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Mark A. Knepper, M.D., Ph.D.

Publications


Principal Investigator thumbnail image

Mark A. Knepper
Senior Investigator

P: +1 301 496 3064
F: +1 301 402 1443
knepperm@nhlbi.nih.gov


Full Publications Listing

Vasopressin and the regulation of aquaporin-2.
Wilson JL, Miranda CA, Knepper MA.
Clin Exp Nephrol..
[Text Abstract on PubMed]

Global analysis of neuronal phosphoproteome regulation by chondroitin sulfate proteoglycans.
Yu P, Pisitkun T, Wang G, Wang R, Katagiri Y, Gucek M, Knepper MA, Geller HM.
PLoS One. 2013 01;8(3):e59285.
[Text Abstract on PubMed]

Urea channel inhibitors: a new functional class of aquaretics.
Knepper MA, Miranda CA.
Kidney Int. 2013 Jun;83(6):991-3.
[Text Abstract on PubMed]

Systems biology in physiology: the vasopressin signaling network in kidney.
Knepper MA.
Am. J. Physiol., Cell Physiol. 2012 Dec;303(11):C1115-24.
[Text Abstract on PubMed]

Vasopressin inhibits apoptosis in renal collecting duct cells.
Miller RL, Sandoval PC, Pisitkun T, Knepper MA, Hoffert JD.
Am. J. Physiol. Renal Physiol. 2012 Nov 28.
[Text Abstract on PubMed]

Quantitative phosphoproteomics in nuclei of vasopressin-sensitive renal collecting duct cells.
Bolger SJ, Hurtado PA, Hoffert JD, Saeed F, Pisitkun T, Knepper MA.
Am. J. Physiol., Cell Physiol. 2012 Nov 15;303(10):C1006-20.
[Text Abstract on PubMed]

Aquaporin-2 regulation in health and disease.
Judith Radin M, Yu MJ, Stoedkilde L, Lance Miller R, Hoffert JD, Frokiaer J, Pisitkun T, Knepper MA.
Vet Clin Pathol. 2012 Nov 6.
[Text Abstract on PubMed]

CPhos: A program to calculate and visualize evolutionarily conserved functional phosphorylation sites.
Zhao B, Pisitkun T, Hoffert JD, Knepper MA, Saeed F.
Proteomics. 2012 Nov;12(22):3299-303.
[Text Abstract on PubMed]

Identifying protein kinase target preferences using mass spectrometry.
Douglass J, Gunaratne R, Bradford D, Saeed F, Hoffert JD, Steinbach PJ, Knepper MA, Pisitkun T.
Am. J. Physiol., Cell Physiol. 2012 Oct 1;303(7):C715-27.
[Text Abstract on PubMed]

New and improved proteomics technologies for understanding complex biological systems: addressing a grand challenge in the life sciences.
Hood LE, Omenn GS, Moritz RL, Aebersold R, Yamamoto KR, Amos M, Hunter-Cevera J, Locascio L, Workshop Participants.
Proteomics. 2012 Sep;12(18):2773-83.
[Text Abstract on PubMed]

Quantitative proteomics identifies vasopressin-responsive nuclear proteins in collecting duct cells.
Schenk LK, Bolger SJ, Luginbuhl K, Gonzales PA, Rinschen MM, Yu MJ, Hoffert JD, Pisitkun T, Knepper MA.
J. Am. Soc. Nephrol. 2012 Jun;23(6):1008-18.
[Text Abstract on PubMed]

Application of systems biology principles to protein biomarker discovery: urinary exosomal proteome in renal transplantation.
Pisitkun T, Gandolfo MT, Das S, Knepper MA, Bagnasco SM.
Proteomics Clin Appl. 2012 Jun;6(5-6):268-78.
[Text Abstract on PubMed]

Gene expression databases for kidney epithelial cells.
Huling JC, Pisitkun T, Song JH, Yu MJ, Hoffert JD, Knepper MA.
Am. J. Physiol. Renal Physiol. 2012 Feb 15;302(4):F401-7.
[Text Abstract on PubMed]

Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics.
Hoffert JD, Pisitkun T, Saeed F, Song JH, Chou CL, Knepper MA.
Mol. Cell Proteomics. 2012 Feb;11(2):M111.014613.
[Text Abstract on PubMed]

Large-scale phosphotyrosine proteomic profiling of rat renal collecting duct epithelium reveals predominance of proteins involved in cell polarity determination.
Zhao B, Knepper MA, Chou CL, Pisitkun T.
Am. J. Physiol., Cell Physiol. 2012 Jan 1;302(1):C27-45.
[Text Abstract on PubMed]

NHLBI-AbDesigner: an online tool for design of peptide-directed antibodies.
Pisitkun T, Hoffert JD, Saeed F, Knepper MA.
Am. J. Physiol., Cell Physiol. 2012 Jan 1;302(1):C154-64.
[Text Abstract on PubMed]

Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases.
van Balkom BW, Pisitkun T, Verhaar MC, Knepper MA.
Kidney Int. 2011 Dec;80(11):1138-45.
[Text Abstract on PubMed]

Bilateral ureteral obstruction induces early downregulation and redistribution of AQP2 and phosphorylated AQP2.
Stødkilde L, Nørregaard R, Fenton RA, Wang G, Knepper MA, Frøkiær J.
Am. J. Physiol. Renal Physiol. 2011 Jul;301(1):F226-35.
[Text Abstract on PubMed]

Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule.
Feric M, Zhao B, Hoffert JD, Pisitkun T, Knepper MA.
Am. J. Physiol., Cell Physiol. 2011 Apr;300(4):C755-70.
[Text Abstract on PubMed]

Phosphoproteomics of vasopressin signaling in the kidney.
Hoffert JD, Pisitkun T, Knepper MA.
Expert Rev Proteomics. 2011 Apr;8(2):157-63.
[Text Abstract on PubMed]

Quantitative protein and mRNA profiling shows selective post-transcriptional control of protein expression by vasopressin in kidney cells.
Khositseth S, Pisitkun T, Slentz DH, Wang G, Hoffert JD, Knepper MA, Yu MJ.
Mol. Cell Proteomics. 2011 Jan;10(1):M110.004036.
[Text Abstract on PubMed]

A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.
Li JH, Chou CL, Li B, Gavrilova O, Eisner C, Schnermann J, Anderson SA, Deng CX, Knepper MA, Wess J.
J. Clin. Invest. 2009 Oct;119(10):3115-26.
[Text Abstract on PubMed]

Common sense approaches to urinary biomarker study design.
Knepper MA.
J. Am. Soc. Nephrol. 2009 Jun;20(6):1175-8.
[Text Abstract on PubMed]

Aquaporin-2 in the "-omics" era.
Hoffert JD, Chou CL, Knepper MA.
J. Biol. Chem. 2009 May 29;284(22):14683-7.
[Text Abstract on PubMed]

Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations.
Bockenhauer D, Feather S, Stanescu HC, Bandulik S, Zdebik AA, Reichold M, Tobin J, Lieberer E, Sterner C, Landoure G, Arora R, Sirimanna T, Thompson D, Cross JH, van't Hoff W, Al Masri O, Tullus K, Yeung S, Anikster Y, Klootwijk E, Hubank M, Dillon MJ, Heitzmann D, Arcos-Burgos M, Knepper MA, Dobbie A, Gahl WA, Warth R, Sheridan E, Kleta R.
N. Engl. J. Med. 2009 May 7;360(19):1960-70.
[Text Abstract on PubMed]

Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating.
Moeller HB, MacAulay N, Knepper MA, Fenton RA.
Am. J. Physiol. Renal Physiol. 2009 Mar;296(3):F649-57.
[Text Abstract on PubMed]

Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry.
Zwang NA, Hoffert JD, Pisitkun T, Moeller HB, Fenton RA, Knepper MA.
J. Proteome Res. 2009 Mar;8(3):1540-54.
[Text Abstract on PubMed]

Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct.
Yu MJ, Miller RL, Uawithya P, Rinschen MM, Khositseth S, Braucht DW, Chou CL, Pisitkun T, Nelson RD, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 2009 Feb 17;106(7):2441-6.
[Text Abstract on PubMed]

Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells.
Moeller HB, Knepper MA, Fenton RA.
Kidney Int. 2009 Feb;75(3):295-303.
[Text Abstract on PubMed]

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA.
J. Am. Soc. Nephrol. 2009 Feb;20(2):363-79.
[Text Abstract on PubMed]

LC-MS/MS analysis of differential centrifugation fractions from native inner medullary collecting duct of rat.
Sachs AN, Pisitkun T, Hoffert JD, Yu MJ, Knepper MA.
Am. J. Physiol. Renal Physiol. 2008 Dec;295(6):F1799-806.
[Text Abstract on PubMed]

Physiology: Courier service for ammonia.
Knepper MA.
Nature. 2008 Nov 20;456(7220):336-7.
[Text Abstract on PubMed]

Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities.
Jacob VA, Harbaugh CM, Dietz JR, Fenton RA, Kim SM, Castrop H, Schnermann J, Knepper MA, Chou CL, Anderson SA.
Kidney Int. 2008 Nov;74(9):1202-8.
[Text Abstract on PubMed]

Akt and ERK1/2 pathways are components of the vasopressin signaling network in rat native IMCD.
Pisitkun T, Jacob V, Schleicher SM, Chou CL, Yu MJ, Knepper MA.
Am. J. Physiol. Renal Physiol. 2008 Oct;295(4):F1030-43.
[Text Abstract on PubMed]

Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2.
Hoffert JD, Fenton RA, Moeller HB, Simons B, Tchapyjnikov D, McDill BW, Yu MJ, Pisitkun T, Chen F, Knepper MA.
J. Biol. Chem. 2008 Sep 5;283(36):24617-27.
[Text Abstract on PubMed]

Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct.
Yu MJ, Pisitkun T, Wang G, Aranda JF, Gonzales PA, Tchapyjnikov D, Shen RF, Alonso MA, Knepper MA.
Am. J. Physiol., Cell Physiol. 2008 Sep;295(3):C661-78.
[Text Abstract on PubMed]

Roles of basolateral solute uptake via NKCC1 and of myosin II in vasopressin-induced cell swelling in inner medullary collecting duct.
Chou CL, Yu MJ, Kassai EM, Morris RG, Hoffert JD, Wall SM, Knepper MA.
Am. J. Physiol. Renal Physiol. 2008 Jul;295(1):F192-201.
[Text Abstract on PubMed]

Enrichment of distinct microfilament-associated and GTP-binding-proteins in membrane/microvilli fractions from lymphoid cells.
Hao JJ, Wang G, Pisitkun T, Patino-Lopez G, Nagashima K, Knepper MA, Shen RF, Shaw S.
J. Proteome Res. 2008 Jul;7(7):2911-27.
[Text Abstract on PubMed]

PhosphoScore: an open-source phosphorylation site assignment tool for MSn data.
Ruttenberg BE, Pisitkun T, Knepper MA, Hoffert JD.
J. Proteome Res. 2008 Jul;7(7):3054-9.
[Text Abstract on PubMed]

Urinary exosomes: is there a future?
Gonzales P, Pisitkun T, Knepper MA.
Nephrol. Dial. Transplant. 2008 Jun;23(6):1799-801.
[Text Abstract on PubMed]

Towards standard protocols and guidelines for urine proteomics: a report on the Human Kidney and Urine Proteome Project (HKUPP) symposium and workshop, 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA.
Yamamoto T, Langham RG, Ronco P, Knepper MA, Thongboonkerd V.
Proteomics. 2008 Jun;8(11):2156-9.
[Text Abstract on PubMed]

