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Howard S. Kruth, M.D.


Principal Investigator thumbnail image

Howard S. Kruth
Senior Investigator

P: +1 301 496 4826
F: +1 301 402 4359

Full Publications Listing

Fluid-Phase Pinocytosis of LDL by Macrophages: A Novel Target to Reduce Macrophage Cholesterol Accumulation in Atherosclerotic Lesions.
Kruth HS.
Curr Pharm Des..
[Text Abstract on PubMed]

Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation.
Barthwal MK, Anzinger JJ, Xu Q, Bohnacker T, Wymann MP, Kruth HS.
PLoS One. 2013 01;8(3):e58054.
[Text Abstract on PubMed]

The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes.
Nickerson ML, Bosley AD, Weiss JS, Kostiha BN, Hirota Y, Brandt W, Esposito D, Kinoshita S, Wessjohann L, Morham SG, Andresson T, Kruth HS, Okano T, Dean M.
Hum. Mutat. 2012 Nov 20.
[Text Abstract on PubMed]

Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3K?-dependent fluid-phase pinocytosis of native LDL.
Anzinger JJ, Chang J, Xu Q, Barthwal MK, Bohnacker T, Wymann MP, Kruth HS.
J. Lipid Res. 2012 Jan;53(1):34-42.
[Text Abstract on PubMed]

Phospholipase A2 mediates apolipoprotein-independent uptake of chylomicron remnant-like particles by human macrophages.
Napolitano M, Kruth HS, Bravo E.
Int J Vasc Med. 2012;2012:501954.
[Text Abstract on PubMed]

Passage of low-density lipoproteins through Bruch's membrane and choroid.
Cankova Z, Huang JD, Kruth HS, Johnson M.
Exp. Eye Res. 2011 Dec;93(6):947-55.
[Text Abstract on PubMed]

The bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression.
Fredericks WJ, McGarvey T, Wang H, Lal P, Puthiyaveettil R, Tomaszewski J, Sepulveda J, Labelle E, Weiss JS, Nickerson ML, Kruth HS, Brandt W, Wessjohann LA, Malkowicz SB.
DNA Cell Biol. 2011 Nov;30(11):851-64.
[Text Abstract on PubMed]

Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles.
Kruth HS.
Curr. Opin. Lipidol. 2011 Oct;22(5):386-93.
[Text Abstract on PubMed]

Triglycidyl amine crosslinking combined with ethanol inhibits bioprosthetic heart valve calcification.
Connolly JM, Bakay MA, Alferiev IS, Gorman RC, Gorman, Kruth HS, Ashworth PE, Kutty JK, Schoen FJ, Bianco RW, Levy RJ.
Ann. Thorac. Surg. 2011 Sep;92(3):858-65.
[Text Abstract on PubMed]

Evaluation of transduction efficiency in macrophage colony-stimulating factor differentiated human macrophages using HIV-1 based lentiviral vectors.
Leyva FJ, Anzinger JJ, McCoy, Kruth HS.
BMC Biotechnol. 2011;11:13.
[Text Abstract on PubMed]

Native low-density lipoprotein uptake by macrophage colony-stimulating factor-differentiated human macrophages is mediated by macropinocytosis and micropinocytosis.
Anzinger JJ, Chang J, Xu Q, Buono C, Li Y, Leyva FJ, Park BC, Greene LE, Kruth HS.
Arterioscler. Thromb. Vasc. Biol. 2010 Oct;30(10):2022-31.
[Text Abstract on PubMed]

Extracellular cholesterol-rich microdomains generated by human macrophages and their potential function in reverse cholesterol transport.
Ong DS, Anzinger JJ, Leyva FJ, Rubin N, Addadi L, Kruth HS.
J. Lipid Res. 2010 Aug;51(8):2303-13.
[Text Abstract on PubMed]

UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy.
Nickerson ML, Kostiha BN, Brandt W, Fredericks W, Xu KP, Yu FS, Gold B, Chodosh J, Goldberg M, Lu da W, Yamada M, Tervo TM, Grutzmacher R, Croasdale C, Hoeltzenbein M, Sutphin J, Malkowicz SB, Wessjohann L, Kruth HS, Dean M, Weiss JS.
PLoS ONE. 2010;5(5):e10760.
[Text Abstract on PubMed]

Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions.
Buono C, Anzinger JJ, Amar M, Kruth HS.
J. Clin. Invest. 2009 May;119(5):1373-81.
[Text Abstract on PubMed]

Heterogeneity of human macrophages in culture and in atherosclerotic plaques.
Waldo SW, Li Y, Buono C, Zhao B, Billings EM, Chang J, Kruth HS.
Am. J. Pathol. 2008 Apr;172(4):1112-26.
[Text Abstract on PubMed]

Genetic analysis of 14 families with Schnyder crystalline corneal dystrophy reveals clues to UBIAD1 protein function.
Weiss JS, Kruth HS, Kuivaniemi H, Tromp G, Karkera J, Mahurkar S, Lisch W, Dupps, White PS, Winters RS, Kim C, Rapuano CJ, Sutphin J, Reidy J, Hu FR, Lu da W, Ebenezer N, Nickerson ML.
Am. J. Med. Genet. A. 2008 Feb 1;146(3):271-83.
[Text Abstract on PubMed]

Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL.
Buono C, Li Y, Waldo SW, Kruth HS.
J. Lipid Res. 2007 Nov;48(11):2411-8.
[Text Abstract on PubMed]

Mutations in the UBIAD1 gene on chromosome short arm 1, region 36, cause Schnyder crystalline corneal dystrophy.
Weiss JS, Kruth HS, Kuivaniemi H, Tromp G, White PS, Winters RS, Lisch W, Henn W, Denninger E, Krause M, Wasson P, Ebenezer N, Mahurkar S, Nickerson ML.
Invest. Ophthalmol. Vis. Sci. 2007 Nov;48(11):5007-12.
[Text Abstract on PubMed]

Protein kinase C beta and delta isoenzymes mediate cholesterol accumulation in PMA-activated macrophages.
Ma HT, Lin WW, Zhao B, Wu WT, Huang W, Li Y, Jones NL, Kruth HS.
Biochem. Biophys. Res. Commun. 2006 Oct 13;349(1):214-20.
[Text Abstract on PubMed]

Constitutive receptor-independent low density lipoprotein uptake and cholesterol accumulation by macrophages differentiated from human monocytes with macrophage-colony-stimulating factor (M-CSF).
Zhao B, Li Y, Buono C, Waldo SW, Jones NL, Mori M, Kruth HS.
J. Biol. Chem. 2006 Jun 9;281(23):15757-62.
[Text Abstract on PubMed]

Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy.
Curcio CA, Presley JB, Malek G, Medeiros NE, Avery DV, Kruth HS.
Exp. Eye Res. 2005 Dec;81(6):731-41.
[Text Abstract on PubMed]

Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization.
Li CM, Chung BH, Presley JB, Malek G, Zhang X, Dashti N, Li L, Chen J, Bradley K, Kruth HS, Curcio CA.
Invest. Ophthalmol. Vis. Sci. 2005 Jul;46(7):2576-86.
[Text Abstract on PubMed]

Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein.
Kruth HS, Jones NL, Huang W, Zhao B, Ishii I, Chang J, Combs CA, Malide D, Zhang WY.
J. Biol. Chem. 2005 Jan 21;280(3):2352-60.
[Text Abstract on PubMed]

Retention of aggregated LDL by cultured human coronary artery endothelial cells.
Zhao B, Huang W, Zhang WY, Ishii I, Kruth HS.
Biochem. Biophys. Res. Commun. 2004 Aug 27;321(3):728-35.
[Text Abstract on PubMed]

Intraplaque hemorrhage and progression of coronary atheroma.
Kolodgie FD, Gold HK, Burke AP, Fowler DR, Kruth HS, Weber DK, Farb A, Guerrero LJ, Hayase M, Kutys R, Narula J, Finn AV, Virmani R.
N. Engl. J. Med. 2003 Dec 11;349(24):2316-25.
[Text Abstract on PubMed]

Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels.
Cusick M, Chew EY, Chan CC, Kruth HS, Murphy RP, Ferris.
Ophthalmology. 2003 Nov;110(11):2126-33.
[Text Abstract on PubMed]

Accumulation of cholesterol in the lesions of focal segmental glomerulosclerosis.
Lee HS, Kruth HS.
Nephrology (Carlton). 2003 Oct;8(5):224-3.
[Text Abstract on PubMed]

