Gregory J. Kato, M.D.

Publications

Gregory J. Kato
Investigator

P: +1 301 451 8497
gkato@mail.nih.gov

Atorvastatin reduces serum cholesterol and triglycerides with limited improvement in vascular function in adults with sickle cell anemia.
Bereal-Williams C, Machado RF, McGowan, Chi A, Hunter CJ, Kato GJ.
Haematologica. 2012 Nov;97(11):1768-70.
[Text Abstract on PubMed]

Infrared imaging of nitric oxide-mediated blood flow in human sickle cell disease.
Gorbach AM, Ackerman HC, Liu WM, Meyer JM, Littel PL, Seamon C, Footman E, Chi A, Zorca S, Krajewski ML, Cuttica MJ, Machado RF, Cannon, Kato GJ.
Microvasc. Res. 2012 Nov;84(3):262-9.
[Text Abstract on PubMed]

Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function.
Aicher BO, Haser EK, Freeman LA, Carnie AV, Stonik JA, Wang X, Remaley AT, Kato GJ, Cannon.
Obesity (Silver Spring). 2012 Oct;20(10):2057-62.
[Text Abstract on PubMed]

A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease.
Desai AA, Zhou T, Ahmad H, Zhang W, Mu W, Trevino S, Wade MS, Raghavachari N, Kato GJ, Peters-Lawrence MH, Thiruvoipati T, Turner K, Artz N, Huang Y, Patel AR, Yuan JX, Gordeuk VR, Lang RM, Garcia JG, Machado RF.
Am. J. Respir. Crit. Care Med. 2012 Aug 15;186(4):359-68.
[Text Abstract on PubMed]

Infusion of hemolyzed red blood cells within peripheral blood stem cell grafts in patients with and without sickle cell disease.
Fitzhugh CD, Unno H, Hathaway V, Coles WA, Link ME, Weitzel RP, Zhao X, Wright EC, Stroncek DF, Kato GJ, Hsieh MM, Tisdale JF.
Blood. 2012 Jun 14;119(24):5671-3.
[Text Abstract on PubMed]

TRV: a physiological biomarker in sickle cell disease.
Kato GJ.
Pediatr Blood Cancer. 2012 Jun;58(6):831-2.
[Text Abstract on PubMed]

Mortality in adults with sickle cell disease and pulmonary hypertension.
Mehari A, Gladwin MT, Tian X, Machado RF, Kato GJ.
JAMA. 2012 Mar 28;307(12):1254-6.
[Text Abstract on PubMed]

Framing the research agenda for sickle cell trait: building on the current understanding of clinical events and their potential implications.
Goldsmith JC, Bonham VL, Joiner CH, Kato GJ, Noonan AS, Steinberg MH.
Am. J. Hematol. 2012 Mar;87(3):340-6.
[Text Abstract on PubMed]

Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates.
Novelli EM, Kato GJ, Ragni MV, Zhang Y, Hildesheim ME, Nouraie M, Barge S, Meyer MP, Hassett AC, Gordeuk VR, Gladwin MT, Isenberg JS.
Am. J. Hematol. 2012 Mar;87(3):326-30.
[Text Abstract on PubMed]

High-density lipoprotein cholesterol efflux, nitration of apolipoprotein A-I, and endothelial function in obese women.
Vazquez E, Sethi AA, Freeman L, Zalos G, Chaudhry H, Haser E, Aicher BO, Aponte A, Gucek M, Kato GJ, Waclawiw MA, Remaley AT, Cannon.
Am. J. Cardiol. 2012 Feb 15;109(4):527-32.
[Text Abstract on PubMed]

Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia.
Darbari DS, Onyekwere O, Nouraie M, Minniti CP, Luchtman-Jones L, Rana S, Sable C, Ensing G, Dham N, Campbell A, Arteta M, Gladwin MT, Castro O, Taylor, Kato GJ, Gordeuk V.
J. Pediatr. 2012 Feb;160(2):286-90.
[Text Abstract on PubMed]

Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHL(R200W) mutation (Chuvash polycythemia).
Sable CA, Aliyu ZY, Dham N, Nouraie M, Sachdev V, Sidenko S, Miasnikova GY, Polyakova LA, Sergueeva AI, Okhotin DJ, Bushuev V, Remaley AT, Niu X, Castro OL, Gladwin MT, Kato GJ, Prchal JT, Gordeuk VR.
Haematologica. 2012 Feb;97(2):193-200.
[Text Abstract on PubMed]

Priapism in sickle-cell disease: a hematologist's perspective.
Kato GJ.
J Sex Med. 2012 Jan;9(1):70-8.
[Text Abstract on PubMed]

A systematic comparison and evaluation of high density exon arrays and RNA-seq technology used to unravel the peripheral blood transcriptome of sickle cell disease.
Raghavachari N, Barb J, Yang Y, Liu P, Woodhouse K, Levy D, O'Donnell CJ, Munson PJ, Kato GJ.
BMC Med Genomics. 2012;5:28.
[Text Abstract on PubMed]

Anti-haemolytic effect of senicapoc and decrease in NT-proBNP in adults with sickle cell anaemia.
Minniti CP, Wilson J, Mendelsohn L, Rigdon GC, Stocker JW, Remaley AT, Kato GJ.
Br. J. Haematol. 2011 Dec;155(5):634-6.
[Text Abstract on PubMed]

Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom.
Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Taylor, Hannoush H, Goldsmith JC, Gladwin MT, Gordeuk VR, Walk-PHASST Investigators.
Circulation. 2011 Sep 27;124(13):1452-60.
[Text Abstract on PubMed]

Predictors of osteoclast activity in patients with sickle cell disease.
Nouraie M, Cheng K, Niu X, Moore-King E, Fadojutimi-Akinsi MF, Minniti CP, Sable C, Rana S, Dham N, Campbell A, Ensing G, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR.
Haematologica. 2011 Aug;96(8):1092-8.
[Text Abstract on PubMed]

Laboratory and echocardiography markers in sickle cell patients with leg ulcers.
Minniti CP, Taylor, Hildesheim M, O'Neal P, Wilson J, Castro O, Gordeuk VR, Kato GJ.
Am. J. Hematol. 2011 Aug;86(8):705-8.
[Text Abstract on PubMed]

NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease.
Machado RF, Hildesheim M, Mendelsohn L, Remaley AT, Kato GJ, Gladwin MT.
Br. J. Haematol. 2011 Aug;154(4):512-20.
[Text Abstract on PubMed]

Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity.
Machado RF, Barst RJ, Yovetich NA, Hassell KL, Kato GJ, Gordeuk VR, Gibbs JS, Little JA, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Onyekwere O, Castro OL, Sachdev V, Waclawiw MA, Woolson R, Goldsmith JC, Gladwin MT, walk-PHaSST Investigators and Patients.
Blood. 2011 Jul 28;118(4):855-64.
[Text Abstract on PubMed]

Ancestry of African Americans with sickle cell disease.
Solovieff N, Hartley SW, Baldwin CT, Klings ES, Gladwin MT, Taylor, Kato GJ, Farrer LA, Steinberg MH, Sebastiani P.
Blood Cells Mol. Dis. 2011 Jun 15;47(1):41-5.
[Text Abstract on PubMed]

Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial.
Gladwin MT, Kato GJ, Weiner D, Onyekwere OC, Dampier C, Hsu L, Hagar RW, Howard T, Nuss R, Okam MM, Tremonti CK, Berman B, Villella A, Krishnamurti L, Lanzkron S, Castro O, Gordeuk VR, Coles WA, Peters-Lawrence M, Nichols J, Hall MK, Hildesheim M, Blackwelder WC, Baldassarre J, Casella JF, DeNOVO Investigators.
JAMA. 2011 Mar 2;305(9):893-902.
[Text Abstract on PubMed]

Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia.
Gordeuk VR, Minniti CP, Nouraie M, Campbell AD, Rana SR, Luchtman-Jones L, Sable C, Dham N, Ensing G, Prchal JT, Kato GJ, Gladwin MT, Castro OL.
Haematologica. 2011 Jan;96(1):33-40.
[Text Abstract on PubMed]

The proteome of sickle cell disease: insights from exploratory proteomic profiling.
Yuditskaya S, Suffredini AF, Kato GJ.
Expert Rev Proteomics. 2010 Dec;7(6):833-48.
[Text Abstract on PubMed]