Taking aim at shotgun phosphoproteomics.
Hoffert JD, Knepper MA.
Anal. Biochem. 2008 Apr 1;375(1):1-10.
[Text Abstract on PubMed]

Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2.
Kim GH, Choi NW, Jung JY, Song JH, Lee CH, Kang CM, Knepper MA.
Am. J. Physiol. Renal Physiol. 2008 Apr;294(4):F702-9.
[Text Abstract on PubMed]

Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation.
Nielsen J, Hoffert JD, Knepper MA, Agre P, Nielsen S, Fenton RA.
Proc. Natl. Acad. Sci. U.S.A. 2008 Mar 4;105(9):3634-9.
[Text Abstract on PubMed]

Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin.
Fenton RA, Moeller HB, Hoffert JD, Yu MJ, Nielsen S, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 2008 Feb 26;105(8):3134-9.
[Text Abstract on PubMed]

Defective ENaC processing and function in tissue kallikrein-deficient mice.
Picard N, Eladari D, El Moghrabi S, Planès C, Bourgeois S, Houillier P, Wang Q, Burnier M, Deschenes G, Knepper MA, Meneton P, Chambrey R.
J. Biol. Chem. 2008 Feb 22;283(8):4602-11.
[Text Abstract on PubMed]

Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.
Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA.
Physiol. Genomics. 2008 Jan 17;32(2):229-53.
[Text Abstract on PubMed]

Vasopressin: friend or foe?
Knepper MA, Star RA.
Nat. Med. 2008 Jan;14(1):14-6.
[Text Abstract on PubMed]

Proteomic approaches for the study of cell signaling in the renal collecting duct.
Hoorn EJ, Pisitkun T, Yu MJ, Knepper MA.
Contrib Nephrol. 2008;160:172-85.
[Text Abstract on PubMed]

Tandem mass spectrometry in physiology.
Pisitkun T, Hoffert JD, Yu MJ, Knepper MA.
Physiology (Bethesda). 2007 Dec;22:390-400.
[Text Abstract on PubMed]

Exosomes in urine: who would have thought...?
Knepper MA, Pisitkun T.
Kidney Int. 2007 Nov;72(9):1043-5.
[Text Abstract on PubMed]

Ciclosporin-induced hypertension is associated with increased sodium transporter of the loop of Henle (NKCC2).
Esteva-Font C, Ars E, Guillen-Gomez E, Campistol JM, Sanz L, Jiménez W, Knepper MA, Torres F, Torra R, Ballarín JA, Fernández-Llama P.
Nephrol. Dial. Transplant. 2007 Oct;22(10):2810-6.
[Text Abstract on PubMed]

Mouse models and the urinary concentrating mechanism in the new millennium.
Fenton RA, Knepper MA.
Physiol. Rev. 2007 Oct;87(4):1083-112.
[Text Abstract on PubMed]

Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone.
Dvorak MM, De Joussineau C, Carter DH, Pisitkun T, Knepper MA, Gamba G, Kemp PJ, Riccardi D.
J. Am. Soc. Nephrol. 2007 Sep;18(9):2509-16.
[Text Abstract on PubMed]

An automated platform for analysis of phosphoproteomic datasets: application to kidney collecting duct phosphoproteins.
Hoffert JD, Wang G, Pisitkun T, Shen RF, Knepper MA.
J. Proteome Res. 2007 Sep;6(9):3501-8.
[Text Abstract on PubMed]

Altered expression of epithelial sodium channel in rats with bilateral or unilateral ureteral obstruction.
Li C, Wang W, Norregaard R, Knepper MA, Nielsen S, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2007 Jul;293(1):F333-41.
[Text Abstract on PubMed]

Identification and quantification of basic and acidic proteins using solution-based two-dimensional protein fractionation and label-free or 18O-labeling mass spectrometry.
Wu WW, Wang G, Yu MJ, Knepper MA, Shen RF.
J. Proteome Res. 2007 Jul;6(7):2447-59.
[Text Abstract on PubMed]

Chronic furosemide or hydrochlorothiazide administration increases H+-ATPase B1 subunit abundance in rat kidney.
Na KY, Kim GH, Joo KW, Lee JW, Jang HR, Oh YK, Jeon US, Chae SW, Knepper MA, Han JS.
Am. J. Physiol. Renal Physiol. 2007 Jun;292(6):F1701-9.
[Text Abstract on PubMed]

Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator.
Cheruvanky A, Zhou H, Pisitkun T, Kopp JB, Knepper MA, Yuen PS, Star RA.
Am. J. Physiol. Renal Physiol. 2007 May;292(5):F1657-61.
[Text Abstract on PubMed]

COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction.
Nørregaard R, Jensen BL, Topcu SO, Diget M, Schweer H, Knepper MA, Nielsen S, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2007 May;292(5):F1322-33.
[Text Abstract on PubMed]

Urea and renal function in the 21st century: insights from knockout mice.
Fenton RA, Knepper MA.
J. Am. Soc. Nephrol. 2007 Mar;18(3):679-88.
[Text Abstract on PubMed]

Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct.
Hoffert JD, Nielsen J, Yu MJ, Pisitkun T, Schleicher SM, Nielsen S, Knepper MA.
Am. J. Physiol. Renal Physiol. 2007 Feb;292(2):F691-700.
[Text Abstract on PubMed]

Proteomic analysis of the adaptive response of rat renal proximal tubules to metabolic acidosis.
Curthoys NP, Taylor L, Hoffert JD, Knepper MA.
Am. J. Physiol. Renal Physiol. 2007 Jan;292(1):F140-7.
[Text Abstract on PubMed]

Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade.
Nielsen J, Kwon TH, Frøkiaer J, Knepper MA, Nielsen S.
Am. J. Physiol. Renal Physiol. 2007 Jan;292(1):F382-94.
[Text Abstract on PubMed]

Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction.
Jensen AM, Li C, Praetorius HA, Nørregaard R, Frische S, Knepper MA, Nielsen S, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2006 Nov;291(5):F1021-32.
[Text Abstract on PubMed]

LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells.
Yu MJ, Pisitkun T, Wang G, Shen RF, Knepper MA.
Mol. Cell Proteomics. 2006 Nov;5(11):2131-45.
[Text Abstract on PubMed]

Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury.
Zhou H, Pisitkun T, Aponte A, Yuen PS, Hoffert JD, Yasuda H, Hu X, Chawla L, Shen RF, Knepper MA, Star RA.
Kidney Int. 2006 Nov;70(10):1847-57.
[Text Abstract on PubMed]

Discovery of urinary biomarkers.
Pisitkun T, Johnstone R, Knepper MA.
Mol. Cell Proteomics. 2006 Oct;5(10):1760-71.
[Text Abstract on PubMed]

Dysregulation of renal sodium transporters in gentamicin-treated rats.
Sassen MC, Kim SW, Kwon TH, Knepper MA, Miller RT, Frøkiaer J, Nielsen S.
Kidney Int. 2006 Sep;70(6):1026-37.
[Text Abstract on PubMed]

Automated quantification tool for high-throughput proteomics using stable isotope labeling and LC-MSn.
Wang G, Wu WW, Pisitkun T, Hoffert JD, Knepper MA, Shen RF.
Anal. Chem. 2006 Aug 15;78(16):5752-61.
[Text Abstract on PubMed]

Long-term regulation of proximal tubule acid-base transporter abundance by angiotensin II.
Turban S, Beutler KT, Morris RG, Masilamani S, Fenton RA, Knepper MA, Packer RK.
Kidney Int. 2006 Aug;70(4):660-8.
[Text Abstract on PubMed]

Gamble's "economy of water" revisited: studies in urea transporter knockout mice.
Fenton RA, Chou CL, Sowersby H, Smith CP, Knepper MA.
Am. J. Physiol. Renal Physiol. 2006 Jul;291(1):F148-54.
[Text Abstract on PubMed]

Hypokalemia in a mouse model of Gitelman's syndrome.
Morris RG, Hoorn EJ, Knepper MA.
Am. J. Physiol. Renal Physiol. 2006 Jun;290(6):F1416-20.
[Text Abstract on PubMed]

Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.
Hoffert JD, Pisitkun T, Wang G, Shen RF, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 2006 May 2;103(18):7159-64.
[Text Abstract on PubMed]

Lithium-induced NDI in rats is associated with loss of alpha-ENaC regulation by aldosterone in CCD.
Nielsen J, Kwon TH, Frøkiaer J, Knepper MA, Nielsen S.
Am. J. Physiol. Renal Physiol. 2006 May;290(5):F1222-33.
[Text Abstract on PubMed]

High-throughput identification of IMCD proteins using LC-MS/MS.
Pisitkun T, Bieniek J, Tchapyjnikov D, Wang G, Wu WW, Shen RF, Knepper MA.
Physiol. Genomics. 2006 Apr 13;25(2):263-76.
[Text Abstract on PubMed]

Effect of peristaltic contractions of the renal pelvic wall on solute concentrations of the renal inner medulla in the hamster.
Pruitt ME, Knepper MA, Graves B, Schmidt-Nielsen B.
Am. J. Physiol. Renal Physiol. 2006 Apr;290(4):F892-6.
[Text Abstract on PubMed]

Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery.
Zhou H, Yuen PS, Pisitkun T, Gonzales PA, Yasuda H, Dear JW, Gross P, Knepper MA, Star RA.
Kidney Int. 2006 Apr;69(8):1471-6.
[Text Abstract on PubMed]

Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats.
Kim SW, de Seigneux S, Sassen MC, Lee J, Kim J, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2006 Mar;290(3):F674-87.
[Text Abstract on PubMed]

Hypotension in NKCC1 null mice: role of the kidneys.
Wall SM, Knepper MA, Hassell KA, Fischer MP, Shodeinde A, Shin W, Pham TD, Meyer JW, Lorenz JN, Beierwaltes WH, Dietz JR, Shull GE, Kim YH.
Am. J. Physiol. Renal Physiol. 2006 Feb;290(2):F409-16.
[Text Abstract on PubMed]

Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus.
Nielsen J, Kwon TH, Praetorius J, Frøkiaer J, Knepper MA, Nielsen S.
Am. J. Physiol. Renal Physiol. 2006 Feb;290(2):F438-49.
[Text Abstract on PubMed]

Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking.
Wang W, Li C, Nejsum LN, Li H, Kim SW, Kwon TH, Jonassen TE, Knepper MA, Thomsen K, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2006 Feb;290(2):F530-41.
[Text Abstract on PubMed]

Ultrastructural localization of UT-A and UT-B in rat kidneys with different hydration status.
Lim SW, Han KH, Jung JY, Kim WY, Yang CW, Sands JM, Knepper MA, Madsen KM, Kim J.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006 Feb;290(2):R479-92.
[Text Abstract on PubMed]

alpha-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction.
Li C, Shi Y, Wang W, Sardeli C, Kwon TH, Thomsen K, Jonassen T, Djurhuus JC, Knepper MA, Nielsen S, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2006 Feb;290(2):F384-96.
[Text Abstract on PubMed]

UT-A urea transporter promoter, UT-Aalpha, targets principal cells of the renal inner medullary collecting duct.
Fenton RA, Shodeinde A, Knepper MA.
Am. J. Physiol. Renal Physiol. 2006 Jan;290(1):F188-95.
[Text Abstract on PubMed]