Structural information about organized cholesterol domains from specific antibody recognition.
Addadi L, Geva M, Kruth HS.
Biochim. Biophys. Acta. 2003 Mar 10;1610(2):208-16.
[Text Abstract on PubMed]

Sequestration of aggregated low-density lipoproteins by macrophages.
Kruth HS.
Curr. Opin. Lipidol. 2002 Oct;13(5):483-8.
[Text Abstract on PubMed]

Macrophage foam cell formation with native low density lipoprotein.
Kruth HS, Huang W, Ishii I, Zhang WY.
J. Biol. Chem. 2002 Sep 13;277(37):34573-80.
[Text Abstract on PubMed]

PMA activation of macrophages alters macrophage metabolism of aggregated LDL.
Huang W, Ishii I, Zhang WY, Sonobe M, Kruth HS.
J. Lipid Res. 2002 Aug;43(8):1275-82.
[Text Abstract on PubMed]

Lipoprotein cholesterol and atherosclerosis.
Kruth HS.
Curr. Mol. Med. 2001 Dec;1(6):633-53.
[Text Abstract on PubMed]

Monoclonal antibody detection of plasma membrane cholesterol microdomains responsive to cholesterol trafficking.
Kruth HS, Ifrim I, Chang J, Addadi L, Perl-Treves D, Zhang WY.
J. Lipid Res. 2001 Sep;42(9):1492-500.
[Text Abstract on PubMed]

Macrophage foam cells and atherosclerosis.
Kruth HS.
Front. Biosci. 2001 Mar 1;6:D429-55.
[Text Abstract on PubMed]

Accumulation of cholesterol with age in human Bruch's membrane.
Curcio CA, Millican CL, Bailey T, Kruth HS.
Invest. Ophthalmol. Vis. Sci. 2001 Jan;42(1):265-74.
[Text Abstract on PubMed]

Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration.
Milam AH, Curcio CA, Cideciyan AV, Saxena S, John SK, Kruth HS, Malek G, Heckenlively JR, Weleber RG, Jacobson SG.
Ophthalmology. 2000 Dec;107(12):2256-66.
[Text Abstract on PubMed]

Plasmin-mediated macrophage reversal of low density lipoprotein aggregation.
Zhang WY, Ishii I, Kruth HS.
J. Biol. Chem. 2000 Oct 20;275(42):33176-83.
[Text Abstract on PubMed]

Apolipoprotein B stimulates formation of monocyte-macrophage surface-connected compartments and mediates uptake of low density lipoprotein-derived liposomes into these compartments.
Kruth HS, Zhang WY, Skarlatos SI, Chao FF.
J. Biol. Chem. 1999 Mar 12;274(11):7495-500.
[Text Abstract on PubMed]

Characterization of patocytosis: endocytosis into macrophage surface-connected compartments.
Kruth HS, Chang J, Ifrim I, Zhang WY.
Eur. J. Cell Biol. 1999 Feb;78(2):91-9.
[Text Abstract on PubMed]

Aggregated low density lipoprotein induces and enters surface-connected compartments of human monocyte-macrophages. Uptake occurs independently of the low density lipoprotein receptor.
Zhang WY, Gaynor PM, Kruth HS.
J. Biol. Chem. 1997 Dec 12;272(50):31700-6.
[Text Abstract on PubMed]

The fate of lipoprotein cholesterol entering the arterial wall.
Kruth HS.
Curr. Opin. Lipidol. 1997 Oct;8(5):246-52.
[Text Abstract on PubMed]

Prevention of bioprosthetic heart valve calcification by ethanol preincubation. Efficacy and mechanisms.
Vyavahare N, Hirsch D, Lerner E, Baskin JZ, Schoen FJ, Bianco R, Kruth HS, Zand R, Levy RJ.
Circulation. 1997 Jan 21;95(2):479-88.
[Text Abstract on PubMed]

Cholesterol deposition in atherosclerotic lesions.
Kruth HS.
Subcell. Biochem. 1997;28:319-62.
[Text Abstract on PubMed]

Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors.
Zhang WY, Gaynor PM, Kruth HS.
J. Biol. Chem. 1996 Nov 8;271(45):28641-6.
[Text Abstract on PubMed]

Cholesterol accumulation in human cornea: evidence that extracellular cholesteryl ester-rich lipid particles deposit independently of foam cells.
Gaynor PM, Zhang WY, Salehizadeh B, Pettiford B, Kruth HS.
J. Lipid Res. 1996 Sep;37(9):1849-61.
[Text Abstract on PubMed]

Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits.
Duverger N, Kruth H, Emmanuel F, Caillaud JM, Viglietta C, Castro G, Tailleux A, Fievet C, Fruchart JC, Houdebine LM, Denefle P.
Circulation. 1996 Aug 15;94(4):713-7.
[Text Abstract on PubMed]

Accumulation of HDL apolipoproteins accompanies abnormal cholesterol accumulation in Schnyder's corneal dystrophy.
Gaynor PM, Zhang WY, Weiss JS, Skarlatos SI, Rodrigues MM, Kruth HS.
Arterioscler. Thromb. Vasc. Biol. 1996 Aug;16(8):992-9.
[Text Abstract on PubMed]

Glycosphingolipid accumulation in the aortic wall is another feature of human atherosclerosis.
Mukhin DN, Chao FF, Kruth HS.
Arterioscler. Thromb. Vasc. Biol. 1995 Oct;15(10):1607-15.
[Text Abstract on PubMed]

Sequestration of acetylated LDL and cholesterol crystals by human monocyte-derived macrophages.
Kruth HS, Skarlatos SI, Lilly K, Chang J, Ifrim I.
J. Cell Biol. 1995 Apr;129(1):133-45.
[Text Abstract on PubMed]

Cholesterol efflux from human monocyte-derived macrophages in the presence of LpA-I:A-II.
Skarlatos SI, Duverger N, Rader D, Kruth HS.
Biochim. Biophys. Acta. 1995 Jan 25;1270(1):19-25.
[Text Abstract on PubMed]

Detection of cholesterol associated with calcium mineral using confocal fluorescence microscopy.
Sarig S, Weiss TA, Katz I, Kahana F, Azoury R, Okon E, Kruth HS.
Lab. Invest. 1994 Nov;71(5):782-7.
[Text Abstract on PubMed]

Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux.
Kruth HS, Skarlatos SI, Gaynor PM, Gamble W.
J. Biol. Chem. 1994 Sep 30;269(39):24511-8.
[Text Abstract on PubMed]

Evidence for loss of apo B from LDL in human atherosclerotic lesions: extracellular cholesteryl ester lipid particles lacking apo B.
Kruth HS, Shekhonin B.
Atherosclerosis. 1994 Feb;105(2):227-34.
[Text Abstract on PubMed]

Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits.
Chao FF, Blanchette-Mackie EJ, Dickens BF, Gamble W, Kruth HS.
J. Lipid Res. 1994 Jan;35(1):71-83.
[Text Abstract on PubMed]

Apolipoprotein A-I and B distribution in the human cornea.
Ashraf F, Cogan DG, Kruth HS.
Invest. Ophthalmol. Vis. Sci. 1993 Dec;34(13):3574-8.
[Text Abstract on PubMed]

Heterogeneity of cellular cholesteryl ester accumulation by human monocyte-derived macrophages.
Skarlatos SI, Rouis M, Chapman MJ, Kruth HS.
Atherosclerosis. 1993 Mar;99(2):229-40.
[Text Abstract on PubMed]

Absence of triglyceride accumulation in lipoprotein lipase-deficient human monocyte-macrophages incubated with human very low density lipoprotein.
Skarlatos SI, Dichek HL, Fojo SS, Brewer HB, Kruth HS.
J. Clin. Endocrinol. Metab. 1993 Mar;76(3):793-6.
[Text Abstract on PubMed]

Colocalization of cholesterol and hydroxyapatite in human atherosclerotic lesions.
Hirsch D, Azoury R, Sarig S, Kruth HS.
Calcif. Tissue Int. 1993 Feb;52(2):94-8.
[Text Abstract on PubMed]

Phospholipid loss in dying platelets.
Skarlatos SI, Rao R, Dickens BF, Kruth HS.
Virchows Arch., B, Cell Pathol. 1993;64(4):241-5.
[Text Abstract on PubMed]

Unesterified cholesterol in granular, lattice, and macular dystrophies.
Rodrigues MM, Kruth HS, Rajagopalan S, Jones K.
Am. J. Ophthalmol. 1993 Jan;115(1):112-4.
[Text Abstract on PubMed]

Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages.
Lesnik P, Rouis M, Skarlatos S, Kruth HS, Chapman MJ.
Proc. Natl. Acad. Sci. U.S.A. 1992 Nov 1;89(21):10370-4.
[Text Abstract on PubMed]

Corneal opacity in LCAT disease.
Cogan DG, Kruth HS, Datilis MB, Martin N.
Cornea. 1992 Nov;11(6):595-9.
[Text Abstract on PubMed]

Panstromal Schnyder's corneal dystrophy. Ultrastructural and histochemical studies.
Weiss JS, Rodrigues MM, Kruth HS, Rajagopalan S, Rader DJ, Kachadoorian H.
Ophthalmology. 1992 Jul;99(7):1072-81.
[Text Abstract on PubMed]

Hydrolysis of cholesteryl ester in low density lipoprotein converts this lipoprotein to a liposome.
Chao FF, Blanchette-Mackie EJ, Tertov VV, Skarlatos SI, Chen YJ, Kruth HS.
J. Biol. Chem. 1992 Mar 5;267(7):4992-8.
[Text Abstract on PubMed]

Expression of cytokeratin 8 in human aortic smooth muscle cells.
Glukhova MA, Shekhonin BV, Kruth H, Koteliansky VE.
Am. J. Physiol. 1991 Oct;261(4 Suppl):72-7.
[Text Abstract on PubMed]

Type C Niemann-Pick disease: cellular uncoupling of cholesterol homeostasis is linked to the severity of disruption in the intracellular transport of exogenously derived cholesterol.
Argoff CE, Comly ME, Blanchette-Mackie J, Kruth HS, Pye HT, Goldin E, Kaneski C, Vanier MT, Brady RO, Pentchev PG.
Biochim. Biophys. Acta. 1991 Jun 5;1096(4):319-27.
[Text Abstract on PubMed]

Cholesterol localization in ultrathin frozen sections in Schnyder's corneal crystalline dystrophy.
Rodrigues MM, Kruth HS, Krachmer JH, Vrabec MP, Blanchette-Mackie J.
Am. J. Ophthalmol. 1990 Nov 15;110(5):513-7.
[Text Abstract on PubMed]

Lipid deposits posterior to impermeable intracorneal lenses in rhesus monkeys: clinical, histochemical, and ultrastructural studies.
Rodrigues MM, McCarey BE, Waring, Hidayat AA, Kruth HS.
Refract Corneal Surg. 1990 Jan-Feb;6(1):32-7.
[Text Abstract on PubMed]

Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes.
Blanchette-Mackie EJ, Dwyer NK, Amende LM, Kruth HS, Butler JD, Sokol J, Comly ME, Vanier MT, August JT, Brady RO.
Proc. Natl. Acad. Sci. U.S.A. 1988 Nov;85(21):8022-6.
[Text Abstract on PubMed]

Biochemical characterization of isolated cholesterol-phospholipid particles continuously released from rat and human platelets after activation.
Skarlatos SI, Amende LM, Chao FF, Blanchette-Mackie EJ, Gamble W, Kruth HS.
Lab. Invest. 1988 Sep;59(3):344-52.
[Text Abstract on PubMed]

Unesterified cholesterol-rich lipid particles in atherosclerotic lesions of human and rabbit aortas.
Chao FF, Amende LM, Blanchette-Mackie EJ, Skarlatos SI, Gamble W, Resau JH, Mergner WT, Kruth HS.
Am. J. Pathol. 1988 Apr;131(1):73-83.
[Text Abstract on PubMed]

Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol.
Sokol J, Blanchette-Mackie J, Kruth HS, Dwyer NK, Amende LM, Butler JD, Robinson E, Patel S, Brady RO, Comly ME.
J. Biol. Chem. 1988 Mar 5;263(7):3411-7.
[Text Abstract on PubMed]

Unesterified cholesterol in Schnyder's corneal crystalline dystrophy.
Rodrigues MM, Kruth HS, Krachmer JH, Willis R.
Am. J. Ophthalmol. 1987 Aug 15;104(2):157-63.
[Text Abstract on PubMed]

Effects of meprobamate on plasma lipids, lipoproteins, and experimental atherosclerosis.
Wong HY, Cheng KS, Kruth HS.
J Natl Med Assoc. 1987 Aug;79(8):855-64.
[Text Abstract on PubMed]

