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Andre Larochelle, M.D., Ph.D.

Publications


Principal Investigator thumbnail image

Andre Larochelle
Investigator

P: +1 301 451 7139
F: +1 301 496 8396
larochea@nhlbi.nih.gov


Full Publications Listing

Cord blood culture in hypoxia: making the cells feel at home.
Larochelle A.
Cytotherapy. 2012 Sep;14(8):900-1.
[Text Abstract on PubMed]

Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain.
Larochelle A, Gillette JM, Desmond R, Ichwan B, Cantilena A, Cerf A, Barrett AJ, Wayne AS, Lippincott-Schwartz J, Dunbar CE.
Blood. 2012 Feb 23;119(8):1848-55.
[Text Abstract on PubMed]

Transient silencing of PTEN in human CD34(+) cells enhances their proliferative potential and ability to engraft immunodeficient mice.
Kim I, Kim YJ, Métais JY, Dunbar CE, Larochelle A.
Exp. Hematol. 2012 Jan;40(1):84-91.
[Text Abstract on PubMed]

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells.
Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, Kao WM, Battista M, Tesio M, Kollet O, Cohen NN, Margalit R, Buss EC, Baleux F, Oishi S, Fujii N, Larochelle A, Dunbar CE, Broxmeyer HE, Frenette PS, Lapidot T.
Leukemia. 2011 Aug;25(8):1286-96.
[Text Abstract on PubMed]

CD9 up-regulation on CD34+ cells with ingenol 3,20-dibenzoate does not improve homing in NSG mice.
Desmond R, Dunfee A, Racke F, Dunbar CE, Larochelle A.
Blood. 2011 May 26;117(21):5774-6.
[Text Abstract on PubMed]

Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers.
Larochelle A, Savona M, Wiggins M, Anderson S, Ichwan B, Keyvanfar K, Morrison SJ, Dunbar CE.
Blood. 2011 Feb 3;117(5):1550-4.
[Text Abstract on PubMed]

Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.
Sellers S, Gomes TJ, Larochelle A, Lopez R, Adler R, Krouse A, Donahue RE, Childs RW, Dunbar CE.
Mol. Ther. 2010 Sep;18(9):1633-9.
[Text Abstract on PubMed]

Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate.
Xie J, Larochelle A, Maric I, Faulhaber M, Donahue RE, Dunbar CE.
Hum. Gene Ther. 2010 Jun;21(6):695-703.
[Text Abstract on PubMed]

Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer.
Salcido CD, Larochelle A, Taylor BJ, Dunbar CE, Varticovski L.
Br. J. Cancer. 2010 May 25;102(11):1636-44.
[Text Abstract on PubMed]

Gene therapy activates EVI1, destabilizes chromosomes.
Dunbar CE, Larochelle A.
Nat. Med. 2010 Feb;16(2):163-5.
[Text Abstract on PubMed]

In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
Larochelle A, Choi U, Shou Y, Naumann N, Loktionova NA, Clevenger JR, Krouse A, Metzger M, Donahue RE, Kang E, Stewart C, Persons D, Malech HL, Dunbar CE, Sorrentino BP.
J. Clin. Invest. 2009 Jul;119(7):1952-63.
[Text Abstract on PubMed]

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells.
Kim YJ, Kim YS, Larochelle A, Renaud G, Wolfsberg TG, Adler R, Donahue RE, Hematti P, Hong BK, Roayaei J, Akagi K, Riberdy JM, Nienhuis AW, Dunbar CE, Persons DA.
Blood. 2009 May 28;113(22):5434-43.
[Text Abstract on PubMed]

Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche.
Gillette JM, Larochelle A, Dunbar CE, Lippincott-Schwartz J.
Nat. Cell Biol. 2009 Mar;11(3):303-11.
[Text Abstract on PubMed]

HOXB4 and retroviral vectors: adding fuel to the fire.
Larochelle A, Dunbar CE.
J. Clin. Invest. 2008 Apr;118(4):1350-3.
[Text Abstract on PubMed]

Hematopoietic stem-cell behavior in nonhuman primates.
Shepherd BE, Kiem HP, Lansdorp PM, Dunbar CE, Aubert G, LaRochelle A, Seggewiss R, Guttorp P, Abkowitz JL.
Blood. 2007 Sep 15;110(6):1806-13.
[Text Abstract on PubMed]

Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors.
Hu J, Ferris A, Larochelle A, Krouse AE, Metzger ME, Donahue RE, Hughes SH, Dunbar CE.
Hum. Gene Ther. 2007 Aug;18(8):691-700.
[Text Abstract on PubMed]

Mobilization as a preparative regimen for hematopoietic stem cell transplantation.
Chen J, Larochelle A, Fricker S, Bridger G, Dunbar CE, Abkowitz JL.
Blood. 2006 May 1;107(9):3764-71.
[Text Abstract on PubMed]

AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.
Larochelle A, Krouse A, Metzger M, Orlic D, Donahue RE, Fricker S, Bridger G, Dunbar CE, Hematti P.
Blood. 2006 May 1;107(9):3772-8.
[Text Abstract on PubMed]

Hematopoietic stem cell gene therapy: dead or alive?
Ferguson C, Larochelle A, Dunbar CE.
Trends Biotechnol. 2005 Dec;23(12):589-97.
[Text Abstract on PubMed]

Genetic manipulation of hematopoietic stem cells.
Larochelle A, Dunbar CE.
Semin. Hematol. 2004 Oct;41(4):257-71.
[Text Abstract on PubMed]

Comparison of retroviral transduction efficiency in CD34+ cells derived from bone marrow versus G-CSF-mobilized or G-CSF plus stem cell factor-mobilized peripheral blood in nonhuman primates.
Hematti P, Tuchman S, Larochelle A, Metzger ME, Donahue RE, Tisdale JF.
Stem Cells. 2004;22(6):1062-9.
[Text Abstract on PubMed]

23-year-old woman with diffuse muscle and joint pain.
Larochelle A, Phillips MB.
Mayo Clin. Proc. 2003 Aug;78(8):1041-4.
[Text Abstract on PubMed]

Lentiviral vector targeting.
Larochelle A, Peng KW, Russell SJ.
Curr. Top. Microbiol. Immunol. 2002;261:143-63.
[Text Abstract on PubMed]

Erythropoiesis: Pyruvate Kinase Deficiency which Causes Nonspherocytic Hemolytic Anemia: The Gene and its Mutations.
Larochelle A, Magny P, Tremblay S, Médicis ÉD.
Hematology. 1999;4(1):77-87.
[Text Abstract on PubMed]

Differential maintenance of primitive human SCID-repopulating cells, clonogenic progenitors, and long-term culture-initiating cells after incubation on human bone marrow stromal cells.
Gan OI, Murdoch B, Larochelle A, Dick JE.
Blood. 1997 Jul 15;90(2):641-50.
[Text Abstract on PubMed]

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy.
Larochelle A, Vormoor J, Hanenberg H, Wang JC, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick JE.
Nat. Med. 1996 Dec;2(12):1329-37.
[Text Abstract on PubMed]

Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols.
Larochelle A, Vormoor J, Lapidot T, Sher G, Furukawa T, Li Q, Shultz LD, Olivieri NF, Stamatoyannopoulos G, Dick JE.
Hum. Mol. Genet. 1995 Feb;4(2):163-72.
[Text Abstract on PubMed]

Increased expression of a novel leukocytic factor in patients with hemolytic anemia.
Larochelle A, Marceau D, de Médicis E.
J. Leukoc. Biol. 1994 Jan;55(1):1-6.
[Text Abstract on PubMed]

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