Biphasic changes of epithelial sodium channel abundance and trafficking in common bile duct ligation-induced liver cirrhosis.
Kim SW, Wang W, Sassen MC, Choi KC, Han JS, Knepper MA, Jonassen TE, Frøkiaer J, Nielsen S.
Kidney Int. 2006 Jan;69(1):89-98.
[Text Abstract on PubMed]

The application of DIGE-based proteomics to renal physiology.
Hoorn EJ, Hoffert JD, Knepper MA.
Nephron Physiol. 2006;104(1):p61-72.
[Text Abstract on PubMed]

In vacuo isotope coded alkylation technique (IVICAT); an N-terminal stable isotopic label for quantitative liquid chromatography/mass spectrometry proteomics.
Simons BL, Wang G, Shen RF, Knepper MA.
Rapid Commun. Mass Spectrom. 2006;20(16):2463-77.
[Text Abstract on PubMed]

Role of collecting duct urea transporters in the kidney--insights from mouse models.
Fenton RA, Smith CP, Knepper MA.
J. Membr. Biol. 2006;212(2):119-31.
[Text Abstract on PubMed]

Increased expression of ENaC subunits and increased apical targeting of AQP2 in the kidneys of spontaneously hypertensive rats.
Kim SW, Wang W, Kwon TH, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2005 Nov;289(5):F957-68.
[Text Abstract on PubMed]

Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis.
Kim SW, Schou UK, Peters CD, de Seigneux S, Kwon TH, Knepper MA, Jonassen TE, Frøkiaer J, Nielsen S.
J. Am. Soc. Nephrol. 2005 Nov;16(11):3196-210.
[Text Abstract on PubMed]

Combined proteomics and pathways analysis of collecting duct reveals a protein regulatory network activated in vasopressin escape.
Hoorn EJ, Hoffert JD, Knepper MA.
J. Am. Soc. Nephrol. 2005 Oct;16(10):2852-63.
[Text Abstract on PubMed]

Molecular physiology of renal aquaporins and sodium transporters: exciting approaches to understand regulation of renal water handling.
Frøkiaer J, Nielsen S, Knepper MA.
J. Am. Soc. Nephrol. 2005 Oct;16(10):2827-9.
[Text Abstract on PubMed]

COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction.
Nørregaard R, Jensen BL, Li C, Wang W, Knepper MA, Nielsen S, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2005 Aug;289(2):F322-33.
[Text Abstract on PubMed]

Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct.
Barile M, Pisitkun T, Yu MJ, Chou CL, Verbalis MJ, Shen RF, Knepper MA.
Mol. Cell Proteomics. 2005 Aug;4(8):1095-106.
[Text Abstract on PubMed]

Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout mice.
Morris RG, Uchida S, Brooks H, Knepper MA, Chou CL.
Am. J. Physiol. Renal Physiol. 2005 Jul;289(1):F194-9.
[Text Abstract on PubMed]

Renal phenotype of UT-A urea transporter knockout mice.
Fenton RA, Flynn A, Shodeinde A, Smith CP, Schnermann J, Knepper MA.
J. Am. Soc. Nephrol. 2005 Jun;16(6):1583-92.
[Text Abstract on PubMed]

Prospects for urinary proteomics: exosomes as a source of urinary biomarkers.
Hoorn EJ, Pisitkun T, Zietse R, Gross P, Frokiaer J, Wang NS, Gonzales PA, Star RA, Knepper MA.
Nephrology (Carlton). 2005 Jun;10(3):283-90.
[Text Abstract on PubMed]

Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct.
Hoffert JD, Chou CL, Fenton RA, Knepper MA.
J. Biol. Chem. 2005 Apr 8;280(14):13624-30.
[Text Abstract on PubMed]

Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats.
Kwon TH, Nielsen J, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2005 Apr;288(4):F673-84.
[Text Abstract on PubMed]

Sodium retention in cirrhotic rats is associated with increased renal abundance of sodium transporter proteins.
Fernández-Llama P, Ageloff S, Fernández-Varo G, Ros J, Wang X, Garra N, Esteva-Font C, Ballarin J, Barcelo P, Arroyo V, Stokes JB, Knepper MA, Jiménez W.
Kidney Int. 2005 Feb;67(2):622-30.
[Text Abstract on PubMed]

Effects of dietary fat, NaCl, and fructose on renal sodium and water transporter abundances and systemic blood pressure.
Song J, Hu X, Shi M, Knepper MA, Ecelbarger CA.
Am. J. Physiol. Renal Physiol. 2004 Dec;287(6):F1204-12.
[Text Abstract on PubMed]

Non-muscle myosin II and myosin light chain kinase are downstream targets for vasopressin signaling in the renal collecting duct.
Chou CL, Christensen BM, Frische S, Vorum H, Desai RA, Hoffert JD, de Lanerolle P, Nielsen S, Knepper MA.
J. Biol. Chem. 2004 Nov 19;279(47):49026-35.
[Text Abstract on PubMed]

Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-Cl co-transporter, and epithelial sodium channel.
Kim GH, Lee JW, Oh YK, Chang HR, Joo KW, Na KY, Earm JH, Knepper MA, Han JS.
J. Am. Soc. Nephrol. 2004 Nov;15(11):2836-43.
[Text Abstract on PubMed]

Structural biology. The atomic architecture of a gas channel.
Knepper MA, Agre P.
Science. 2004 Sep 10;305(5690):1573-4.
[Text Abstract on PubMed]

Identification and proteomic profiling of exosomes in human urine.
Pisitkun T, Shen RF, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 2004 Sep 7;101(36):13368-73.
[Text Abstract on PubMed]

VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx.
Singh BB, Lockwich TP, Bandyopadhyay BC, Liu X, Bollimuntha S, Brazer SC, Combs C, Das S, Leenders AG, Sheng ZH, Knepper MA, Ambudkar SV, Ambudkar IS.
Mol. Cell. 2004 Aug 27;15(4):635-46.
[Text Abstract on PubMed]

Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney.
Lim SW, Li C, Sun BK, Han KH, Kim WY, Oh YW, Lee JU, Kador PF, Knepper MA, Sands JM, Kim J, Yang CW.
Am. J. Physiol. Renal Physiol. 2004 Jul;287(1):F139-51.
[Text Abstract on PubMed]

Neonatal ureteral obstruction alters expression of renal sodium transporters and aquaporin water channels.
Shi Y, Li C, Thomsen K, Jørgensen TM, Knepper MA, Nielsen S, Djurhuus JC, Frøkiaer J.
Kidney Int. 2004 Jul;66(1):203-15.
[Text Abstract on PubMed]

Early release of neonatal ureteral obstruction preserves renal function.
Shi Y, Pedersen M, Li C, Wen JG, Thomsen K, Stødkilde-Jørgensen H, Jørgensen TM, Knepper MA, Nielsen S, Djurhuus JC, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2004 Jun;286(6):F1087-99.
[Text Abstract on PubMed]

Altered expression of urea transporters in response to ureteral obstruction.
Li C, Klein JD, Wang W, Knepper MA, Nielsen S, Sands JM, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2004 Jun;286(6):F1154-62.
[Text Abstract on PubMed]

Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct.
Fenton RA, Chou CL, Stewart GS, Smith CP, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 2004 May 11;101(19):7469-74.
[Text Abstract on PubMed]

Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats.
Kim SW, Wang W, Nielsen J, Praetorius J, Kwon TH, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2004 May;286(5):F922-35.
[Text Abstract on PubMed]

Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys.
Hoagland KM, Flasch AK, Dahly-Vernon AJ, dos Santos EA, Knepper MA, Roman RJ.
Hypertension. 2004 Apr;43(4):860-5.
[Text Abstract on PubMed]

Peter Agre, 2003 Nobel Prize winner in chemistry.
Knepper MA, Nielsen S.
J. Am. Soc. Nephrol. 2004 Apr;15(4):1093-5.
[Text Abstract on PubMed]

Na+-H+ exchange activity in taste receptor cells.
Vinnikova AK, Alam RI, Malik SA, Ereso GL, Feldman GM, McCarty JM, Knepper MA, Heck GL, DeSimone JA, Lyall V.
J. Neurophysiol. 2004 Mar;91(3):1297-313.
[Text Abstract on PubMed]

Reduced expression of renal Na+ transporters in rats with PTH-induced hypercalcemia.
Wang W, Li C, Kwon TH, Miller RT, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2004 Mar;286(3):F534-45.
[Text Abstract on PubMed]

Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat.
van Balkom BW, Hoffert JD, Chou CL, Knepper MA.
Am. J. Physiol. Renal Physiol. 2004 Feb;286(2):F216-24.
[Text Abstract on PubMed]

Rosiglitazone activates renal sodium- and water-reabsorptive pathways and lowers blood pressure in normal rats.
Song J, Knepper MA, Hu X, Verbalis JG, Ecelbarger CA.
J. Pharmacol. Exp. Ther. 2004 Feb;308(2):426-33.
[Text Abstract on PubMed]

Application of difference gel electrophoresis to the identification of inner medullary collecting duct proteins.
Hoffert JD, van Balkom BW, Chou CL, Knepper MA.
Am. J. Physiol. Renal Physiol. 2004 Jan;286(1):F170-9.
[Text Abstract on PubMed]

Acute endotoxemia in rats induces down-regulation of V2 vasopressin receptors and aquaporin-2 content in the kidney medulla.
Grinevich V, Knepper MA, Verbalis J, Reyes I, Aguilera G.
Kidney Int. 2004 Jan;65(1):54-62.
[Text Abstract on PubMed]

Increased renal ENaC subunit and sodium transporter abundances in streptozotocin-induced type 1 diabetes.
Song J, Knepper MA, Verbalis JG, Ecelbarger CA.
Am. J. Physiol. Renal Physiol. 2003 Dec;285(6):F1125-37.
[Text Abstract on PubMed]

Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI.
Nielsen J, Kwon TH, Praetorius J, Kim YH, Frøkiaer J, Knepper MA, Nielsen S.
Am. J. Physiol. Renal Physiol. 2003 Dec;285(6):F1198-209.
[Text Abstract on PubMed]

Expression of urea transporters in potassium-depleted mouse kidney.
Jung JY, Madsen KM, Han KH, Yang CW, Knepper MA, Sands JM, Kim J.
Am. J. Physiol. Renal Physiol. 2003 Dec;285(6):F1210-24.
[Text Abstract on PubMed]

Regulation of NHE3, NKCC2, and NCC abundance in kidney during aldosterone escape phenomenon: role of NO.
Turban S, Wang XY, Knepper MA.
Am. J. Physiol. Renal Physiol. 2003 Nov;285(5):F843-51.
[Text Abstract on PubMed]

Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction.
Li C, Wang W, Kwon TH, Knepper MA, Nielsen S, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2003 Nov;285(5):F889-901.
[Text Abstract on PubMed]

Effect of primary polydipsia on aquaporin and sodium transporter abundance.
Cadnapaphornchai MA, Summer SN, Falk S, Thurman JM, Knepper MA, Schrier RW.
Am. J. Physiol. Renal Physiol. 2003 Nov;285(5):F965-71.
[Text Abstract on PubMed]

Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II.
Kwon TH, Nielsen J, Kim YH, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2003 Jul;285(1):F152-65.
[Text Abstract on PubMed]

Increased collecting duct urea transporter expression in Dahl salt-sensitive rats.
Fenton RA, Chou CL, Ageloff S, Brandt W, Stokes JB, Knepper MA.
Am. J. Physiol. Renal Physiol. 2003 Jul;285(1):F143-51.
[Text Abstract on PubMed]

Downregulation of renal aquaporins in response to unilateral ureteral obstruction.
Li C, Wang W, Knepper MA, Nielsen S, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2003 May;284(5):F1066-79.
[Text Abstract on PubMed]