Group C Niemann-Pick disease: faulty regulation of low-density lipoprotein uptake and cholesterol storage in cultured fibroblasts.
Pentchev PG, Comly ME, Kruth HS, Tokoro T, Butler J, Sokol J, Filling-Katz M, Quirk JM, Marshall DC, Patel S.
FASEB J. 1987 Jul;1(1):40-5.
[Text Abstract on PubMed]

A familial basis for the heterogeneity in coronary atherosclerotic disease.
Sprecher DL, Kruth HS, Pierce JE, Lakatos E, Papadopoulos N.
Atherosclerosis. 1987 May;65(1-2):167-72.
[Text Abstract on PubMed]

Method for detection and isolation of cholesteryl ester-containing "foam" cells using flow cytometry.
Kruth HS, Cupp JE, Khan MA.
Cytometry. 1987 Mar;8(2):146-52.
[Text Abstract on PubMed]

Flow cytometric quantification of cholesteryl ester-containing "foam" cells. II. Analysis of aortas from cholesterol-fed swine.
Cupp JE, Khan MA, Campbell G, Henderson G, Kruth HS.
Exp. Mol. Pathol. 1987 Feb;46(1):52-63.
[Text Abstract on PubMed]

Flow cytometric quantification of cholesteryl ester-containing "foam" cells. I. Analysis of aortas from normolipidemic swine.
Cupp JE, Campbell G, Khan MA, Kruth HS.
Exp. Mol. Pathol. 1987 Feb;46(1):40-51.
[Text Abstract on PubMed]

Accumulation of unesterified cholesterol in limbal cornea and conjunctiva of rabbits fed a high-cholesterol diet. Detection with filipin.
Kruth HS.
Atherosclerosis. 1987 Jan;63(1):1-6.
[Text Abstract on PubMed]

Niemann-pick variant disorders: comparison of errors of cellular cholesterol homeostasis in group D and group C fibroblasts.
Butler JD, Comly ME, Kruth HS, Vanier M, Filling-Katz M, Fink J, Barton N, Weintroub H, Quirk JM, Tokoro T.
Proc. Natl. Acad. Sci. U.S.A. 1987 Jan;84(2):556-60.
[Text Abstract on PubMed]

Type C Niemann-Pick disease. Abnormal metabolism of low density lipoprotein in homozygous and heterozygous fibroblasts.
Kruth HS, Comly ME, Butler JD, Vanier MT, Fink JK, Wenger DA, Patel S, Pentchev PG.
J. Biol. Chem. 1986 Dec 15;261(35):16769-74.
[Text Abstract on PubMed]

Type C Niemann-Pick disease. A parallel loss of regulatory responses in both the uptake and esterification of low density lipoprotein-derived cholesterol in cultured fibroblasts.
Pentchev PG, Kruth HS, Comly ME, Butler JD, Vanier MT, Wenger DA, Patel S.
J. Biol. Chem. 1986 Dec 15;261(35):16775-80.
[Text Abstract on PubMed]

Multiple flexor tendon xanthomas and contractures in the hands of a child with familial hypercholesterolemia.
Gunther SF, Gunther AG, Hoeg JM, Kruth HS.
J Hand Surg Am. 1986 Jul;11(4):588-93.
[Text Abstract on PubMed]

The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease.
Pentchev PG, Comly ME, Kruth HS, Patel S, Proestel M, Weintroub H.
J. Biol. Chem. 1986 Feb 25;261(6):2772-7.
[Text Abstract on PubMed]

Cholesterol accumulation in vascular smooth muscle cells incorporated into platelet-rich plasma clots.
Kruth HS.
Lab. Invest. 1985 Dec;53(6):634-8.
[Text Abstract on PubMed]

A defect in cholesterol esterification in Niemann-Pick disease (type C) patients.
Pentchev PG, Comly ME, Kruth HS, Vanier MT, Wenger DA, Patel S, Brady RO.
Proc. Natl. Acad. Sci. U.S.A. 1985 Dec;82(23):8247-51.
[Text Abstract on PubMed]

Lipid deposition in human tendon xanthoma.
Kruth HS.
Am. J. Pathol. 1985 Nov;121(2):311-5.
[Text Abstract on PubMed]

Subendothelial accumulation of unesterified cholesterol. An early event in atherosclerotic lesion development.
Kruth HS.
Atherosclerosis. 1985 Nov;57(2-3):337-41.
[Text Abstract on PubMed]

