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Andrew Johnson, Ph.D.

Andrew Johnson
Andrew Johnson, Ph.D.
Building PERINI Room SUITE 2
Framingham, MA 01702
P: +1 (508) 663-4082


Andrew Johnson earned a B.S. in vertebrate physiology from the Pennsylvania State University in 1998. He subsequently worked on gene regulatory research in C. elegans and neuroelectrophysiology in rodents before entering graduate school in 2003. He earned a Ph.D. in biomedical sciences from Ohio State University in 2007 with dual emphases in bioinformatics and pharmacogenomics. He came to the NIH for post-doctoral training in 2007 and became a tenure track investigator in 2012. Dr. Johnson has been nominated for and received numerous awards including the NHLBI Lenfant Fellowship and Genome Technology’s Young Investigator Award, and was elected as a Fellow of the American Heart Association. He has published more than 100 papers and has served as a reviewer for more than 20 journals. Dr. Johnson is active on several committees of the Functional Genomics and Translational Biology Council of the American Heart Association. He is also a member of the American Society for Human Genetics and the International Society for Computational Biology.

Research Interests

Cardiovascular disease (CVD) has a complex etiology, and CVD patients show a wide range of responses to therapeutic interventions. Dr. Johnson’s laboratory research focuses on understanding genetic and genomic underpinnings of this individual variability in therapeutically targeted CVD pathways. In particular, his work focuses on understanding individual variability in platelet development, function, and response to treatment. Drugs that decrease platelet reactivity, such as aspirin, are commonly used to reduce the risks of cardiovascular events such as myocardial infarction. Dr. Johnson is interested in the pharmacogenetics of anti-platelet treatments and resulting CVD outcomes. His laboratory applies population-scale approaches to the problem including genetic studies, collaboration with clinician-scientists, studies of gene expression variability in human tissues, and bioinformatics and systems biology approaches. His group makes particular use of the Framingham Heart Study and the rich amount of epidemiologic and genetic data it has accumulated over the years.

Additionally, the Johnson laboratory creates and applies cutting edge genomic and bioinformatics resources. To date these resources include SNAP (SNP Annotation and Proxy Search), a fast human linkage disequilibrium query and annotation interface for worldwide population genetic samples; and GRASP (Genome-wide Repository of Associations between SNPs and Phenotypes), one of the largest and deepest databases of human genetic associations.

In addition to advancing the goals of his research group and others at the NHLBI, these resources will also be made freely available to benefit the wider scientific community, and help advance our understanding of CVD variability.

Selected Publications

Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study.
Johnson AD, Hwang SJ, Voorman A, Morrison A, Peloso GM, Hsu YH, Thanassoulis G, Newton-Cheh C, Rogers IS, Hoffmann U, Freedman JE, Fox CS, Psaty BM, Boerwinkle E, Cupples LA, O'Donnell CJ
Circulation 2013 Feb 19;127(7):799-810.
The genetics of common variation affecting platelet development, function and pharmaceutical targeting.
Johnson AD
J. Thromb. Haemost. 2011 Jul;9 Suppl 1:246-57.
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
Johnson AD, Yanek LR, Chen MH, Faraday N, Larson MG, Tofler G, Lin SJ, Kraja AT, Province MA, Yang Q, Becker DM, O'Donnell CJ, Becker LC
Nat. Genet. 2010 Jul;42(7):608-13.
An open access database of genome-wide association results.
Johnson AD, O'Donnell CJ
BMC Med. Genet. 2009;10:6.
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap.
Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O'Donnell CJ, de Bakker PI
Bioinformatics 2008 Dec 15;24(24):2938-9.
Andrew Johnson's Full List of Publications