Long-term regulation of ENaC expression in kidney by angiotensin II.
Beutler KT, Masilamani S, Turban S, Nielsen J, Brooks HL, Ageloff S, Fenton RA, Packer RK, Knepper MA.
Hypertension. 2003 May;41(5):1143-50.
[Text Abstract on PubMed]

Database for renal collecting duct regulatory and transporter proteins.
Legato J, Knepper MA, Star RA, Mejia R.
Physiol. Genomics. 2003 Apr 16;13(2):179-81.
[Text Abstract on PubMed]

Renal tubule sodium transporter abundance profiling in rat kidney: response to aldosterone and variations in NaCl intake.
Knepper MA, Kim GH, Masilamani S.
Ann. N. Y. Acad. Sci. 2003 Apr;986:562-9.
[Text Abstract on PubMed]

Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechano-osmotic transducer.
Knepper MA, Saidel GM, Hascall VC, Dwyer T.
Am. J. Physiol. Renal Physiol. 2003 Mar;284(3):F433-46.
[Text Abstract on PubMed]

Upregulation of Na+ transporter abundances in response to chronic thiazide or loop diuretic treatment in rats.
Na KY, Oh YK, Han JS, Joo KW, Lee JS, Earm JH, Knepper MA, Kim GH.
Am. J. Physiol. Renal Physiol. 2003 Jan;284(1):F133-43.
[Text Abstract on PubMed]

Altered expression of major renal Na transporters in rats with unilateral ureteral obstruction.
Li C, Wang W, Kwon TH, Knepper MA, Nielsen S, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2003 Jan;284(1):F155-66.
[Text Abstract on PubMed]

cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion.
Brooks HL, Ageloff S, Kwon TH, Brandt W, Terris JM, Seth A, Michea L, Nielsen S, Fenton R, Knepper MA.
Am. J. Physiol. Renal Physiol. 2003 Jan;284(1):F218-28.
[Text Abstract on PubMed]

Oxytocin induces apical and basolateral redistribution of aquaporin-2 in rat kidney.
Jeon US, Joo KW, Na KY, Kim YS, Lee JS, Kim J, Kim GH, Nielsen S, Knepper MA, Han JS.
Nephron Exp. Nephrol. 2003 Jan;93(1):e36-45.
[Text Abstract on PubMed]

Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats.
Elkjaer ML, Kwon TH, Wang W, Nielsen J, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2002 Dec;283(6):F1376-88.
[Text Abstract on PubMed]

AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors.
Wang W, Li C, Kwon TH, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2002 Dec;283(6):F1313-25.
[Text Abstract on PubMed]

Regulation of collecting duct AQP3 expression: response to mineralocorticoid.
Kwon TH, Nielsen J, Masilamani S, Hager H, Knepper MA, Frokiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2002 Dec;283(6):F1403-21.
[Text Abstract on PubMed]

Sodium transporter abundance profiling in kidney: effect of spironolactone.
Nielsen J, Kwon TH, Masilamani S, Beutler K, Hager H, Nielsen S, Knepper MA.
Am. J. Physiol. Renal Physiol. 2002 Nov;283(5):F923-33.
[Text Abstract on PubMed]

Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction.
Masilamani S, Wang X, Kim GH, Brooks H, Nielsen J, Nielsen S, Nakamura K, Stokes JB, Knepper MA.
Am. J. Physiol. Renal Physiol. 2002 Oct;283(4):F648-57.
[Text Abstract on PubMed]

Upregulation of renal BSC1 and TSC in prenatally programmed hypertension.
Manning J, Beutler K, Knepper MA, Vehaskari VM.
Am. J. Physiol. Renal Physiol. 2002 Jul;283(1):F202-6.
[Text Abstract on PubMed]

Mechanisms through which ammonia regulates cortical collecting duct net proton secretion.
Frank AE, Wingo CS, Andrews PM, Ageloff S, Knepper MA, Weiner ID.
Am. J. Physiol. Renal Physiol. 2002 Jun;282(6):F1120-8.
[Text Abstract on PubMed]

Dysregulation of renal salt and water transport proteins in diabetic Zucker rats.
Bickel CA, Knepper MA, Verbalis JG, Ecelbarger CA.
Kidney Int. 2002 Jun;61(6):2099-110.
[Text Abstract on PubMed]

Proteomics and the kidney.
Knepper MA.
J. Am. Soc. Nephrol. 2002 May;13(5):1398-408.
[Text Abstract on PubMed]

Glucocorticoid-stimulated lung epithelial Na(+) transport is associated with regulated ENaC and sgk1 expression.
Itani OA, Auerbach SD, Husted RF, Volk KA, Ageloff S, Knepper MA, Stokes JB, Thomas CP.
Am. J. Physiol. Lung Cell Mol. Physiol. 2002 Apr;282(4):L631-41.
[Text Abstract on PubMed]

Decreased abundance of collecting duct urea transporters UT-A1 and UT-A3 with ECF volume expansion.
Wang XY, Beutler K, Nielsen J, Nielsen S, Knepper MA, Masilamani S.
Am. J. Physiol. Renal Physiol. 2002 Apr;282(4):F577-84.
[Text Abstract on PubMed]

Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia.
Breton S, Inoue T, Knepper MA, Brown D.
Am. J. Physiol. Renal Physiol. 2002 Mar;282(3):F523-9.
[Text Abstract on PubMed]

Expression of urea transporters in the developing rat kidney.
Kim YH, Kim DU, Han KH, Jung JY, Sands JM, Knepper MA, Madsen KM, Kim J.
Am. J. Physiol. Renal Physiol. 2002 Mar;282(3):F530-40.
[Text Abstract on PubMed]

Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene.
Takahashi N, Brooks HL, Wade JB, Liu W, Kondo Y, Ito S, Knepper MA, Smithies O.
J. Am. Soc. Nephrol. 2002 Mar;13(3):604-10.
[Text Abstract on PubMed]

Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice.
Brooks HL, Allred AJ, Beutler KT, Coffman TM, Knepper MA.
Hypertension. 2002 Feb;39(2 Pt 2):470-3.
[Text Abstract on PubMed]

Reduced expression of Na-K-2Cl cotransporter in medullary TAL in vitamin D-induced hypercalcemia in rats.
Wang W, Kwon TH, Li C, Frøkiaer J, Knepper MA, Nielsen S.
Am. J. Physiol. Renal Physiol. 2002 Jan;282(1):F34-44.
[Text Abstract on PubMed]

Aquaporins in the kidney: from molecules to medicine.
Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA.
Physiol. Rev. 2002 Jan;82(1):205-44.
[Text Abstract on PubMed]

Regulation of renal salt and water transporters during vasopressin escape.
Ecelbarger CA, Murase T, Tian Y, Nielsen S, Knepper MA, Verbalis JG.
Prog. Brain Res. 2002;139:75-84.
[Text Abstract on PubMed]

Increased renal Na-K-ATPase, NCC, and beta-ENaC abundance in obese Zucker rats.
Bickel CA, Verbalis JG, Knepper MA, Ecelbarger CA.
Am. J. Physiol. Renal Physiol. 2001 Oct;281(4):F639-48.
[Text Abstract on PubMed]

Regulation of the abundance of renal sodium transporters and channels by vasopressin.
Ecelbarger CA, Kim GH, Wade JB, Knepper MA.
Exp. Neurol. 2001 Oct;171(2):227-34.
[Text Abstract on PubMed]

Regulation of the sodium transporters NHE3, NKCC2 and NCC in the kidney.
Knepper MA, Brooks HL.
Curr. Opin. Nephrol. Hypertens. 2001 Sep;10(5):655-9.
[Text Abstract on PubMed]

Aquaporin-4 expression in adult and developing mouse and rat kidney.
Kim YH, Earm JH, Ma T, Verkman AS, Knepper MA, Madsen KM, Kim J.
J. Am. Soc. Nephrol. 2001 Sep;12(9):1795-804.
[Text Abstract on PubMed]

Targeted proteomics in the kidney using ensembles of antibodies.
Knepper MA, Masilamani S.
Acta Physiol. Scand. 2001 Sep;173(1):11-21.
[Text Abstract on PubMed]

97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation.
Bradford AD, Terris JM, Ecelbarger CA, Klein JD, Sands JM, Chou CL, Knepper MA.
Am. J. Physiol. Renal Physiol. 2001 Jul;281(1):F133-43.
[Text Abstract on PubMed]

Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect.
Li C, Wang W, Kwon TH, Isikay L, Wen JG, Marples D, Djurhuus JC, Stockwell A, Knepper MA, Nielsen S, Frøkiaer J.
Am. J. Physiol. Renal Physiol. 2001 Jul;281(1):F163-71.
[Text Abstract on PubMed]

The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon.
Wang XY, Masilamani S, Nielsen J, Kwon TH, Brooks HL, Nielsen S, Knepper MA.
J. Clin. Invest. 2001 Jul;108(2):215-22.
[Text Abstract on PubMed]

Immunocytochemical and immunoelectron microscopic localization of alpha-, beta-, and gamma-ENaC in rat kidney.
Hager H, Kwon TH, Vinnikova AK, Masilamani S, Brooks HL, Frøkiaer J, Knepper MA, Nielsen S.
Am. J. Physiol. Renal Physiol. 2001 Jun;280(6):F1093-106.
[Text Abstract on PubMed]

Altered expression of renal aquaporins and Na(+) transporters in rats treated with L-type calcium blocker.
Wang W, Kwon TH, Li C, Flyvbjerg A, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001 Jun;280(6):R1632-41.
[Text Abstract on PubMed]

Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus.
Nejsum LN, Kwon TH, Marples D, Flyvbjerg A, Knepper MA, Frøkiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2001 Apr;280(4):F715-26.
[Text Abstract on PubMed]

Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion.
Royaux IE, Wall SM, Karniski LP, Everett LA, Suzuki K, Knepper MA, Green ED.
Proc. Natl. Acad. Sci. U.S.A. 2001 Mar 27;98(7):4221-6.
[Text Abstract on PubMed]

SNARE proteins are critical for regulated exocytosis of ECP from human eosinophils.
Hoffmann HJ, Bjerke T, Karawajczyk M, Dahl R, Knepper MA, Nielsen S.
Biochem. Biophys. Res. Commun. 2001 Mar 23;282(1):194-9.
[Text Abstract on PubMed]

Increased abundance of distal sodium transporters in rat kidney during vasopressin escape.
Ecelbarger CA, Knepper MA, Verbalis JG.
J. Am. Soc. Nephrol. 2001 Feb;12(2):207-17.
[Text Abstract on PubMed]

Profiling of renal tubule Na+ transporter abundances in NHE3 and NCC null mice using targeted proteomics.
Brooks HL, Sorensen AM, Terris J, Schultheis PJ, Lorenz JN, Shull GE, Knepper MA.
J. Physiol. (Lond.). 2001 Feb 1;530(Pt 3):359-66.
[Text Abstract on PubMed]

UT-A3: localization and characterization of an additional urea transporter isoform in the IMCD.
Terris JM, Knepper MA, Wade JB.
Am. J. Physiol. Renal Physiol. 2001 Feb;280(2):F325-32.
[Text Abstract on PubMed]

SNARE proteins are critical for regulated exocytosis of ECP from human eosinophils.
Hoffmann HJ, Bjerke T, Karawajczyk M, Dahl R, Knepper MA, Nielsen S.
Biochem. Biophys. Res. Commun. 2001 Jan 12;280(1):172-6.
[Text Abstract on PubMed]

