):2426-33.
[Text Abstract on PubMed]

IL-21 mediates suppressive effects via its induction of IL-10.
Spolski R, Kim HP, Zhu W, Levy DE, Leonard WJ.
J. Immunol. 2009 Mar 1;182(5):2859-67.
[Text Abstract on PubMed]

Cytokine mediators of Th17 function.
Spolski R, Leonard WJ.
Eur. J. Immunol. 2009 Mar;39(3):658-61.
[Text Abstract on PubMed]

A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice.
Bubier JA, Sproule TJ, Foreman O, Spolski R, Shaffer DJ, Morse, Leonard WJ, Roopenian DC.
Proc. Natl. Acad. Sci. U.S.A. 2009 Feb 3;106(5):1518-23.
[Text Abstract on PubMed]

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M.
J. Exp. Med. 2009 Jan 16;206(1):69-78.
[Text Abstract on PubMed]

Angiostatic activity of the antitumor cytokine interleukin-21.
Castermans K, Tabruyn SP, Zeng R, van Beijnum JR, Eppolito C, Leonard WJ, Shrikant PA, Griffioen AW.
Blood. 2008 Dec 15;112(13):4940-7.
[Text Abstract on PubMed]

The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation.
Wu Z, Xue HH, Bernard J, Zeng R, Issakov D, Bollenbacher-Reilley J, Belyakov IM, Oh S, Berzofsky JA, Leonard WJ.
Blood. 2008 Dec 1;112(12):4411-9.
[Text Abstract on PubMed]

The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis.
Rochman Y, Leonard WJ.
J. Immunol. 2008 Dec 1;181(11):7699-705.
[Text Abstract on PubMed]

Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression.
Liao W, Schones DE, Oh J, Cui Y, Cui K, Roh TY, Zhao K, Leonard WJ.
Nat. Immunol. 2008 Nov;9(11):1288-96.
[Text Abstract on PubMed]

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73: 147-157. 1993.
Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS, McBride OW, Leonard WJ.
J. Immunol. 2008 Nov 1;181(9):5817-27.
[Text Abstract on PubMed]

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Mazzucchelli R, Hixon JA, Spolski R, Chen X, Li WQ, Hall VL, Willette-Brown J, Hurwitz AA, Leonard WJ, Durum SK.
Blood. 2008 Oct 15;112(8):3283-92.
[Text Abstract on PubMed]

IL-21 signaling is critical for the development of type I diabetes in the NOD mouse.
Spolski R, Kashyap M, Robinson C, Yu Z, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 2008 Sep 16;105(37):14028-33.
[Text Abstract on PubMed]

Interleukin 21: a cytokine/cytokine receptor system that has come of age.
Leonard WJ, Zeng R, Spolski R.
J. Leukoc. Biol. 2008 Aug;84(2):348-56.
[Text Abstract on PubMed]

Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function.
Xue HH, Jing X, Bollenbacher-Reilley J, Zhao DM, Haring JS, Yang B, Liu C, Bishop GA, Harty JT, Leonard WJ.
Mol. Cell. Biol. 2008 Jul;28(13):4300-9.
[Text Abstract on PubMed]

T-cell development and function are modulated by dual specificity phosphatase DUSP5.
Kovanen PE, Bernard J, Al-Shami A, Liu C, Bollenbacher-Reilley J, Young L, Pise-Masison C, Spolski R, Leonard WJ.
J. Biol. Chem. 2008 Jun 20;283(25):17362-9.
[Text Abstract on PubMed]

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.
Hinrichs CS, Spolski R, Paulos CM, Gattinoni L, Kerstann KW, Palmer DC, Klebanoff CA, Rosenberg SA, Leonard WJ, Restifo NP.
Blood. 2008 Jun 1;111(11):5326-33.
[Text Abstract on PubMed]

Thymic stromal lymphopoietin: a new cytokine in asthma.
Rochman Y, Leonard WJ.
Curr Opin Pharmacol. 2008 Jun;8(3):249-54.
[Text Abstract on PubMed]

The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer.
Spolski R, Leonard WJ.
Curr. Opin. Immunol. 2008 Jun;20(3):295-301.
[Text Abstract on PubMed]

Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1.
Chandele A, Joshi NS, Zhu J, Paul WE, Leonard WJ, Kaech SM.
J. Immunol. 2008 Apr 15;180(8):5309-19.
[Text Abstract on PubMed]

Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection.
Haring JS, Jing X, Bollenbacher-Reilley J, Xue HH, Leonard WJ, Harty JT.
J. Immunol. 2008 Mar 1;180(5):2855-62.
[Text Abstract on PubMed]

Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling.
Kashyap M, Thornton AM, Norton SK, Barnstein B, Macey M, Brenzovich J, Shevach E, Leonard WJ, Ryan JJ.
J. Immunol. 2008 Feb 15;180(4):2039-43.
[Text Abstract on PubMed]

Critical role for Rsk2 in T-lymphocyte activation.
Lin JX, Spolski R, Leonard WJ.
Blood. 2008 Jan 15;111(2):525-33.
[Text Abstract on PubMed]

Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor.
Guimond M, Leonard WJ, Spolski R, Rossi SW, Veenstra RG, Hollander GA, Mackall CL, Blazar BR.
Blood. 2008 Jan 15;111(2):969-70.
[Text Abstract on PubMed]

GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression.
Crook MF, Olive M, Xue HH, Langenickel TH, Boehm M, Leonard WJ, Nabel EG.
FASEB J. 2008 Jan;22(1):225-35.
[Text Abstract on PubMed]

A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling.
Bessette K, Lang ML, Fava RA, Grundy M, Heinen J, Horne L, Spolski R, Al-Shami A, Morse, Leonard WJ, Kelly JA.
Blood. 2008 Jan 1;111(1):344-50.
[Text Abstract on PubMed]

Interleukin-21: basic biology and implications for cancer and autoimmunity.
Spolski R, Leonard WJ.
Annu. Rev. Immunol. 2008;26:57-79.
[Text Abstract on PubMed]

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.
Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR.
Nat. Immunol. 2007 Sep;8(9):967-74.
[Text Abstract on PubMed]

Measurement of interleukin-21.
Zeng R, Spolski R, Leonard WJ.
Curr Protoc Immunol. 2007 Aug;Chapter 6:Unit 6.30.
[Text Abstract on PubMed]

CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation.
Kim HP, Leonard WJ.
J. Exp. Med. 2007 Jul 9;204(7):1543-51.
[Text Abstract on PubMed]

Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells.
Rochman I, Watanabe N, Arima K, Liu YJ, Leonard WJ.
J. Immunol. 2007 Jun 1;178(11):6720-4.
[Text Abstract on PubMed]

The molecular basis of IL-21-mediated proliferation.
Zeng R, Spolski R, Casas E, Zhu W, Levy DE, Leonard WJ.
Blood. 2007 May 15;109(10):4135-42.
[Text Abstract on PubMed]

The transcription factor GABP is a critical regulator of B lymphocyte development.
Xue HH, Bollenbacher-Reilley J, Wu Z, Spolski R, Jing X, Zhang YC, McCoy JP, Leonard WJ.
Immunity. 2007 Apr;26(4):421-31.
[Text Abstract on PubMed]

Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins.
Pang L, Xue HH, Szalai G, Wang X, Wang Y, Watson DK, Leonard WJ, Blobel GA, Poncz M.
Blood. 2006 Oct 1;108(7):2198-206.
[Text Abstract on PubMed]

Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.
Kim HP, Imbert J, Leonard WJ.
Cytokine Growth Factor Rev. 2006 Oct;17(5):349-66.
[Text Abstract on PubMed]

Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells.
Ozaki K, Hishiya A, Hatanaka K, Nakajima H, Wang G, Hwu P, Kitamura T, Ozawa K, Leonard WJ, Nosaka T.
Int. J. Hematol. 2006 Oct;84(3):224-30.
[Text Abstract on PubMed]

IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.
Ettinger R, Sims GP, Fairhurst AM, Robbins R, da Silva YS, Spolski R, Leonard WJ, Lipsky PE.
J. Immunol. 2005 Dec 15;175(12):7867-79.
[Text Abstract on PubMed]

Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity.
Wu Z, Kim HP, Xue HH, Liu H, Zhao K, Leonard WJ.
Mol. Cell. Biol. 2005 Nov;25(22):9741-52.
[Text Abstract on PubMed]

Smad-dependent cooperative regulation of interleukin 2 receptor alpha chain gene expression by T cell receptor and transforming growth factor-beta.
Kim HP, Kim BG, Letterio J, Leonard WJ.
J. Biol. Chem. 2005 Oct 7;280(40):34042-7.
[Text Abstract on PubMed]

A role for TSLP in the development of inflammation in an asthma model.
Al-Shami A, Spolski R, Kelly J, Keane-Myers A, Leonard WJ.
J. Exp. Med. 2005 Sep 19;202(6):829-39.
[Text Abstract on PubMed]

Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation.
Leonard WJ, Spolski R.
Nat. Rev. Immunol. 2005 Sep;5(9):688-98.
[Text Abstract on PubMed]

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.
Kovanen PE, Young L, Al-Shami A, Rovella V, Pise-Masison CA, Radonovich MF, Powell J, Fu J, Brady JN, Munson PJ, Leonard WJ.
Int. Immunol. 2005 Aug;17(8):1009-21.
[Text Abstract on PubMed]

Calcium-dependent activation of interleukin-21 gene expression in T cells.
Kim HP, Korn LL, Gamero AM, Leonard WJ.
J. Biol. Chem. 2005 Jul 1;280(26):25291-7.
[Text Abstract on PubMed]

Defective B cell responses in the absence of SH2D1A.
Morra M, Barrington RA, Abadia-Molina AC, Okamoto S, Julien A, Gullo C, Kalsy A, Edwards MJ, Chen G, Spolski R, Leonard WJ, Huber BT, Borrow P, Biron CA, Satoskar AR, Carroll MC, Terhorst C.
Proc. Natl. Acad. Sci. U.S.A. 2005 Mar 29;102(13):4819-23.
[Text Abstract on PubMed]

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.
Zeng R, Spolski R, Finkelstein SE, Oh S, Kovanen PE, Hinrichs CS, Pise-Masison CA, Radonovich MF, Brady JN, Restifo NP, Berzofsky JA, Leonard WJ.
J. Exp. Med. 2005 Jan 3;201(1):139-48.
[Text Abstract on PubMed]

Interleukin-7 deficiency in rheumatoid arthritis.
Leonard WJ.
Arthritis Res. Ther. 2005;7(1):42-3.
[Text Abstract on PubMed]

Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways.
Kovanen PE, Leonard WJ.
Immunol. Rev. 2004 Dec;202:67-83.
[Text Abstract on PubMed]

Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6.
Ozaki K, Spolski R, Ettinger R, Kim HP, Wang G, Qi CF, Hwu P, Shaffer DJ, Akilesh S, Roopenian DC, Morse, Lipsky PE, Leonard WJ.
J. Immunol. 2004 Nov 1;173(9):5361-71.
[Text Abstract on PubMed]

GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells.
Xue HH, Bollenbacher J, Rovella V, Tripuraneni R, Du YB, Liu CY, Williams A, McCoy JP, Leonard WJ.
Nat. Immunol. 2004 Oct;5(10):1036-44.
[Text Abstract on PubMed]

A role for thymic stromal lymphopoietin in CD4(+) T cell development.
Al-Shami A, Spolski R, Kelly J, Fry T, Schwartzberg PL, Pandey A, Mackall CL, Leonard WJ.
J. Exp. Med. 2004 Jul 19;200(2):159-68.
[Text Abstract on PubMed]

In vivo antitumor activity of interleukin 21 mediated by natural killer cells.
Wang G, Tschoi M, Spolski R, Lou Y, Ozaki K, Feng C, Kim G, Leonard WJ, Hwu P.
Cancer Res. 2003 Dec 15;63(24):9016-22.
[Text Abstract on PubMed]

Immune deficiencies due to defects in cytokine signaling.
Kelly J, Leonard WJ.
Curr Allergy Asthma Rep. 2003 Sep;3(5):396-401.
[Text Abstract on PubMed]

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.
Kelly JA, Spolski R, Kovanen PE, Suzuki T, Bollenbacher J, Pise-Masison CA, Radonovich MF, Lee S, Jenkins NA, Copeland NG, Morse, Leonard WJ.
J. Exp. Med. 2003 Jul 7;198(1):79-89.
[Text Abstract on PubMed]

Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling.
Kovanen PE, Rosenwald A, Fu J, Hurt EM, Lam LT, Giltnane JM, Wright G, Staudt LM, Leonard WJ.
J. Biol. Chem. 2003 Feb 14;278(7):5205-13.
[Text Abstract on PubMed]

A role for Stat5 in CD8+ T cell homeostasis.
Kelly J, Spolski R, Imada K, Bollenbacher J, Lee S, Leonard WJ.
J. Immunol. 2003 Jan 1;170(1):210-7.
[Text Abstract on PubMed]

A critical role for IL-21 in regulating immunoglobulin production.
Ozaki K, Spolski R, Feng CG, Qi CF, Cheng J, Sher A, Morse, Liu C, Schwartzberg PL, Leonard WJ.
Science. 2002 Nov 22;298(5598):1630-4.
[Text Abstract on PubMed]

Serine phosphorylation of Stat5 proteins in lymphocytes stimulated with IL-2.
Xue HH, Fink, Zhang X, Qin J, Turck CW, Leonard WJ.
Int. Immunol. 2002 Nov;14(11):1263-71.
[Text Abstract on PubMed]

IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.
Xue HH, Kovanen PE, Pise-Masison CA, Berg M, Radovich MF, Brady JN, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 2002 Oct 15;99(21):13759-64.
[Text Abstract on PubMed]

Cytokine and cytokine receptor pleiotropy and redundancy.
Ozaki K, Leonard WJ.
J. Biol. Chem. 2002 Aug 16;277(33):29355-8.
[Text Abstract on PubMed]

TSLP: finally in the limelight.
Leonard WJ.
Nat. Immunol. 2002 Jul;3(7):605-7.
[Text Abstract on PubMed]

The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements.
Kim HP, Leonard WJ.
EMBO J. 2002 Jun 17;21(12):3051-9.
[Text Abstract on PubMed]

Cytokines and immunodeficiency diseases.
Leonard WJ.
Nat. Rev. Immunol. 2001 Dec;1(3):200-8.
[Text Abstract on PubMed]

HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G.
Blood. 2001 Aug 1;98(3):823-9.
[Text Abstract on PubMed]

The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements.
Kim HP, Kelly J, Leonard WJ.
Immunity. 2001 Jul;15(1):159-72.
[Text Abstract on PubMed]

Role of Jak kinases and STATs in cytokine signal transduction.
Leonard WJ.
Int. J. Hematol. 2001 Apr;73(3):271-7.
[Text Abstract on PubMed]

JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.
Sporri B, Kovanen PE, Sasaki A, Yoshimura A, Leonard WJ.
Blood. 2001 Jan 1;97(1):221-6.
[Text Abstract on PubMed]

Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.
Ozaki K, Kikly K, Michalovich D, Young PR, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 2000 Oct 10;97(21):11439-44.
[Text Abstract on PubMed]

X-linked severe combined immunodeficiency: from molecular cause to gene therapy within seven years.
Leonard WJ.
Mol Med Today. 2000 Oct;6(10):403-7.
[Text Abstract on PubMed]

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling.
Zhang S, Fukuda S, Lee Y, Hangoc G, Cooper S, Spolski R, Leonard WJ, Broxmeyer HE.
J. Exp. Med. 2000 Sep 4;192(5):719-28.
[Text Abstract on PubMed]

Mutations in the gene for the IL-7 receptor result in T(-)B(+)NK(+) severe combined immunodeficiency disease.
Puel A, Leonard WJ.
Curr. Opin. Immunol. 2000 Aug;12(4):468-73.
[Text Abstract on PubMed]

Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor alpha gene.
Reeves R, Leonard WJ, Nissen MS.
Mol. Cell. Biol. 2000 Jul;20(13):4666-79.
[Text Abstract on PubMed]

Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin.
Pandey A, Ozaki K, Baumann H, Levin SD, Puel A, Farr AG, Ziegler SF, Leonard WJ, Lodish HF.
Nat. Immunol. 2000 Jul;1(1):59-64.
[Text Abstract on PubMed]

The role of Stat5a and Stat5b in signaling by IL-2 family cytokines.
Lin JX, Leonard WJ.
Oncogene. 2000 May 15;19(21):2566-76.
[Text Abstract on PubMed]

Cytokine receptor signaling pathways.
Leonard WJ, Lin JX.
J. Allergy Clin. Immunol. 2000 May;105(5):877-88.
[Text Abstract on PubMed]

Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue.
Kagami Si, Nakajima H, Kumano K, Suzuki K, Suto A, Imada K, Davey HW, Saito Y, Takatsu K, Leonard WJ, Iwamoto I.
Blood. 2000 Feb 15;95(4):1370-7.
[Text Abstract on PubMed]

Role of the common cytokine receptor gamma chain (gammac) in thymocyte selection.
Nakajima H, Noguchi M, Leonard WJ.
Immunol. Today. 2000 Feb;21(2):88-94.
[Text Abstract on PubMed]

Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice.
Suzuki K, Nakajima H, Saito Y, Saito T, Leonard WJ, Iwamoto I.
Int. Immunol. 2000 Feb;12(2):123-32.
[Text Abstract on PubMed]

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.
Soldaini E, John S, Moro S, Bollenbacher J, Schindler U, Leonard WJ.
Mol. Cell. Biol. 2000 Jan;20(1):389-401.
[Text Abstract on PubMed]

The Jak-STAT pathway.
Imada K, Leonard WJ.
Mol. Immunol. 2000 Jan-Feb;37(1-2):1-11.
[Text Abstract on PubMed]

Use of chimeric receptor molecules to dissect signal transduction mechanisms.
Leonard WJ.
Meth. Enzymol. 2000;327:228-39.
[Text Abstract on PubMed]

Inhibitors keep cytokines in check.
Kovanen PE, Leonard WJ.
Curr. Biol. 1999 Dec 2;9(23):R899-902.
[Text Abstract on PubMed]

Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach.
Lo M, Bloom ML, Imada K, Berg M, Bollenbacher JM, Bloom ET, Kelsall BL, Leonard WJ.
Blood. 1999 Nov 1;94(9):3027-36.
[Text Abstract on PubMed]

CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling.
Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu Mh, Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard WJ.
J. Biol. Chem. 1999 Oct 15;274(42):30266-72.
[Text Abstract on PubMed]

The significance of tetramerization in promoter recruitment by Stat5.
John S, Vinkemeier U, Soldaini E, Darnell, Leonard WJ.
Mol. Cell. Biol. 1999 Mar;19(3):1910-8.
[Text Abstract on PubMed]

Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity.
Nakajima H, Leonard WJ.
J. Immunol. 1999 Jan 15;162(2):782-90.
[Text Abstract on PubMed]

Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
Zhu M, John S, Berg M, Leonard WJ.
Cell. 1999 Jan 8;96(1):121-30.
[Text Abstract on PubMed]

Signaling via the IL-2 and IL-7 receptors from the membrane to the nucleus.
Leonard WJ, Imada K, Nakajima H, Puel A, Soldaini E, John S.
Cold Spring Harb. Symp. Quant. Biol. 1999;64:417-24.
[Text Abstract on PubMed]

Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.
Durum SK, Candèias S, Nakajima H, Leonard WJ, Baird AM, Berg LJ, Muegge K.
J. Exp. Med. 1998 Dec 21;188(12):2233-41.
[Text Abstract on PubMed]

Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity.
Imada K, Bloom ET, Nakajima H, Horvath-Arcidiacono JA, Udy GB, Davey HW, Leonard WJ.
J. Exp. Med. 1998 Dec 7;188(11):2067-74.
[Text Abstract on PubMed]

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.
Puel A, Ziegler SF, Buckley RH, Leonard WJ.
Nat. Genet. 1998 Dec;20(4):394-7.
[Text Abstract on PubMed]

Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation.
Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ.
Mol. Cell. Biol. 1998 Nov;18(11):6416-22.
[Text Abstract on PubMed]

Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation.
Mulloy JC, Migone TS, Ross TM, Ton N, Green PL, Leonard WJ, Franchini G.
J. Virol. 1998 May;72(5):4408-12.
[Text Abstract on PubMed]

Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.
Zhu MH, Berry JA, Russell SM, Leonard WJ.
J. Biol. Chem. 1998 Apr 24;273(17):10719-25.
[Text Abstract on PubMed]

Infection of mice lacking the common cytokine receptor gamma-chain (gamma(c)) reveals an unexpected role for CD4+ T lymphocytes in early IFN-gamma-dependent resistance to Toxoplasma gondii.
Scharton-Kersten T, Nakajima H, Yap G, Sher A, Leonard WJ.
J. Immunol. 1998 Mar 15;160(6):2565-9.
[Text Abstract on PubMed]

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins.
Takemoto S, Mulloy JC, Cereseto A, Migone TS, Patel BK, Matsuoka M, Yamaguchi K, Takatsuki K, Kamihira S, White JD, Leonard WJ, Waldmann T, Franchini G.
Proc. Natl. Acad. Sci. U.S.A. 1997 Dec 9;94(25):13897-902.
[Text Abstract on PubMed]

Cytokine signaling: cytokine-inducible signaling inhibitors.
Aman MJ, Leonard WJ.
Curr. Biol. 1997 Dec 1;7(12):R784-8.
[Text Abstract on PubMed]

Signaling from the IL-2 receptor to the nucleus.
Lin JX, Leonard WJ.
Cytokine Growth Factor Rev. 1997 Dec;8(4):313-32.
[Text Abstract on PubMed]

Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice.
Nakajima H, Leonard WJ.
J. Immunol. 1997 Nov 15;159(10):4737-44.
[Text Abstract on PubMed]

An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction.
Nakajima H, Liu XW, Wynshaw-Boris A, Rosenthal LA, Imada K, Finbloom DS, Hennighausen L, Leonard WJ.
Immunity. 1997 Nov;7(5):691-701.
[Text Abstract on PubMed]

Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain.
Noguchi M, Sarin A, Aman MJ, Nakajima H, Shores EW, Henkart PA, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 1997 Oct 14;94(21):11534-9.
[Text Abstract on PubMed]

STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression.
Feldman GM, Rosenthal LA, Liu X, Hayes MP, Wynshaw-Boris A, Leonard WJ, Hennighausen L, Finbloom DS.
Blood. 1997 Sep 1;90(5):1768-76.
[Text Abstract on PubMed]

Genetic effects on immunity. Protein tyrosine kinases: disease loci for inherited immunodeficiencies.
Leonard WJ.
Curr. Opin. Immunol. 1997 Aug;9(4):525-7.
[Text Abstract on PubMed]

Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development.
Boesteanu A, Silva AD, Nakajima H, Leonard WJ, Peschon JJ, Joyce S.
J. Exp. Med. 1997 Jul 21;186(2):331-6.
[Text Abstract on PubMed]

The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites.
Lin JX, Leonard WJ.
Mol. Cell. Biol. 1997 Jul;17(7):3714-22.
[Text Abstract on PubMed]

Interleukin-2 (IL-2)-mediated induction of the IL-2 receptor alpha chain gene. Critical role of two functionally redundant tyrosine residues in the IL-2 receptor beta chain cytoplasmic domain and suggestion that these residues mediate more than Stat5 activation.
Ascherman DP, Migone TS, Friedmann MC, Leonard WJ.
J. Biol. Chem. 1997 Mar 28;272(13):8704-9.
[Text Abstract on PubMed]

The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.
He YW, Nakajima H, Leonard WJ, Adkins B, Malek TR.
J. Immunol. 1997 Mar 15;158(6):2592-9.
[Text Abstract on PubMed]

The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis.
Nakajima H, Shores EW, Noguchi M, Leonard WJ.
J. Exp. Med. 1997 Jan 20;185(2):189-95.
[Text Abstract on PubMed]

cDNA cloning and characterization of the human interleukin 13 receptor alpha chain.
Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ.
J. Biol. Chem. 1996 Nov 15;271(46):29265-70.
[Text Abstract on PubMed]

An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.
John S, Robbins CM, Leonard WJ.
EMBO J. 1996 Oct 15;15(20):5627-35.
[Text Abstract on PubMed]

STATs and cytokine specificity.
Leonard WJ.
Nat. Med. 1996 Sep;2(9):968-9.
[Text Abstract on PubMed]

