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Jennifer C. Lee, Ph.D.


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Jennifer C. Lee

P: +1 301 496 3741
F: +1 301 402 3404

Full Publications Listing

Molecular Origin of pH-Dependent Fibril Formation of a Functional Amyloid.
McGlinchey RP, Jiang Z, Lee JC.
Chembiochem. 2014 Jul 21;15(11):1569-72.
[Text Abstract on PubMed]

Amyloid triangles, squares, and loops of apolipoprotein C-III.
de Messieres M, Huang RK, He Y, Lee JC.
Biochemistry. 2014 May 27;53(20):3261-3.
[Text Abstract on PubMed]

Alpha-synuclein lipid-dependent membrane binding and translocation through the α-hemolysin channel.
Gurnev PA, Yap TL, Pfefferkorn CM, Rostovtseva TK, Berezhkovskii AM, Lee JC, Parsegian VA, Bezrukov SM.
Biophys J. 2014 Feb 4;106(3):556-65.
[Text Abstract on PubMed]

Mechanism of assembly of the non-covalent spectrin tetramerization domain from intrinsically disordered partners.
Hill SA, Kwa LG, Shammas SL, Lee JC, Clarke J.
J Mol Biol. 2014 Jan 9;426(1):21-35.
[Text Abstract on PubMed]

Membrane Remodeling by α-Synuclein and Effects on Amyloid Formation.
Jiang Z, de Messieres M, Lee JC.
J Am Chem Soc. 2013 Oct 30;135(43):15970-3.
[Text Abstract on PubMed]

Saposin C Protects Glucocerebrosidase against α-Synuclein Inhibition.
Yap TL, Gruschus JM, Velayati A, Sidransky E, Lee JC.
Biochemistry. 2013 Oct 15;52(41):7161-3.
[Text Abstract on PubMed]

NMR Structure of Calmodulin Complexed to an N-Terminally Acetylated α-Synuclein Peptide.
Gruschus JM, Yap TL, Pistolesi S, Maltsev AS, Lee JC.
Biochemistry. 2013 May 21;52(20):3426-45.
[Text Abstract on PubMed]

Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity.
Yap TL, Velayati A, Sidransky E, Lee JC.
Mol Genet Metab. 2013 Jan;108(1):56-64.
[Text Abstract on PubMed]

Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease.
McGlinchey RP, Lee JC.
Biochem Soc Trans. 2013 Dec ;41(6):1509-12.
[Text Abstract on PubMed]

Depth of a-synuclein in a bilayer determined by fluorescence, neutron reflectometry, and computation.
Pfefferkorn CM, Heinrich F, Sodt AJ, Maltsev AS, Pastor RW, Lee JC.
Biophys. J. 2012 Feb 8;102(3):613-21.
[Text Abstract on PubMed]

Biophysics of a-synuclein membrane interactions.
Pfefferkorn CM, Jiang Z, Lee JC.
Biochim. Biophys. Acta. 2012 Feb;1818(2):162-71.
[Text Abstract on PubMed]

The yin and yang of amyloid: insights from a-synuclein and repeat domain of Pmel17.
McGlinchey RP, Yap TL, Lee JC.
Phys Chem Chem Phys. 2011 Dec 7;13(45):20066-75.
[Text Abstract on PubMed]

Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases.
Yap TL, Gruschus JM, Velayati A, Westbroek W, Goldin E, Moaven N, Sidransky E, Lee JC.
J. Biol. Chem. 2011 Aug 12;286(32):28080-8.
[Text Abstract on PubMed]

Residue-specific fluorescent probes of a-synuclein: detection of early events at the N- and C-termini during fibril assembly.
Yap TL, Pfefferkorn CM, Lee JC.
Biochemistry. 2011 Mar 29;50(12):1963-5.
[Text Abstract on PubMed]

Deuteration of Escherichia coli enzyme I(Ntr) alters its stability.
Piszczek G, Lee JC, Tjandra N, Lee CR, Seok YJ, Levine RL, Peterkofsky A.
Arch. Biochem. Biophys. 2011 Mar 15;507(2):332-42.
[Text Abstract on PubMed]

Copper(II) enhances membrane-bound a-synuclein helix formation.
Lucas HR, Lee JC.
Metallomics. 2011 Mar;3(3):280-3.
[Text Abstract on PubMed]

Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17.
Pfefferkorn CM, McGlinchey RP, Lee JC.
Proc. Natl. Acad. Sci. U.S.A. 2010 Dec 14;107(50):21447-52.
[Text Abstract on PubMed]

Evidence for copper-dioxygen reactivity during alpha-synuclein fibril formation.
Lucas HR, Debeer S, Hong MS, Lee JC.
J. Am. Chem. Soc. 2010 May 19;132(19):6636-7.
[Text Abstract on PubMed]