Activation of epithelial Na channels during short-term Na deprivation.
Frindt G, Masilamani S, Knepper MA, Palmer LG.
Am. J. Physiol. Renal Physiol. 2001 Jan;280(1):F112-8.
[Text Abstract on PubMed]

Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance.
Promeneur D, Kwon TH, Yasui M, Kim GH, Frøkiaer J, Knepper MA, Agre P, Nielsen S.
Am. J. Physiol. Renal Physiol. 2000 Dec;279(6):F1014-26.
[Text Abstract on PubMed]

Regulation of aquaporin-2 trafficking by vasopressin in the renal collecting duct. Roles of ryanodine-sensitive Ca2+ stores and calmodulin.
Chou CL, Yip KP, Michea L, Kador K, Ferraris JD, Wade JB, Knepper MA.
J. Biol. Chem. 2000 Nov 24;275(47):36839-46.
[Text Abstract on PubMed]

Detection of Na(+) transporter proteins in urine.
McKee JA, Kumar S, Ecelbarger CA, Fernández-Llama P, Terris J, Knepper MA.
J. Am. Soc. Nephrol. 2000 Nov;11(11):2128-32.
[Text Abstract on PubMed]

Long-term regulation of renal Na-dependent cotransporters and ENaC: response to altered acid-base intake.
Kim GH, Martin SW, Fernández-Llama P, Masilamani S, Packer RK, Knepper MA.
Am. J. Physiol. Renal Physiol. 2000 Sep;279(3):F459-67.
[Text Abstract on PubMed]

Altered expression of renal AQPs and Na(+) transporters in rats with lithium-induced NDI.
Kwon TH, Laursen UH, Marples D, Maunsbach AB, Knepper MA, Frokiaer J, Nielsen S.
Am. J. Physiol. Renal Physiol. 2000 Sep;279(3):F552-64.
[Text Abstract on PubMed]

Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.
Ho HT, Chung SK, Law JW, Ko BC, Tam SC, Brooks HL, Knepper MA, Chung SS.
Mol. Cell. Biol. 2000 Aug;20(16):5840-6.
[Text Abstract on PubMed]

Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats.
Promeneur D, Kwon TH, Frøkiaer J, Knepper MA, Nielsen S.
Am. J. Physiol. Renal Physiol. 2000 Aug;279(2):F370-82.
[Text Abstract on PubMed]

Dysregulation of renal aquaporins and Na-Cl cotransporter in CCl4-induced cirrhosis.
Fernández-Llama P, Jimenez W, Bosch-Marcé M, Arroyo V, Nielsen S, Knepper MA.
Kidney Int. 2000 Jul;58(1):216-28.
[Text Abstract on PubMed]

Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney.
Ecelbarger CA, Kim GH, Terris J, Masilamani S, Mitchell C, Reyes I, Verbalis JG, Knepper MA.
Am. J. Physiol. Renal Physiol. 2000 Jul;279(1):F46-53.
[Text Abstract on PubMed]

Decreased abundance of major Na(+) transporters in kidneys of rats with ischemia-induced acute renal failure.
Kwon TH, Frøkiaer J, Han JS, Knepper MA, Nielsen S.
Am. J. Physiol. Renal Physiol. 2000 Jun;278(6):F925-39.
[Text Abstract on PubMed]

Key Roles of Renal Aquaporins in Water Balance and Water-Balance Disorders.
Nielsen S, Kwon TH, Frøkiaer J, Knepper MA.
News Physiol. Sci. 2000 Jun;15:136-143.
[Text Abstract on PubMed]

Localization of epithelial sodium channel and aquaporin-2 in rabbit kidney cortex.
Loffing J, Loffing-Cueni D, Macher A, Hebert SC, Olson B, Knepper MA, Rossier BC, Kaissling B.
Am. J. Physiol. Renal Physiol. 2000 Apr;278(4):F530-9.
[Text Abstract on PubMed]

Cellular localization of P2Y(2) purinoceptor in rat renal inner medulla and lung.
Kishore BK, Ginns SM, Krane CM, Nielsen S, Knepper MA.
Am. J. Physiol. Renal Physiol. 2000 Jan;278(1):F43-51.
[Text Abstract on PubMed]

UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin.
Wade JB, Lee AJ, Liu J, Ecelbarger CA, Mitchell C, Bradford AD, Terris J, Kim GH, Knepper MA.
Am. J. Physiol. Renal Physiol. 2000 Jan;278(1):F52-62.
[Text Abstract on PubMed]

Kidney aquaporin-2 expression during escape from antidiuresis is not related to plasma or tissue osmolality.
Murase T, Ecelbarger CA, Baker EA, Tian Y, Knepper MA, Verbalis JG.
J. Am. Soc. Nephrol. 1999 Oct;10(10):2067-75.
[Text Abstract on PubMed]

Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney.
Masilamani S, Kim GH, Mitchell C, Wade JB, Knepper MA.
J. Clin. Invest. 1999 Oct;104(7):R19-23.
[Text Abstract on PubMed]

Renal expression of aquaporins in liver cirrhosis induced by chronic common bile duct ligation in rats.
Fernández-Llama P, Turner R, Dibona G, Knepper MA.
J. Am. Soc. Nephrol. 1999 Sep;10(9):1950-7.
[Text Abstract on PubMed]

Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by alpha-MSH.
Kwon TH, Frøkiaer J, Fernández-Llama P, Knepper MA, Nielsen S.
Am. J. Physiol. 1999 Sep;277(3 Pt 2):F413-27.
[Text Abstract on PubMed]

Decreased renal Na-K-2Cl cotransporter abundance in mice with heterozygous disruption of the G(s)alpha gene.
Ecelbarger CA, Yu S, Lee AJ, Weinstein LS, Knepper MA.
Am. J. Physiol. 1999 Aug;277(2 Pt 2):F235-44.
[Text Abstract on PubMed]

Altered expression of Na transporters NHE-3, NaPi-II, Na-K-ATPase, BSC-1, and TSC in CRF rat kidneys.
Kwon TH, Frøkiaer J, Fernández-Llama P, Maunsbach AB, Knepper MA, Nielsen S.
Am. J. Physiol. 1999 Aug;277(2 Pt 2):F257-70.
[Text Abstract on PubMed]

Decreased abundance of collecting duct aquaporins in post-ischemic renal failure in rats.
Fernández-Llama P, Andrews P, Turner R, Saggi S, Dimari J, Kwon TH, Nielsen S, Safirstein R, Knepper MA.
J. Am. Soc. Nephrol. 1999 Aug;10(8):1658-68.
[Text Abstract on PubMed]

Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia.
Yasui M, Kwon TH, Knepper MA, Nielsen S, Agre P.
Proc. Natl. Acad. Sci. U.S.A. 1999 May 11;96(10):5808-13.
[Text Abstract on PubMed]

Regulation of thick ascending limb ion transporter abundance in response to altered acid/base intake.
Kim GH, Ecelbarger C, Knepper MA, Packer RK.
J. Am. Soc. Nephrol. 1999 May;10(5):935-42.
[Text Abstract on PubMed]

Developmental expression of aquaporin 1 in the rat renal vasculature.
Kim J, Kim WY, Han KH, Knepper MA, Nielsen S, Madsen KM.
Am. J. Physiol. 1999 Apr;276(4 Pt 2):F498-509.
[Text Abstract on PubMed]

Vasopressin regulates apical targeting of aquaporin-2 but not of UT1 urea transporter in renal collecting duct.
Inoue T, Terris J, Ecelbarger CA, Chou CL, Nielsen S, Knepper MA.
Am. J. Physiol. 1999 Apr;276(4 Pt 2):F559-66.
[Text Abstract on PubMed]

Regulation of thick ascending limb transport by vasopressin.
Knepper MA, Kim GH, Fernández-Llama P, Ecelbarger CA.
J. Am. Soc. Nephrol. 1999 Mar;10(3):628-34.
[Text Abstract on PubMed]

Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice.
Chou CL, Knepper MA, Hoek AN, Brown D, Yang B, Ma T, Verkman AS.
J. Clin. Invest. 1999 Feb;103(4):491-6.
[Text Abstract on PubMed]

Low aquaporin-2 levels in polyuric DI +/+ severe mice with constitutively high cAMP-phosphodiesterase activity.
Frøkiaer J, Marples D, Valtin H, Morris JF, Knepper MA, Nielsen S.
Am. J. Physiol. 1999 Feb;276(2 Pt 2):F179-90.
[Text Abstract on PubMed]

Ultrastructural localization of Na-K-2Cl cotransporter in thick ascending limb and macula densa of rat kidney.
Nielsen S, Maunsbach AB, Ecelbarger CA, Knepper MA.
Am. J. Physiol. 1998 Dec;275(6 Pt 2):F885-93.
[Text Abstract on PubMed]

Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats.
Earm JH, Christensen BM, Frøkiaer J, Marples D, Han JS, Knepper MA, Nielsen S.
J. Am. Soc. Nephrol. 1998 Dec;9(12):2181-93.
[Text Abstract on PubMed]

The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein.
Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 1998 Nov 24;95(24):14552-7.
[Text Abstract on PubMed]

Reduced AQP1, -2, and -3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass.
Kwon TH, Frøkiaer J, Knepper MA, Nielsen S.
Am. J. Physiol. 1998 Nov;275(5 Pt 2):F724-41.
[Text Abstract on PubMed]

SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles.
Inoue T, Nielsen S, Mandon B, Terris J, Kishore BK, Knepper MA.
Am. J. Physiol. 1998 Nov;275(5 Pt 2):F752-60.
[Text Abstract on PubMed]

Pathophysiology of aquaporin-2 in water balance disorders.
Frøkiaer J, Marples D, Knepper MA, Nielsen S.
Am. J. Med. Sci. 1998 Nov;316(5):291-9.
[Text Abstract on PubMed]

Long-term regulation of urinary concentrating capacity.
Knepper MA.
Am. J. Physiol. 1998 Sep;275(3 Pt 2):F332-3.
[Text Abstract on PubMed]

Dehydration reverses vasopressin antagonist-induced diuresis and aquaporin-2 downregulation in rats.
Marples D, Christensen BM, Frokiaer J, Knepper MA, Nielsen S.
Am. J. Physiol. 1998 Sep;275(3 Pt 2):F400-9.
[Text Abstract on PubMed]

Disordered water channel expression and distribution in acquired nephrogenic diabetes insipidus.
Marples D, Frøkiaer J, Knepper MA, Nielsen S.
Proc. Assoc. Am. Physicians. 1998 Sep-Oct;110(5):401-6.
[Text Abstract on PubMed]

Renal aquaporins: key roles in water balance and water balance disorders.
Nielsen S, Frør J, Knepper MA.
Curr. Opin. Nephrol. Hypertens. 1998 Sep;7(5):509-16.
[Text Abstract on PubMed]

Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice.
Schnermann J, Chou CL, Ma T, Traynor T, Knepper MA, Verkman AS.
Proc. Natl. Acad. Sci. U.S.A. 1998 Aug 4;95(16):9660-4.
[Text Abstract on PubMed]

Expression of synaptotagmin VIII in rat kidney.
Kishore BK, Wade JB, Schorr K, Inoue T, Mandon B, Knepper MA.
Am. J. Physiol. 1998 Jul;275(1 Pt 2):F131-42.
[Text Abstract on PubMed]