Apolipoprotein A-I and serum amyloid A plasma levels are biomarkers of acute painful episodes in patients with sickle cell disease.
Tumblin A, Tailor A, Hoehn GT, Mack AK, Mendelsohn L, Freeman L, Xu X, Remaley AT, Munson PJ, Suffredini AF, Kato GJ.
Haematologica. 2010 Sep;95(9):1467-72.
[Text Abstract on PubMed]

Increased pulmonary pressures and myocardial wall stress in children with severe malaria.
Janka JJ, Koita OA, Traoré B, Traoré JM, Mzayek F, Sachdev V, Wang X, Sanogo K, Sangaré L, Mendelsohn L, Masur H, Kato GJ, Gladwin MT, Krogstad DJ.
J. Infect. Dis. 2010 Sep 1;202(5):791-800.
[Text Abstract on PubMed]

Pulmonary hypertension and NO in sickle cell.
Gladwin MT, Barst RJ, Castro OL, Gordeuk VR, Hillery CA, Kato GJ, Kim-Shapiro DB, Machado R, Morris CR, Steinberg MH, Vichinsky EP.
Blood. 2010 Aug 5;116(5):852-4.
[Text Abstract on PubMed]

High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension.
Sundaram N, Tailor A, Mendelsohn L, Wansapura J, Wang X, Higashimoto T, Pauciulo MW, Gottliebson W, Kalra VK, Nichols WC, Kato GJ, Malik P.
Blood. 2010 Jul 8;116(1):109-12.
[Text Abstract on PubMed]

Diastolic dysfunction in sickle cell.
Kato GJ, Sachdev V.
Blood. 2010 Jul 8;116(1):1-2.
[Text Abstract on PubMed]

Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia.
Cho CS, Kato GJ, Yang SH, Bae SW, Lee JS, Gladwin MT, Rhee SG.
Antioxid. Redox Signal. 2010 Jul 1;13(1):1-11.
[Text Abstract on PubMed]

NT-proBNP as a marker of cardiopulmonary status in sickle cell anaemia in Africa.
Aliyu ZY, Suleiman A, Attah E, Mamman AI, Babadoko A, Nouraie M, Mendelsohn L, Kato GJ, Gordeuk VR, Gladwin MT.
Br. J. Haematol. 2010 Jul;150(1):102-7.
[Text Abstract on PubMed]

Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia.
Nouraie M, Reading NS, Campbell A, Minniti CP, Rana SR, Luchtman-Jones L, Kato GJ, Gladwin MT, Castro OL, Prchal JT, Gordeuk VR.
Br. J. Haematol. 2010 Jul;150(2):218-25.
[Text Abstract on PubMed]

Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension.
Zorca S, Freeman L, Hildesheim M, Allen D, Remaley AT, Taylor, Kato GJ.
Br. J. Haematol. 2010 May;149(3):436-45.
[Text Abstract on PubMed]

Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension.
Linguraru MG, Pura JA, Van Uitert RL, Mukherjee N, Summers RM, Minniti C, Gladwin MT, Kato G, Machado RF, Wood BJ.
Med Phys. 2010 Apr;37(4):1522-32.
[Text Abstract on PubMed]

Pleiotropic effects of intravascular haemolysis on vascular homeostasis.
Kato GJ, Taylor.
Br. J. Haematol. 2010 Mar;148(5):690-701.
[Text Abstract on PubMed]

Effects of a single sickling event on the mechanical fragility of sickle cell trait erythrocytes.
Presley TD, Perlegas AS, Bain LE, Ballas SK, Nichols JS, Sabio H, Gladwin MT, Kato GJ, Kim-Shapiro DB.
Hemoglobin. 2010;34(1):24-36.
[Text Abstract on PubMed]

Vascular complications after splenectomy for hematologic disorders.
Kato GJ.
Blood. 2009 Dec 17;114(26):5404.
[Text Abstract on PubMed]

Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease.
Minniti CP, Machado RF, Coles WA, Sachdev V, Gladwin MT, Kato GJ.
Br. J. Haematol. 2009 Dec;147(5):737-43.
[Text Abstract on PubMed]