Dysfunctional cytokine receptor signaling in severe combined immunodeficiency.
Leonard WJ.
J. Investig. Med. 1996 Aug;44(6):304-11.
[Text Abstract on PubMed]

Distinct tumorigenic potential of abl and raf in B cell neoplasia: abl activates the IL-6 signaling pathway.
Hilbert DM, Migone TS, Kopf M, Leonard WJ, Rudikoff S.
Immunity. 1996 Jul;5(1):81-9.
[Text Abstract on PubMed]

The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.
Mulloy JC, Crownley RW, Fullen J, Leonard WJ, Franchini G.
J. Virol. 1996 Jun;70(6):3599-605.
[Text Abstract on PubMed]

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.
Lin JX, Mietz J, Modi WS, John S, Leonard WJ.
J. Biol. Chem. 1996 May 3;271(18):10738-44.
[Text Abstract on PubMed]

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.
Friedmann MC, Migone TS, Russell SM, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 1996 Mar 5;93(5):2077-82.
[Text Abstract on PubMed]

Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expression.
John S, Marais R, Child R, Light Y, Leonard WJ.
J. Exp. Med. 1996 Mar 1;183(3):743-50.
[Text Abstract on PubMed]

The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling.
Leonard WJ.
Annu. Rev. Med. 1996;47:229-39.
[Text Abstract on PubMed]

Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development.
Leonard WJ, Shores EW, Love PE.
Immunol. Rev. 1995 Dec;148:97-114.
[Text Abstract on PubMed]

Genetic mapping of the interleukin 1 receptor alpha and beta chain genes in the mouse.
Kozak CA, Leonard WJ.
Mamm. Genome. 1995 Nov;6(11):823-4.
[Text Abstract on PubMed]

Activation of natural killer cells by the mAb YTA-1 that recognizes leukocyte function-associated antigen-1.
Sugie K, Nakamura K, Teshigawara K, Diamond MS, Springer TA, Nakamura Y, Leonard WJ, Uchida A, Yodoi J.
Int. Immunol. 1995 May;7(5):763-9.
[Text Abstract on PubMed]

Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15.
Obiri NI, Debinski W, Leonard WJ, Puri RK.
J. Biol. Chem. 1995 Apr 14;270(15):8797-804.
[Text Abstract on PubMed]

Retroviral vector for gene therapy of X-linked severe combined immunodeficiency syndrome.
Qazilbash MH, Walsh CE, Russell SM, Noguchi M, Mann MM, Leonard WJ, Liu JM.
J Hematother. 1995 Apr;4(2):91-8.
[Text Abstract on PubMed]

Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.
John S, Reeves RB, Lin JX, Child R, Leiden JM, Thompson CB, Leonard WJ.
Mol. Cell. Biol. 1995 Mar;15(3):1786-96.
[Text Abstract on PubMed]

Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency.
Schmalstieg FC, Leonard WJ, Noguchi M, Berg M, Rudloff HE, Denney RM, Dave SK, Brooks EG, Goldman AS.
J. Clin. Invest. 1995 Mar;95(3):1169-73.
[Text Abstract on PubMed]

Reconstitution of a functional interleukin (IL)-7 receptor demonstrates that the IL-2 receptor gamma chain is required for IL-7 signal transduction.
Ziegler SE, Morella KK, Anderson D, Kumaki N, Leonard WJ, Cosman D, Baumann H.
Eur. J. Immunol. 1995 Feb;25(2):399-404.
[Text Abstract on PubMed]

Expression of interleukin-2 receptor gamma on human monocytes: characterization of lineage specific post-translational modifications.
Epling-Burnette PK, Wei S, Liu JH, Pericle F, Ussery D, Russell SM, Leonard WJ, Djeu JY.
Eur. J. Immunol. 1995 Jan;25(1):291-4.
[Text Abstract on PubMed]

Expression of interleukin-2 receptor gamma chain on human neutrophils.
Liu JH, Wei S, Ussery D, Epling-Burnette PK, Leonard WJ, Djeu JY.
Blood. 1994 Dec 1;84(11):3870-5.
[Text Abstract on PubMed]

The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: implications for cytokine pleiotropy and redundancy.
Leonard WJ.
Curr. Opin. Immunol. 1994 Aug;6(4):631-5.
[Text Abstract on PubMed]

The gamma subunit of the interleukin-2 receptor is expressed in human monocytes and modulated by interleukin-2, interferon gamma, and transforming growth factor beta 1.
Bosco MC, Espinoza-Delgado I, Schwabe M, Russell SM, Leonard WJ, Longo DL, Varesio L.
Blood. 1994 Jun 15;83(12):3462-7.
[Text Abstract on PubMed]

Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling.
Nakamura Y, Russell SM, Mess SA, Friedmann M, Erdos M, Francois C, Jacques Y, Adelstein S, Leonard WJ.
Nature. 1994 May 26;369(6478):330-3.
[Text Abstract on PubMed]

The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.
Leonard WJ, Noguchi M, Russell SM, McBride OW.
Immunol. Rev. 1994 Apr;138:61-86.
[Text Abstract on PubMed]

High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR.
Lodi PJ, Garrett DS, Kuszewski J, Tsang ML, Weatherbee JA, Leonard WJ, Gronenborn AM, Clore GM.
Science. 1994 Mar 25;263(5154):1762-7.
[Text Abstract on PubMed]

Sharing of a common gamma chain, gamma c, by the IL-2, IL-4, and IL-7 receptors: implications for X-linked severe combined immunodeficiency (XSCID).
Leonard WJ, Noguchi M, Russell SM.
Adv. Exp. Med. Biol. 1994;365:225-32.
[Text Abstract on PubMed]

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.
Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ.
Science. 1993 Dec 17;262(5141):1877-80.
[Text Abstract on PubMed]

Tyrosine kinase(s) regulate apoptosis and bcl-2 expression in a growth factor-dependent cell line.
Otani H, Erdos M, Leonard WJ.
J. Biol. Chem. 1993 Oct 25;268(30):22733-6.
[Text Abstract on PubMed]

Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.
Lin JX, Bhat NK, John S, Queale WS, Leonard WJ.
Mol. Cell. Biol. 1993 Oct;13(10):6201-10.
[Text Abstract on PubMed]