Platelet-mediated cholesterol accumulation in cultured aortic smooth muscle cells.
Kruth HS.
Science. 1985 Mar 8;227(4691):1243-5.
[Text Abstract on PubMed]

Histochemical detection and differentiation of free and esterified cholesterol in swine atherosclerosis using filipin.
Kruth HS, Fry DL.
Exp. Mol. Pathol. 1984 Jun;40(3):288-94.
[Text Abstract on PubMed]

2,4,5,2',4',5'-Hexachlorobiphenyl-lipoprotein (LDL, HDL, VLDL) interaction and induced lipidosis in cultured skin fibroblasts.
Kling D, Becker MM, Kruth HS, Gamble W.
Environ. Res. 1984 Jun;34(1):87-102.
[Text Abstract on PubMed]

A genetic storage disorder in BALB/C mice with a metabolic block in esterification of exogenous cholesterol.
Pentchev PG, Boothe AD, Kruth HS, Weintroub H, Stivers J, Brady RO.
J. Biol. Chem. 1984 May 10;259(9):5784-91.
[Text Abstract on PubMed]

Histochemical detection of esterified cholesterol within human atherosclerotic lesions using the fluorescent probe filipin.
Kruth HS.
Atherosclerosis. 1984 May-Jun;51(2-3):281-92.
[Text Abstract on PubMed]

Localization of unesterified cholesterol in human atherosclerotic lesions. Demonstration of filipin-positive, oil-red-O-negative particles.
Kruth HS.
Am. J. Pathol. 1984 Feb;114(2):201-8.
[Text Abstract on PubMed]

Filipin-positive, oil red O-negative particles in atherosclerotic lesions induced by cholesterol feeding.
Kruth HS.
Lab. Invest. 1984 Jan;50(1):87-93.
[Text Abstract on PubMed]

Subcellular localization and quantification of cholesterol in cultured human fibroblasts exposed to human low density lipoprotein.
Kruth HS, Blanchette-Mackie J, Avigan J, Gamble W, Vaughan M.
J. Lipid Res. 1982 Nov;23(8):1128-35.
[Text Abstract on PubMed]

Flow cytometry: rapid biochemical analysis of single cells.
Kruth HS.
Anal. Biochem. 1982 Sep 15;125(2):225-42.
[Text Abstract on PubMed]

Correlated analysis of cellular DNA, membrane antigens and light scatter of human lymphoid cells.
Braylan RC, Benson NA, Nourse V, Kruth HS.
Cytometry. 1982 Mar;2(5):337-43.
[Text Abstract on PubMed]

Simultaneous analysis of DNA and cell surface immunoglobulin in human B-cell lymphomas by flow cytometry.
Kruth HS, Braylan RC, Benson NA, Nourse VA.
Cancer Res. 1981 Dec;41(12 Pt 1):4895-9.
[Text Abstract on PubMed]

Quantification of low density lipoprotein binding and cholesterol accumulation by single human fibroblasts using fluorescence microscopy.
Kruth HS, Vaughan M.
J. Lipid Res. 1980 Jan;21(1):123-30.
[Text Abstract on PubMed]

Effect of cell density on binding and uptake of low density lipoprotein by human fibroblasts.
Kruth HS, Avigan J, Gamble W, Vaughan M.
J. Cell Biol. 1979 Dec;83(3):588-94.
[Text Abstract on PubMed]

Arrest of cultured cells in the G1 phase of the cell cycle by indomethacin.
Bayer BM, Kruth HS, Vaughan M, Beaven MA.
J. Pharmacol. Exp. Ther. 1979 Jul;210(1):106-11.
[Text Abstract on PubMed]

Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells.
Gamble W, Vaughan M, Kruth HS, Avigan J.
J. Lipid Res. 1978 Nov;19(8):1068-70.
[Text Abstract on PubMed]

The TERE1 (UBIAD1) bladder tumor suppressor protein interacts with mitochondrial TBL2: regulation of trans-membrane potential, oxidative stress and SXR signaling to the nucleus.
Fredericks WJ, McGarvey T, Wang H, Zheng Y, Fredericks NJ, Yin H, Wang LP, Hsiao W, Lee R, Weiss JS, Nickerson ML, Kruth HS, Rauscher FJ 3rd, Malkowicz SB.
J Cell Biochem..
[Text Abstract on PubMed]