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease.
Gordeuk VR, Campbell A, Rana S, Nouraie M, Niu X, Minniti CP, Sable C, Darbari D, Dham N, Onyekwere O, Ammosova T, Nekhai S, Kato GJ, Gladwin MT, Castro OL.
Blood. 2009 Nov 19;114(21):4639-44.
[Text Abstract on PubMed]

Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients.
Campbell A, Minniti CP, Nouraie M, Arteta M, Rana S, Onyekwere O, Sable C, Ensing G, Dham N, Luchtman-Jones L, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR.
Br. J. Haematol. 2009 Nov;147(3):352-9.
[Text Abstract on PubMed]

Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions.
Kato GJ, Hebbel RP, Steinberg MH, Gladwin MT.
Am. J. Hematol. 2009 Sep;84(9):618-25.
[Text Abstract on PubMed]

Prospective echocardiography assessment of pulmonary hypertension and its potential etiologies in children with sickle cell disease.
Dham N, Ensing G, Minniti C, Campbell A, Arteta M, Rana S, Darbari D, Nouraie M, Onyekwere O, Lasota M, Kato GJ, Gladwin MT, Castro O, Gordeuk V, Sable C.
Am. J. Cardiol. 2009 Sep 1;104(5):713-20.
[Text Abstract on PubMed]

Improvement in hemolysis and pulmonary arterial systolic pressure in adult patients with sickle cell disease during treatment with hydroxyurea.
Olnes M, Chi A, Haney C, May R, Minniti C, Taylor, Kato GJ.
Am. J. Hematol. 2009 Aug;84(8):530-32.
[Text Abstract on PubMed]

Haptoglobin halts hemoglobin's havoc.
Kato GJ.
J. Clin. Invest. 2009 Aug;119(8):2140-2.
[Text Abstract on PubMed]

Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
Kato GJ, Wang Z, Machado RF, Blackwelder WC, Taylor, Hazen SL.
Br. J. Haematol. 2009 May;145(4):506-13.
[Text Abstract on PubMed]

Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy.
Little JA, Hauser KP, Martyr SE, Harris A, Maric I, Morris CR, Suh JH, Taylor J, Castro O, Machado R, Kato G, Gladwin MT.
Eur. J. Haematol. 2009 Apr;82(4):315-21.
[Text Abstract on PubMed]

Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation.
Minniti CP, Sable C, Campbell A, Rana S, Ensing G, Dham N, Onyekwere O, Nouraie M, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR.
Haematologica. 2009 Mar;94(3):340-7.
[Text Abstract on PubMed]

Near-infrared spectra absorbance of blood from sickle cell patients and normal individuals.
Nahavandi M, Nichols JP, Hassan M, Gandjbakhche A, Kato GJ.
Hematology. 2009 Feb;14(1):46-8.
[Text Abstract on PubMed]

Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease.
Yuditskaya S, Tumblin A, Hoehn GT, Wang G, Drake SK, Xu X, Ying S, Chi AH, Remaley AT, Shen RF, Munson PJ, Suffredini AF, Kato GJ.
Blood. 2009 Jan 29;113(5):1122-8.
[Text Abstract on PubMed]

Strategic plan for pediatric respiratory diseases research: an NHLBI working group report.
Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ.
Proc Am Thorac Soc. 2009 Jan 15;6(1):1-10.
[Text Abstract on PubMed]

Strategic plan for pediatric respiratory diseases research: an NHLBI working group report.
Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G, NHLBI working group report.
Pediatr. Pulmonol. 2009 Jan;44(1):2-13.
[Text Abstract on PubMed]

Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease.
Niu X, Nouraie M, Campbell A, Rana S, Minniti CP, Sable C, Darbari D, Dham N, Reading NS, Prchal JT, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR.
PLoS ONE. 2009;4(11):e7956.
[Text Abstract on PubMed]

Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy.
Kato GJ, Gladwin MT.
JAMA. 2008 Dec 10;300(22):2638-46.
[Text Abstract on PubMed]

Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders.
Morris CR, Gladwin MT, Kato GJ.
Curr. Mol. Med. 2008 Nov;8(7):620-32.
[Text Abstract on PubMed]

Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study.
Mack AK, McGowan Ii VR, Tremonti CK, Ackah D, Barnett C, Machado RF, Gladwin MT, Kato GJ.
Br. J. Haematol. 2008 Sep;142(6):971-8.
[Text Abstract on PubMed]

Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in Nigeria.
Aliyu ZY, Gordeuk V, Sachdev V, Babadoko A, Mamman AI, Akpanpe P, Attah E, Suleiman Y, Aliyu N, Yusuf J, Mendelsohn L, Kato GJ, Gladwin MT.
Am. J. Hematol. 2008 Jun;83(6):485-90.
[Text Abstract on PubMed]

Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease.
Strouse JJ, Takemoto CM, Keefer JR, Kato GJ, Casella JF.
Pediatr Blood Cancer. 2008 May;50(5):1006-12.
[Text Abstract on PubMed]

Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia.
Kumkhaek C, Taylor, Zhu J, Hoppe C, Kato GJ, Rodgers GP.
Br. J. Haematol. 2008 Apr;141(2):254-9.
[Text Abstract on PubMed]

Pulmonary hypertension in children and adolescents with sickle cell disease.
Onyekwere OC, Campbell A, Teshome M, Onyeagoro S, Sylvan C, Akintilo A, Hutchinson S, Ensing G, Gaskin P, Kato G, Rana S, Kwagyan J, Gordeuk V, Williams J, Castro O.
Pediatr Cardiol. 2008 Mar;29(2):309-12.
[Text Abstract on PubMed]

Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency.
Gordeuk VR, Sachdev V, Taylor JG, Gladwin MT, Kato G, Castro OL.
Am. J. Hematol. 2008 Jan;83(1):15-8.
[Text Abstract on PubMed]

Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease.
Taylor, Ackah D, Cobb C, Orr N, Percy MJ, Sachdev V, Machado R, Castro O, Kato GJ, Chanock SJ, Gladwin MT.
Am. J. Hematol. 2008 Jan;83(1):6-14.
[Text Abstract on PubMed]

Severe pulmonary hypertension in an adolescent with sickle cell disease.
Taylor, Woods GM, Machado R, Kato GJ, Gladwin MT.
Am. J. Hematol. 2008 Jan;83(1):71-2.
[Text Abstract on PubMed]

Sickle cell disease and pulmonary hypertension in Africa: a global perspective and review of epidemiology, pathophysiology, and management.
Aliyu ZY, Kato GJ, Taylor, Babadoko A, Mamman AI, Gordeuk VR, Gladwin MT.
Am. J. Hematol. 2008 Jan;83(1):63-70.
[Text Abstract on PubMed]

Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and blood) thickens!
Gladwin MT, Kato GJ.
Haematologica. 2008 Jan;93(1):1-3.
[Text Abstract on PubMed]

Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain.
Taylor, Nolan VG, Mendelsohn L, Kato GJ, Gladwin MT, Steinberg MH.
PLoS ONE. 2008;3(5):e2095.
[Text Abstract on PubMed]

Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I.
Kato GJ.
Hematology Am Soc Hematol Educ Program. 2008;:186-92.
[Text Abstract on PubMed]

A network model to predict the risk of death in sickle cell disease.
Sebastiani P, Nolan VG, Baldwin CT, Abad-Grau MM, Wang L, Adewoye AH, McMahon LC, Farrer LA, Taylor, Kato GJ, Gladwin MT, Steinberg MH.
Blood. 2007 Oct 1;110(7):2727-35.
[Text Abstract on PubMed]

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin.
Villagra J, Shiva S, Hunter LA, Machado RF, Gladwin MT, Kato GJ.
Blood. 2007 Sep 15;110(6):2166-72.
[Text Abstract on PubMed]

Pulmonary hypertension in sickle cell disease: relevance to children.
Kato GJ, Onyekwere OC, Gladwin MT.
Pediatr Hematol Oncol. 2007 Apr-May;24(3):159-70.
[Text Abstract on PubMed]

Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease.
Raghavachari N, Xu X, Harris A, Villagra J, Logun C, Barb J, Solomon MA, Suffredini AF, Danner RL, Kato G, Munson PJ, Morris, Gladwin MT.
Circulation. 2007 Mar 27;115(12):1551-62.
[Text Abstract on PubMed]

Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease.
Sachdev V, Machado RF, Shizukuda Y, Rao YN, Sidenko S, Ernst I, St Peter M, Coles WA, Rosing DR, Blackwelder WC, Castro O, Kato GJ, Gladwin MT.
J. Am. Coll. Cardiol. 2007 Jan 30;49(4):472-9.
[Text Abstract on PubMed]

Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes.
Kato GJ, Gladwin MT, Steinberg MH.
Blood Rev. 2007 Jan;21(1):37-47.
[Text Abstract on PubMed]

Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease.
Machado RF, Mack AK, Martyr S, Barnett C, Macarthur P, Sachdev V, Ernst I, Hunter LA, Coles WA, Nichols JP, Kato GJ, Gladwin MT.
Br. J. Haematol. 2007 Jan;136(2):319-25.
[Text Abstract on PubMed]

Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review.
Little JA, McGowan VR, Kato GJ, Partovi KS, Feld JJ, Maric I, Martyr S, Taylor, Machado RF, Heller T, Castro O, Gladwin MT.
Haematologica. 2006 Aug;91(8):1076-83.
[Text Abstract on PubMed]

N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease.
Machado RF, Anthi A, Steinberg MH, Bonds D, Sachdev V, Kato GJ, Taveira-DaSilva AM, Ballas SK, Blackwelder W, Xu X, Hunter L, Barton B, Waclawiw M, Castro O, Gladwin MT, MSH Investigators.
JAMA. 2006 Jul 19;296(3):310-8.
[Text Abstract on PubMed]

Cerebrovascular disease associated with sickle cell pulmonary hypertension.
Kato GJ, Hsieh M, Machado R, Taylor, Little J, Butman JA, Lehky T, Tisdale J, Gladwin MT.
Am. J. Hematol. 2006 Jul;81(7):503-10.
[Text Abstract on PubMed]

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.
Kato GJ, McGowan V, Machado RF, Little JA, Taylor, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris, Gladwin MT.
Blood. 2006 Mar 15;107(6):2279-85.
[Text Abstract on PubMed]

Current therapy of sickle cell disease.
Aliyu ZY, Tumblin AR, Kato GJ.
Haematologica. 2006 Jan;91(1):7-10.
[Text Abstract on PubMed]

Sickle cell disease and nitric oxide: a paradigm shift?
Mack AK, Kato GJ.
Int. J. Biochem. Cell Biol. 2006;38(8):1237-43.
[Text Abstract on PubMed]

Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality.
Kato GJ, Martyr S, Blackwelder WC, Nichols JS, Coles WA, Hunter LA, Brennan ML, Hazen SL, Gladwin MT.
Br. J. Haematol. 2005 Sep;130(6):943-53.
[Text Abstract on PubMed]

Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension.
Machado RF, Martyr S, Kato GJ, Barst RJ, Anthi A, Robinson MR, Hunter L, Coles W, Nichols J, Hunter C, Sachdev V, Castro O, Gladwin MT.
Br. J. Haematol. 2005 Aug;130(3):445-53.
[Text Abstract on PubMed]

Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris, Gladwin MT.
JAMA. 2005 Jul 6;294(1):81-90.
[Text Abstract on PubMed]

Cardiopulmonary complications of sickle cell disease: role of nitric oxide and hemolytic anemia.
Gladwin MT, Kato GJ.
Hematology Am Soc Hematol Educ Program. 2005;:51-7.
[Text Abstract on PubMed]

Hemolysis-associated pulmonary hypertension in thalassemia.
Morris CR, Kuypers FA, Kato GJ, Lavrisha L, Larkin S, Singer T, Vichinsky EP.
Ann. N. Y. Acad. Sci. 2005;1054:481-5.
[Text Abstract on PubMed]

Images in clinical medicine. Tumor pseudosyncytiae.
Kato GJ, Loeb DM.
N. Engl. J. Med. 2003 Apr 3;348(14):1348.
[Text Abstract on PubMed]

Identification and characterization of the novel centrosome-associated protein CCCAP.
Kenedy AA, Cohen KJ, Loveys DA, Kato GJ, Dang CV.
Gene. 2003 Jan 16;303:35-46.
[Text Abstract on PubMed]

Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells.
Ogawa R, Streiff MB, Bugayenko A, Kato GJ.
Blood. 2002 May 1;99(9):3390-7.
[Text Abstract on PubMed]

Homozygous factor-V mutation as a genetic cause of perinatal thrombosis and cerebral palsy.
Harum KH, Hoon, Kato GJ, Casella JF, Breiter SN, Johnston MV.
Dev Med Child Neurol. 1999 Nov;41(11):777-80.
[Text Abstract on PubMed]

Human genetic diseases of proteolysis.
Kato GJ.
Hum. Mutat. 1999;13(2):87-98.
[Text Abstract on PubMed]

The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors.
Loveys DA, Streiff MB, Schaefer TS, Kato GJ.
Gene. 1997 Nov 12;201(1-2):169-77.
[Text Abstract on PubMed]

Successful treatment of life-threatening acute chest syndrome of sickle cell disease with venovenous extracorporeal membrane oxygenation.
Pelidis MA, Kato GJ, Resar LM, Dover GJ, Nichols DG, Walker LK, Casella JF.
J. Pediatr. Hematol. Oncol. 1997 Sep-Oct;19(5):459-61.
[Text Abstract on PubMed]

E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein.
Loveys DA, Streiff MB, Kato GJ.
Nucleic Acids Res. 1996 Jul 15;24(14):2813-20.
[Text Abstract on PubMed]

High glucocorticoid receptor content of leukemic blasts is a favorable prognostic factor in childhood acute lymphoblastic leukemia.
Kato GJ, Quddus FF, Shuster JJ, Boyett J, Pullen JD, Borowitz MJ, Whitehead VM, Crist WM, Leventhal BG.
Blood. 1993 Oct 15;82(8):2304-9.
[Text Abstract on PubMed]

Function of the c-Myc oncoprotein.
Kato GJ, Dang CV.
FASEB J. 1992 Sep;6(12):3065-72.
[Text Abstract on PubMed]

Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells.
Barrett J, Birrer MJ, Kato GJ, Dosaka-Akita H, Dang CV.
Mol. Cell. Biol. 1992 Jul;12(7):3130-7.
[Text Abstract on PubMed]

Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins.
Dang CV, Dolde C, Gillison ML, Kato GJ.
Proc. Natl. Acad. Sci. U.S.A. 1992 Jan 15;89(2):599-602.
[Text Abstract on PubMed]

DNA binding by the Myc oncoproteins.
Kato GJ, Wechsler DS, Dang CV.
Cancer Treat. Res. 1992;63:313-25.
[Text Abstract on PubMed]

Max: functional domains and interaction with c-Myc.
Kato GJ, Lee WM, Chen LL, Dang CV.
Genes Dev. 1992 Jan;6(1):81-92.
[Text Abstract on PubMed]

Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization.
Dang CV, Barrett J, Villa-Garcia M, Resar LM, Kato GJ, Fearon ER.
Mol. Cell. Biol. 1991 Feb;11(2):954-62.
[Text Abstract on PubMed]

Low-dose methotrexate therapy for hepatoblastoma.
Weitman SD, Kato GJ, Barbosa JL, Kamen BA.
Cancer Chemother. Pharmacol. 1991;28(3):233-4.
[Text Abstract on PubMed]

A potential transcriptional activation element in the p53 protein.
O'Rourke RW, Miller CW, Kato GJ, Simon KJ, Chen DL, Dang CV, Koeffler HP.
Oncogene. 1990 Dec;5(12):1829-32.
[Text Abstract on PubMed]

Childhood Hodgkin and non-Hodgkin lymphomas.
Leventhal BG, Kato GJ.
Pediatr Rev. 1990 Dec;12(6):171-9.
[Text Abstract on PubMed]

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.
Kato GJ, Barrett J, Villa-Garcia M, Dang CV.
Mol. Cell. Biol. 1990 Nov;10(11):5914-20.
[Text Abstract on PubMed]

Steroid receptors, transcription factors, and gene expression. AACR special conference in cancer research.
Denner L, Ji HJ, Owen RD, Kato GJ, Clarke CL, Lee HY, Richardson PM, Pati UK.
Cancer Res. 1990 Oct 1;50(19):6430-5.
[Text Abstract on PubMed]