Characterization of the human interleukin-2 receptor gamma chain gene.
Noguchi M, Adelstein S, Cao X, Leonard WJ.
J. Biol. Chem. 1993 Jun 25;268(18):13601-8.
[Text Abstract on PubMed]

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans.
Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS, McBride OW, Leonard WJ.
Cell. 1993 Apr 9;73(1):147-57.
[Text Abstract on PubMed]

Characterization of a receptor for macrophage inflammatory protein 1 alpha and related proteins on human and murine cells.
Graham GJ, Zhou L, Weatherbee JA, Tsang ML, Napolitano M, Leonard WJ, Pragnell IB.
Cell Growth Differ. 1993 Mar;4(3):137-46.
[Text Abstract on PubMed]

Activation of tumor necrosis factor-alpha production from human neutrophils by IL-2 via IL-2-R beta.
Wei S, Blanchard DK, Liu JH, Leonard WJ, Djeu JY.
J. Immunol. 1993 Mar 1;150(5):1979-87.
[Text Abstract on PubMed]

Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2.
Djeu JY, Liu JH, Wei S, Rui H, Pearson CA, Leonard WJ, Blanchard DK.
J. Immunol. 1993 Feb 1;150(3):960-70.
[Text Abstract on PubMed]

N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65.
Toledano MB, Ghosh D, Trinh F, Leonard WJ.
Mol. Cell. Biol. 1993 Feb;13(2):852-60.
[Text Abstract on PubMed]

Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.
Otani H, Siegel JP, Erdos M, Gnarra JR, Toledano MB, Sharon M, Mostowski H, Feinberg MB, Pierce JH, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 1992 Apr 1;89(7):2789-93.
[Text Abstract on PubMed]

Interleukin (IL)-2 activation of p21ras in murine myeloid cells transfected with human IL-2 receptor beta chain.
Izquierdo M, Downward J, Otani H, Leonard WJ, Cantrell DA.
Eur. J. Immunol. 1992 Mar;22(3):817-21.
[Text Abstract on PubMed]

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.
Toledano MB, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 1991 May 15;88(10):4328-32.
[Text Abstract on PubMed]

Sp1 represses IL-2 receptor alpha chain gene expression.
Roman DG, Toledano MB, Leonard WJ.
New Biol. 1990 Jul;2(7):642-7.
[Text Abstract on PubMed]

Identification of cell surface receptors for the Act-2 cytokine.
Napolitano M, Seamon KB, Leonard WJ.
J. Exp. Med. 1990 Jul 1;172(1):285-9.
[Text Abstract on PubMed]

A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the alpha and beta chains.
Sharon M, Gnarra JR, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 1990 Jun;87(12):4869-73.
[Text Abstract on PubMed]

Structure, function, and regulation of the interleukin-2 receptor and identification of a novel immune activation gene.
Leonard WJ, Gnarra JR, Napolitano M, Sharon M.
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 1990 Mar 12;327(1239):187-92.
[Text Abstract on PubMed]

The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.
Toledano MB, Roman DG, Halden NF, Lin BB, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 1990 Mar;87(5):1830-4.
[Text Abstract on PubMed]

Quark-meson coupling model for baryon wave functions and properties.
Leonard, Gerace.
Phys. Rev., D. 1990 Feb 1;41(3):924-936.
[Text Abstract on PubMed]

Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene.
Lin BB, Cross SL, Halden NF, Roman DG, Toledano MB, Leonard WJ.
Mol. Cell. Biol. 1990 Feb;10(2):850-3.
[Text Abstract on PubMed]

The multisubunit interleukin-2 receptor.
Leonard WJ, Gnarra JR, Sharon M.
Ann. N. Y. Acad. Sci. 1990;594:200-6.
[Text Abstract on PubMed]

Structure and function of interleukin-2 receptors.
Leonard WJ, Sharon M, Gnarra JR.
Prog. Clin. Biol. Res. 1990;352:179-87.
[Text Abstract on PubMed]

The beta-chain of the IL-2 receptor (p70) is tyrosine-phosphorylated on YT and HUT-102B2 cells.
Sharon M, Gnarra JR, Leonard WJ.
J. Immunol. 1989 Oct 15;143(8):2530-3.
[Text Abstract on PubMed]

Identification of a novel site specific endonuclease produced by Mycoplasma fermentans: discovery while characterizing DNA binding proteins in T lymphocyte cell lines.
Halden NF, Wolf JB, Leonard WJ.
Nucleic Acids Res. 1989 May 11;17(9):3491-9.
[Text Abstract on PubMed]

Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes.
Cross SL, Halden NF, Lenardo MJ, Leonard WJ.
Science. 1989 Apr 28;244(4903):466-9.
[Text Abstract on PubMed]

The human interleukin-2 receptor. Structure and molecular regulation.
Leonard WJ, Sharon M, Cross SL.
Year Immunol. 1989;5:46-58.
[Text Abstract on PubMed]

Identification, cloning, and characterization of an immune activation gene.
Lipes MA, Napolitano M, Jeang KT, Chang NT, Leonard WJ.
Proc. Natl. Acad. Sci. U.S.A. 1988 Dec;85(24):9704-8.
[Text Abstract on PubMed]

Possible association between IL-2 receptors and class I HLA molecules on T cells.
Sharon M, Gnarra JR, Baniyash M, Leonard WJ.
J. Immunol. 1988 Nov 15;141(10):3512-5.
[Text Abstract on PubMed]

The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells.
Sharon M, Siegel JP, Tosato G, Yodoi J, Gerrard TL, Leonard WJ.
J. Exp. Med. 1988 Mar 1;167(3):1265-70.
[Text Abstract on PubMed]

The IL-2 receptor beta chain (p70): role in mediating signals for LAK, NK, and proliferative activities.
Siegel JP, Sharon M, Smith PL, Leonard WJ.
Science. 1987 Oct 2;238(4823):75-8.
[Text Abstract on PubMed]

Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I.
Cross SL, Feinberg MB, Wolf JB, Holbrook NJ, Wong-Staal F, Leonard WJ.
Cell. 1987 Apr 10;49(1):47-56.
[Text Abstract on PubMed]