Escape from vasopressin-induced antidiuresis: role of vasopressin resistance of the collecting duct.
Ecelbarger CA, Chou CL, Lee AJ, DiGiovanni SR, Verbalis JG, Knepper MA.
Am. J. Physiol. 1998 Jun;274(6 Pt 2):F1161-6.
[Text Abstract on PubMed]

Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome.
Fernández-Llama P, Andrews P, Nielsen S, Ecelbarger CA, Knepper MA.
Kidney Int. 1998 May;53(5):1244-53.
[Text Abstract on PubMed]

Long-term regulation of renal urea transporter protein expression in rat.
Terris J, Ecelbarger CA, Sands JM, Knepper MA.
J. Am. Soc. Nephrol. 1998 May;9(5):729-36.
[Text Abstract on PubMed]

Long-term regulation of inner medullary collecting duct urea transport in rat.
Kato A, Naruse M, Knepper MA, Sands JM.
J. Am. Soc. Nephrol. 1998 May;9(5):737-45.
[Text Abstract on PubMed]

Phosphoinositide signaling in rat inner medullary collecting duct.
Chou CL, Rapko SI, Knepper MA.
Am. J. Physiol. 1998 Mar;274(3 Pt 2):F564-72.
[Text Abstract on PubMed]

Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice.
Chou CL, Ma T, Yang B, Knepper MA, Verkman AS.
Am. J. Physiol. 1998 Feb;274(2 Pt 1):C549-54.
[Text Abstract on PubMed]

Dynein and dynactin colocalize with AQP2 water channels in intracellular vesicles from kidney collecting duct.
Marples D, Schroer TA, Ahrens N, Taylor A, Knepper MA, Nielsen S.
Am. J. Physiol. 1998 Feb;274(2 Pt 2):F384-94.
[Text Abstract on PubMed]

Studies of renal aquaporin-2 expression during renal escape from vasopressin-induced antidiuresis.
Verbalis JG, Murase T, Ecelbarger CA, Nielsen S, Knepper MA.
Adv. Exp. Med. Biol. 1998;449:395-406.
[Text Abstract on PubMed]

Expression of syntaxins in rat kidney.
Mandon B, Nielsen S, Kishore BK, Knepper MA.
Am. J. Physiol. 1997 Nov;273(5 Pt 2):F718-30.
[Text Abstract on PubMed]

Regulation of aquaporin-2 water channel trafficking by vasopressin.
Knepper MA, Inoue T.
Curr. Opin. Cell Biol. 1997 Aug;9(4):560-4.
[Text Abstract on PubMed]

Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction.
Frøkiaer J, Christensen BM, Marples D, Djurhuus JC, Jensen UB, Knepper MA, Nielsen S.
Am. J. Physiol. 1997 Aug;273(2 Pt 2):F213-23.
[Text Abstract on PubMed]

Role of aquaporins in water balance disorders.
Knepper MA, Verbalis JG, Nielsen S.
Curr. Opin. Nephrol. Hypertens. 1997 Jul;6(4):367-71.
[Text Abstract on PubMed]

Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct.
Nielsen S, Terris J, Andersen D, Ecelbarger C, Frokiaer J, Jonassen T, Marples D, Knepper MA, Petersen JS.
Proc. Natl. Acad. Sci. U.S.A. 1997 May 13;94(10):5450-5.
[Text Abstract on PubMed]

Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta.
Pallone TL, Kishore BK, Nielsen S, Agre P, Knepper MA.
Am. J. Physiol. 1997 May;272(5 Pt 2):F587-96.
[Text Abstract on PubMed]

Segmental localization of urea transporter mRNAs in rat kidney.
Shayakul C, Knepper MA, Smith CP, DiGiovanni SR, Hediger MA.
Am. J. Physiol. 1997 May;272(5 Pt 2):F654-60.
[Text Abstract on PubMed]

Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat.
Ecelbarger CA, Nielsen S, Olson BR, Murase T, Baker EA, Knepper MA, Verbalis JG.
J. Clin. Invest. 1997 Apr 15;99(8):1852-63.
[Text Abstract on PubMed]

Inhibition of IMCD 11 beta-hydroxysteroid dehydrogenase type 2 by low pH and acute acid loading.
Nolan PJ, Knepper MA, Packer RK.
J. Am. Soc. Nephrol. 1997 Apr;8(4):530-4.
[Text Abstract on PubMed]

Ultramicrodetermination of vasopressin-regulated urea transporter protein in microdissected renal tubules.
Kishore BK, Terris J, Fernández-Llama P, Knepper MA.
Am. J. Physiol. 1997 Apr;272(4 Pt 2):F531-7.
[Text Abstract on PubMed]

Reduced renal medullary water channel expression in puromycin aminonucleoside--induced nephrotic syndrome.
Apostol E, Ecelbarger CA, Terris J, Bradford AD, Andrews P, Knepper MA.
J. Am. Soc. Nephrol. 1997 Jan;8(1):15-24.
[Text Abstract on PubMed]

Molecular physiology of urinary concentrating mechanism: regulation of aquaporin water channels by vasopressin.
Knepper MA.
Am. J. Physiol. 1997 Jan;272(1 Pt 2):F3-12.
[Text Abstract on PubMed]

Role of adrenal steroids in stimulating ammonium excretion during acute metabolic acidosis.
Nolan PJ, Knepper MA, Packer RK.
Contrib Nephrol. 1997;121:55-61.
[Text Abstract on PubMed]

Immunolocalization of the secretory isoform of Na-K-Cl cotransporter in rat renal intercalated cells.
Ginns SM, Knepper MA, Ecelbarger CA, Terris J, He X, Coleman RA, Wade JB.
J. Am. Soc. Nephrol. 1996 Dec;7(12):2533-42.
[Text Abstract on PubMed]

Localization and regulation of the rat renal Na(+)-K(+)-2Cl- cotransporter, BSC-1.
Ecelbarger CA, Terris J, Hoyer JR, Nielsen S, Wade JB, Knepper MA.
Am. J. Physiol. 1996 Sep;271(3 Pt 2):F619-28.
[Text Abstract on PubMed]

Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking.
Mandon B, Chou CL, Nielsen S, Knepper MA.
J. Clin. Invest. 1996 Aug 15;98(4):906-13.
[Text Abstract on PubMed]

Long-term regulation of four renal aquaporins in rats.
Terris J, Ecelbarger CA, Nielsen S, Knepper MA.
Am. J. Physiol. 1996 Aug;271(2 Pt 2):F414-22.
[Text Abstract on PubMed]

Quantitation of aquaporin-2 abundance in microdissected collecting ducts: axial distribution and control by AVP.
Kishore BK, Terris JM, Knepper MA.
Am. J. Physiol. 1996 Jul;271(1 Pt 2):F62-70.
[Text Abstract on PubMed]

Expression of aquaporins-1 and -2 during nephrogenesis and in autosomal dominant polycystic kidney disease.
Devuyst O, Burrow CR, Smith BL, Agre P, Knepper MA, Wilson PD.
Am. J. Physiol. 1996 Jul;271(1 Pt 2):F169-83.
[Text Abstract on PubMed]

Rat renal arcade segment expresses vasopressin-regulated water channel and vasopressin V2 receptor.
Kishore BK, Mandon B, Oza NB, DiGiovanni SR, Coleman RA, Ostrowski NL, Wade JB, Knepper MA.
J. Clin. Invest. 1996 Jun 15;97(12):2763-71.
[Text Abstract on PubMed]

Renal aquaporins.
Knepper MA, Wade JB, Terris J, Ecelbarger CA, Marples D, Mandon B, Chou CL, Kishore BK, Nielsen S.
Kidney Int. 1996 Jun;49(6):1712-7.
[Text Abstract on PubMed]

Cellular and subcellular localization of the vasopressin- regulated urea transporter in rat kidney.
Nielsen S, Terris J, Smith CP, Hediger MA, Ecelbarger CA, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 1996 May 28;93(11):5495-500.
[Text Abstract on PubMed]

Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex.
Marples D, Frøkiaer J, Dørup J, Knepper MA, Nielsen S.
J. Clin. Invest. 1996 Apr 15;97(8):1960-8.
[Text Abstract on PubMed]

Evidence for dual signaling pathways for V2 vasopressin receptor in rat inner medullary collecting duct.
Ecelbarger CA, Chou CL, Lolait SJ, Knepper MA, DiGiovanni SR.
Am. J. Physiol. 1996 Apr;270(4 Pt 2):F623-33.
[Text Abstract on PubMed]

Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney.
Frøkiaer J, Marples D, Knepper MA, Nielsen S.
Am. J. Physiol. 1996 Apr;270(4 Pt 2):F657-68.
[Text Abstract on PubMed]

Permeability criteria for effective function of passive countercurrent multiplier.
Layton HE, Knepper MA, Chou CL.
Am. J. Physiol. 1996 Jan;270(1 Pt 2):F9-20.
[Text Abstract on PubMed]

Distribution of aquaporin-4 water channel expression within rat kidney.
Terris J, Ecelbarger CA, Marples D, Knepper MA, Nielsen S.
Am. J. Physiol. 1995 Dec;269(6 Pt 2):F775-85.
[Text Abstract on PubMed]

Extracellular nucleotide receptor inhibits AVP-stimulated water permeability in inner medullary collecting duct.
Kishore BK, Chou CL, Knepper MA.
Am. J. Physiol. 1995 Dec;269(6 Pt 2):F863-9.
[Text Abstract on PubMed]

Aquaporin-3 water channel localization and regulation in rat kidney.
Ecelbarger CA, Terris J, Frindt G, Echevarria M, Marples D, Nielsen S, Knepper MA.
Am. J. Physiol. 1995 Nov;269(5 Pt 2):F663-72.
[Text Abstract on PubMed]

Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct.
Marples D, Knepper MA, Christensen EI, Nielsen S.
Am. J. Physiol. 1995 Sep;269(3 Pt 1):C655-64.
[Text Abstract on PubMed]

Cloning and regulation of expression of the rat kidney urea transporter (rUT2).
Smith CP, Lee WS, Martial S, Knepper MA, You G, Sands JM, Hediger MA.
J. Clin. Invest. 1995 Sep;96(3):1556-63.
[Text Abstract on PubMed]

Oxytocin as an antidiuretic hormone. I. Concentration dependence of action.
Chou CL, DiGiovanni SR, Mejia R, Nielsen S, Knepper MA.
Am. J. Physiol. 1995 Jul;269(1 Pt 2):F70-7.
[Text Abstract on PubMed]

Oxytocin as an antidiuretic hormone. II. Role of V2 vasopressin receptor.
Chou CL, DiGiovanni SR, Luther A, Lolait SJ, Knepper MA.
Am. J. Physiol. 1995 Jul;269(1 Pt 2):F78-85.
[Text Abstract on PubMed]

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.
Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 1995 Feb 14;92(4):1013-7.
[Text Abstract on PubMed]

Quantification of Aquaporin-CHIP water channel protein in microdissected renal tubules by fluorescence-based ELISA.
Maeda Y, Smith BL, Agre P, Knepper MA.
J. Clin. Invest. 1995 Jan;95(1):422-8.
[Text Abstract on PubMed]

Extracellular ATP increases intracellular calcium in rat terminal collecting duct via a nucleotide receptor.
Ecelbarger CA, Maeda Y, Gibson CC, Knepper MA.
Am. J. Physiol. 1994 Dec;267(6 Pt 2):F998-1006.
[Text Abstract on PubMed]

Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat.
DiGiovanni SR, Nielsen S, Christensen EI, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 1994 Sep 13;91(19):8984-8.
[Text Abstract on PubMed]