Tryptophan probes at the alpha-synuclein and membrane interface.
Pfefferkorn CM, Lee JC.
J Phys Chem B. 2010 Apr 8;114(13):4615-22.
[Text Abstract on PubMed]

Energy transfer ligands of the GluR2 ligand binding core.
Petrik AF, Strub MP, Lee JC.
Biochemistry. 2010 Mar 9;49(9):2051-7.
[Text Abstract on PubMed]

Effect of dioxygen on copper(II) binding to alpha-synuclein.
Lucas HR, Lee JC.
J. Inorg. Biochem. 2010 Mar;104(3):245-9.
[Text Abstract on PubMed]

Identification of the minimal copper(II)-binding alpha-synuclein sequence.
Jackson MS, Lee JC.
Inorg Chem. 2009 Oct 5;48(19):9303-7.
[Text Abstract on PubMed]

Folding energy landscape of cytochrome cb562.
Kimura T, Lee JC, Gray HB, Winkler JR.
Proc. Natl. Acad. Sci. U.S.A. 2009 May 12;106(19):7834-9.
[Text Abstract on PubMed]

Synchronous vs asynchronous chain motion in alpha-synuclein contact dynamics.
Urie KG, Angulo D, Lee JC, Kozak JJ, Gray HB, Winkler JR.
J Phys Chem B. 2009 Jan 15;113(2):522-30.
[Text Abstract on PubMed]

Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants.
Grabenauer M, Bernstein SL, Lee JC, Wyttenbach T, Dupuis NF, Gray HB, Winkler JR, Bowers MT.
J Phys Chem B. 2008 Sep 4;112(35):11147-54.
[Text Abstract on PubMed]

Copper(II) binding to alpha-synuclein, the Parkinson's protein.
Lee JC, Gray HB, Winkler JR.
J. Am. Chem. Soc. 2008 Jun 4;130(22):6898-9.
[Text Abstract on PubMed]

Equilibrium unfolding of the poly(glutamic acid)20 helix.
Finke JM, Jennings PA, Lee JC, Onuchic JN, Winkler JR.
Biopolymers. 2007 Jun 15;86(3):193-211.
[Text Abstract on PubMed]

Alpha-synuclein tertiary contact dynamics.
Lee JC, Lai BT, Kozak JJ, Gray HB, Winkler JR.
J Phys Chem B. 2007 Mar 1;111(8):2107-12.
[Text Abstract on PubMed]

Site-specific collapse dynamics guide the formation of the cytochrome c' four-helix bundle.
Kimura T, Lee JC, Gray HB, Winkler JR.
Proc. Natl. Acad. Sci. U.S.A. 2007 Jan 2;104(1):117-22.
[Text Abstract on PubMed]

Alpha-synuclein structures probed by 5-fluorotryptophan fluorescence and 19F NMR spectroscopy.
Winkler GR, Harkins SB, Lee JC, Gray HB.
J Phys Chem B. 2006 Apr 6;110(13):7058-61.
[Text Abstract on PubMed]

Tertiary contact formation in alpha-synuclein probed by electron transfer.
Lee JC, Gray HB, Winkler JR.
J. Am. Chem. Soc. 2005 Nov 30;127(47):16388-9.
[Text Abstract on PubMed]

Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease.
Lee JC, Langen R, Hummel PA, Gray HB, Winkler JR.
Proc. Natl. Acad. Sci. U.S.A. 2004 Nov 23;101(47):16466-71.
[Text Abstract on PubMed]

Alpha-synuclein: stable compact and extended monomeric structures and pH dependence of dimer formation.
Bernstein SL, Liu D, Wyttenbach T, Bowers MT, Lee JC, Gray HB, Winkler JR.
J. Am. Soc. Mass Spectrom. 2004 Oct;15(10):1435-43.
[Text Abstract on PubMed]

The protein-folding speed limit: intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c.
Chang IJ, Lee JC, Winkler JR, Gray HB.
Proc. Natl. Acad. Sci. U.S.A. 2003 Apr 1;100(7):3838-40.
[Text Abstract on PubMed]

Cloning, heterologous expression, and characterization of recombinant class II cytochromes c from Rhodopseudomonas palustris.
McGuirl MA, Lee JC, Lyubovitsky JG, Thanyakoop C, Richards JH, Gray HB, Winkler JR.
Biochim. Biophys. Acta. 2003 Jan 2;1619(1):23-8.
[Text Abstract on PubMed]

Structural features of cytochrome c' folding intermediates revealed by fluorescence energy-transfer kinetics.
Lee JC, Engman KC, Tezcan FA, Gray HB, Winkler JR.
Proc. Natl. Acad. Sci. U.S.A. 2002 Nov 12;99(23):14778-82.
[Text Abstract on PubMed]

The cytochrome c folding landscape revealed by electron-transfer kinetics.
Lee JC, Chang IJ, Gray HB, Winkler JR.
J. Mol. Biol. 2002 Jul 5;320(2):159-64.
[Text Abstract on PubMed]