Trans-activator gene of HTLV-II: interpretation.
Greene WC, Leonard WJ, Wano Y, Svetlik PB, Peffer NJ, Sodroski JG, Rosen CA, Goh WC, Haseltine WA.
Science. 1987 Feb 27;235(4792):1073.
[Text Abstract on PubMed]

Human interleukin 2 receptor (Tac antigen).
Greene WC, Leonard WJ.
Meth. Enzymol. 1987;150:682-700.
[Text Abstract on PubMed]

Expression of human interleukin-2 receptor cDNA in E. coli.
Chanda PK, Chen GF, Baine Y, Leonard WJ, Greene WC, Chang TW, Chang NT.
Biochem. Biophys. Res. Commun. 1986 Dec 15;141(2):804-11.
[Text Abstract on PubMed]

Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions.
Sharon M, Klausner RD, Cullen BR, Chizzonite R, Leonard WJ.
Science. 1986 Nov 14;234(4778):859-63.
[Text Abstract on PubMed]

The human interleukin-2 receptor: normal and abnormal expression in T cells and in leukemias induced by the human T-lymphotropic retroviruses.
Greene WC, Leonard WJ, Depper JM, Nelson DL, Waldmann TA.
Ann. Intern. Med. 1986 Oct;105(4):560-72.
[Text Abstract on PubMed]

The human interleukin-2 receptor: analysis of structure and function.
Greene WC, Depper JM, Krönke M, Leonard WJ.
Immunol. Rev. 1986 Aug;92:29-48.
[Text Abstract on PubMed]

Importance of quadrupole coupling for low energy pion charge exchange reactions.
Gerace, Leonard, Sparrow.
Phys. Rev., C Nucl. Phys. 1986 Jul;34(1):353-356.
[Text Abstract on PubMed]

A secreted form of the human interleukin 2 receptor encoded by an "anchor minus" cDNA.
Treiger BF, Leonard WJ, Svetlik P, Rubin LA, Nelson DL, Greene WC.
J. Immunol. 1986 Jun 1;136(11):4099-105.
[Text Abstract on PubMed]

Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
Greene WC, Leonard WJ, Wano Y, Svetlik PB, Peffer NJ, Sodroski JG, Rosen CA, Goh WC, Haseltine WA.
Science. 1986 May 16;232(4752):877-80.
[Text Abstract on PubMed]

Growth of human T lymphocytes: an analysis of interleukin 2 and its cellular receptor.
Greene WC, Leonard WJ, Depper JM.
Prog Hematol. 1986;14:283-301.
[Text Abstract on PubMed]

The human interleukin-2 receptor: role in normal T-cell growth and association with HTLV-I-induced T-cell leukemia.
Greene WC, Depper JM, Krönke M, Leonard WJ.
Cold Spring Harb. Symp. Quant. Biol. 1986;51 Pt 2:731-7.
[Text Abstract on PubMed]

The human interleukin-2 receptor.
Greene WC, Leonard WJ.
Annu. Rev. Immunol. 1986;4:69-95.
[Text Abstract on PubMed]

Structure of the human interleukin-2 receptor gene.
Leonard WJ, Depper JM, Kanehisa M, Krönke M, Peffer NJ, Svetlik PB, Sullivan M, Greene WC.
Science. 1985 Nov 8;230(4726):633-9.
[Text Abstract on PubMed]

Interleukin 2 receptor (Tac antigen) expression in HTLV-I-associated adult T-cell leukemia.
Waldmann TA, Longo DL, Leonard WJ, Depper JM, Thompson CB, Krönke M, Goldman CK, Sharrow S, Bongiovanni K, Greene WC.
Cancer Res. 1985 Sep;45(9 Suppl):4559s-4562s.
[Text Abstract on PubMed]

Interleukin 2 receptor gene expression in normal human T lymphocytes.
Leonard WJ, Krönke M, Peffer NJ, Depper JM, Greene WC.
Proc. Natl. Acad. Sci. U.S.A. 1985 Sep;82(18):6281-5.
[Text Abstract on PubMed]

Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.
Greene WC, Robb RJ, Svetlik PB, Rusk CM, Depper JM, Leonard WJ.
J. Exp. Med. 1985 Jul 1;162(1):363-8.
[Text Abstract on PubMed]

Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.
Leonard WJ, Donlon TA, Lebo RV, Greene WC.
Science. 1985 Jun 28;228(4707):1547-9.
[Text Abstract on PubMed]

Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia.
Krönke M, Leonard WJ, Depper JM, Greene WC.
Science. 1985 Jun 7;228(4704):1215-7.
[Text Abstract on PubMed]

Adult T cell leukemia: a potential target for ricin A chain immunotoxins.
Krönke M, Depper JM, Leonard WJ, Vitetta ES, Waldmann TA, Greene WC.
Blood. 1985 Jun;65(6):1416-21.
[Text Abstract on PubMed]

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.
Depper JM, Leonard WJ, Drogula C, Krönke M, Waldmann TA, Greene WC.
Proc. Natl. Acad. Sci. U.S.A. 1985 Jun;82(12):4230-4.
[Text Abstract on PubMed]

Sequential expression of genes involved in human T lymphocyte growth and differentiation.
Krönke M, Leonard WJ, Depper JM, Greene WC.
J. Exp. Med. 1985 Jun 1;161(6):1593-8.
[Text Abstract on PubMed]

Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA.
Miller J, Malek TR, Leonard WJ, Greene WC, Shevach EM, Germain RN.
J. Immunol. 1985 Jun;134(6):4212-7.
[Text Abstract on PubMed]

The human receptor for T-cell growth factor. Evidence for variable post-translational processing, phosphorylation, sulfation, and the ability of precursor forms of the receptor to bind T-cell growth factor.
Leonard WJ, Depper JM, Krönke M, Robb RJ, Waldmann TA, Greene WC.
J. Biol. Chem. 1985 Feb 10;260(3):1872-80.
[Text Abstract on PubMed]

Activators of protein kinase C and 5-azacytidine induce IL-2 receptor expression on human T lymphocytes.
Depper JM, Leonard WJ, Drogula CL, Krönke M, Waldmann TA, Greene WC.
J. Cell. Biochem. 1985;27(3):267-76.
[Text Abstract on PubMed]