Dissociation of ammoniagenic enzyme adaptation in rat S1 proximal tubules and ammonium excretion response.
DiGiovanni SR, Madsen KM, Luther AD, Knepper MA.
Am. J. Physiol. 1994 Sep;267(3 Pt 2):F407-14.
[Text Abstract on PubMed]

The aquaporin family of molecular water channels.
Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 1994 Jul 5;91(14):6255-8.
[Text Abstract on PubMed]

Mechanism of vasopressin action in the renal collecting duct.
Knepper MA, Nielsen S, Chou CL, DiGiovanni SR.
Semin. Nephrol. 1994 Jul;14(4):302-21.
[Text Abstract on PubMed]

Long-term regulation of collecting duct water permeability: freeze-fracture analysis of isolated perfused tubules.
Wade JB, Nielsen S, Coleman RA, Knepper MA.
Am. J. Physiol. 1994 May;266(5 Pt 2):F723-30.
[Text Abstract on PubMed]

Vasopressin-independent regulation of collecting duct water permeability.
Han JS, Maeda Y, Ecelbarger C, Knepper MA.
Am. J. Physiol. 1994 Jan;266(1 Pt 2):F139-46.
[Text Abstract on PubMed]

An RT-PCR approach to study the regulation of mRNA levels for phosphate-dependent glutaminase.
DiGiovanni SR, Knepper MA.
Contrib Nephrol. 1994;110:81-7.
[Text Abstract on PubMed]

Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney.
Nielsen S, DiGiovanni SR, Christensen EI, Knepper MA, Harris HW.
Proc. Natl. Acad. Sci. U.S.A. 1993 Dec 15;90(24):11663-7.
[Text Abstract on PubMed]

Structural-functional correlation in chinchilla long loop of Henle thin limbs: a novel papillary subsegment.
Chou CL, Nielsen S, Knepper MA.
Am. J. Physiol. 1993 Dec;265(6 Pt 2):F863-74.
[Text Abstract on PubMed]

Expression of vasopressin V1a and V2 receptor messenger ribonucleic acid in the liver and kidney of embryonic, developing, and adult rats.
Ostrowski NL, Young, Knepper MA, Lolait SJ.
Endocrinology. 1993 Oct;133(4):1849-59.
[Text Abstract on PubMed]

Vasopressin activates collecting duct urea transporters and water channels by distinct physical processes.
Nielsen S, Knepper MA.
Am. J. Physiol. 1993 Aug;265(2 Pt 2):F204-13.
[Text Abstract on PubMed]

Kinetic model of water and urea permeability regulation by vasopressin in collecting duct.
Knepper MA, Nielsen S.
Am. J. Physiol. 1993 Aug;265(2 Pt 2):F214-24.
[Text Abstract on PubMed]

Vasopressin- and cAMP-induced changes in ultrastructure of isolated perfused inner medullary collecting ducts.
Nielsen S, Muller J, Knepper MA.
Am. J. Physiol. 1993 Aug;265(2 Pt 2):F225-38.
[Text Abstract on PubMed]

Vasopressin and oxytocin receptors coupled to Ca2+ mobilization in rat inner medullary collecting duct.
Maeda Y, Han JS, Gibson CC, Knepper MA.
Am. J. Physiol. 1993 Jul;265(1 Pt 2):F15-25.
[Text Abstract on PubMed]

Dual actions of vasopressin and oxytocin in regulation of water permeability in terminal collecting duct.
Han JS, Maeda Y, Knepper MA.
Am. J. Physiol. 1993 Jul;265(1 Pt 2):F26-34.
[Text Abstract on PubMed]

Ammonium and bicarbonate transport in isolated perfused rodent ascending limbs of the loop of Henle.
Flessner MF, Knepper MA.
Am. J. Physiol. 1993 May;264(5 Pt 2):F837-44.
[Text Abstract on PubMed]

Ammonium and bicarbonate transport in isolated perfused rodent long-loop thin descending limbs.
Flessner MF, Mejia R, Knepper MA.
Am. J. Physiol. 1993 Mar;264(3 Pt 2):F388-96.
[Text Abstract on PubMed]

Model of ammonium and bicarbonate transport along LDL: implications for alkalinization of luminal fluid.
Mejia R, Flessner MF, Knepper MA.
Am. J. Physiol. 1993 Mar;264(3 Pt 2):F397-403.
[Text Abstract on PubMed]

Urinary concentrating mechanism: the role of the inner medulla.
Chou CL, Knepper MA, Layton HE.
Semin. Nephrol. 1993 Mar;13(2):168-81.
[Text Abstract on PubMed]

In vitro perfusion of chinchilla thin limb segments: urea and NaCl permeabilities.
Chou CL, Knepper MA.
Am. J. Physiol. 1993 Feb;264(2 Pt 2):F337-43.
[Text Abstract on PubMed]

CHIP28 water channels are localized in constitutively water-permeable segments of the nephron.
Nielsen S, Smith BL, Christensen EI, Knepper MA, Agre P.
J. Cell Biol. 1993 Jan;120(2):371-83.
[Text Abstract on PubMed]

How is urine concentrated by the renal inner medulla?
Knepper MA, Chou CL, Layton HE.
Contrib Nephrol. 1993;102:144-60.
[Text Abstract on PubMed]

In vitro perfusion of chinchilla thin limb segments: segmentation and osmotic water permeability.
Chou CL, Knepper MA.
Am. J. Physiol. 1992 Sep;263(3 Pt 2):F417-26.
[Text Abstract on PubMed]

Hormone and autacoid regulation of cAMP production in rat IMCD subsegments.
Maeda Y, Terada Y, Nonoguchi H, Knepper MA.
Am. J. Physiol. 1992 Aug;263(2 Pt 2):F319-27.
[Text Abstract on PubMed]

Kinetics of urea and water permeability activation by vasopressin in rat terminal IMCD.
Wall SM, Han JS, Chou CL, Knepper MA.
Am. J. Physiol. 1992 Jun;262(6 Pt 2):F989-98.
[Text Abstract on PubMed]

Experimental tests of three-dimensional model of urinary concentrating mechanism.
Han JS, Thompson KA, Chou CL, Knepper MA.
J. Am. Soc. Nephrol. 1992 Jun;2(12):1677-88.
[Text Abstract on PubMed]

Time course of renal glutamate dehydrogenase induction during NH4Cl loading in rats.
Wright PA, Packer RK, Garcia-Perez A, Knepper MA.
Am. J. Physiol. 1992 Jun;262(6 Pt 2):F999-1006.
[Text Abstract on PubMed]

Ammonium and bicarbonate transport in rat outer medullary collecting ducts.
Flessner MF, Wall SM, Knepper MA.
Am. J. Physiol. 1992 Jan;262(1 Pt 2):F1-7.
[Text Abstract on PubMed]

RT-PCR microlocalization of mRNA for guanylyl cyclase-coupled ANF receptor in rat kidney.
Terada Y, Moriyama T, Martin BM, Knepper MA, Garcia-Perez A.
Am. J. Physiol. 1991 Dec;261(6 Pt 2):F1080-7.
[Text Abstract on PubMed]

Renal tubular actions of ANF.
Knepper MA, Lankford SP, Terada Y.
Can. J. Physiol. Pharmacol. 1991 Oct;69(10):1537-45.
[Text Abstract on PubMed]

Regulation of collecting duct water permeability independent of cAMP-mediated AVP response.
Lankford SP, Chou CL, Terada Y, Wall SM, Wade JB, Knepper MA.
Am. J. Physiol. 1991 Sep;261(3 Pt 2):F554-66.
[Text Abstract on PubMed]

NH4+ transport in the kidney.
Knepper MA.
Kidney Int. Suppl. 1991 Jul;33:S95-102.
[Text Abstract on PubMed]

Role of countercurrent multiplication in renal ammonium handling: regulation of medullary ammonium accumulation.
Packer RK, Desai SS, Hornbuckle K, Knepper MA.
J. Am. Soc. Nephrol. 1991 Jul;2(1):77-83.
[Text Abstract on PubMed]

Distribution of luminal carbonic anhydrase activity along rat inner medullary collecting duct.
Wall SM, Flessner MF, Knepper MA.
Am. J. Physiol. 1991 May;260(5 Pt 2):F738-48.
[Text Abstract on PubMed]

Permeabilities of rat collecting duct segments to NH3 and NH4+.
Flessner MF, Wall SM, Knepper MA.
Am. J. Physiol. 1991 Feb;260(2 Pt 2):F264-72.
[Text Abstract on PubMed]

Regulation of renal medullary ammonium accumulation.
Knepper MA, Desai SS, Hornbuckle K, Packer RK.
Contrib Nephrol. 1991;92:119-23.
[Text Abstract on PubMed]

Mapping ammoniagenic enzyme activities along the rat nephron.
Wright PA, Knepper MA.
Contrib Nephrol. 1991;92:130-5.
[Text Abstract on PubMed]

Phosphate-dependent glutaminase activity in rat renal cortical and medullary tubule segments.
Wright PA, Knepper MA.
Am. J. Physiol. 1990 Dec;259(6 Pt 2):F961-70.
[Text Abstract on PubMed]

The vasopressin-regulated urea transporter in renal inner medullary collecting duct.
Knepper MA, Star RA.
Am. J. Physiol. 1990 Sep;259(3 Pt 2):F393-401.
[Text Abstract on PubMed]

Thiazide-sensitive NaCl absorption in rat cortical collecting duct.
Terada Y, Knepper MA.
Am. J. Physiol. 1990 Sep;259(3 Pt 2):F519-28.
[Text Abstract on PubMed]

Glutamate dehydrogenase activities in microdissected rat nephron segments: effects of acid-base loading.
Wright PA, Knepper MA.
Am. J. Physiol. 1990 Jul;259(1 Pt 2):F53-9.
[Text Abstract on PubMed]

Urea gradient-associated fluid absorption with sigma urea = 1 in rat terminal collecting duct.
Chou CL, Sands JM, Nonoguchi H, Knepper MA.
Am. J. Physiol. 1990 May;258(5 Pt 2):F1173-80.
[Text Abstract on PubMed]

Apical acidification by rabbit papillary surface epithelium.
Chandhoke PS, Packer RK, Knepper MA.
Am. J. Physiol. 1990 Apr;258(4 Pt 2):F893-9.
[Text Abstract on PubMed]

Concentration dependence of urea and thiourea transport in rat inner medullary collecting duct.
Chou CL, Sands JM, Nonoguchi H, Knepper MA.
Am. J. Physiol. 1990 Mar;258(3 Pt 2):F486-94.
[Text Abstract on PubMed]

Acid-base transport in the inner medullary collecting duct.
Wall SM, Knepper MA.
Semin. Nephrol. 1990 Mar;10(2):148-58.
[Text Abstract on PubMed]

Mechanisms of ammonium excretion: role of the renal medulla.
Good DW, Knepper MA.
Semin. Nephrol. 1990 Mar;10(2):166-73.
[Text Abstract on PubMed]

Microdissection of kidney tubule segments.
Wright PA, Burg MB, Knepper MA.
Meth. Enzymol. 1990;191:226-31.
[Text Abstract on PubMed]

Ammonium transport in collecting ducts.
Flessner MF, Knepper MA.
Miner Electrolyte Metab. 1990;16(5):299-307.
[Text Abstract on PubMed]

Net acid transport by isolated perfused inner medullary collecting ducts.
Wall SM, Sands JM, Flessner MF, Nonoguchi H, Spring KR, Knepper MA.
Am. J. Physiol. 1990 Jan;258(1 Pt 2):F75-84.
[Text Abstract on PubMed]