The human interleukin-2 receptor.
Greene WC, Depper JM, Krönke M, Leonard WJ.
J. Cell Sci. Suppl. 1985;3:97-106.
[Text Abstract on PubMed]

Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen.
Depper JM, Leonard WJ, Krönke M, Noguchi PD, Cunningham RE, Waldmann TA, Greene WC.
J. Immunol. 1984 Dec;133(6):3054-61.
[Text Abstract on PubMed]

Expression of interleukin 2 receptors on activated human B cells.
Waldmann TA, Goldman CK, Robb RJ, Depper JM, Leonard WJ, Sharrow SO, Bongiovanni KF, Korsmeyer SJ, Greene WC.
J. Exp. Med. 1984 Nov 1;160(5):1450-66.
[Text Abstract on PubMed]

Augmented T cell growth factor receptor expression in HTLV-1-infected human leukemic T cells.
Depper JM, Leonard WJ, Krönke M, Waldmann TA, Greene WC.
J. Immunol. 1984 Oct;133(4):1691-5.
[Text Abstract on PubMed]

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.
Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik PB, Peffer NJ, Waldmann TA.
Nature. 1984 Oct 18-24;311(5987):626-31.
[Text Abstract on PubMed]

Phorbol diester induces expression of Tac antigen on human acute T lymphocytic leukemic cells.
Greene WC, Robb RJ, Depper JM, Leonard WJ, Drogula C, Svetlik PB, Wong-Staal F, Gallo RC, Waldmann TA.
J. Immunol. 1984 Aug;133(2):1042-7.
[Text Abstract on PubMed]

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.
Krönke M, Leonard WJ, Depper JM, Arya SK, Wong-Staal F, Gallo RC, Waldmann TA, Greene WC.
Proc. Natl. Acad. Sci. U.S.A. 1984 Aug;81(16):5214-8.
[Text Abstract on PubMed]

Biosynthesis and compartmentalization of rat-intestinal vitamin-D-dependent calcium-binding protein.
Leonard WJ, Strauss AW, Go MF, Alpers DH, Gordon JI.
Eur. J. Biochem. 1984 Mar 15;139(3):561-71.
[Text Abstract on PubMed]

Interleukin-2 receptor expression in retrovirus associated adult T-cell leukemia.
Waldmann TA, Leonard WJ, Depper JM, Krönke M, Goldman CK, Oh T, Greene WC.
Int. Symp. Princess Takamatsu Cancer Res. Fund. 1984;15:259-68.
[Text Abstract on PubMed]

Interleukin-2 receptors on activated malignant and normal B-cells.
Waldmann TA, Goldman CK, Leonard WJ, Depper JM, Robb RJ, Korsmeyer SJ, Greene WC.
Curr. Top. Microbiol. Immunol. 1984;113:96-101.
[Text Abstract on PubMed]

Characterization of the human receptor for T-cell growth factor.
Leonard WJ, Depper JM, Robb RJ, Waldmann TA, Greene WC.
Proc. Natl. Acad. Sci. U.S.A. 1983 Nov;80(22):6957-61.
[Text Abstract on PubMed]

Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation.
Depper JM, Leonard WJ, Robb RJ, Waldmann TA, Greene WC.
J. Immunol. 1983 Aug;131(2):690-6.
[Text Abstract on PubMed]

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.
Korsmeyer SJ, Greene WC, Cossman J, Hsu SM, Jensen JP, Neckers LM, Marshall SL, Bakhshi A, Depper JM, Leonard WJ, Jaffe ES, Waldmann TA.
Proc. Natl. Acad. Sci. U.S.A. 1983 Jul;80(14):4522-6.
[Text Abstract on PubMed]

Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen.
Cossman J, Neckers LM, Leonard WJ, Greene WC.
J. Exp. Med. 1983 Mar 1;157(3):1064-9.
[Text Abstract on PubMed]

Construction of human suppressor T cell hybridomas.
Greene WC, Depper JM, Leonard WJ, Fleisher TA, Waldmann TA.
Lymphokine Res. 1983;2(2):53-60.
[Text Abstract on PubMed]

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.
Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC.
Nature. 1982 Nov 18;300(5889):267-9.
[Text Abstract on PubMed]

Characterization of a soluble suppressor of human B cell function produced by a continuous human suppressor T cell line. II. Evidence for suppression through a direct action of CTC-SISS-B on human B cells.
Greene WC, Fleisher TA, Depper JM, Leonard WJ, Stanton GJ, Waldmann TA.
J. Immunol. 1982 Sep;129(3):1120-3.
[Text Abstract on PubMed]

THE MICROHETEROGENEITY OF PLASMA ALBUMINS. I. CRITICAL EVIDENCE FOR AND DESCRIPTION OF THE MICROHETEROGENEITY MODEL.
FOSTER JF, SOGAMI M, PETERSEN HA, LEONARD.
J. Biol. Chem. 1965 Jun;240:2495-502.
[Text Abstract on PubMed]

INFLUENCE OF HELIX CONTENT AND SOLVENT ENVIRONMENT ON THE OPTICAL ROTATORY DISPERSION PARAMETERS OF POLYPEPTIDES.
LEONARD, FOSTER JF.
J. Mol. Biol. 1963 Nov;7:590-8.
[Text Abstract on PubMed]

A structural transformation in bovine and human plasma albumins in alkaline solution as revealed by rotatory dispersion studies.
LEONARD, VIJAI KK, FOSTER JF.
J. Biol. Chem. 1963 Jun;238:1984-8.
[Text Abstract on PubMed]

Statistical evaluation of the rotatory dispersion parameters for helical polymers and proteins: two proposed methods and their application to data on polyglutamic acid and plasma albumin.
SOGAMI M, LEONARD, FOSTER JF.
Arch. Biochem. Biophys. 1963 Feb;100:260-9.
[Text Abstract on PubMed]

Changes in optical rotation in the acid transformations of plasma albumin. Evidence for the contribution of tertiary structure to rotatory behavior.
LEONARD, FOSTER JF.
J. Biol. Chem. 1961 Oct;236:2662-9.
[Text Abstract on PubMed]

The N-F transition as the basis for cooperative detergent binding of bovine plasma albumin.
LEONARD, FOSTER JF.
J. Biol. Chem. 1961 Oct;236:PC73-PC75.
[Text Abstract on PubMed]

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