Renal actions of atrial natriuretic factor: a mathematical modeling study.
Mejia R, Sands JM, Stephenson JL, Knepper MA.
Am. J. Physiol. 1989 Dec;257(6 Pt 2):F1146-57.
[Text Abstract on PubMed]

Continuous-flow quantitation of Na+ and K+ in nanoliter samples using chromogenic macrocyclic ionophores.
Terada Y, Knepper MA.
Am. J. Physiol. 1989 Nov;257(5 Pt 2):F893-8.
[Text Abstract on PubMed]

Inhibition of urea transport in inner medullary collecting duct by phloretin and urea analogues.
Chou CL, Knepper MA.
Am. J. Physiol. 1989 Sep;257(3 Pt 2):F359-65.
[Text Abstract on PubMed]

Chloride and osmotic water permeabilities of isolated rabbit renal papillary surface epithelium.
Packer RK, Sands JM, Knepper MA.
Am. J. Physiol. 1989 Aug;257(2 Pt 2):F218-24.
[Text Abstract on PubMed]

Role of organic anions in renal response to dietary acid and base loads.
Brown JC, Packer RK, Knepper MA.
Am. J. Physiol. 1989 Aug;257(2 Pt 2):F170-6.
[Text Abstract on PubMed]

Aldose reductase activities in microdissected rat renal tubule segments.
Sands JM, Terada Y, Bernard LM, Knepper MA.
Am. J. Physiol. 1989 Apr;256(4 Pt 2):F563-9.
[Text Abstract on PubMed]

Independence of urea and water transport in rat inner medullary collecting duct.
Knepper MA, Sands JM, Chou CL.
Am. J. Physiol. 1989 Apr;256(4 Pt 2):F610-21.
[Text Abstract on PubMed]

Na+-K+-ATPase activities in renal tubule segments of rat inner medulla.
Terada Y, Knepper MA.
Am. J. Physiol. 1989 Feb;256(2 Pt 2):F218-23.
[Text Abstract on PubMed]

ANF inhibits NaCl and fluid absorption in cortical collecting duct of rat kidney.
Nonoguchi H, Sands JM, Knepper MA.
Am. J. Physiol. 1989 Jan;256(1 Pt 2):F179-86.
[Text Abstract on PubMed]

Ammonium transport in the kidney.
Knepper MA, Packer R, Good DW.
Physiol. Rev. 1989 Jan;69(1):179-249.
[Text Abstract on PubMed]

Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.
Nonoguchi H, Sands JM, Knepper MA.
J. Clin. Invest. 1988 Oct;82(4):1383-90.
[Text Abstract on PubMed]

Hormone effects on NaCl permeability of rat inner medullary collecting duct.
Sands JM, Nonoguchi H, Knepper MA.
Am. J. Physiol. 1988 Sep;255(3 Pt 2):F421-8.
[Text Abstract on PubMed]

Active NH4+ absorption by the thick ascending limb.
Garvin JL, Burg MB, Knepper MA.
Am. J. Physiol. 1988 Jul;255(1 Pt 2):F57-65.
[Text Abstract on PubMed]

Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct.
Star RA, Nonoguchi H, Balaban R, Knepper MA.
J. Clin. Invest. 1988 Jun;81(6):1879-88.
[Text Abstract on PubMed]

Disequilibrium pH and ammonia transport in isolated perfused cortical collecting ducts.
Star RA, Kurtz I, Mejia R, Burg MB, Knepper MA.
Am. J. Physiol. 1987 Dec;253(6 Pt 2):F1232-42.
[Text Abstract on PubMed]

Vasopressin effects on urea and H2O transport in inner medullary collecting duct subsegments.
Sands JM, Nonoguchi H, Knepper MA.
Am. J. Physiol. 1987 Nov;253(5 Pt 2):F823-32.
[Text Abstract on PubMed]

Bicarbonate and ammonia transport in isolated perfused rat proximal straight tubules.
Garvin JL, Knepper MA.
Am. J. Physiol. 1987 Aug;253(2 Pt 2):F277-81.
[Text Abstract on PubMed]

Ammonium, urea, and systemic pH regulation.
Knepper MA, Burg MB, Orloff J, Berliner RW, Rector.
Am. J. Physiol. 1987 Jul;253(1 Pt 2):F199-202.
[Text Abstract on PubMed]

Luminal disequilibrium pH and ammonia transport in outer medullary collecting duct [corrected and issued with original paging in Am J Physiol 1987 Aug;253(2 Pt 2)].
Star RA, Burg MB, Knepper MA.
Am. J. Physiol. 1987 Jun;252(6 Pt 2):F1148-57.
[Text Abstract on PubMed]

Effects of atrial natriuretic factor on cyclic guanosine monophosphate and cyclic adenosine monophosphate accumulation in microdissected nephron segments from rats.
Nonoguchi H, Knepper MA, Manganiello VC.
J. Clin. Invest. 1987 Feb;79(2):500-7.
[Text Abstract on PubMed]

Pathways of urea transport in the mammalian kidney.
Knepper MA, Roch-Ramel F.
Kidney Int. 1987 Feb;31(2):629-33.
[Text Abstract on PubMed]

NH3 and NH4+ transport by rabbit renal proximal straight tubules.
Garvin JL, Burg MB, Knepper MA.
Am. J. Physiol. 1987 Feb;252(2 Pt 2):F232-9.
[Text Abstract on PubMed]

Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium.
Sands JM, Knepper MA.
J. Clin. Invest. 1987 Jan;79(1):138-47.
[Text Abstract on PubMed]

Spontaneous luminal disequilibrium pH in S3 proximal tubules. Role in ammonia and bicarbonate transport.
Kurtz I, Star R, Balaban RS, Garvin JL, Knepper MA.
J. Clin. Invest. 1986 Oct;78(4):989-96.
[Text Abstract on PubMed]

Na-K-Cl cotransport in apical membrane of rabbit renal papillary surface epithelium.
Sands JM, Knepper MA, Spring KR.
Am. J. Physiol. 1986 Sep;251(3 Pt 2):F475-84.
[Text Abstract on PubMed]

Single tubule perfusion techniques.
Burg MB, Knepper MA.
Kidney Int. 1986 Aug;30(2):166-70.
[Text Abstract on PubMed]

Effects of vasopressin and bradykinin on anion transport by the rat cortical collecting duct. Evidence for an electroneutral sodium chloride transport pathway.
Tomita K, Pisano JJ, Burg MB, Knepper MA.
J. Clin. Invest. 1986 Jan;77(1):136-41.
[Text Abstract on PubMed]

Ammonia and bicarbonate transport by rat cortical collecting ducts perfused in vitro.
Knepper MA, Good DW, Burg MB.
Am. J. Physiol. 1985 Dec;249(6 Pt 2):F870-7.
[Text Abstract on PubMed]

Ammonium replaces potassium in supporting sodium transport by the Na-K-ATPase of renal proximal straight tubules.
Garvin JL, Burg MB, Knepper MA.
Am. J. Physiol. 1985 Nov;249(5 Pt 2):F785-8.
[Text Abstract on PubMed]

Role of inner medullary collecting duct NaCl transport in urinary concentration.
Chandhoke PS, Saidel GM, Knepper MA.
Am. J. Physiol. 1985 Nov;249(5 Pt 2):F688-97.
[Text Abstract on PubMed]

Bicarbonate secretion and chloride absorption by rabbit cortical collecting ducts. Role of chloride/bicarbonate exchange.
Star RA, Burg MB, Knepper MA.
J. Clin. Invest. 1985 Sep;76(3):1123-30.
[Text Abstract on PubMed]

Deoxycorticosterone-stimulated bicarbonate secretion in rabbit cortical collecting ducts: effects of luminal chloride removal and in vivo acid loading.
Garcia-Austt J, Good DW, Burg MB, Knepper MA.
Am. J. Physiol. 1985 Aug;249(2 Pt 2):F205-12.
[Text Abstract on PubMed]

Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone.
Tomita K, Pisano JJ, Knepper MA.
J. Clin. Invest. 1985 Jul;76(1):132-6.
[Text Abstract on PubMed]

Ammonia transport in the mammalian kidney.
Good DW, Knepper MA.
Am. J. Physiol. 1985 Apr;248(4 Pt 2):F459-71.
[Text Abstract on PubMed]

Mechanism of ammonia secretion by rabbit cortical collecting ducts. Quantitative considerations.
Knepper MA, Good DW, Burg MB.
Contrib Nephrol. 1985;47:116-24.
[Text Abstract on PubMed]

Mechanism of ammonia secretion by cortical collecting ducts of rabbits.
Knepper MA, Good DW, Burg MB.
Am. J. Physiol. 1984 Nov;247(5 Pt 2):F729-38.
[Text Abstract on PubMed]

Ammonia and bicarbonate transport by thick ascending limb of rat kidney.
Good DW, Knepper MA, Burg MB.
Am. J. Physiol. 1984 Jul;247(1 Pt 2):F35-44.
[Text Abstract on PubMed]

Nitrogen-14 nuclear magnetic resonance spectroscopy of mammalian tissues.
Balaban RS, Knepper MA.
Am. J. Physiol. 1983 Nov;245(5 Pt 1):C439-44.
[Text Abstract on PubMed]

Urea transport in isolated thick ascending limbs and collecting ducts from rats.
Knepper MA.
Am. J. Physiol. 1983 Nov;245(5 Pt 1):F634-9.
[Text Abstract on PubMed]

Urea transport in nephron segments from medullary rays of rabbits.
Knepper MA.
Am. J. Physiol. 1983 Jun;244(6):F622-7.
[Text Abstract on PubMed]

Distribution of immunoreactive kallikrein along the rat nephron.
Proud D, Knepper MA, Pisano JJ.
Am. J. Physiol. 1983 May;244(5):F510-5.
[Text Abstract on PubMed]

Measurement of osmolality in kidney slices using vapor pressure osmometry.
Knepper MA.
Kidney Int. 1982 Apr;21(4):653-5.
[Text Abstract on PubMed]

A colorimeter for measurement of picomole quantities of urea.
Vurek GG, Knepper MA.
Kidney Int. 1982 Apr;21(4):656-8.
[Text Abstract on PubMed]

Increased fluid absorption and cell volume in isolated rabbit proximal straight tubules after in vivo DOCA administration.
Knepper MA, Burg MB.
Am. J. Physiol. 1981 Nov;241(5):F502-8.
[Text Abstract on PubMed]

Mineralocorticoid effects on Na-K-ATPase in individual nephron segments.
Garg LC, Knepper MA, Burg MB.
Am. J. Physiol. 1981 Jun;240(6):F536-44.
[Text Abstract on PubMed]

Quantitative analysis of renal medullary anatomy in rats and rabbits.
Knepper MA, Danielson RA, Saidel GM, Post RS.
Kidney Int. 1977 Nov;12(5):313-23.
[Text Abstract on PubMed]

Mathematical model of renal regulation of urea excretion.
Knepper MA, Saidel GM, Palatt PJ.
Med Biol Eng. 1976 Jul;14(4):408-26.
[Text Abstract on PubMed]

Effects of glucagon on renal function in protein--deprived rats.
Knepper MA, Gunter CV, Danielson RA.
Surg Forum. 1976;27(62):29-31.
[Text Abstract on PubMed]

Effects of dietary protein restriction and glucocorticoid administration on urea excretion in rats.
Knepper MA, Danielson RA, Saidel GM, Johnston KH.
Kidney Int. 1975 Nov;8(5):303-15.
[Text Abstract on PubMed]